8I5D
| Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (VVGAVGVGK) | 分子名称: | Beta-2-microglobulin, MHC class I antigen (Fragment), TCR alpha chain, ... | 著者 | Lu, D, Chen, Y, Jiang, M, Tan, S.G, Chai, Y, Gao, G.F. | 登録日 | 2023-01-25 | 公開日 | 2023-08-23 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (VVGAVGVGK) Nat Commun, 2023
|
|
5LPJ
| |
5LTL
| |
8HUA
| Serial synchrotron crystallography structure of ba3-type cytochrome c oxidase from Thermus thermophilus using a goniometer compatible flow-cell | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, COPPER (II) ION, Cytochrome c oxidase polypeptide 2A, ... | 著者 | Ghosh, S, Zoric, D, Bjelcic, M, Johannesson, J, Sandelin, E, Branden, G, Neutze, R. | 登録日 | 2022-12-22 | 公開日 | 2023-03-01 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | A simple goniometer-compatible flow cell for serial synchrotron X-ray crystallography. J.Appl.Crystallogr., 56, 2023
|
|
5LPK
| |
5LVX
| Crystal structure of glucocerebrosidase with an inhibitory quinazoline modulator | 分子名称: | 11-[(2~{R})-2-[(2-pyridin-3-ylquinazolin-4-yl)amino]-2,3-dihydro-1~{H}-inden-5-yl]undec-10-ynoic acid, 11-[(2~{S})-2-[(2-pyridin-3-ylquinazolin-4-yl)amino]-2,3-dihydro-1~{H}-inden-5-yl]undec-10-ynoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zheng, J, Chen, L, Skinner, O.S, Lansbury, P, Skerlj, R, Mrosek, M, Heunisch, U, Krapp, S, Weigand, S, Charrow, J, Schwake, M, Kelleher, N.L, Silverman, R.B, Krainc, D. | 登録日 | 2016-09-14 | 公開日 | 2017-10-25 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | beta-Glucocerebrosidase Modulators Promote Dimerization of beta-Glucocerebrosidase and Reveal an Allosteric Binding Site. J. Am. Chem. Soc., 140, 2018
|
|
8IF4
| Structure of human alpha-2/delta-1 without mirogabalin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Voltage-dependent calcium channel subunit alpha-2/delta-1 | 著者 | Kozai, D, Numoto, N, Fujiyoshi, Y. | 登録日 | 2023-02-17 | 公開日 | 2023-04-05 | 最終更新日 | 2023-04-12 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Recognition Mechanism of a Novel Gabapentinoid Drug, Mirogabalin, for Recombinant Human alpha 2 delta 1, a Voltage-Gated Calcium Channel Subunit. J.Mol.Biol., 435, 2023
|
|
8IF3
| Structure of human alpha-2/delta-1 with mirogabalin | 分子名称: | 2-[(1R,5S,6S)-6-(aminomethyl)-3-ethyl-6-bicyclo[3.2.0]hept-3-enyl]acetic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kozai, D, Numoto, N, Fujiyoshi, Y. | 登録日 | 2023-02-17 | 公開日 | 2023-04-05 | 最終更新日 | 2023-04-12 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Recognition Mechanism of a Novel Gabapentinoid Drug, Mirogabalin, for Recombinant Human alpha 2 delta 1, a Voltage-Gated Calcium Channel Subunit. J.Mol.Biol., 435, 2023
|
|
8IHP
| Structure of Semliki Forest virus VLP in complex with the receptor VLDLR-LA3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Capsid protein, ... | 著者 | Cao, D, Ma, B, Cao, Z, Zhang, X, Xiang, Y. | 登録日 | 2023-02-23 | 公開日 | 2023-04-12 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure of Semliki Forest virus in complex with its receptor VLDLR. Cell, 186, 2023
|
|
5LPL
| Crystal structure of the bromodomain of human CREBBP bound to the inhibitor XDM3c | 分子名称: | CREB-binding protein, ~{N}-[(1~{R},2~{R})-7-chloranyl-2-oxidanyl-1,2,3,4-tetrahydronaphthalen-1-yl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide | 著者 | Wohlwend, D, Huegle, M. | 登録日 | 2016-08-13 | 公開日 | 2017-08-16 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles. Angew. Chem. Int. Ed. Engl., 56, 2017
|
|
7O4W
| |
6Z3Z
| |
5LPM
| Crystal structure of the bromodomain of human Ep300 bound to the inhibitor XDM3d | 分子名称: | ACETATE ION, Histone acetyltransferase p300, ~{N}-[(1~{S},2~{S})-7-chloranyl-2-oxidanyl-1,2,3,4-tetrahydronaphthalen-1-yl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole -2-carboxamide | 著者 | Huegle, M, Wohlwend, D, Gerhardt, S. | 登録日 | 2016-08-13 | 公開日 | 2017-08-16 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles. Angew. Chem. Int. Ed. Engl., 56, 2017
|
|
5LMD
| The crystal structure of hCA II in complex with a benzoxaborole inhibitor | 分子名称: | 1-[7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1,3,5-trien-4-yl]-3-(2-methoxy-5-methyl-phenyl)urea, Carbonic anhydrase 2, ZINC ION | 著者 | De Simone, G, Alterio, V, Esposito, D, Di Fiore, A. | 登録日 | 2016-07-29 | 公開日 | 2016-10-19 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Benzoxaborole as a new chemotype for carbonic anhydrase inhibition. Chem.Commun.(Camb.), 52, 2016
|
|
5LOC
| |
8I5C
| Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (VVGAVGVGK) | 分子名称: | Beta-2-microglobulin, MHC class I antigen (Fragment), TCR alpha chain, ... | 著者 | Lu, D, Chen, Y, Jiang, M, Tan, S.G, Chai, Y, Gao, G.F. | 登録日 | 2023-01-24 | 公開日 | 2023-08-23 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (3.34 Å) | 主引用文献 | Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (VVGAVGVGK) Nat Commun, 2023
|
|
5LCN
| |
8I5E
| Crystal structure of HLA-A*11:01 in complex with KRAS peptide (VVGAGGVGK) | 分子名称: | Beta-2-microglobulin, KRAS-G12wt-9, MHC class I antigen (Fragment) | 著者 | Lu, D, Chen, Y, Jiang, M, Tan, S.G, Chai, Y, Gao, G.F. | 登録日 | 2023-01-25 | 公開日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (VVGAVGVGK) Nat Commun, 2023
|
|
8IMX
| Cryo-EM structure of GPI-T with a chimeric GPI-anchored protein | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Xu, Y, Li, T, Qu, Q, Li, D. | 登録日 | 2023-03-07 | 公開日 | 2023-08-16 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Structures of liganded glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis. Nat Commun, 14, 2023
|
|
8IHS
| Cryo-EM structure of ochratoxin A-detoxifying amidohydrolase ADH3 in complex with ochratoxin A | 分子名称: | (2~{S})-2-[[(3~{R})-5-chloranyl-3-methyl-8-oxidanyl-1-oxidanylidene-3,4-dihydroisochromen-7-yl]carbonylamino]-3-phenyl-propanoic acid, Amidohydrolase family protein, ZINC ION | 著者 | Dai, L.H, Niu, D, Huang, J.-W, Li, X, Shen, P.P, Li, H, Hu, Y.M, Yang, Y, Chen, C.-C, Guo, R.-T. | 登録日 | 2023-02-23 | 公開日 | 2023-08-30 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Cryo-EM structure and rational engineering of a superefficient ochratoxin A-detoxifying amidohydrolase. J Hazard Mater, 458, 2023
|
|
8IM5
| |
8IMY
| Cryo-EM structure of GPI-T (inactive mutant) with GPI and proULBP2, a proprotein substrate | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Li, T, Xu, Y, Qu, Q, Li, D. | 登録日 | 2023-03-07 | 公開日 | 2023-08-16 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Structures of liganded glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis. Nat Commun, 14, 2023
|
|
5LJN
| Structure of the HOIP PUB domain bound to SPATA2 PIM peptide | 分子名称: | E3 ubiquitin-protein ligase RNF31, GLYCEROL, SULFATE ION, ... | 著者 | Elliott, P.R, Komander, D. | 登録日 | 2016-07-18 | 公開日 | 2016-08-24 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | 主引用文献 | SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling. Mol.Cell, 63, 2016
|
|
4CRF
| Creating novel F1 inhibitors through fragment based lead generation and structure aided drug design | 分子名称: | CHLORIDE ION, Coagulation factor XIa light chain, GLYCEROL, ... | 著者 | Sandmark, J, Oster, L, Fjellstrom, O, Akkaya, S, Beisel, H.G, Eriksson, P.O, Erixon, K, Gustafsson, D, Jurva, U, Kang, D, Karis, D, Knecht, W, Nerme, V, Nilsson, I, Olsson, T, Redzic, A, Roth, R, Tigerstrom, A. | 登録日 | 2014-02-26 | 公開日 | 2015-02-11 | 最終更新日 | 2022-05-04 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Creating Novel Activated Factor Xi Inhibitors Through Fragment Based Lead Generation and Structure Aided Drug Design. Plos One, 10, 2015
|
|
6TLZ
| N-Domain P40/P90 Mycoplasma pneumoniae complexed with 3'SL | 分子名称: | Mgp-operon protein 3, N-acetyl-alpha-neuraminic acid, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, ... | 著者 | Vizarraga, D, Aparicio, D, Illanes, R, Fita, I, Perez-Luque, R, Martin, J. | 登録日 | 2019-12-03 | 公開日 | 2020-11-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Immunodominant proteins P1 and P40/P90 from human pathogen Mycoplasma pneumoniae. Nat Commun, 11, 2020
|
|