3KKZ
| Crystal structure of the Q5LES9_BACFN protein from Bacteroides fragilis. Northeast Structural Genomics Consortium Target BfR250. | 分子名称: | S-ADENOSYLMETHIONINE, uncharacterized protein Q5LES9 | 著者 | Vorobiev, S, Neely, H, Seetharaman, J, Wang, D, Ciccosanti, C, Foote, E.L, Sahdev, S, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2009-11-06 | 公開日 | 2009-11-24 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (1.677 Å) | 主引用文献 | Crystal structure of the Q5LES9_BACFN protein from Bacteroides fragilis. To be Published
|
|
4GCH
| |
6SZ2
| Crystal structure of YTHDC1 with fragment 3 (DHU_DC1_149) | 分子名称: | SULFATE ION, YTH domain-containing protein 1, ~{N}-methyl-1,6-naphthyridin-4-amine | 著者 | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | 登録日 | 2019-10-01 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
|
|
6STA
| Crystal structure of the strawberry pathogenesis-related 10 (PR-10) Fra a 1.02 protein, E46A D48A mutant | 分子名称: | Major strawberry allergen Fra a 1-2 | 著者 | Orozco-Navarrete, B, Kaczmarska, Z, Dupeux, F, Pott, D, Diaz Perales, A, Casanal, A, Marquez, J.A, Valpuesta, V, Merchante, C. | 登録日 | 2019-09-10 | 公開日 | 2019-12-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Structural Bases for the Allergenicity of Fra a 1.02 in Strawberry Fruits. J.Agric.Food Chem., 68, 2020
|
|
6FI0
| Crystal structure of BAZ2A PHD zinc finger in complex with Fr 19 | 分子名称: | 2-azanyl-1-(6,7-dihydro-4~{H}-thieno[3,2-c]pyridin-5-yl)ethanone, Bromodomain adjacent to zinc finger domain protein 2A, GLYCEROL, ... | 著者 | Amato, A, Lucas, X, Bortoluzzi, A, Wright, D, Ciulli, A. | 登録日 | 2018-01-16 | 公開日 | 2018-03-21 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach. ACS Chem. Biol., 13, 2018
|
|
6SXH
| Crystal structure of the accessory translocation ATPase, SecA2, from Clostridium difficile | 分子名称: | Protein translocase subunit SecA 2 | 著者 | Lindic, N, Loboda, J, Usenik, A, Turk, D. | 登録日 | 2019-09-26 | 公開日 | 2020-10-07 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of the accessory translocation ATPase, SecA2, from Clostridium difficile To Be Published
|
|
3KP1
| Crystal structure of ornithine 4,5 aminomutase (Resting State) | 分子名称: | 5'-DEOXYADENOSINE, COBALAMIN, D-ornithine aminomutase E component, ... | 著者 | Wolthers, K.R, Levy, C.W, Scrutton, N.S, Leys, D. | 登録日 | 2009-11-14 | 公開日 | 2010-01-26 | 最終更新日 | 2019-10-30 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Large-scale domain dynamics and adenosylcobalamin reorientation orchestrate radical catalysis in ornithine 4,5-aminomutase. J.Biol.Chem., 285, 2010
|
|
3KOW
| Crystal Structure of ornithine 4,5 aminomutase backsoaked complex | 分子名称: | 5'-DEOXYADENOSINE, COBALAMIN, D-ornithine aminomutase E component, ... | 著者 | Wolthers, K.R, Levy, C.W, Scrutton, N.S, Leys, D. | 登録日 | 2009-11-14 | 公開日 | 2010-01-26 | 最終更新日 | 2012-10-24 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Large-scale domain dynamics and adenosylcobalamin reorientation orchestrate radical catalysis in ornithine 4,5-aminomutase. J.Biol.Chem., 285, 2010
|
|
6FKO
| Deoxyguanylosuccinate synthase (DgsS) quaternary structure with ATP, dGMP, hadacidin at 2.1 Angstrom resolution | 分子名称: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Adenylosuccinate synthetase, ... | 著者 | Sleiman, D, Loc'h, J, Haouz, A, Kaminski, P.A. | 登録日 | 2018-01-24 | 公開日 | 2019-06-26 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Deoxyguanylosuccinate synthase (DgsS) quaternary structure with ATP, dGMP, HAdacidin at 2.1 Angstrom resolution To Be Published
|
|
6FFA
| FMDV Leader protease bound to substrate ISG15 | 分子名称: | GLYCEROL, Lbpro, SULFATE ION, ... | 著者 | Swatek, K.N, Pruneda, J.N, Komander, D. | 登録日 | 2018-01-05 | 公開日 | 2018-02-21 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
6T08
| Crystal structure of YTHDC1 with fragment 21 (DHU_DC1_131) | 分子名称: | SULFATE ION, YTHDC1, ~{N}-(1~{H}-imidazol-2-yl)thiophene-2-sulfonamide | 著者 | Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. | 登録日 | 2019-10-02 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | 主引用文献 | Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
|
|
3KRU
| Crystal Structure of the Thermostable Old Yellow Enzyme from Thermoanaerobacter pseudethanolicus E39 | 分子名称: | ACETATE ION, FLAVIN MONONUCLEOTIDE, NADH:flavin oxidoreductase/NADH oxidase | 著者 | Adalbjornsson, B.V, Toogood, H.S, Leys, D, Scrutton, N.S. | 登録日 | 2009-11-19 | 公開日 | 2009-12-08 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Biocatalysis with thermostable enzymes: structure and properties of a thermophilic 'ene'-reductase related to old yellow enzyme. Chembiochem, 11, 2010
|
|
6FFW
| Phosphotriesterase PTE_A53_5 | 分子名称: | (4~{S},6~{R})-2,2,6-trimethyl-1,3-dioxan-4-ol, 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | 著者 | Dym, O, Aggarwal, N, Albeck, S, Unger, T, Hamer Rogotner, S, Silman, I, Leader, H, Ashani, Y, Goldsmith, M, Greisen, P, Tawfik, D, Sussman, L.J. | 登録日 | 2018-01-09 | 公開日 | 2019-03-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.495 Å) | 主引用文献 | Phosphotriesterase
PTE_A53_5 To Be Published
|
|
6FGU
| Crystal Structure of BAZ2B bromodomain in complex with 1-methylpyridinone compound 4 | 分子名称: | 1-methyl-6-oxidanylidene-~{N}-(2-pyrrolidin-1-ylethyl)pyridine-3-carboxamide, Bromodomain adjacent to zinc finger domain protein 2B | 著者 | Dalle Vedove, A, Spiliotopoulos, D, Lolli, G, Caflisch, A. | 登録日 | 2018-01-11 | 公開日 | 2018-05-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains. ChemMedChem, 13, 2018
|
|
6T1H
| OXA-51-like beta-lactamase OXA-66 | 分子名称: | Beta-lactamase OXA-66, ZINC ION | 著者 | Takebayashi, Y, Chirgadze, D, Henderson, S, Warburton, P.J, Evans, B.E. | 登録日 | 2019-10-04 | 公開日 | 2020-10-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure of the OXA-51-like beta-lactamase OXA-66 To Be Published
|
|
3KTM
| Structure of the Heparin-induced E1-Dimer of the Amyloid Precursor Protein (APP) | 分子名称: | (3R)-butane-1,3-diol, ACETATE ION, Amyloid beta A4 protein, ... | 著者 | Dahms, S.O, Hoefgen, S, Roeser, D, Schlott, B, Guhrs, K.H, Than, M.E. | 登録日 | 2009-11-25 | 公開日 | 2010-02-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
6FLF
| |
3KVZ
| Structural basis of the activity and substrate specificity of the fluoroacetyl-CoA thiesterase FlK - wild type FlK in complex with FAcCPan | 分子名称: | (2R)-N-{3-[(5-fluoro-4-oxopentyl)amino]-3-oxopropyl}-2,4-dihydroxy-3,3-dimethylbutanamide, Fluoroacetyl-CoA thioesterase FlK | 著者 | Dias, M.V.B, Huang, F, Chirgadze, D.Y, Tosin, M, Spiteller, D, Valentine, E.F, Leadlay, P.F, Spencer, J.B, Blundell, T.L. | 登録日 | 2009-11-30 | 公開日 | 2010-04-28 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK. J.Biol.Chem., 285, 2010
|
|
3KVI
| Structural basis of the activity and substrate specificity of the fluoroacetyl-CoA thioesterase FlK - T42A mutant in complex with fluoro-acetate | 分子名称: | Fluoroacetyl-CoA thioesterase FlK, fluoroacetic acid | 著者 | Dias, M.V.B, Huang, F, Chirgadze, D.Y, Tosin, M, Spiteller, D, Valentine, E.F, Leadlay, P.F, Spencer, J.B, Blundell, T.L. | 登録日 | 2009-11-30 | 公開日 | 2010-04-28 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK. J.Biol.Chem., 285, 2010
|
|
3KZH
| |
6FQD
| Escherichia Coli Signal Recognition Particle Receptor FtsY NGdN1 | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, POTASSIUM ION, Signal recognition particle receptor FtsY | 著者 | Mrusek, D. | 登録日 | 2018-02-13 | 公開日 | 2018-05-09 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.10000563 Å) | 主引用文献 | Co-translational Folding Intermediate Dictates Membrane Targeting of the Signal Recognition Particle Receptor. J. Mol. Biol., 430, 2018
|
|
6FQI
| GluA2(flop) G724C ligand binding core dimer bound to L-Glutamate (Form B) at 2.91 Angstrom resolution | 分子名称: | GLUTAMIC ACID, Glutamate receptor 2 | 著者 | Coombs, I.D, Soto, D, Gold, M.G, Farrant, M.F, Cull-Candy, S.G. | 登録日 | 2018-02-14 | 公開日 | 2019-03-13 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.91001153 Å) | 主引用文献 | Homomeric GluA2(R) AMPA receptors can conduct when desensitized. Nat Commun, 10, 2019
|
|
3L04
| Crystal structure of N-acetyl-L-ornithine transcarbamylase E92P mutant complexed with carbamyl phosphate and N-succinyl-L-norvaline | 分子名称: | N-(3-CARBOXYPROPANOYL)-L-NORVALINE, N-acetylornithine carbamoyltransferase, PHOSPHORIC ACID MONO(FORMAMIDE)ESTER, ... | 著者 | Shi, D, Yu, X, Allewell, N.M, Tuchman, M. | 登録日 | 2009-12-09 | 公開日 | 2010-03-31 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A single mutation in the active site swaps the substrate specificity of N-acetyl-L-ornithine transcarbamylase and N-succinyl-L-ornithine transcarbamylase. Protein Sci., 16, 2007
|
|
6FS1
| MCL1 in complex with an indole acid ligand | 分子名称: | 1,2-ETHANEDIOL, 7-[3-[(1,5-dimethylpyrazol-3-yl)methylsulfanylmethyl]-1,5-dimethyl-pyrazol-4-yl]-3-(3-naphthalen-1-yloxypropyl)-1~{H}-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | 著者 | Kasmirski, S, Hargreaves, D. | 登録日 | 2018-02-18 | 公開日 | 2018-12-26 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia. Nat Commun, 9, 2018
|
|
3L0L
| |