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PDB: 22172 件
1G6G
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X-RAY STRUCTURE OF THE N-TERMINAL FHA DOMAIN FROM S. CEREVISIAE RAD53P IN COMPLEX WITH A PHOSPHOTHREONINE PEPTIDE AT 1.6 A RESOLUTION
分子名称: PROTEIN KINASE RAD53, SER-LEU-GLU-VAL-TPO-GLU-ALA-ASPALA-THR-PHE-ALA-LYS
著者Durocher, D, Taylor, I.A.
登録日2000-11-06
公開日2000-12-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms.
Mol.Cell, 6, 2000
4JVE
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Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
分子名称: (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid, E3 ubiquitin-protein ligase Mdm2
著者Huang, X, Gonzalez-Lopez de Turiso, F, Sun, D, Yosup, R, Bartberger, M.D, Beck, H.P, Cannon, J, Shaffer, P, Oliner, J.D, Olson, S.H, Medina, J.C.
登録日2013-03-25
公開日2013-05-01
最終更新日2013-06-05
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors.
J.Med.Chem., 56, 2013
1TLO
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High resolution crystal structure of calpain I protease core in complex with E64
分子名称: CALCIUM ION, Calpain 1, large [catalytic] subunit, ...
著者Moldoveanu, T, Campbell, R.L, Cuerrier, D, Davies, P.L.
登録日2004-06-09
公開日2004-11-02
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal Structures of Calpain-E64 and -Leupeptin Inhibitor Complexes Reveal Mobile Loops Gating the Active Site
J.Mol.Biol., 343, 2004
1UWH
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The complex of wild type B-RAF and BAY439006.
分子名称: 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE, CHLORIDE ION
著者Barford, D, Roe, S.M, Wan, P.T.C, Cancer Genome Project
登録日2004-02-05
公開日2004-03-19
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Mechanism of Activation of the Raf-Erk Signaling Pathway by Oncogenic Mutations of B-Raf
Cell(Cambridge,Mass.), 116, 2004
1UT5
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Divalent metal ions (manganese) bound to T5 5'-exonuclease
分子名称: EXODEOXYRIBONUCLEASE, MANGANESE (II) ION
著者Ceska, T.A, Sayers, J.R, Suck, D.
登録日2003-12-04
公開日2004-02-05
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Roles of Divalent Metal Ions in Flap Endonuclease-Substrate Interactions
Nat.Struct.Mol.Biol., 11, 2004
1UT8
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Divalent metal ions (zinc) bound to T5 5'-exonuclease
分子名称: EXODEOXYRIBONUCLEASE, ZINC ION
著者Ceska, T.A, Sayers, J.R, Suck, D.
登録日2003-12-04
公開日2004-02-05
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Roles of Divalent Metal Ions in Flap Endonuclease-Substrate Interactions
Nat.Struct.Mol.Biol., 11, 2004
1H3O
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Crystal Structure of the Human TAF4-TAF12 (TAFII135-TAFII20) Complex
分子名称: TRANSCRIPTION INITIATION FACTOR TFIID 135 KDA SUBUNIT, TRANSCRIPTION INITIATION FACTOR TFIID 20/15 KDA SUBUNITS
著者Werten, S, Mitschler, A, Moras, D.
登録日2002-09-12
公開日2002-09-26
最終更新日2019-07-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structure of a Subcomplex of Human Transcription Factor TFIID Formed by TATA Binding Protein-Associated Factors Htaf4 (Htaf(II)135) and Htaf12 (Htaf(II)20).
J.Biol.Chem., 277, 2002
1H6B
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Reduced Precursor Form of Glucose-Fructose Oxidoreductase from Zymomonas mobilis complexed with glycerol
分子名称: GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PRECURSOR FORM OF GLUCOSE-FRUCTOSE OXIDOREDUCTASE
著者Nurizzo, D, Baker, E.N.
登録日2001-06-11
公開日2001-11-28
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structures of the Precursor Form of Glucose-Fructose Oxidoreductase from Zymomonas Mobilis and its Complexes with Bound Ligands
Biochemistry, 40, 2001
1UWJ
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The complex of mutant V599E B-RAF and BAY439006.
分子名称: 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
著者Barford, D, Roe, S.M, Wan, P.T.C, Cancer Genome Project
登録日2004-02-05
公開日2004-03-19
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Mechanism of Activation of the Raf-Erk Signaling Pathway by Oncogenic Mutations of B-Raf
Cell(Cambridge,Mass.), 116, 2004
1GZN
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Structure of PKB kinase domain
分子名称: RAC-BETA SERINE/THREONINE PROTEIN KINASE
著者Barford, D, Yang, J, Hemmings, B.A.
登録日2002-05-24
公開日2003-05-22
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Molecular Mechanism for the Regulation of Protein Kinase B/Akt by Hydrophobic Motif Phosphorylation
Mol.Cell, 9, 2002
1GZO
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Structure of protein kinase B unphosphorylated
分子名称: RAC-BETA SERINE/THREONINE PROTEIN KINASE
著者Barford, D, Yang, J, Hemmings, B.A.
登録日2002-05-24
公開日2003-05-22
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Molecular Mechanism for the Regulation of Protein Kinase B/Akt by Hydrophobic Motif Phosphorylation
Mol.Cell, 9, 2002
1H4K
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Sulfurtransferase from Azotobacter vinelandii in complex with hypophosphite
分子名称: 1,2-ETHANEDIOL, HYPOPHOSPHITE, SULFATE ION, ...
著者Bordo, D, Forlani, F, Spallarossa, A, Colnaghi, R, Carpen, A, Pagani, S, Bolognesi, M.
登録日2001-05-11
公開日2002-05-16
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献A Persulfurated Cysteine Promotes Active Site Reactivity in Azotobacter Vinelandii Rhodanse
Biol.Chem., 382, 2001
1GZK
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Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation
分子名称: RAC-BETA SERINE/THREONINE PROTEIN KINASE
著者Barford, D, Yang, J, Hemmings, B.A.
登録日2002-05-23
公開日2003-05-22
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Molecular Mechanism for the Regulation of Protein Kinase B/Akt by Hydrophobic Motif Phosphorylation
Mol.Cell, 9, 2002
1H6C
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BU of 1h6c by Molmil
Oxidized Precursor Form of Glucose-Fructose Oxidoreductase from Zymomonas mobilis complexed with succinate
分子名称: GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PRECURSOR FORM OF GLUCOSE-FRUCTOSE OXIDOREDUCTASE, ...
著者Nurizzo, D, Baker, E.N.
登録日2001-06-11
公開日2001-11-28
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal Structures of the Precursor Form of Glucose-Fructose Oxidoreductase from Zymomonas Mobilis and its Complexes with Bound Ligands
Biochemistry, 40, 2001
1H4M
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Sulfurtransferase from Azotobacter vinelandii in complex with phosphate
分子名称: 1,2-ETHANEDIOL, PUTATIVE THIOSULFATE SULFURTRANSFERASE
著者Bordo, D, Forlani, F, Spallarossa, A, Colnaghi, R, Carpen, A, Pagani, S, Bolognesi, M.
登録日2001-05-11
公開日2002-05-16
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A Persulfurated Cysteine Promotes Active Site Reactivity in Azotobacter Vinelandii Rhodanse
Biol.Chem., 382, 2001
1H6D
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BU of 1h6d by Molmil
Oxidized Precursor Form of Glucose-Fructose Oxidoreductase from Zymomonas mobilis complexed with glycerol
分子名称: GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PRECURSOR FORM OF GLUCOSE-FRUCTOSE OXIDOREDUCTASE
著者Nurizzo, D, Baker, E.N.
登録日2001-06-12
公開日2001-11-28
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal Structures of the Precursor Form of Glucose-Fructose Oxidoreductase from Zymomonas Mobilis and its Complexes with Bound Ligands
Biochemistry, 40, 2001
1H6A
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BU of 1h6a by Molmil
Reduced Precursor Form of Glucose-Fructose Oxidoreductase from Zymomonas mobilis
分子名称: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PRECURSOR FORM OF GLUCOSE-FRUCTOSE OXIDOREDUCTASE
著者Nurizzo, D, Baker, E.N.
登録日2001-06-11
公開日2001-11-28
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structures of the Precursor Form of Glucose-Fructose Oxidoreductase from Zymomonas Mobilis and its Complexes with Bound Ligands(,)
Biochemistry, 40, 2001
1SVL
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BU of 1svl by Molmil
Co-crystal structure of SV40 large T antigen helicase domain and ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ZINC ION, ...
著者Gai, D, Zhao, R, Finkielstein, C.V, Chen, X.S.
登録日2004-03-29
公開日2004-10-19
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen.
Cell(Cambridge,Mass.), 119, 2004
1SVM
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Co-crystal structure of SV40 large T antigen helicase domain and ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ZINC ION, ...
著者Gai, D, Zhao, R, Finkielstein, C.V, Chen, X.S.
登録日2004-03-29
公開日2004-10-19
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen.
Cell(Cambridge,Mass.), 119, 2004
1VS0
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Crystal Structure of the Ligase Domain from M. tuberculosis LigD at 2.4A
分子名称: CHLORIDE ION, MAGNESIUM ION, Putative DNA ligase-like protein Rv0938/MT0965, ...
著者Akey, D, Martins, A, Aniukwu, J, Glickman, M.S, Shuman, S, Berger, J.M, TB Structural Genomics Consortium (TBSGC)
登録日2006-01-27
公開日2006-02-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structure and Nonhomologous End-joining Function of the Ligase Component of Mycobacterium DNA Ligase D.
J.Biol.Chem., 281, 2006
1VJQ
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Designed protein based on backbone conformation of procarboxypeptidase-A (1AYE) with sidechains chosen for maximal predicted stability.
分子名称: designed protein
著者Merritt, E.A, Baker, D, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2004-03-19
公開日2004-03-30
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.098 Å)
主引用文献Designed protein based on backbone conformation of procarboxypeptidase-A (1AYE) with sidechains chosen for maximal predicted stability.
To be Published
6YZ7
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H11-D4, SARS-CoV-2 RBD, CR3022 ternary complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Cr3022, Antibody light chain, ...
著者Naismith, J.H, Ren, J, Zhou, D, Zhao, Y, Stuart, D.I.
登録日2020-05-06
公開日2020-06-03
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structural characterisation of a nanobody derived from a naive library that neutralises SARS-CoV-2
To Be Published, 2020
8EV1
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Dual Modulators
分子名称: (3aR,4S,9bS)-4-(4-hydroxyphenyl)-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[c]quinoline-8-sulfonamide, (3aS,4R,9bR)-4-(4-hydroxyphenyl)-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[c]quinoline-8-sulfonamide, Estrogen Receptor, ...
著者Tinivella, A, Nwachukwu, J.C, Angeli, A, Foschi, F, Benatti, A.L, Pinzi, L, Izard, T, Ferraroni, M, Rangarajan, E.S, Christodoulou, M, Passarella, D, Supuran, C, Nettles, K.W, Rastelli, G.
登録日2022-10-19
公開日2022-12-28
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Design, synthesis, biological evaluation and crystal structure determination of dual modulators of carbonic anhydrases and estrogen receptors.
Eur.J.Med.Chem., 246, 2022
8EV2
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Dual Modulators
分子名称: (3aS,4R,9bR)-4-(2-chloro-4-hydroxyphenyl)-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[c]quinoline-8-sulfonamide, (3~{a}~{R},4~{S},9~{b}~{S})-4-(2-chloranyl-4-oxidanyl-phenyl)-2,3,3~{a},4,5,9~{b}-hexahydro-1~{H}-cyclopenta[c]quinoline-8-sulfonamide, Estrogen receptor, ...
著者Tinivella, A, Nwachukwu, J.C, Angeli, A, Foschi, F, Benatti, A.L, Pinzi, L, Izard, T, Ferraroni, M, Rangarajan, E.S, Christodoulou, M, Passarella, D, Supuran, C, Nettles, K.W, Rastelli, G.
登録日2022-10-19
公開日2022-12-28
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Design, synthesis, biological evaluation and crystal structure determination of dual modulators of carbonic anhydrases and estrogen receptors.
Eur.J.Med.Chem., 246, 2022
2LKH
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WSA minor conformation
分子名称: Acetylcholine receptor
著者Xu, Y, Mowrey, D, Cui, T, Perez-Aguilar, J, Saven, J.G, Eckenhoff, R, Tang, P.
登録日2011-10-11
公開日2012-01-11
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献NMR structure and dynamics of a designed water-soluble transmembrane domain of nicotinic acetylcholine receptor.
Biochim.Biophys.Acta, 1818, 2011

222415

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