7ZZ2
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![BU of 7zz2 by Molmil](/molmil-images/mine/7zz2) | Cryo-EM structure of "CT pyr" conformation of Lactococcus lactis pyruvate carboxylase with acetyl-CoA | Descriptor: | MAGNESIUM ION, MANGANESE (II) ION, PYRUVIC ACID, ... | Authors: | Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. | Deposit date: | 2022-05-25 | Release date: | 2022-10-12 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.48 Å) | Cite: | CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase. Nat Commun, 13, 2022
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8D2V
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![BU of 8d2v by Molmil](/molmil-images/mine/8d2v) | Zebrafish MFSD2A isoform B in inward open ligand 1B conformation | Descriptor: | DODECYL-BETA-D-MALTOSIDE, FAB heavy chain, FAB light chain, ... | Authors: | Nguyen, C, Lei, H.T, Lai, L.T.F, Gallentino, M.J, Mu, X, Matthies, D, Gonen, T. | Deposit date: | 2022-05-30 | Release date: | 2023-05-10 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Lipid flipping in the omega-3 fatty-acid transporter. Nat Commun, 14, 2023
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7ZZ0
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![BU of 7zz0 by Molmil](/molmil-images/mine/7zz0) | Cryo-EM structure of "CT empty" conformation of Lactococcus lactis pyruvate carboxylase with acetyl-CoA | Descriptor: | MAGNESIUM ION, MANGANESE (II) ION, Pyruvate carboxylase | Authors: | Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. | Deposit date: | 2022-05-25 | Release date: | 2022-10-12 | Last modified: | 2022-11-02 | Method: | ELECTRON MICROSCOPY (2.26 Å) | Cite: | CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase. Nat Commun, 13, 2022
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4RF3
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![BU of 4rf3 by Molmil](/molmil-images/mine/4rf3) | Crystal Structure of ketoreductase from Lactobacillus kefir, mutant A94F | Descriptor: | GLYCEROL, MAGNESIUM ION, NADPH dependent R-specific alcohol dehydrogenase | Authors: | Tang, Y, Tibrewal, N, Cascio, D. | Deposit date: | 2014-09-24 | Release date: | 2015-09-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.694 Å) | Cite: | Origins of stereoselectivity in evolved ketoreductases. Proc.Natl.Acad.Sci.USA, 112, 2015
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8CWK
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![BU of 8cwk by Molmil](/molmil-images/mine/8cwk) | |
4QRG
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![BU of 4qrg by Molmil](/molmil-images/mine/4qrg) | |
4QRV
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![BU of 4qrv by Molmil](/molmil-images/mine/4qrv) | Crystal structure of I86F mutant of papain | Descriptor: | CHLORIDE ION, Papain, SODIUM ION | Authors: | Dutta, S, Choudhury, D, Roy, S. | Deposit date: | 2014-07-02 | Release date: | 2015-08-12 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (1.978 Å) | Cite: | Pro-peptide regulates the substrate specificity and zymogen activation process of papain: A structural and mechanistic insight to be published
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8D02
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![BU of 8d02 by Molmil](/molmil-images/mine/8d02) | Crystal Structure of Bacillus anthracis BxpB | Descriptor: | BxpB, CALCIUM ION | Authors: | Chattopadhyay, D, Turnbough, C.L. | Deposit date: | 2022-05-25 | Release date: | 2023-05-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Crystal structure and induced stability of trimeric BxpB: implications for the assembly of BxpB-BclA complexes in the exosporium of Bacillus anthracis. Mbio, 14, 2023
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7ZYY
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![BU of 7zyy by Molmil](/molmil-images/mine/7zyy) | Cryo-EM structure of Lactococcus lactis pyruvate carboxylase with acetyl-CoA | Descriptor: | ACETYL COENZYME *A, ADENOSINE-5'-DIPHOSPHATE, BICARBONATE ION, ... | Authors: | Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. | Deposit date: | 2022-05-25 | Release date: | 2022-10-12 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.12 Å) | Cite: | CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase. Nat Commun, 13, 2022
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7ZZ4
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![BU of 7zz4 by Molmil](/molmil-images/mine/7zz4) | Cryo-EM structure of "BC closed" conformation of Lactococcus lactis pyruvate carboxylase with acetyl-CoA | Descriptor: | ACETYL COENZYME *A, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Lopez-Alonso, J.P, Lazaro, M, Gil, D, Choi, P.H, Tong, L, Valle, M. | Deposit date: | 2022-05-25 | Release date: | 2022-10-12 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.63 Å) | Cite: | CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase. Nat Commun, 13, 2022
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7C1K
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![BU of 7c1k by Molmil](/molmil-images/mine/7c1k) | Crystal structure of the starter condensation domain of rhizomide synthetase RzmA mutant R148A | Descriptor: | Non-ribosomal peptide synthetase modules | Authors: | Zhong, L, Diao, X, Zhang, N, Li, F.W, Zhou, H.B, Chen, H.N, Ren, X, Zhang, Y, Wu, D, Bian, X. | Deposit date: | 2020-05-04 | Release date: | 2020-11-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.755 Å) | Cite: | Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis. Nat Commun, 12, 2021
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5NEN
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7B9O
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![BU of 7b9o by Molmil](/molmil-images/mine/7b9o) | Crystal structure of Retinoic Acid Receptor alpha (RXRA) in complexed with S169 inhibitor | Descriptor: | 3-(5-(3,5-bis(trifluoromethyl)phenyl)-4-phenyloxazol-2-yl)propanoic acid, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha | Authors: | Ni, X, Chaikuad, A, Schierle, S, Merk, D, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2020-12-14 | Release date: | 2021-02-10 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics. J.Med.Chem., 64, 2021
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5NIK
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![BU of 5nik by Molmil](/molmil-images/mine/5nik) | Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump | Descriptor: | Macrolide export ATP-binding/permease protein MacB, Macrolide export protein MacA, Outer membrane protein TolC | Authors: | Fitzpatrick, A.W.P, Llabres, S, Neuberger, A, Blaza, J.N, Bai, X.-C, Okada, U, Murakami, S, van Veen, H.W, Zachariae, U, Scheres, S.H.W, Luisi, B.F, Du, D. | Deposit date: | 2017-03-24 | Release date: | 2017-05-24 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump. Nat Microbiol, 2, 2017
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8D2U
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![BU of 8d2u by Molmil](/molmil-images/mine/8d2u) | Zebrafish MFSD2A isoform B in inward open ligand 1A conformation | Descriptor: | DODECYL-BETA-D-MALTOSIDE, FAB heavy chain, FAB light chain, ... | Authors: | Nguyen, C, Lei, H.T, Lai, L.T.F, Gallentino, M.J, Mu, X, Matthies, D, Gonen, T. | Deposit date: | 2022-05-30 | Release date: | 2023-05-10 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Lipid flipping in the omega-3 fatty-acid transporter. Nat Commun, 14, 2023
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7ZXK
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![BU of 7zxk by Molmil](/molmil-images/mine/7zxk) | Human IL-27 in complex with neutralizing SRF388 FAb fragment | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-27 subunit alpha, Interleukin-27 subunit beta, ... | Authors: | Bloch, Y, Skladanowska, K, Strand, J, Welin, M, Logan, D, Hill, J, Savvides, S.N. | Deposit date: | 2022-05-21 | Release date: | 2022-11-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27. Cell Rep, 41, 2022
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5NK5
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![BU of 5nk5 by Molmil](/molmil-images/mine/5nk5) | Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 1m | Descriptor: | 2-[[3-[(3-aminophenyl)carbamoyl]phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide, Ephrin type-A receptor 2 | Authors: | Kudlinzki, D, Linhard, V.L, Witt, K, Gande, S.L, Saxena, K, Heinzlmeir, S, Medard, G, Kuester, B, Schwalbe, H. | Deposit date: | 2017-03-31 | Release date: | 2017-06-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.329 Å) | Cite: | Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors. ChemMedChem, 12, 2017
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5NKD
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![BU of 5nkd by Molmil](/molmil-images/mine/5nkd) | Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 2i | Descriptor: | 1,2-ETHANEDIOL, 2-[(3~{R})-1-[3-[[5-[(2-chloranyl-6-methyl-phenyl)carbamoyl]-1,3-thiazol-2-yl]amino]phenyl]carbonylpyrrolidin-3-yl]ethanoic acid, Ephrin type-A receptor 2 | Authors: | Kudlinzki, D, Linhard, V.L, Witt, K, Gande, S.L, Saxena, K, Heinzlmeir, S, Medard, G, Kuester, B, Schwalbe, H. | Deposit date: | 2017-03-31 | Release date: | 2017-06-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.408 Å) | Cite: | Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors. ChemMedChem, 12, 2017
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8D2S
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![BU of 8d2s by Molmil](/molmil-images/mine/8d2s) | Zebrafish MFSD2A isoform B in inward open ligand bound conformation | Descriptor: | DODECYL-BETA-D-MALTOSIDE, FAB heavy chain, FAB light chain, ... | Authors: | Nguyen, C, Lei, H.T, Lai, L.T.F, Gallentino, M.J, Mu, X, Matthies, D, Gonen, T. | Deposit date: | 2022-05-30 | Release date: | 2023-05-10 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Lipid flipping in the omega-3 fatty-acid transporter. Nat Commun, 14, 2023
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5NMW
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![BU of 5nmw by Molmil](/molmil-images/mine/5nmw) | Crystal Structure of the pyrrolizidine alkaloid N-oxygenase from Zonocerus variegatus in complex with FAD | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Flavin-containing monooxygenase, MAGNESIUM ION | Authors: | Scheidig, A, Kubitza, C, Faust, A, Ober, D. | Deposit date: | 2017-04-07 | Release date: | 2018-03-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Crystal structure of pyrrolizidine alkaloid N-oxygenase from the grasshopper Zonocerus variegatus. Acta Crystallogr D Struct Biol, 74, 2018
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5NGM
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![BU of 5ngm by Molmil](/molmil-images/mine/5ngm) | 2.9S structure of the 70S ribosome composing the S. aureus 100S complex | Descriptor: | 16S ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Matzov, D, Aibara, S, Zimmerman, E, Bashan, A, Amunts, A, Yonath, A. | Deposit date: | 2017-03-18 | Release date: | 2017-10-04 | Last modified: | 2018-11-28 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus. Nat Commun, 8, 2017
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6ZXJ
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![BU of 6zxj by Molmil](/molmil-images/mine/6zxj) | Fully-loaded anthrax lethal toxin in its heptameric pre-pore state, in which the third lethal factor is masked out (PA7LF3-masked) | Descriptor: | Lethal factor, Protective antigen | Authors: | Quentin, D, Antoni, C, Gatsogiannis, C, Raunser, S. | Deposit date: | 2020-07-29 | Release date: | 2020-09-02 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state. Plos Pathog., 16, 2020
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8D2W
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![BU of 8d2w by Molmil](/molmil-images/mine/8d2w) | Zebrafish MFSD2A isoform B in inward open ligand 2B conformation | Descriptor: | DODECYL-BETA-D-MALTOSIDE, FAB heavy chain, FAB light chain, ... | Authors: | Nguyen, C, Lei, H.T, Lai, L.T.F, Gallentino, M.J, Mu, X, Matthies, D, Gonen, T. | Deposit date: | 2022-05-30 | Release date: | 2023-05-10 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Lipid flipping in the omega-3 fatty-acid transporter. Nat Commun, 14, 2023
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5NG5
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![BU of 5ng5 by Molmil](/molmil-images/mine/5ng5) | multi-drug efflux; membrane transport; RND superfamily; Drug resistance | Descriptor: | 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile, Multidrug efflux pump accessory protein AcrZ, Multidrug efflux pump subunit AcrA, ... | Authors: | Wang, Z, Fan, G, Hryc, C.F, Blaza, J.N, Serysheva, I.I, Schmid, M.F, Chiu, W, Luisi, B.F, Du, D. | Deposit date: | 2017-03-16 | Release date: | 2017-04-19 | Last modified: | 2017-08-02 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump. Elife, 6, 2017
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8D2T
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![BU of 8d2t by Molmil](/molmil-images/mine/8d2t) | Zebrafish MFSD2A isoform B in inward open ligand-free conformation | Descriptor: | DODECYL-BETA-D-MALTOSIDE, FAB heavy chain, FAB light chain, ... | Authors: | Nguyen, C, Lei, H.T, Lai, L.T.F, Gallentino, M.J, Mu, X, Matthies, D, Gonen, T. | Deposit date: | 2022-05-30 | Release date: | 2023-05-10 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Lipid flipping in the omega-3 fatty-acid transporter. Nat Commun, 14, 2023
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