8ZMO
 
 | | Structure of a triple-helix region of human Collagen type XVII from Trautec | | Descriptor: | collagen type XVII | | Authors: | Chu, Y, Zhai, Y, Fan, X, Fu, S, Li, J, Wu, X, Cai, H, Wang, X, Li, D, Feng, P, Cao, K, Qian, S. | | Deposit date: | 2024-05-23 | | Release date: | 2024-06-26 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Structure of a triple-helix region of human Collagen type XVII from Trautec
To Be Published
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9FIF
 | | Crystal Structure of NuoEF variant P228R(NuoF) from Aquifex aeolicus bound to NADH under anoxic conditions | | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, FE2/S2 (INORGANIC) CLUSTER, ... | | Authors: | Wohlwend, D, Friedrich, T, Goeppert-Asadollahpour, S. | | Deposit date: | 2024-05-29 | | Release date: | 2024-07-17 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Structural robustness of the NADH binding site in NADH:ubiquinone oxidoreductase (complex I).
Biochim Biophys Acta Bioenerg, 1865, 2024
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9CBF
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7OV2
 | | Crystal structure of pig purple acid phosphatase in complex with L-glutamine, (poly)ethylene glycol fragments and glycerol | | Descriptor: | 1,2-ETHANEDIOL, CITRIC ACID, FE (III) ION, ... | | Authors: | Feder, D, McGeary, R.P, Guddat, L.W, Schenk, G. | | Deposit date: | 2021-06-14 | | Release date: | 2022-01-12 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Rational Design of Potent Inhibitors of a Metallohydrolase Using a Fragment-Based Approach.
Chemmedchem, 16, 2021
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9CBJ
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8ZFS
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8ZMW
 | | Structure of a triple-helix region of human Collagen type VII from Trautec | | Descriptor: | ACETATE ION, collagen type VII | | Authors: | Chu, Y, Zhai, Y, Fan, X, Fu, S, Li, J, Wu, X, Cai, H, Wang, X, Li, D, Feng, P, Cao, K, Qian, S. | | Deposit date: | 2024-05-24 | | Release date: | 2024-06-26 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structure of a triple-helix region of human Collagen type VII from Trautec
To Be Published
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9F1J
 | | First bromodomain of BRD4 in complex with ISOX-DUAL based degrader 14 | | Descriptor: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N-[2-[2-[2-[2-[2-[2-[2,6-bis(oxidanylidene)piperidin-3-yl]-1,3-bis(oxidanylidene)isoindol-4-yl]oxyethanoylamino]ethoxy]ethoxy]ethoxy]ethyl]-4-[4-[2-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(2-morpholin-4-ylethyl)benzimidazol-2-yl]ethyl]phenoxy]butanamide | | Authors: | Balourdas, D.I, Edmonds, A.K, Marsh, G.P, Maple, H.J, Spencer, J, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) | | Deposit date: | 2024-04-19 | | Release date: | 2024-09-11 | | Method: | X-RAY DIFFRACTION (1.13003039 Å) | | Cite: | First bromodomain of BRD4 in complex with ISOX-DUAL based degrader 14
to be published
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9EML
 | | SARS-CoV-2 methyltransferase nsp10-16 in complex with SAM and m7GpppA (Cap0-analog)/m7GpppAm (Cap1-analog) | | Descriptor: | 1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | | Authors: | Kremling, V, Sprenger, J, Oberthuer, D, Kiene, A. | | Deposit date: | 2024-03-08 | | Release date: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug development
To Be Published
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9BKJ
 | | Cholecystokinin 1 receptor (CCK1R) Y140A mutant, Gq chimera (mGsqi) complex | | Descriptor: | AMINO GROUP, Cholecystokinin receptor type A, Cholecystokinin-8, ... | | Authors: | Cary, B.P, Harikumar, K.G, Zhao, P, Desai, A.J, Mobbs, J.M, Toufaily, C, Furness, S.G.B, Christopoulos, A, Belousoff, M.J, Wootten, D, Sexton, P.M, Miller, L.J. | | Deposit date: | 2024-04-29 | | Release date: | 2024-05-22 | | Last modified: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (2.59 Å) | | Cite: | Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling.
Plos Biol., 22, 2024
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8ZMM
 | | Structure of a triple-helix region of human Collagen type IV from Trautec | | Descriptor: | collagen type IV | | Authors: | Chu, Y, Zhai, Y, Fan, X, Fu, S, Li, J, Wu, X, Cai, H, Wang, X, Li, D, Feng, P, Cao, K, Qian, S. | | Deposit date: | 2024-05-23 | | Release date: | 2024-06-26 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Structure of a triple-helix region of human Collagen type IV from Trautec
To Be Published
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9F1L
 | | First bromodomain of BRD4 in complex with ISOX-DUAL based degrader 35 | | Descriptor: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N-[2-[2-[(3R)-2,6-bis(oxidanylidene)piperidin-3-yl]-1,3-bis(oxidanylidene)isoindol-4-yl]oxyethyl]-2-[4-[2-[2-[2-[4-[3-(dimethylamino)propoxy]phenyl]ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)benzimidazol-1-yl]ethyl]piperazin-1-yl]ethanamide | | Authors: | Balourdas, D.I, Edmonds, A.K, Marsh, G.P, Maple, H.J, Spencer, J, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) | | Deposit date: | 2024-04-19 | | Release date: | 2024-09-11 | | Method: | X-RAY DIFFRACTION (1.30000627 Å) | | Cite: | First bromodomain of BRD4 in complex with ISOX-DUAL based degrader 35
to be published
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9FII
 | | Crystal Structure of oxidized NuoEF variant E222K(NuoF) from Aquifex aeolicus | | Descriptor: | CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ... | | Authors: | Wohlwend, D, Friedrich, T, Goeppert-Asadollahpour, S. | | Deposit date: | 2024-05-29 | | Release date: | 2024-07-17 | | Last modified: | 2024-08-14 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural robustness of the NADH binding site in NADH:ubiquinone oxidoreductase (complex I).
Biochim Biophys Acta Bioenerg, 1865, 2024
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8YSV
 | | Crystal structure of beta - glucosidase 6PG from Enterococcus faecalis | | Descriptor: | 1,2-ETHANEDIOL, 6-phospho-beta-glucosidase, ETHANOL, ... | | Authors: | Wang, W.Y, Li, Y.J, Liu, Z.Y, Han, X.D. | | Deposit date: | 2024-03-23 | | Release date: | 2024-10-02 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Crystal structure of beta - glucosidase 6PG from Enterococcus faecalis
To Be Published
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8ZFN
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9CBG
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9EM9
 | | Structure of SynDLP MGD with GMPPNP | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Slr0869 protein | | Authors: | Junglas, B, Gewehr, L, Schoennenbeck, P, Schneider, D, Sachse, C. | | Deposit date: | 2024-03-07 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.76 Å) | | Cite: | Structural basis for GTPase activity and conformational changes of the bacterial dynamin-like protein SynDLP.
Cell Rep, 43, 2024
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9CYP
 | | Crystal structure of I19V mutant human PTP1B (PTPN1) at room temperature (298 K) | | Descriptor: | BETA-MERCAPTOETHANOL, MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 | | Authors: | Ebrahim, A, Perdikari, A, Woods, V.A, Lawler, K, Bounds, R, Singh, N.I, Mehlman, T, Riley, B.T, Sharma, S, Morris, J.W, Keogh, J.M, Henning, E, Smith, M, Farooqi, I.S, Keedy, D.A. | | Deposit date: | 2024-08-02 | | Release date: | 2024-08-21 | | Last modified: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy.
Biorxiv, 2024
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8ZFR
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9CYO
 | | Crystal structure of wild-type human PTP1B (PTPN1) at room temperature (298 K) | | Descriptor: | BETA-MERCAPTOETHANOL, MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 | | Authors: | Ebrahim, A, Perdikari, A, Woods, V.A, Lawler, K, Bounds, R, Singh, N.I, Mehlman, T, Riley, B.T, Sharma, S, Morris, J.W, Keogh, J.M, Henning, E, Smith, M, Farooqi, I.S, Keedy, D.A. | | Deposit date: | 2024-08-02 | | Release date: | 2024-08-21 | | Last modified: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy.
Biorxiv, 2024
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9CYQ
 | | Crystal structure of Q78R mutant human PTP1B (PTPN1) at room temperature (298 K) | | Descriptor: | BETA-MERCAPTOETHANOL, MAGNESIUM ION, Tyrosine-protein phosphatase non-receptor type 1 | | Authors: | Ebrahim, A, Perdikari, A, Woods, V.A, Lawler, K, Bounds, R, Singh, N.I, Mehlman, T, Riley, B.T, Sharma, S, Morris, J.W, Keogh, J.M, Henning, E, Smith, M, Farooqi, I.S, Keedy, D.A. | | Deposit date: | 2024-08-02 | | Release date: | 2024-08-21 | | Last modified: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy.
Biorxiv, 2024
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9CBK
 | | Crystal Structure of Danio rerio Histone Deacetylase 6 in Complex with p-Aminomethyl Phenylthioketone | | Descriptor: | 1,2-ETHANEDIOL, 1-[4-(aminomethyl)phenyl]-2-sulfanylethan-1-one, Hdac6 protein, ... | | Authors: | Goulart Stollmaier, J, Watson, P.R, Christianson, D.W. | | Deposit date: | 2024-06-19 | | Release date: | 2024-09-11 | | Method: | X-RAY DIFFRACTION (1.46 Å) | | Cite: | Design, Synthesis, and Structural Evaluation of Acetylated Phenylthioketone Inhibitors of HDAC10
To be Published
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9BJY
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9AVT
 | | Structure of TAB2 NZF domain bound to K6 / Lys6-linked diubiquitin | | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, SULFATE ION, TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, ... | | Authors: | Michel, M.A, Scutts, S, Komander, D. | | Deposit date: | 2024-03-04 | | Release date: | 2024-07-31 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure of TAB2 NZF domain bound to K6 / Lys6-linked diubiquitin
To be published
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9BK4
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