7YWX
 
 | | Structure of the human CCAN CENP-A alpha-satellite complex | | 分子名称: | Centromere protein C, Centromere protein H, Centromere protein I, ... | | 著者 | Yatskevich, S, Muir, K.W, Bellini, D, Zhang, Z, Yang, J, Tischer, T, Predin, M, Dendooven, T, McLaughlin, S.H, Barford, D. | | 登録日 | 2022-02-14 | | 公開日 | 2022-05-18 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (12 Å) | | 主引用文献 | Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome.
Science, 376, 2022
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7RXF
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7RZN
 | | Crystal Structure of Ferritin grown by microbatch method in presence of agarose and electric field 2.1KV | | 分子名称: | CADMIUM ION, Ferritin light chain, SULFATE ION | | 著者 | Aditya, S, Priyadharshine, R, Maham, I, Miller, J.D, Stojanoff, V. | | 登録日 | 2021-08-27 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Crystal Structure of Ferritin grown by microbatch method in presence of agarose and electric field 2.1KV
To Be Published
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5UGO
 | | DNA polymerase beta nick complex with imidodiphosphate | | 分子名称: | CALCIUM ION, DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3'), ... | | 著者 | Freudenthal, B.D, Wilson, S.H, Beard, W.A. | | 登録日 | 2017-01-09 | | 公開日 | 2017-07-26 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.897 Å) | | 主引用文献 | Modulating the DNA polymerase beta reaction equilibrium to dissect the reverse reaction.
Nat. Chem. Biol., 13, 2017
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6UX6
 | | Cruzain covalently bound by a vinylsulfone compound | | 分子名称: | Cruzipain, GLYCEROL, Nalpha-[(benzyloxy)carbonyl]-N-[(2S)-1-phenyl-4-(phenylsulfonyl)butan-2-yl]-L-phenylalaninamide | | 著者 | Zhai, X, Tang, S, Chenna, B.C, Meek, T.D, Sacchettini, J.C. | | 登録日 | 2019-11-06 | | 公開日 | 2020-11-25 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Cruzain covalently bound by a vinylsulfone compound
To Be Published
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7JTJ
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3HG0
 | | Crystal structure of a DARPin in complex with ORF49 from Lactococcal phage TP901-1 | | 分子名称: | Baseplate protein, Designed Ankyrin Repeat Protein (DARPin) 20 | | 著者 | Veesler, D, Dreier, B, Blangy, S, Lichiere, J, Tremblay, D, Moineau, S, Spinelli, S, Tegoni, M, Pluckthun, A, Campanacci, V, Cambillau, C. | | 登録日 | 2009-05-13 | | 公開日 | 2009-09-08 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure and function of a DARPin neutralizing inhibitor of lactococcal phage TP901-1: comparison of DARPin and camelid VHH binding mode.
J.Biol.Chem., 284, 2009
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5MN8
 | | S. aureus FtsZ 12-316 F138A GTP Closed form (5FCm) | | 分子名称: | Cell division protein FtsZ, GUANOSINE-5'-TRIPHOSPHATE | | 著者 | Wagstaff, J.M, Tsim, M, Kureisaite-Ciziene, D, Lowe, J. | | 登録日 | 2016-12-12 | | 公開日 | 2017-01-11 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | A Polymerization-Associated Structural Switch in FtsZ That Enables Treadmilling of Model Filaments.
MBio, 8, 2017
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7SEH
 | | Glucose-6-phosphate 1-dehydrogenase (K403QdLtL) | | 分子名称: | Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Mathews, I.I, Garcia, A.A, Wakatsuki, S, Mochly-Rosen, D. | | 登録日 | 2021-09-30 | | 公開日 | 2022-08-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical variants.
J.Biol.Chem., 298, 2022
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8HHK
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6RRX
 | | GOLGI ALPHA-MANNOSIDASE II in complex with (2S,3R)-2-(Hydroxymethyl)-3-piperidinol | | 分子名称: | (2~{S},3~{R})-2-(hydroxymethyl)piperidin-3-ol, 1,2-ETHANEDIOL, Alpha-mannosidase 2, ... | | 著者 | Armstrong, Z, Lahav, D, Johnson, R, Kuo, C.L, Beenakker, T.J.M, de Boer, C, Wong, C.S, van Rijssel, E.R, Debets, M, Geurink, P.P, Ovaa, H, van der Stelt, M, Codee, J.D.C, Aerts, J.M.F.G, Wu, L, Overkleeft, H.S, Davies, G.J. | | 登録日 | 2019-05-20 | | 公開日 | 2020-07-08 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Manno- epi -cyclophellitols Enable Activity-Based Protein Profiling of Human alpha-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors.
J.Am.Chem.Soc., 142, 2020
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7RYW
 | | Crystal structure of Ferritin grown by the microbatch method in the presence of Agarose | | 分子名称: | CADMIUM ION, Ferritin light chain, SULFATE ION | | 著者 | Aditya, S, Priyadharshine, R, Maham, I, Miller, D.J, Stojanoff, V. | | 登録日 | 2021-08-26 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Crystal structure of Ferritin grown by microbatch method in the presence of agarose
To Be Published
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7RZX
 | | Crystal Structure of Ferritin grown by microbatch method in presence of agarose and electric field 4.3KV | | 分子名称: | CADMIUM ION, Ferritin light chain, SULFATE ION | | 著者 | Aditya, S, Priyadharshine, R, Maham, I, Miller, J.D, Stojanoff, V. | | 登録日 | 2021-08-27 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Crystal Structure of Ferritin grown by microbatch method in presence of agarose and electric field 4.3KV
To Be Published
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6B2Y
 | | Apo YiuA Crystal Form 2 | | 分子名称: | SODIUM ION, Solute-binding periplasmic protein of iron/siderophore ABC transporter | | 著者 | Radka, C.D, DeLucas, L.J, Aller, S.G. | | 登録日 | 2017-09-20 | | 公開日 | 2017-11-15 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | The crystal structure of the Yersinia pestis iron chaperone YiuA reveals a basic triad binding motif for the chelated metal.
Acta Crystallogr D Struct Biol, 73, 2017
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7RXK
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7RY4
 | | Multi-conformer model of Ketosteroid Isomerase Y57F/D40N mutant from Pseudomonas Putida (pKSI) bound to a transition state analog at 250 K | | 分子名称: | (9beta,13alpha)-3-hydroxyestra-1,3,5(10)-trien-17-one, CHLORIDE ION, MAGNESIUM ION, ... | | 著者 | Yabukarski, F, Doukov, T, Herschlag, D. | | 登録日 | 2021-08-24 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.11 Å) | | 主引用文献 | Ensemble-function relationships to dissect mechanisms of enzyme catalysis.
Sci Adv, 8, 2022
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6RLL
 | | CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX with JNJ44064146 | | 分子名称: | (2~{R},3~{R},4~{S},5~{R})-2-(4-azanylpyrrolo[2,3-d]pyrimidin-7-yl)-5-(1,8-diazaspiro[4.5]decan-1-ylmethyl)oxolane-3,4-diol, Methylosome protein 50, Protein arginine N-methyltransferase 5 | | 著者 | Brown, D.G, Robinson, C.M, Pande, V. | | 登録日 | 2019-05-02 | | 公開日 | 2020-06-03 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | A chemical probe for the methyl transferase PRMT5 with a novel
binding mode
To Be Published
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5MOV
 | | Crystal structure of Ck2alpha with ZT0633 bound | | 分子名称: | 4'-HYDROXYCINNAMIC ACID, Casein kinase II subunit alpha | | 著者 | Brear, P, De Fusco, C, Georgiou, K, Iegre, J, Sore, H, Hyvonen, M, Spring, D. | | 登録日 | 2016-12-14 | | 公開日 | 2017-05-24 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.
Bioorg. Med. Chem., 25, 2017
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8HHI
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7JTB
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5MPM
 | | SERCA2a from pig heart | | 分子名称: | (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE, MAGNESIUM ION, POTASSIUM ION, ... | | 著者 | Drachmann, N.D, Sitsel, A, Andersen, J.L, Nissen, P, Olesen, C. | | 登録日 | 2016-12-16 | | 公開日 | 2018-01-17 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structures of the heart specific SERCA2a Ca2+-ATPase.
Embo J., 38, 2019
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5MPZ
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6UQ2
 | | RNA polymerase II elongation complex with dG in state 1 | | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | | 著者 | Oh, J, Wang, D. | | 登録日 | 2019-10-18 | | 公開日 | 2020-06-10 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | RNA polymerase II stalls on oxidative DNA damage via a torsion-latch mechanism involving lone pair-pi and CH-pi interactions.
Proc.Natl.Acad.Sci.USA, 117, 2020
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7PFM
 | | A SARS-CoV2 major protease non-covalent ligand structure determined to 2.0 A resolution | | 分子名称: | N-[(1R)-2-(tert-butylamino)-2-oxidanylidene-1-pyridin-3-yl-ethyl]-N-(4-tert-butylphenyl)-1H-imidazole-5-carboxamide, Replicase polyprotein 1ab | | 著者 | Moche, M, Moodie, L, Strandback, E, Nyman, T, Sandstrom, A, Akaberi, D, Lennerstrand, J. | | 登録日 | 2021-08-11 | | 公開日 | 2022-08-24 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The SARS-CoV2 major protease (Mpro) in complex with a non-covalent inhibitory ligand at 2 A resolution
To Be Published
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6F90
 | | Structure of the family GH92 alpha-mannosidase BT3130 from Bacteroides thetaiotaomicron in complex with Mannoimidazole (ManI) | | 分子名称: | (5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL, Alpha-1,2-mannosidase, putative, ... | | 著者 | Thompson, A.J, Spears, R.J, Zhu, Y, Suits, M.D.L, Williams, S.J, Gilbert, H.J, Davies, G.J. | | 登録日 | 2017-12-13 | | 公開日 | 2018-05-02 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Bacteroides thetaiotaomicron generates diverse alpha-mannosidase activities through subtle evolution of a distal substrate-binding motif.
Acta Crystallogr D Struct Biol, 74, 2018
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