6RLL

CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX with JNJ44064146

Summary for 6RLL

• Entry DOI: 10.2210/pdb6rll/pdb
• Descriptor: Protein arginine N-methyltransferase 5, Methylosome protein 50, (2~{R},3~{R},4~{S},5~{R})-2-(4-azanylpyrrolo[2,3-d]pyrimidin-7-yl)-5-(1,8-diazaspiro[4.5]decan-1-ylmethyl)oxolane-3,4-diol, ... (4 entities in total)
• Functional Keywords: prmt5, mep50, ligand, translocase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 111738.21

Authors

Brown, D.G.,Robinson, C.M.,Pande, V. (deposition date: 2019-05-02, release date: 2020-06-03, Last modification date: 2024-01-24)

• Primary citation: Brown, D.G.,Robinson, C.M.,Pandeet, V.; A chemical probe for the methyl transferase PRMT5 with a novel binding mode; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.22 Å)