6RLL
CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX with JNJ44064146
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Protein arginine N-methyltransferase 5 | polymer | 645 | 73763.6 | 1 | UniProt (O14744) Pfam (PF17285) Pfam (PF05185) Pfam (PF17286) In PDB | Homo sapiens (Human) | 72 kDa ICln-binding protein,Histone-arginine N-methyltransferase PRMT5,Jak-binding protein 1,Shk1 kinase-binding protein 1 homolog,SKB1Hs |
2 | B | Methylosome protein 50 | polymer | 348 | 37586.1 | 1 | UniProt (Q9BQA1) Pfam (PF00400) In PDB | Homo sapiens (Human) | MEP-50,Androgen receptor cofactor p44,WD repeat-containing protein 77,p44/Mep50 |
3 | A | (2~{R},3~{R},4~{S},5~{R})-2-(4-azanylpyrrolo[2,3-d]pyrimidin-7-yl)-5-(1,8-diazaspiro[4.5]decan-1-ylmethyl)oxolane-3,4-diol | non-polymer | 388.5 | 1 | Chemie (K8H) | |||
4 | water | water | 18.0 | 94 | Chemie (HOH) |
Sequence modifications
A: 2 - 637 (UniProt: O14744)
B: 2 - 342 (UniProt: Q9BQA1)
PDB | External Database | Details |
---|---|---|
Met -7 | - | initiating methionine |
Asp -6 | - | expression tag |
Tyr -5 | - | expression tag |
Lys -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Asp 0 | - | expression tag |
Lys 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -5 | - | initiating methionine |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
His 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 111349.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 388.5 | |
All* | Total formula weight | 111738.2 |