7RKC
 
 | | Computationally designed tunable C2 symmetric tandem repeat homodimer, D_3_633 | | 分子名称: | ACETATE ION, D_3_633 | | 著者 | Kennedy, M.A, Stoddard, B.L, Hicks, D.R, Bera, A.K. | | 登録日 | 2021-07-22 | | 公開日 | 2022-05-18 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | De novo design of protein homodimers containing tunable symmetric protein pockets.
Proc.Natl.Acad.Sci.USA, 119, 2022
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4XTS
 | | Salmonella typhimurium AhpC T43A mutant | | 分子名称: | Alkyl hydroperoxide reductase subunit C, CHLORIDE ION | | 著者 | Perkins, A, Nelson, K, Parsonage, D, Poole, L, Karplus, P.A. | | 登録日 | 2015-01-24 | | 公開日 | 2016-01-27 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.704 Å) | | 主引用文献 | Experimentally Dissecting the Origins of Peroxiredoxin Catalysis.
Antioxid.Redox Signal., 28, 2018
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6V1D
 | | Crystal structure of human trefoil factor 1 | | 分子名称: | Trefoil factor 1 | | 著者 | Jarva, M.A, Lingford, J.P, John, A, Scott, N.E, Goddard-Borger, E.D. | | 登録日 | 2019-11-20 | | 公開日 | 2019-12-11 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Trefoil factors share a lectin activity that defines their role in mucus.
Nat Commun, 11, 2020
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8GFA
 | | Cryo-EM structure of human TRPV1 in complex with the analgesic drug SB-366791 | | 分子名称: | (2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, ... | | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | | 登録日 | 2023-03-07 | | 公開日 | 2023-05-10 | | 実験手法 | ELECTRON MICROSCOPY (2.29 Å) | | 主引用文献 | Human TRPV1 structure and inhibition by the analgesic SB-366791.
Nat Commun, 14, 2023
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5MCW
 | | New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LWC2) | | 分子名称: | Cellular tumor antigen p53, DNA, FORMYL GROUP, ... | | 著者 | Golovenko, D, Rozenberg, H, Shakked, Z. | | 登録日 | 2016-11-10 | | 公開日 | 2018-06-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.897 Å) | | 主引用文献 | New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins.
Structure, 26, 2018
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7RGO
 | | DfrA5 complexed with NADPH and 4'-chloro-3'-(4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl)-[1,1'-biphenyl]-4-carboxamide (UCP1228) | | 分子名称: | 4'-chloro-3'-[(2S)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl][1,1'-biphenyl]-4-carboxamide, Dihydrofolate reductase type 5, GLYCEROL, ... | | 著者 | Lombardo, M.N, Wright, D.L. | | 登録日 | 2021-07-15 | | 公開日 | 2022-05-25 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens.
Commun Biol, 5, 2022
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4XG0
 | | Crystal structure of a domain of unknown function (DUF1537) from Bordetella bronchiseptica (BB3215), Target EFI-511620, with bound citrate, domain swapped dimer, space group C2221 | | 分子名称: | CHLORIDE ION, CITRIC ACID, SULFATE ION, ... | | 著者 | Vetting, M.W, Al Obaidi, N.F, Toro, R, Morisco, L.L, Benach, J, Wasserman, S.R, Attonito, J.D, Scott Glenn, A, Chamala, S, Chowdhury, S, Lafleur, J, Love, J, Seidel, R.D, Whalen, K.L, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | | 登録日 | 2014-12-30 | | 公開日 | 2015-03-11 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars.
Proc.Natl.Acad.Sci.USA, 113, 2016
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1AG8
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5IVX
 | | Crystal Structure of B4.2.3 T-Cell Receptor and H2-Dd P18-I10 Complex | | 分子名称: | 1,2-ETHANEDIOL, Beta-2-microglobulin, H-2 class I histocompatibility antigen, ... | | 著者 | Natarajan, K, Jiang, J, Margulies, D. | | 登録日 | 2016-03-21 | | 公開日 | 2017-03-29 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | An allosteric site in the T-cell receptor C beta domain plays a critical signalling role.
Nat Commun, 8, 2017
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179D
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5BP4
 | | Modifying region (DH-ER-KR) of a mycocerosic acid synthase-like (MAS-like) PKS | | 分子名称: | Mycocerosic acid synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Herbst, D.A, Jakob, P.R, Zaehringer, F, Maier, T. | | 登録日 | 2015-05-27 | | 公開日 | 2016-03-09 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.75 Å) | | 主引用文献 | Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases.
Nature, 531, 2016
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4EKY
 | | Crystal structure of GPb in complex with DK15 | | 分子名称: | 1-(beta-D-glucopyranosyl)-5-(pent-1-yn-1-yl)pyrimidine-2,4(1H,3H)-dione, Glycogen phosphorylase, muscle form | | 著者 | Kantsadi, A.L, Skamnaki, V.T, Leonidas, D.D. | | 登録日 | 2012-04-10 | | 公開日 | 2012-07-25 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: Synthesis, biochemical and biological assessment.
Eur.J.Med.Chem., 54, 2012
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1A6F
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6M8Z
 | | Crystal structure of human DJ-1 without a modification on Cys-106 | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, Protein/nucleic acid deglycase DJ-1 | | 著者 | Shumilin, I.A, Shabalin, I.G, Shumilina, S.V, Werenskjold, C, Utepbergenov, D, Minor, W. | | 登録日 | 2018-08-22 | | 公開日 | 2018-09-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | A transient post-translational modification of active site cysteine alters binding properties of the parkinsonism protein DJ-1.
Biochem. Biophys. Res. Commun., 504, 2018
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1A6Z
 | | HFE (HUMAN) HEMOCHROMATOSIS PROTEIN | | 分子名称: | BETA-2-MICROGLOBULIN, HFE | | 著者 | Lebron, J.A, Bennett, M.J, Vaughn, D.E, Chirino, A.J, Snow, P.M, Mintier, G.A, Feder, J.N, Bjorkman, P.J. | | 登録日 | 1998-03-04 | | 公開日 | 1999-03-23 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor.
Cell(Cambridge,Mass.), 93, 1998
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5UGO
 | | DNA polymerase beta nick complex with imidodiphosphate | | 分子名称: | CALCIUM ION, DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3'), ... | | 著者 | Freudenthal, B.D, Wilson, S.H, Beard, W.A. | | 登録日 | 2017-01-09 | | 公開日 | 2017-07-26 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.897 Å) | | 主引用文献 | Modulating the DNA polymerase beta reaction equilibrium to dissect the reverse reaction.
Nat. Chem. Biol., 13, 2017
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1AIU
 | | HUMAN THIOREDOXIN (D60N MUTANT, REDUCED FORM) | | 分子名称: | THIOREDOXIN | | 著者 | Andersen, J.F, Gasdaska, J.R, Sanders, D.A.R, Weichsel, A, Powis, G, Montfort, W.R. | | 登録日 | 1997-04-25 | | 公開日 | 1997-07-07 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Human thioredoxin homodimers: regulation by pH, role of aspartate 60, and crystal structure of the aspartate 60 --> asparagine mutant.
Biochemistry, 36, 1997
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8GH7
 | | 142D6 bound to BIR3-XIAP | | 分子名称: | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, BIR3 inhibitor MAA-CHG-PRO-ZHW, E3 ubiquitin-protein ligase XIAP, ... | | 著者 | Garza-Granados, A, McGuire, J, Baggio, C, Pellecchia, M, Pegan, S.D. | | 登録日 | 2023-03-09 | | 公開日 | 2023-07-05 | | 最終更新日 | 2023-07-12 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist.
J.Med.Chem., 66, 2023
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5IZ3
 | | P. patens sedoheptulose-1,7-bisphosphatase | | 分子名称: | IMIDAZOLE, PHOSPHATE ION, Predicted protein, ... | | 著者 | Einsle, O, Guetle, D. | | 登録日 | 2016-03-24 | | 公開日 | 2016-06-08 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Chloroplast FBPase and SBPase are thioredoxin-linked enzymes with similar architecture but different evolutionary histories.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5MN8
 | | S. aureus FtsZ 12-316 F138A GTP Closed form (5FCm) | | 分子名称: | Cell division protein FtsZ, GUANOSINE-5'-TRIPHOSPHATE | | 著者 | Wagstaff, J.M, Tsim, M, Kureisaite-Ciziene, D, Lowe, J. | | 登録日 | 2016-12-12 | | 公開日 | 2017-01-11 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | A Polymerization-Associated Structural Switch in FtsZ That Enables Treadmilling of Model Filaments.
MBio, 8, 2017
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6RST
 | | TBK1 in complex with inhibitor compound 24 | | 分子名称: | 1-[4-[(1~{R})-1-[2-[[5-[1-(cyclopropylmethyl)pyrazol-4-yl]-1~{H}-benzimidazol-2-yl]amino]pyridin-4-yl]ethyl]piperazin-1-yl]-3,3,3-tris(fluoranyl)propan-1-one, Serine/threonine-protein kinase TBK1 | | 著者 | Panne, D, Hillig, R.C, Rengachari, S. | | 登録日 | 2019-05-22 | | 公開日 | 2020-01-01 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | | 主引用文献 | Discovery of BAY-985, a Highly Selective TBK1/IKK epsilon Inhibitor.
J.Med.Chem., 63, 2020
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4XM5
 | | C. glabrata Slx1. | | 分子名称: | CHLORIDE ION, Structure-specific endonuclease subunit SLX1, ZINC ION | | 著者 | Gaur, V, Wyatt, H.D.M, Komorowska, W, Szczepanowski, R.H, de Sanctis, D, Gorecka, K.M, West, S.C, Nowotny, M. | | 登録日 | 2015-01-14 | | 公開日 | 2015-03-25 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Structural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease.
Cell Rep, 10, 2015
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6RUT
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8B1S
 | | co-crystal of SUDV VP40 with salicylic acid | | 分子名称: | 2-HYDROXYBENZOIC ACID, Matrix protein VP40 | | 著者 | Werner, A.-D, Krapoth, N, Norris, M.J, Heine, A, Klebe, G, Ollmann Saphire, E, Becker, S. | | 登録日 | 2022-09-12 | | 公開日 | 2023-09-27 | | 最終更新日 | 2024-08-14 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Development of a Crystallographic Screening to Identify Sudan Virus VP40 Ligands.
Acs Omega, 9, 2024
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8AFQ
 | | Tube assembly of Atg18-PR72AA | | 分子名称: | Autophagy-related protein 18 | | 著者 | Mann, D, Fromm, S, Martinez-Sanchez, A, Gopaldass, N, Mayer, A, Sachse, C. | | 登録日 | 2022-07-18 | | 公開日 | 2023-11-01 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Atg18 oligomer organization in assembled tubes and on lipid membrane scaffolds.
Nat Commun, 14, 2023
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