9C7A
 
 | | Crystal structure of R149W neurodevelopmental disease-associated U2AF2 variant | | 分子名称: | DNA/RNA (5'-R(P*UP*U)-D(P*U)-R(P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), GLYCEROL, SODIUM ION, ... | | 著者 | Maji, D, Jenkins, J.L, Kielkopf, C.L. | | 登録日 | 2024-06-10 | | 公開日 | 2024-10-02 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Recurrent Neurodevelopmentally Associated Variants of the Pre-mRNA Splicing Factor U2AF2 Alter RNA Binding Affinities and Interactions.
Biochemistry, 63, 2024
|
|
6GP0
 | | Structure of mEos4b in the red fluorescent state | | 分子名称: | Green to red photoconvertible GFP-like protein EosFP | | 著者 | De Zitter, E, Adam, V, Byrdin, M, Van Meervelt, L, Dedecker, P, Bourgeois, D. | | 登録日 | 2018-06-04 | | 公開日 | 2019-05-22 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Mechanistic investigation of mEos4b reveals a strategy to reduce track interruptions in sptPALM.
Nat.Methods, 16, 2019
|
|
7NHV
 | | Crystal structure of the human METTL3-METTL14 complex with compound UOZ016 | | 分子名称: | (R)-N-((1-(6-(benzylamino)pyrimidin-4-yl)-3-hydroxypiperidin-3-yl)methyl)-4-((4,4-dimethylpiperidin-1-yl)methyl)benzamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | | 著者 | Bedi, R.K, Huang, D, Caflisch, A. | | 登録日 | 2021-02-11 | | 公開日 | 2021-10-20 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023
|
|
8TQ6
 | | Crystal structure of Fab.B1.23.2 in complex with MHC-I (HLA-B*44:05) | | 分子名称: | Beta-2-microglobulin, Fab B1.23.2 Heavy Chain, Fab B1.23.2 Light Chain, ... | | 著者 | Jiang, J, Natarajan, K, Boyd, L.F, Margulies, D.H. | | 登録日 | 2023-08-06 | | 公開日 | 2025-02-05 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Crystal structure of Fab.B1.23.2 in complex with MHC-I (HLA-B*44:05)
To Be Published
|
|
9C7B
 | |
7NIA
 | |
6QGG
 | | Structure of human Bcl-2 in complex with analogue of ABT-737 | | 分子名称: | Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Bcl-2-like protein 1, [(3~{R})-3-[[4-[[4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]phenyl]carbonylsulfamoyl]-2-nitro-phenyl]amino]-4-phenylsulfanyl-butyl]-(2-hydroxy-2-oxoethyl)-dimethyl-azanium | | 著者 | Dokurno, P, Murray, J, Davidson, J, Chen, I, Davis, B, Graham, C.J, Harris, R, Jordan, A.M, Matassova, N, Pedder, C, Ray, S, Roughley, S, Smith, J, Walmsley, C, Wang, Y, Whitehead, N, Williamson, D.S, Casara, P, Le Diguarher, T, Hickman, J, Stark, J, Kotschy, A, Geneste, O, Hubbard, R.E. | | 登録日 | 2019-01-11 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1.
Acs Omega, 4, 2019
|
|
7NI9
 | |
7NHH
 | |
6N78
 | | Structure of the human JAK1 kinase domain with compound 21 | | 分子名称: | GLYCEROL, N-{3-[5-chloro-2-(difluoromethoxy)phenyl]-1-methyl-1H-pyrazol-4-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide, Tyrosine-protein kinase JAK1 | | 著者 | Lupardus, P.J, Brown, D. | | 登録日 | 2018-11-27 | | 公開日 | 2019-04-24 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.
Bioorg.Med.Chem.Lett., 29, 2019
|
|
7NI7
 | | Crystal structure of the human METTL3-METTL14 complex with compound UOZ031 | | 分子名称: | (R)-4-((4,4-dimethylpiperidin-1-yl)methyl)-2-hydroxy-N-((3-hydroxy-1-(6-((3-(methylcarbamoyl)benzyl)amino)pyrimidin-4-yl)piperidin-3-yl)methyl)benzamide, ACETATE ION, MAGNESIUM ION, ... | | 著者 | Bedi, R.K, Huang, D, Caflisch, A. | | 登録日 | 2021-02-11 | | 公開日 | 2021-10-20 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023
|
|
6N7A
 | | Structure of the human JAK1 kinase domain with compound 39 | | 分子名称: | GLYCEROL, N-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-yl]-2-methyl-2H-pyrazolo[4,3-c]pyridine-7-carboxamide, Tyrosine-protein kinase JAK1 | | 著者 | Lupardus, P.J, Brown, D. | | 登録日 | 2018-11-27 | | 公開日 | 2019-04-24 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | | 主引用文献 | Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.
Bioorg.Med.Chem.Lett., 29, 2019
|
|
7NID
 | | Crystal structure of the human METTL3-METTL14 complex with compound UOZ078 | | 分子名称: | (R)-1-(6-(benzylamino)pyrimidin-4-yl)-3-(((6-((4,4-dimethylpiperidin-1-yl)methyl)naphthalen-1-yl)amino)methyl)piperidin-3-ol, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | | 著者 | Bedi, R.K, Huang, D, Caflisch, A. | | 登録日 | 2021-02-11 | | 公開日 | 2021-10-20 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023
|
|
6QLT
 | | Galectin-3C in complex with fluoroaryltriazole monothiogalactoside derivative-7 | | 分子名称: | (2~{R},3~{R},4~{S},5~{R},6~{S})-4-[4-(2-fluorophenyl)-1,2,3-triazol-1-yl]-2-(hydroxymethyl)-6-(4-methylphenyl)sulfanyl-oxane-3,5-diol, DI(HYDROXYETHYL)ETHER, Galectin-3 | | 著者 | Kumar, R, Peterson, K, Nilsson, U.J, Logan, D.T. | | 登録日 | 2019-02-01 | | 公開日 | 2019-07-10 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Structure and Energetics of Ligand-Fluorine Interactions with Galectin-3 Backbone and Side-Chain Amides: Insight into Solvation Effects and Multipolar Interactions.
Chemmedchem, 14, 2019
|
|
7AZC
 | | DNA polymerase sliding clamp from Escherichia coli with peptide 22 bound | | 分子名称: | Beta sliding clamp, GLYCEROL, Peptide 22 | | 著者 | Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y. | | 登録日 | 2020-11-16 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
J.Med.Chem., 64, 2021
|
|
7NHJ
 | |
7AZF
 | | DNA polymerase sliding clamp from Escherichia coli with peptide 8 bound | | 分子名称: | Beta sliding clamp, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y. | | 登録日 | 2020-11-16 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
J.Med.Chem., 64, 2021
|
|
7NI8
 | |
6WVS
 | | Hyperstable de novo TIM barrel variant DeNovoTIM15 | | 分子名称: | DeNovoTIM15 hyperstable de novo TIM barrel | | 著者 | Bick, M.J, Haydon, I.C, Caldwell, S.J, Zeymer, C, Huang, P, Fernandez-Velasco, D.A, Baker, D. | | 登録日 | 2020-05-06 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.202 Å) | | 主引用文献 | Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
9BK5
 | | Structure of LNG binder complex | | 分子名称: | Alpha-cobratoxin, LNG binder | | 著者 | Bera, A.K, Torres, S.V, Kang, A, Baker, D. | | 登録日 | 2024-04-26 | | 公開日 | 2024-10-09 | | 最終更新日 | 2025-03-12 | | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | | 主引用文献 | De novo designed proteins neutralize lethal snake venom toxins.
Nature, 639, 2025
|
|
6WYC
 | |
7UUJ
 | | Crystal structure of aminoglycoside resistance enzyme ApmA, complex with gentamicin | | 分子名称: | (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, 1,2-ETHANEDIOL, Aminocyclitol acetyltransferase ApmA, ... | | 著者 | Stogios, P.J, Evdokimova, E, Osipiuk, J, Di Leo, R, Bordeleau, E, Wright, G.D, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID) | | 登録日 | 2022-04-28 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Crystal structure of aminoglycoside resistance enzyme ApmA, complex with gentamicin
To Be Published
|
|
5FD9
 | | X-ray Crystal Structure of ESCRT-III Snf7 core domain (conformation B) | | 分子名称: | Vacuolar-sorting protein SNF7 | | 著者 | Tang, S, Henne, W.M, Borbat, P.P, Buchkovich, N.J, Freed, J.H, Mao, Y, Fromme, J.C, Emr, S.D. | | 登録日 | 2015-12-15 | | 公開日 | 2015-12-30 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments.
Elife, 4, 2015
|
|
6WZ6
 | | Complex of mutant (K173M) of Pseudomonas 7A Glutaminase-Asparaginase with L-Glu at pH 5. Covalent acyl-enzyme intermediate | | 分子名称: | 1,2-ETHANEDIOL, GLUTAMIC ACID, Glutaminase-asparaginase | | 著者 | Strzelczyk, P, Zhang, D, Wlodawer, A, Lubkowski, J. | | 登録日 | 2020-05-13 | | 公開日 | 2020-10-14 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Generalized enzymatic mechanism of catalysis by tetrameric L-asparaginases from mesophilic bacteria.
Sci Rep, 10, 2020
|
|
9C6F
 | | cryoEM structure of CRISPR associated effector, CARF-Adenosine deaminase 1, Cad1, in apo form with ATP (Asymmetric sites). | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Adenosine deaminase domain-containing protein, MAGNESIUM ION | | 著者 | Majumder, P, Patel, D.J. | | 登録日 | 2024-06-07 | | 公開日 | 2024-10-30 | | 最終更新日 | 2024-12-25 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | The CRISPR-associated adenosine deaminase Cad1 converts ATP to ITP to provide antiviral immunity.
Cell, 187, 2024
|
|
