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PDB: 53266 件

6PZU
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Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with AP-1-62-A
分子名称: Hdac6 protein, N-[(benzyloxy)carbonyl]-L-leucyl-N-{[4-(hydroxycarbamoyl)phenyl]methyl}-L-alaninamide, POTASSIUM ION, ...
著者Osko, J.D, Christianson, D.W.
登録日2019-08-01
公開日2020-02-05
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6.
J.Med.Chem., 63, 2020
6VON
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BU of 6von by Molmil
Chloroplast ATP synthase (R1, CF1FO)
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase delta chain, ...
著者Yang, J.-H, Williams, D, Kandiah, E, Fromme, P, Chiu, P.-L.
登録日2020-01-30
公開日2020-09-09
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献Structural basis of redox modulation on chloroplast ATP synthase.
Commun Biol, 3, 2020
7O3X
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BU of 7o3x by Molmil
Structural basis for VIPP1 oligomerization and maintenance of thylakoid membrane integrity
分子名称: ADENOSINE-5'-DIPHOSPHATE, Protein sll0617
著者Gupta, T.K, Klumpe, S, Gries, K, Strauss, M, Rudack, T, Schuller, J.M, Schroda, M, Engel, B.D.
登録日2021-04-03
公開日2021-06-30
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural basis for VIPP1 oligomerization and maintenance of thylakoid membrane integrity.
Cell, 184, 2021
6GE9
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BU of 6ge9 by Molmil
Structure of Mycobacterium tuberculosis GlmU bound to Glc-1P and Ac-CoA
分子名称: 1,2-ETHANEDIOL, 1-O-phosphono-alpha-D-glucopyranose, ACETYL COENZYME *A, ...
著者Craggs, P.D, Mouilleron, S, Rejzek, M, de Chiara, C, Young, R.J, Field, R.A, Argyrou, A, de Carvalho, L.P.S.
登録日2018-04-25
公開日2018-05-02
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献The Mechanism of Acetyl Transfer Catalyzed by Mycobacterium tuberculosis GlmU.
Biochemistry, 57, 2018
6GEN
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BU of 6gen by Molmil
Chromatin remodeller-nucleosome complex at 4.5 A resolution.
分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin-like protein ARP6, BERYLLIUM TRIFLUORIDE ION, ...
著者Willhoft, O, Chua, E.Y.D, Wilkinson, M, Wigley, D.B.
登録日2018-04-27
公開日2018-10-17
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structure and dynamics of the yeast SWR1-nucleosome complex.
Science, 362, 2018
8VEX
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BU of 8vex by Molmil
Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 28
分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, GLYCEROL, ...
著者Whittington, D.A.
登録日2023-12-20
公開日2024-04-24
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP -Deleted Cancers.
J.Med.Chem., 67, 2024
8FC7
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BU of 8fc7 by Molmil
Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK2798745
分子名称: 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Kwon, D.H, Lee, S.-Y, Zhang, F.
登録日2022-12-01
公開日2023-07-12
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.
Nat Commun, 14, 2023
6ZTZ
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BU of 6ztz by Molmil
Assembly intermediates of orthoreovirus captured in the cell
分子名称: Inner capsid protein lambda-1, Inner capsid protein sigma-2, Outer capsid protein lambda-2, ...
著者Sutton, G.C, Stuart, D.I.
登録日2020-07-20
公開日2020-09-16
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY
主引用文献Assembly intermediates of orthoreovirus captured in the cell.
Nat Commun, 11, 2020
6GEJ
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BU of 6gej by Molmil
Chromatin remodeller-nucleosome complex at 3.6 A resolution.
分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin-like protein ARP6, BERYLLIUM TRIFLUORIDE ION, ...
著者Willhoft, O, Chua, E.Y.D, Wilkinson, M, Wigley, D.B.
登録日2018-04-26
公開日2018-10-17
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structure and dynamics of the yeast SWR1-nucleosome complex.
Science, 362, 2018
5M32
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BU of 5m32 by Molmil
Human 26S proteasome in complex with Oprozomib
分子名称: 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ...
著者Haselbach, D, Schrader, J, Lambrecht, F, Henneberg, F, Chari, A, Stark, H.
登録日2016-10-14
公開日2017-07-05
最終更新日2019-12-11
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs.
Nat Commun, 8, 2017
7OGM
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BU of 7ogm by Molmil
A cooperative PNPase-Hfq-RNA carrier complex facilitates bacterial riboregulation. PNPase-3'ETS(leuZ)-Hfq
分子名称: 3'ETS(LeuZ), Polyribonucleotide nucleotidyltransferase, RNA-binding protein Hfq
著者Dendooven, T, Sinha, D, Roesoleva, A, Cameron, T.A, De Lay, N, Luisi, B.F, Bandyra, K.
登録日2021-05-06
公開日2021-07-07
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献A cooperative PNPase-Hfq-RNA carrier complex facilitates bacterial riboregulation.
Mol.Cell, 81, 2021
7NWN
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BU of 7nwn by Molmil
A carbohydrate binding module family 9 (CBM9) from Caldicellulsiruptor kristjanssonii
分子名称: 1,2-ETHANEDIOL, Beta-xylanase, CALCIUM ION, ...
著者Krska, D, Mazurkewich, S, Navarro Poulsen, J, Larsbrink, J, Lo Leggio, L.
登録日2021-03-17
公開日2021-07-07
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Structural and Functional Analysis of a Multimodular Hyperthermostable Xylanase-Glucuronoyl Esterase from Caldicellulosiruptor kristjansonii .
Biochemistry, 60, 2021
6Q31
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BU of 6q31 by Molmil
Dye type peroxidase Aa from Streptomyces lividans: 156.8 kGy structure
分子名称: Deferrochelatase/peroxidase, PROTOPORPHYRIN IX CONTAINING FE
著者Ebrahim, A, Moreno-Chicano, T, Worrall, J.A.R, Strange, R.W, Axford, D, Sherrell, D.A, Appleby, M, Owen, R.L.
登録日2018-12-03
公開日2019-07-31
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Dose-resolved serial synchrotron and XFEL structures of radiation-sensitive metalloproteins.
Iucrj, 6, 2019
6O0I
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BU of 6o0i by Molmil
NMR ensemble of computationally designed protein XAA
分子名称: Design construct XAA
著者Wei, K.Y, Moschidi, D, Nerli, S, Sgourakis, N, Baker, D.
登録日2019-02-16
公開日2020-04-22
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Computational design of closely related proteins that adopt two well-defined but structurally divergent folds.
Proc.Natl.Acad.Sci.USA, 117, 2020
5U7O
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BU of 5u7o by Molmil
Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-626529 in Complex with Human Antibodies PGT122 and 35O22 at 3.8 Angstrom
分子名称: 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Pancera, M, Lai, Y.-T, Kwong, P.D.
登録日2016-12-12
公開日2017-08-30
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.031 Å)
主引用文献Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.
Nat. Chem. Biol., 13, 2017
6W47
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BU of 6w47 by Molmil
Peptoid-Containing Collagen Peptide
分子名称: 1,2-ETHANEDIOL, Collagen-like peptide
著者Chenoweth, D.M, Melton, S.D.
登録日2020-03-10
公開日2020-08-12
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Rules for the design of aza-glycine stabilized triple-helical collagen peptides.
Chem Sci, 11, 2020
8FF0
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BU of 8ff0 by Molmil
Structure of BTK kinase domain with the second-generation inhibitor tirabrutinib
分子名称: 6-azanyl-9-[(3~{R})-1-[(~{E})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one, Tyrosine-protein kinase BTK
著者Lin, D.Y, Andreotti, A.H.
登録日2022-12-07
公開日2023-07-05
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of BTK kinase domain with the second-generation inhibitors acalabrutinib and tirabrutinib.
Plos One, 18, 2023
8JZS
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BU of 8jzs by Molmil
Outward-facing SLC15A4 dimer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, lysosomal transporter
著者Zhang, S.S, Chen, X.D, Xie, M.
登録日2023-07-06
公開日2023-09-27
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (2.95 Å)
主引用文献Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling.
Nat Commun, 14, 2023
6NK6
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BU of 6nk6 by Molmil
Electron Cryo-Microscopy Of Chikungunya VLP in complex with mouse Mxra8 receptor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid protein, E1 glycoprotein, ...
著者Basore, K, Kim, A.S, Nelson, C.A, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2019-01-04
公開日2019-05-22
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (4.06 Å)
主引用文献Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor.
Cell, 177, 2019
8DHW
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BU of 8dhw by Molmil
Treponema lecithinolyticum beta-glucuronidase in complex with a UNC4917-glucuronide conjugate
分子名称: 4-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-2,7-bis(methylamino)pyrido[3',2':4,5]thieno[3,2-d]pyrimidine, Glycosyl hydrolase family 2, TIM barrel domain protein, ...
著者Lietzan, A.D, Redinbo, M.R.
登録日2022-06-28
公開日2023-05-17
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Microbial beta-glucuronidases drive human periodontal disease etiology.
Sci Adv, 9, 2023
6W8U
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BU of 6w8u by Molmil
Cryo-EM of the Pyrobaculum arsenaticum pilus
分子名称: pilin
著者Wang, F, Baquero, D.P, Su, Z, Beltran, L.C, Prangishvili, D, Krupovic, M, Egelman, E.H.
登録日2020-03-21
公開日2020-07-08
最終更新日2021-10-06
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献The structures of two archaeal type IV pili illuminate evolutionary relationships.
Nat Commun, 11, 2020
6XU4
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BU of 6xu4 by Molmil
Crystal structure of the genetically-encoded FGCaMP calcium indicator in its calcium-bound state
分子名称: CALCIUM ION, FGCamp
著者Boyko, K.M, Nikolaeva, A.Y, Korzhenevskiy, D.A, Barykina, N.V, Subach, O.M, Subach, F.V.
登録日2020-01-17
公開日2020-04-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.18 Å)
主引用文献FGCaMP7, an Improved Version of Fungi-Based Ratiometric Calcium Indicator for In Vivo Visualization of Neuronal Activity.
Int J Mol Sci, 21, 2020
6T5J
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BU of 6t5j by Molmil
Structure of NUDT15 in complex with inhibitor TH1760
分子名称: 6-[4-(1~{H}-indol-5-ylcarbonyl)piperazin-1-yl]sulfonyl-3~{H}-1,3-benzoxazol-2-one, CHLORIDE ION, MAGNESIUM ION, ...
著者Carter, M, Rehling, D, Desroses, M, Zhang, S.M, Hagenkort, A, Valerie, N.C.K, Helleday, T, Stenmark, P.
登録日2019-10-16
公開日2020-07-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Development of a chemical probe against NUDT15.
Nat.Chem.Biol., 16, 2020
6VLG
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BU of 6vlg by Molmil
Crystal structure of mouse alpha 1,6-fucosyltransferase, FUT8 bound to GDP
分子名称: Alpha-(1,6)-fucosyltransferase, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ...
著者Jarva, M.A, Dramicanin, M, Lingford, J.P, Mao, R, John, A, Goddard-Borger, E.D.
登録日2020-01-23
公開日2020-02-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis of substrate recognition and catalysis by fucosyltransferase 8.
J.Biol.Chem., 295, 2020
6Q34
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Dye type peroxidase Aa from Streptomyces lividans: 196 kGy structure
分子名称: Deferrochelatase/peroxidase, PROTOPORPHYRIN IX CONTAINING FE
著者Ebrahim, A, Moreno-Chicano, T, Worrall, J.A.R, Strange, R.W, Axford, D, Sherrell, D.A, Appleby, M, Owen, R.L.
登録日2018-12-03
公開日2019-07-31
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Dose-resolved serial synchrotron and XFEL structures of radiation-sensitive metalloproteins.
Iucrj, 6, 2019

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件を2024-09-04に公開中

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