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PDB: 56 results

3MGX
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BU of 3mgx by Molmil
Crystal Structure of P450 OxyD that is involved in the Biosynthesis of Vancomycin-type Antibiotics
Descriptor: GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, Putative P450 monooxygenase
Authors:Cryle, M.J, Schlichting, I.
Deposit date:2010-04-07
Release date:2010-06-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural characterization of oxyd, a cytochrome p450 involved in {beta}-hydroxytyrosine formation in vancomycin biosynthesis
J.Biol.Chem., 285, 2010
4L0F
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BU of 4l0f by Molmil
Structure of P450sky (CYP163B3), a cytochrome P450 from skyllamycin biosynthesis (open active site)
Descriptor: 1,2-ETHANEDIOL, P450 monooxygenase, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Cryle, M.J.
Deposit date:2013-05-31
Release date:2013-09-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Cytochrome p450sky interacts directly with the nonribosomal Peptide synthetase to generate three amino Acid precursors in skyllamycin biosynthesis.
Acs Chem.Biol., 8, 2013
4L0E
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BU of 4l0e by Molmil
Structure of P450sky (CYP163B3), a cytochrome P450 from skyllamycin biosynthesis (heme-coordinated expression tag)
Descriptor: P450 monooxygenase, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
Authors:Cryle, M.J.
Deposit date:2013-05-31
Release date:2013-09-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Cytochrome p450sky interacts directly with the nonribosomal Peptide synthetase to generate three amino Acid precursors in skyllamycin biosynthesis.
Acs Chem.Biol., 8, 2013
3NC7
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BU of 3nc7 by Molmil
CYP134A1 2-phenylimidazole bound structure
Descriptor: 2-phenyl-1H-imidazole, Cytochrome P450 cypX, MAGNESIUM ION, ...
Authors:Cryle, M.J, Schlichting, I.
Deposit date:2010-06-04
Release date:2010-08-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural and biochemical characterization of the cytochrome P450 CypX (CYP134A1) from Bacillus subtilis: a cyclo-L-leucyl-L-leucyl dipeptide oxidase.
Biochemistry, 49, 2010
3NC5
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BU of 3nc5 by Molmil
CYP134A1 structure with an open substrate binding loop
Descriptor: Cytochrome P450 cypX, GLYCEROL, MAGNESIUM ION, ...
Authors:Cryle, M.J, Schlichting, I.
Deposit date:2010-06-04
Release date:2010-08-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and biochemical characterization of the cytochrome P450 CypX (CYP134A1) from Bacillus subtilis: a cyclo-L-leucyl-L-leucyl dipeptide oxidase.
Biochemistry, 49, 2010
3NC6
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BU of 3nc6 by Molmil
CYP134A1 1-phenylimidazole bound structure
Descriptor: 1-phenyl-1H-imidazole, Cytochrome P450 cypX, MAGNESIUM ION, ...
Authors:Cryle, M.J, Schlichting, I.
Deposit date:2010-06-04
Release date:2010-08-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural and biochemical characterization of the cytochrome P450 CypX (CYP134A1) from Bacillus subtilis: a cyclo-L-leucyl-L-leucyl dipeptide oxidase.
Biochemistry, 49, 2010
3NC3
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BU of 3nc3 by Molmil
CYP134A1 structure with a closed substrate binding loop
Descriptor: Cytochrome P450 cypX, GLYCEROL, MAGNESIUM ION, ...
Authors:Cryle, M.J, Schlichting, I.
Deposit date:2010-06-04
Release date:2010-08-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Structural and biochemical characterization of the cytochrome P450 CypX (CYP134A1) from Bacillus subtilis: a cyclo-L-leucyl-L-leucyl dipeptide oxidase.
Biochemistry, 49, 2010
3O1A
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BU of 3o1a by Molmil
Structure of OxyE (CYP165D3), a Cytochrome P450 Involved in Teicoplanin Biosynthesis
Descriptor: Oxy protein, PROTOPORPHYRIN IX CONTAINING FE
Authors:Cryle, M.J, Schlichting, I.
Deposit date:2010-07-21
Release date:2010-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural characterization of CYP165D3, a cytochrome P450 involved in phenolic coupling in teicoplanin biosynthesis.
Arch.Biochem.Biophys., 507, 2011
5EX9
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BU of 5ex9 by Molmil
Structure of P450 StaF from glycopeptide antibiotic A47934 biosynthesis; glycerol cryo
Descriptor: Cytochrome P450, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE
Authors:Cryle, M.J, Ulrich, V.
Deposit date:2015-11-23
Release date:2017-01-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Biochemical and structural characterisation of the second oxidative crosslinking step during the biosynthesis of the glycopeptide antibiotic A47934.
Beilstein J Org Chem, 12, 2016
5EX8
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BU of 5ex8 by Molmil
Structure of P450 StaF from glycopeptide antibiotic A47934 biosynthesis; ethylene glycol cryo
Descriptor: 1,2-ETHANEDIOL, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE
Authors:Cryle, M.J, Ulrich, V.
Deposit date:2015-11-23
Release date:2017-01-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Biochemical and structural characterisation of the second oxidative crosslinking step during the biosynthesis of the glycopeptide antibiotic A47934.
Beilstein J Org Chem, 12, 2016
5EX6
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BU of 5ex6 by Molmil
Structure of P450 StaH from glycopeptide antibiotic A47934 biosynthesis
Descriptor: 1,2-ETHANEDIOL, Cytochrome P450, GLYCEROL, ...
Authors:Cryle, M.J, Ulrich, V.
Deposit date:2015-11-23
Release date:2016-08-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:More than just recruitment: the X-domain influences catalysis of the first phenolic coupling reaction in A47934 biosynthesis by Cytochrome P450 StaH.
Mol Biosyst, 12, 2016
3EJE
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BU of 3eje by Molmil
Crystal Structure of P450BioI in complex with octadec-9Z-enoic acid ligated Acyl Carrier Protein
Descriptor: Acyl carrier protein, Biotin biosynthesis cytochrome P450-like enzyme, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Cryle, M.J, Schlichting, I.
Deposit date:2008-09-18
Release date:2008-10-07
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3EJD
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BU of 3ejd by Molmil
Crystal Structure of P450BioI in complex with hexadec-9Z-enoic acid ligated Acyl Carrier Protein
Descriptor: Acyl carrier protein, Biotin biosynthesis cytochrome P450-like enzyme, CHLORIDE ION, ...
Authors:Cryle, M.J, Schlichting, I.
Deposit date:2008-09-18
Release date:2008-10-07
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3EJB
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BU of 3ejb by Molmil
Crystal Structure of P450BioI in complex with tetradecanoic acid ligated Acyl Carrier Protein
Descriptor: Acyl carrier protein, Biotin biosynthesis cytochrome P450-like enzyme, CHLORIDE ION, ...
Authors:Cryle, M.J, Schlichting, I.
Deposit date:2008-09-18
Release date:2008-10-07
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex.
Proc.Natl.Acad.Sci.Usa, 105, 2008
8U3N
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BU of 8u3n by Molmil
Structure of P450Blt from Micromonospora sp. MW-13
Descriptor: Cytochrome P450-SU1, POTASSIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Hansen, M.H, Cryle, M.J, Zhao, Y.
Deposit date:2023-09-08
Release date:2024-01-10
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural Insights into a Side Chain Cross-Linking Biarylitide P450 from RiPP Biosynthesis
Acs Catalysis, 2024
8U2M
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BU of 8u2m by Molmil
Structure of P450Blt from Micromonospora sp. MW-13 in Complex with Biarylitide
Descriptor: 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, ACETATE ION, Cytochrome P450-SU1, ...
Authors:Hansen, M.H, Cryle, M.J.
Deposit date:2023-09-06
Release date:2024-01-10
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structural Insights into a Side Chain Cross-Linking Biarylitide P450 from RiPP Biosynthesis
Acs Catalysis, 2024
8UKZ
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BU of 8ukz by Molmil
Structure of P450Blt from Micromonospora sp. MW-13 with E238A Mutation
Descriptor: ACETATE ION, Cytochrome P450-SU1, DI(HYDROXYETHYL)ETHER, ...
Authors:Hansen, M.H, Cryle, M.J.
Deposit date:2023-10-15
Release date:2024-01-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Insights into a Side Chain Cross-Linking Biarylitide P450 from RiPP Biosynthesis
Acs Catalysis, 2024
6FSH
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BU of 6fsh by Molmil
Crystal structure of hybrid P450 OxyBtei(BC/FGvan)
Descriptor: ACETATE ION, OxyB protein, POTASSIUM ION, ...
Authors:Brieke, C, Tarnawski, M, Greule, A, Cryle, M.J.
Deposit date:2018-02-19
Release date:2018-05-23
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Investigating Cytochrome P450 specificity during glycopeptide antibiotic biosynthesis through a homologue hybridization approach.
J. Inorg. Biochem., 185, 2018
8FX6
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BU of 8fx6 by Molmil
Non-ribosomal PCP-C didomain (amide stabilised leucine) acceptor bound state
Descriptor: N-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]-L-leucinamide, PCP-C didomain
Authors:Ho, Y.T.C, Cryle, M.J.
Deposit date:2023-01-24
Release date:2023-06-21
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Not always an innocent bystander: the impact of stabilised phosphopantetheine moieties when studying nonribosomal peptide biosynthesis.
Chem.Commun.(Camb.), 59, 2023
8FX7
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BU of 8fx7 by Molmil
Non-ribosomal PCP-C didomain (ester stabilised leucine) acceptor bound state
Descriptor: 2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl L-leucinate, PCP-C didomain
Authors:Ho, Y.T.C, Cryle, M.J.
Deposit date:2023-01-24
Release date:2023-06-21
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Not always an innocent bystander: the impact of stabilised phosphopantetheine moieties when studying nonribosomal peptide biosynthesis.
Chem.Commun.(Camb.), 59, 2023
6M7L
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BU of 6m7l by Molmil
Complex of OxyA with the X-domain from GPA biosynthesis
Descriptor: PROTOPORPHYRIN IX CONTAINING FE, Putative cytochrome P450 hydroxylase, Putative non-ribosomal peptide synthetase
Authors:Greule, A, Izore, T, Tailhades, J, Peschke, M, Schoppet, M, Ahmed, I, Kulik, A, Adamek, M, Ziemert, N, De Voss, J, Stegmann, E, Cryle, M.J.
Deposit date:2018-08-20
Release date:2019-05-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.648297 Å)
Cite:Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics.
Nat Commun, 10, 2019
4RM4
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BU of 4rm4 by Molmil
The crystal structure of the versatile cytochrome P450 enzyme CYP109B1 from Bacillus subtilis
Descriptor: Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE
Authors:Zhouw, W.H, Zhang, A.L, Zhang, T, Hall, E.A, Hutchinson, S, Cryle, M.J, Wong, L.-L, Bell, S.G.
Deposit date:2014-10-18
Release date:2015-02-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.771 Å)
Cite:The crystal structure of the versatile cytochrome P450 enzyme CYP109B1 from Bacillus subtilis.
Mol Biosyst, 11, 2015
4TX3
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BU of 4tx3 by Molmil
Complex of the X-domain and OxyB from Teicoplanin Biosynthesis
Descriptor: 1,2-ETHANEDIOL, OxyB protein, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Peschke, M, Haslinger, K, Cryle, M.J.
Deposit date:2014-07-02
Release date:2015-02-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis.
Nature, 521, 2015
4TVF
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BU of 4tvf by Molmil
OxyB from Actinoplanes teichomyceticus
Descriptor: OxyB, PROTOPORPHYRIN IX CONTAINING FE
Authors:Haslinger, K, Cryle, M.J.
Deposit date:2014-06-26
Release date:2014-11-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Cytochrome P450 OxyBtei Catalyzes the First Phenolic Coupling Step in Teicoplanin Biosynthesis.
Chembiochem, 15, 2014
4TX2
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BU of 4tx2 by Molmil
Crystal structure of the X-domain from teicoplanin biosynthesis
Descriptor: Non-ribosomal peptide synthetase
Authors:Peschke, M, Haslinger, K, Cryle, M.J.
Deposit date:2014-07-02
Release date:2015-02-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis.
Nature, 521, 2015

 

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