5J02
| Structure of the lariat form of a chimeric derivative of the Oceanobacillus iheyensis group II intron in the presence of NH4+, MG2+ and an inactive 5' exon. | Descriptor: | 5' EXON ANALOG (5'-R(*CP*UP*GP*UP*UP*AP*(5MU))-3'), AMMONIUM ION, GROUP II INTRON LARIAT, ... | Authors: | Costa, M, Walbott, H, Monachello, D, Westhof, E, Michel, F. | Deposit date: | 2016-03-26 | Release date: | 2016-12-14 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.493 Å) | Cite: | Crystal structures of a group II intron lariat primed for reverse splicing. Science, 354, 2016
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5J01
| Structure of the lariat form of a chimeric derivative of the Oceanobacillus iheyensis group II intron in the presence of NH4+ and MG2+. | Descriptor: | AMMONIUM ION, MAGNESIUM ION, group II intron lariat | Authors: | Costa, M, Walbott, H, Monachello, D, Westhof, E, Michel, F. | Deposit date: | 2016-03-26 | Release date: | 2016-12-14 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.39 Å) | Cite: | Crystal structures of a group II intron lariat primed for reverse splicing. Science, 354, 2016
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2FDQ
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1NC6
| Potent, small molecule inhibitors of human mast cell tryptase. Anti-asthmatic action of a dipeptide-based transition state analogue containing benzothiazole ketone | Descriptor: | (2S,4R)-1-ACETYL-N-[(1S)-4-[(AMINOIMINOMETHYL)AMINO]-1-(2-BENZOTHIAZOLYLCARBONYL)BUTYL]-4-HYDROXY-2-PYRROLIDINECARBOXAMIDE, CALCIUM ION, SULFATE ION, ... | Authors: | Costanzo, M.J, Yabut, S.C, Almond Jr, H.R, Andrade-Gordon, P, Corcoran, T.W, de Garavilla, L, Kauffman, J.A, Abraham, W.M, Recacha, R, Chattopadhyay, D, Maryanoff, B.E. | Deposit date: | 2002-12-04 | Release date: | 2003-09-23 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Potent, Small-Molecule Inhibitors of Human Mast Cell Tryptase. Antiasthmatic Action of a Dipeptide-Based Transition-State Analogue Containing a Benzothiazole Ketone. J.Med.Chem., 46, 2003
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3O3P
| Crystal structure of R. xylanophilus MpgS in complex with GDP-Mannose | Descriptor: | CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, ... | Authors: | Macedo-Ribeiro, S, Pereira, P.J.B, Empadinhas, N, da Costa, M.S. | Deposit date: | 2010-07-25 | Release date: | 2010-11-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.529 Å) | Cite: | Functional and structural characterization of a novel mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus reveals its dual substrate specificity Mol.Microbiol., 79, 2011
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2CJJ
| Crystal Structure of the MYB domain of the RAD transcription factor from Antirrhinum majus | Descriptor: | RADIALIS | Authors: | Stevenson, C.E.M, Burton, N, Costa, M.M, Nath, U, Dixon, R.A, Coen, E.S, Lawson, D.M. | Deposit date: | 2006-04-04 | Release date: | 2006-10-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structure of the Myb Domain of the Rad Transcription Factor from Antirrhinum Majus. Proteins: Struct., Funct., Bioinf., 65, 2006
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3F1Y
| Mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Mannosyl-3-phosphoglycerate synthase | Authors: | Macedo-Ribeiro, S, Pereira, P.J.B, Empadinhas, N, da Costa, M.S. | Deposit date: | 2008-10-28 | Release date: | 2009-11-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Functional and structural characterization of a novel mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus reveals its dual substrate specificity Mol.Microbiol., 79, 2011
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3E26
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3E25
| Crystal structure of M. tuberculosis glucosyl-3-phosphoglycerate synthase | Descriptor: | 3-PHOSPHOGLYCERIC ACID, MAGNESIUM ION, Putative uncharacterized protein, ... | Authors: | Pereira, P.J.B, Empadinhas, N, Costa, M.S, Macedo-Ribeiro, S. | Deposit date: | 2008-08-05 | Release date: | 2008-12-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Mycobacterium tuberculosis glucosyl-3-phosphoglycerate synthase: structure of a key enzyme in methylglucose lipopolysaccharide biosynthesis Plos One, 3, 2008
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7KJJ
| Reconstructed ancestor of HIUases and Transthyretins | Descriptor: | 1,2-ETHANEDIOL, 3,5,3',5'-TETRAIODO-L-THYRONINE, TTR ancestor | Authors: | Nagem, R.A.P, Bleicher, L, Costa, M.A.F. | Deposit date: | 2020-10-26 | Release date: | 2021-05-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Reenacting the Birth of a Function: Functional Divergence of HIUases and Transthyretins as Inferred by Evolutionary and Biophysical Studies. J.Mol.Evol., 89, 2021
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7KCN
| Reconstructed ancestor of HIUases and Transthyretins | Descriptor: | 1,2-ETHANEDIOL, HIUase-TTR ancestor, PHOSPHATE ION | Authors: | Nagem, R.A.P, Bleicher, L, Costa, M.A.F. | Deposit date: | 2020-10-06 | Release date: | 2021-05-19 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | Reenacting the Birth of a Function: Functional Divergence of HIUases and Transthyretins as Inferred by Evolutionary and Biophysical Studies. J.Mol.Evol., 89, 2021
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1EA4
| TRANSCRIPTIONAL REPRESSOR COPG/22bp dsDNA COMPLEX | Descriptor: | DNA (5'-D(*TP*AP*AP*CP*CP*GP*TP*GP *CP*AP*CP*TP*CP*AP*AP*TP*GP*CP*AP*AP*TP*C)-3'), DNA(5'-D(*AP*GP*AP*TP*TP*GP*CP*AP*TP *TP*GP*AP*GP*TP*GP*CP*AP*CP*GP*GP*TP*T)-3'), TRANSCRIPTIONAL REPRESSOR COPG | Authors: | Gomis-Rueth, F.X, Costa, M, Sola, M, Acebo, P, Eritja, R, Espinosa, M, Solar, G.D, Coll, M. | Deposit date: | 2000-11-05 | Release date: | 2001-07-05 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Plasmid Transcriptional Repressor Copg Oligomerises to Render Helical Superstructures Unbound and in Complexes with Oligonucleotides J.Mol.Biol., 310, 2001
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1T3K
| NMR structure of a CDC25-like dual-specificity tyrosine phosphatase of Arabidopsis thaliana | Descriptor: | Dual-specificity tyrosine phosphatase, ZINC ION | Authors: | Landrieu, I, da Costa, M, De Veylder, L, Dewitte, F, Vandepoele, K, Hassan, S, Wieruszeski, J.M, Faure, J.D, Inze, D, Lippens, G. | Deposit date: | 2004-04-27 | Release date: | 2004-09-07 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | A small CDC25 dual-specificity tyrosine-phosphatase isoform in Arabidopsis thaliana. Proc.Natl.Acad.Sci.Usa, 101, 2004
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3KIA
| Crystal structure of mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus | Descriptor: | CHLORIDE ION, GUANOSINE-5'-MONOPHOSPHATE, MAGNESIUM ION, ... | Authors: | Macedo-Ribeiro, S, Pereira, P.J.B, Empadinhas, N, da Costa, M.S. | Deposit date: | 2009-11-01 | Release date: | 2010-11-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Functional and structural characterization of a novel mannosyl-3-phosphoglycerate synthase from Rubrobacter xylanophilus reveals its dual substrate specificity Mol.Microbiol., 79, 2011
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5UVD
| Crystal structure of an antigenic nucleotidyltransferase-like protein from Paracoccidioides brasiliensis | Descriptor: | MAGNESIUM ION, Nucleotidyltransferase-like protein | Authors: | Nagem, R.A.P, Costa, M.A.F, Rodrigues, F.T.G, Coitinho, J.B.C. | Deposit date: | 2017-02-20 | Release date: | 2018-01-31 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structural and immunological characterization of a new nucleotidyltransferase-like antigen from Paracoccidioides brasiliensis. Mol.Immunol., 112, 2019
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4KC7
| Crystal Structure of Endo-1,5-alpha-L-arabinanase from Thermotoga petrophila RKU-1 | Descriptor: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, Glycoside hydrolase, ... | Authors: | Nascimento, A.F.Z, Polo, C.C, Santos, C.R, Costa, M.C.M.F, Mesa, A.N, Prade, R.A, Ruller, R, Squina, F.M, Murakami, M.T. | Deposit date: | 2013-04-24 | Release date: | 2014-02-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Mechanistic strategies for catalysis adopted by evolutionary distinct family 43 arabinanases. J.Biol.Chem., 289, 2014
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4KCA
| Crystal Structure of Endo-1,5-alpha-L-arabinanase from a Bovine Ruminal Metagenomic Library | Descriptor: | Endo-1,5-alpha-L-arabinanase, GLYCEROL, IODIDE ION, ... | Authors: | Santos, C.R, Polo, C.C, Costa, M.C.M.F, Nascimento, A.F.Z, Wong, D.W.S, Murakami, M.T. | Deposit date: | 2013-04-24 | Release date: | 2014-02-05 | Last modified: | 2014-04-09 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Mechanistic strategies for catalysis adopted by evolutionary distinct family 43 arabinanases. J.Biol.Chem., 289, 2014
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4KCB
| Crystal Structure of Exo-1,5-alpha-L-arabinanase from Bovine Ruminal Metagenomic Library | Descriptor: | Arabinan endo-1,5-alpha-L-arabinosidase, PHOSPHATE ION | Authors: | Santos, C.R, Polo, C.C, Costa, M.C.M.F, Nascimento, A.F.Z, Wong, D.W.S, Murakami, M.T. | Deposit date: | 2013-04-24 | Release date: | 2014-02-05 | Last modified: | 2014-04-09 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Mechanistic strategies for catalysis adopted by evolutionary distinct family 43 arabinanases. J.Biol.Chem., 289, 2014
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4KC8
| Crystal Structure of Endo-1,5-alpha-L-arabinanase from Thermotoga petrophila RKU-1 in complex with TRIS | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Glycoside hydrolase, ... | Authors: | Nascimento, A.F.Z, Polo, C.C, Santos, C.R, Costa, M.C.M.F, Mesa, A.N, Prade, R.A, Ruller, R, Squina, F.M, Murakami, M.T. | Deposit date: | 2013-04-24 | Release date: | 2014-02-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Mechanistic strategies for catalysis adopted by evolutionary distinct family 43 arabinanases. J.Biol.Chem., 289, 2014
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1SUX
| CRYSTALLOGRAPHIC ANALYSIS OF THE COMPLEX BETWEEN TRIOSEPHOSPHATE ISOMERASE FROM TRYPANOSOMA CRUZI AND 3-(2-benzothiazolylthio)-1-propanesulfonic acid | Descriptor: | 3-(2-BENZOTHIAZOLYLTHIO)-1-PROPANESULFONIC ACID, SULFATE ION, Triosephosphate isomerase, ... | Authors: | Tellez-Valencia, A, Olivares-Illana, V, Hernandez-Santoyo, A, Perez-Montfort, R, Costas, M, Rodriguez-Romero, A, Tuena De Gomez-Puyou, M, Gomez-Puyou, A. | Deposit date: | 2004-03-26 | Release date: | 2004-08-24 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Inactivation of triosephosphate isomerase from Trypanosoma cruzi by an agent that perturbs its dimer interface. J.Mol.Biol., 341, 2004
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2VOM
| Structural basis of human triosephosphate isomerase deficiency. Mutation E104D and correlation to solvent perturbation. | Descriptor: | TRIOSEPHOSPHATE ISOMERASE | Authors: | Rodriguez-Almazan, C, Arreola-Alemon, R, Rodriguez-Larrea, D, Aguirre-Lopez, B, de Gomez-Puyou, M.T, Perez-Montfort, R, Costas, M, Gomez-Puyou, A, Torres-Larios, A. | Deposit date: | 2008-02-19 | Release date: | 2008-06-17 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural Basis of Human Triosephosphate Isomerase Deficiency: Mutation E104D is Related to Alterations of a Conserved Water Network at the Dimer Interface. J.Biol.Chem., 283, 2008
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2JK2
| STRUCTURAL BASIS OF HUMAN TRIOSEPHOSPHATE ISOMERASE DEFICIENCY. CRYSTAL STRUCTURE OF THE WILD TYPE ENZYME. | Descriptor: | TRIOSEPHOSPHATE ISOMERASE | Authors: | Rodriguez-Almazan, C, Arreola-Alemon, R, Rodriguez-Larrea, D, Aguirre-Lopez, B, De Gomez-Puyou, M.T, Perez-Montfort, R, Costas, M, Gomez-Puyou, A, Torres-Larios, A. | Deposit date: | 2008-06-22 | Release date: | 2008-07-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Basis of Human Triosephosphate Isomerase Deficiency: Mutation E104D is Related to Alterations of a Conserved Water Network at the Dimer Interface. J.Biol.Chem., 283, 2008
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1A4W
| CRYSTAL STRUCTURES OF THROMBIN WITH THIAZOLE-CONTAINING INHIBITORS: PROBES OF THE S1' BINDING SITE | Descriptor: | ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRUGEN, ... | Authors: | Matthews, J.H, Krishnan, R, Costanzo, M.J, Maryanoff, B.E, Tulinsky, A. | Deposit date: | 1998-02-06 | Release date: | 1998-04-29 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site. Biophys.J., 71, 1996
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1KWF
| Atomic Resolution Structure of an Inverting Glycosidase in Complex with Substrate | Descriptor: | Endoglucanase A, beta-D-glucopyranose, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose | Authors: | Guerin, D.M.A, Lascombe, M.-B, Costabel, M, Souchon, H, Lamzin, V, Beguin, P, Alzari, P.M. | Deposit date: | 2002-01-29 | Release date: | 2002-03-13 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (0.94 Å) | Cite: | Atomic (0.94 A) resolution structure of an inverting glycosidase in complex with substrate. J.Mol.Biol., 316, 2002
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1DOJ
| Crystal structure of human alpha-thrombin*RWJ-51438 complex at 1.7 A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-THROMBIN, HIRUGEN, ... | Authors: | Recacha, R, Costanzo, M.J, Maryanoff, B.E, Carson, M, DeLucas, L, Chattopadhyay, D. | Deposit date: | 1999-12-21 | Release date: | 2000-11-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure of human alpha-thrombin complexed with RWJ-51438 at 1.7 A: unusual perturbation of the 60A-60I insertion loop. Acta Crystallogr.,Sect.D, 56, 2000
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