2AU3
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![BU of 2au3 by Molmil](/molmil-images/mine/2au3) | Crystal Structure of the Aquifex aeolicus primase (Zinc Binding and RNA Polymerase Domains) | Descriptor: | DNA primase, ZINC ION | Authors: | Corn, J.E, Pease, P.J, Hura, G.L, Berger, J.M. | Deposit date: | 2005-08-26 | Release date: | 2005-11-15 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crosstalk between primase subunits can act to regulate primer synthesis in trans. Mol.Cell, 20, 2005
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3B39
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![BU of 3b39 by Molmil](/molmil-images/mine/3b39) | |
2M0X
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![BU of 2m0x by Molmil](/molmil-images/mine/2m0x) | |
8AFI
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![BU of 8afi by Molmil](/molmil-images/mine/8afi) | GABARAP in complex with LIR motif of HsATG3 | Descriptor: | ACETATE ION, GLYCEROL, Gamma-aminobutyric acid receptor-associated protein, ... | Authors: | Farnung, J, Benoit, R.M, Corn, J.E, Bode, J.W. | Deposit date: | 2022-07-18 | Release date: | 2023-05-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Semisynthetic LC3 Probes for Autophagy Pathways Reveal a Noncanonical LC3 Interacting Region Motif Crucial for the Enzymatic Activity of Human ATG3. Acs Cent.Sci., 9, 2023
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3H08
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![BU of 3h08 by Molmil](/molmil-images/mine/3h08) | Crystal structure of the Ribonuclease H1 from Chlorobium tepidum | Descriptor: | MAGNESIUM ION, Rnh (Ribonuclease H) | Authors: | Ratcliff, K, Corn, J, Marqusee, S. | Deposit date: | 2009-04-08 | Release date: | 2009-05-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure, stability, and folding of ribonuclease H1 from the moderately thermophilic chlorobium tepidum: comparison with thermophilic and mesophilic homologues. Biochemistry, 48, 2009
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3Q9N
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![BU of 3q9n by Molmil](/molmil-images/mine/3q9n) | In silico and in vitro co-evolution of a high affinity complementary protein-protein interface | Descriptor: | CARBAMOYL SARCOSINE, COENZYME A, CoA binding protein, ... | Authors: | Karanicolas, J, Corn, J.E, Chen, I, Joachimiak, L.A, Dym, O, Chung, S, Albeck, S, Unger, T, Hu, W, Liu, G, Delbecq, S, Montelione, G.T, Spiegel, C, Liu, D, Baker, D, Israel Structural Proteomics Center (ISPC) | Deposit date: | 2011-01-09 | Release date: | 2011-04-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A de novo protein binding pair by computational design and directed evolution. Mol.Cell, 42, 2011
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3Q9U
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![BU of 3q9u by Molmil](/molmil-images/mine/3q9u) | In silico and in vitro co-evolution of a high affinity complementary protein-protein interface | Descriptor: | COENZYME A, CoA binding protein, consensus ankyrin repeat | Authors: | Karanicolas, J, Corn, J.E, Chen, I, Joachimiak, L.A, Dym, O, Chung, S, Albeck, S, Unger, T, Hu, W, Liu, G, Delbecq, S, Montelione, G.T, Spiegel, C, Liu, D, Baker, D, Israel Structural Proteomics Center (ISPC) | Deposit date: | 2011-01-10 | Release date: | 2011-04-20 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A de novo protein binding pair by computational design and directed evolution. Mol.Cell, 42, 2011
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5TOG
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![BU of 5tog by Molmil](/molmil-images/mine/5tog) | Room temperature structure of ubiquitin variant u7ub25.2540 | Descriptor: | Polyubiquitin-B, SULFATE ION | Authors: | Biel, J.T, Thompson, M.C, Cunningham, C.N, Corn, J.E, Fraser, J.S. | Deposit date: | 2016-10-17 | Release date: | 2017-05-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin. Structure, 25, 2017
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4E2K
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![BU of 4e2k by Molmil](/molmil-images/mine/4e2k) | The structure of the S. aureus DnaG RNA Polymerase Domain | Descriptor: | BENZAMIDINE, DNA primase | Authors: | Rymer, R.U, Solorio, F.A, Clement, C, Corn, J.E, Wang, J.D, Berger, J.M. | Deposit date: | 2012-03-08 | Release date: | 2012-08-01 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Binding Mechanism of Metal-NTP Substrates and Stringent-Response Alarmones to Bacterial DnaG-Type Primases. Structure, 20, 2012
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4EDT
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![BU of 4edt by Molmil](/molmil-images/mine/4edt) | The structure of the S. aureus DnaG RNA Polymerase Domain bound to ppGpp and Manganese | Descriptor: | BENZAMIDINE, DNA primase, GUANOSINE-5',3'-TETRAPHOSPHATE, ... | Authors: | Rymer, R.U, Solorio, F.A, Chu, C, Corn, J.E, Wang, J.D, Berger, J.M. | Deposit date: | 2012-03-27 | Release date: | 2012-07-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.005 Å) | Cite: | Binding Mechanism of Metal-NTP Substrates and Stringent-Response Alarmones to Bacterial DnaG-Type Primases. Structure, 20, 2012
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4EDR
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![BU of 4edr by Molmil](/molmil-images/mine/4edr) | The structure of the S. aureus DnaG RNA Polymerase Domain bound to UTP and Manganese | Descriptor: | BENZAMIDINE, DNA primase, MANGANESE (II) ION, ... | Authors: | Rymer, R.U, Solorio, F.A, Chu, C, Corn, J.E, Wang, J.D, Berger, J.M. | Deposit date: | 2012-03-27 | Release date: | 2012-07-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Binding Mechanism of Metal-NTP Substrates and Stringent-Response Alarmones to Bacterial DnaG-Type Primases. Structure, 20, 2012
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4EDV
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![BU of 4edv by Molmil](/molmil-images/mine/4edv) | The structure of the S. aureus DnaG RNA Polymerase Domain bound to pppGpp and Manganese | Descriptor: | BENZAMIDINE, DNA primase, MANGANESE (II) ION, ... | Authors: | Rymer, R.U, Solorio, F.A, Chu, C, Corn, J.E, Wang, J.D, Berger, J.M. | Deposit date: | 2012-03-27 | Release date: | 2012-07-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Binding Mechanism of Metal-NTP Substrates and Stringent-Response Alarmones to Bacterial DnaG-Type Primases. Structure, 20, 2012
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5TOF
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![BU of 5tof by Molmil](/molmil-images/mine/5tof) | Room temperature structure of ubiquitin variant u7ub25 | Descriptor: | Polyubiquitin-B, SULFATE ION | Authors: | Biel, J.T, Thompson, M.C, Cunningham, C.N, Corn, J.E, Fraser, J.S. | Deposit date: | 2016-10-17 | Release date: | 2017-05-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin. Structure, 25, 2017
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4EDG
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![BU of 4edg by Molmil](/molmil-images/mine/4edg) | The structure of the S. aureus DnaG RNA Polymerase Domain bound to ATP and Manganese | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, BENZAMIDINE, DNA primase, ... | Authors: | Rymer, R.U, Solorio, F.A, Chu, C, Corn, J.E, Wang, J.D, Berger, J.M. | Deposit date: | 2012-03-27 | Release date: | 2012-07-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.003 Å) | Cite: | Binding Mechanism of Metal-NTP Substrates and Stringent-Response Alarmones to Bacterial DnaG-Type Primases. Structure, 20, 2012
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4EE1
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![BU of 4ee1 by Molmil](/molmil-images/mine/4ee1) | The structure of the S. aureus DnaG RNA Polymerase Domain bound to CTP and Manganese | Descriptor: | BENZAMIDINE, CYTIDINE-5'-TRIPHOSPHATE, DNA primase, ... | Authors: | Rymer, R.U, Solorio, F.A, Chu, C, Corn, J.E, Wang, J.D, Berger, J.M. | Deposit date: | 2012-03-28 | Release date: | 2012-07-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Binding Mechanism of Metal-NTP Substrates and Stringent-Response Alarmones to Bacterial DnaG-Type Primases. Structure, 20, 2012
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4EDK
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![BU of 4edk by Molmil](/molmil-images/mine/4edk) | The structure of the S. aureus DnaG RNA Polymerase Domain bound to GTP and Manganese | Descriptor: | BENZAMIDINE, DNA primase, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Rymer, R.U, Solorio, F.A, Chu, C, Corn, J.E, Wang, J.D, Berger, J.M. | Deposit date: | 2012-03-27 | Release date: | 2012-07-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Binding Mechanism of Metal-NTP Substrates and Stringent-Response Alarmones to Bacterial DnaG-Type Primases. Structure, 20, 2012
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2QBY
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![BU of 2qby by Molmil](/molmil-images/mine/2qby) | Crystal structure of a heterodimer of Cdc6/Orc1 initiators bound to origin DNA (from S. solfataricus) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 6 homolog 1, Cell division control protein 6 homolog 3, ... | Authors: | Cunningham Dueber, E.L, Corn, J.E, Bell, S.D, Berger, J.M. | Deposit date: | 2007-06-18 | Release date: | 2007-09-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | Replication origin recognition and deformation by a heterodimeric archaeal Orc1 complex. Science, 317, 2007
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4LIM
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![BU of 4lim by Molmil](/molmil-images/mine/4lim) | Crystal structure of the catalytic subunit of yeast primase | Descriptor: | DNA primase small subunit, ZINC ION | Authors: | Vaithiyalingam, S, Chazin, W.J, Berger, J.M, Corn, J, Stephenson, S. | Deposit date: | 2013-07-02 | Release date: | 2013-12-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Insights into Eukaryotic Primer Synthesis from Structures of the p48 Subunit of Human DNA Primase. J.Mol.Biol., 426, 2014
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7BCV
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![BU of 7bcv by Molmil](/molmil-images/mine/7bcv) | |
6FSN
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![BU of 6fsn by Molmil](/molmil-images/mine/6fsn) | Catalytic domain of UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum in complex with UDP-glucose (conformation 1) | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Roversi, P, Le Cornu, J.D, Hill, J, Alonzi, D.S, Zitzmann, N. | Deposit date: | 2018-02-19 | Release date: | 2019-03-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.19 Å) | Cite: | Crystal polymorphism in fragment-based lead discovery of ligands of the catalytic domain of UGGT, the glycoprotein folding quality control checkpoint. Front Mol Biosci, 2022
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7ZKC
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![BU of 7zkc by Molmil](/molmil-images/mine/7zkc) | Catalytic domain of UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum (apo form) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, UDP-glucose-glycoprotein glucosyltransferase-like protein | Authors: | Roversi, P, Zitzmann, N, Bayo, Y, Le Cornu, J.D. | Deposit date: | 2022-04-12 | Release date: | 2022-04-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.769 Å) | Cite: | A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint. Iscience, 26, 2023
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7ZHB
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![BU of 7zhb by Molmil](/molmil-images/mine/7zhb) | Catalytic domain of UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum in complex with UDP-glucose (conformation 2) | Descriptor: | 1,3-PROPANDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Roversi, P, Zitzmann, N, Bayo, Y, Le Cornu, J.D. | Deposit date: | 2022-04-06 | Release date: | 2022-04-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein quality control checkpoint To Be Published
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7ZXW
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![BU of 7zxw by Molmil](/molmil-images/mine/7zxw) | Catalytic domain of UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum in complex with the 5-[(morpholin-4-yl)methyl]quinolin-8-ol inhibitor | Descriptor: | 5-(morpholin-4-ylmethyl)quinolin-8-ol, CALCIUM ION, DIMETHYL SULFOXIDE, ... | Authors: | Le Cornu, J.D, Ibba, R, Roversi, P, Zitzmann, N. | Deposit date: | 2022-05-23 | Release date: | 2022-11-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.246 Å) | Cite: | Crystal polymorphism in fragment-based lead discovery of ligands of the catalytic domain of UGGT, the glycoprotein folding quality control checkpoint. Front Mol Biosci, 9, 2022
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7ZLE
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![BU of 7zle by Molmil](/molmil-images/mine/7zle) | Catalytic domain of UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum in complex with UDP | Descriptor: | 1,2-ETHANEDIOL, 1,3-PROPANDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Roversi, P, Zitzmann, N, Bayo, Y, Le Cornu, J.D. | Deposit date: | 2022-04-14 | Release date: | 2022-06-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.823 Å) | Cite: | A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein quality control checkpoint To Be Published
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