2C38
 
 | | RNase PH core of the archaeal exosome in complex with A5 RNA | | Descriptor: | ADENOSINE MONOPHOSPHATE, CHLORIDE ION, PROBABLE EXOSOME COMPLEX EXONUCLEASE 1, ... | | Authors: | Lorentzen, E, Conti, E. | | Deposit date: | 2005-10-04 | | Release date: | 2005-11-23 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural Basis of 3' End RNA Recognition and Exoribonucleolytic Cleavage by an Exosome Rnase Ph Core.
Mol.Cell, 20, 2005
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2C39
 | | RNase PH core of the archaeal exosome in complex with ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, PROBABLE EXOSOME COMPLEX EXONUCLEASE 1, PROBABLE EXOSOME COMPLEX EXONUCLEASE 2 | | Authors: | Lorentzen, E, Conti, E. | | Deposit date: | 2005-10-05 | | Release date: | 2005-11-23 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structural Basis of 3' End RNA Recognition and Exoribonucleolytic Cleavage by an Exosome Rnase Ph Core.
Mol.Cell, 20, 2005
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1OL5
 | | Structure of Aurora-A 122-403, phosphorylated on Thr287, Thr288 and bound to TPX2 1-43 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RESTRICTED EXPRESSION PROLIFERATION ASSOCIATED PROTEIN 100, ... | | Authors: | Bayliss, R, Conti, E. | | Deposit date: | 2003-08-06 | | Release date: | 2003-10-30 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural Basis of Aurora-A Activation by Tpx2 at the Mitotic Spindle
Mol.Cell, 12, 2003
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1OL7
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1OF5
 | | Crystal structure of Mex67-Mtr2 | | Descriptor: | MERCURY (II) ION, MRNA EXPORT FACTOR MEX67, MRNA TRANSPORT REGULATOR MTR2 | | Authors: | Fribourg, S, Conti, E. | | Deposit date: | 2003-04-08 | | Release date: | 2003-07-03 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural similarity in the absence of sequence homology of the messenger RNA export factors Mtr2 and p15.
EMBO Rep., 4, 2003
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4Q8H
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7QDR
 | | Apo human SKI complex in the closed state | | Descriptor: | Helicase SKI2W, Tetratricopeptide repeat protein 37, WD repeat-containing protein 61 | | Authors: | Koegel, A, Keidel, A, Bonneau, F, Schaefer, I.B, Conti, E. | | Deposit date: | 2021-11-29 | | Release date: | 2022-02-02 | | Last modified: | 2022-03-02 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism.
Mol.Cell, 82, 2022
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7QDS
 | | Apo human SKI complex in the open state | | Descriptor: | Helicase SKI2W, Tetratricopeptide repeat protein 37, WD repeat-containing protein 61 | | Authors: | Koegel, A, Keidel, A, Bonneau, A, Schaefer, I.B, Conti, E. | | Deposit date: | 2021-11-30 | | Release date: | 2022-02-02 | | Last modified: | 2022-03-02 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism.
Mol.Cell, 82, 2022
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4TXD
 | | Crystal structure of Thermofilum pendens Csc2 | | Descriptor: | Csc2, ZINC ION | | Authors: | Hrle, A, Conti, E. | | Deposit date: | 2014-07-03 | | Release date: | 2014-08-27 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.818 Å) | | Cite: | Structural analyses of the CRISPR protein Csc2 reveal the RNA-binding interface of the type I-D Cas7 family.
Rna Biol., 11, 2014
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5MC6
 | | Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | Authors: | Schmidt, C, Kowalinski, E, Shanmuganathan, V, Defenouillere, Q, Braunger, K, Heuer, A, Pech, M, Namane, A, Berninghausen, O, Fromont-Racine, M, Jacquier, A, Conti, E, Becker, T, Beckmann, R. | | Deposit date: | 2016-11-09 | | Release date: | 2017-01-18 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex.
Science, 354, 2016
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5C0X
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1JN5
 | | Structural basis for the recognition of a nucleoporin FG-repeat by the NTF2-like domain of TAP-p15 mRNA export factor | | Descriptor: | FG-repeat, TAP, p15 | | Authors: | Fribourg, S, Braun, I.C, Izaurralde, E, Conti, E. | | Deposit date: | 2001-07-23 | | Release date: | 2001-10-17 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor.
Mol.Cell, 8, 2001
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1JKG
 | | Structural basis for the recognition of a nucleoporin FG-repeat by the NTF2-like domain of TAP-p15 mRNA nuclear export factor | | Descriptor: | TAP, p15 | | Authors: | Fribourg, S, Braun, I.C, Izaurralde, E, Conti, E. | | Deposit date: | 2001-07-12 | | Release date: | 2001-10-17 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor.
Mol.Cell, 8, 2001
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5C0Y
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5C0W
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1OL6
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5AOR
 | | Structure of MLE RNA ADP AlF4 complex | | Descriptor: | 5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP)-3', ADENOSINE-5'-DIPHOSPHATE, DOSAGE COMPENSATION REGULATOR, ... | | Authors: | Prabu, J.R, Conti, E. | | Deposit date: | 2015-09-11 | | Release date: | 2015-11-18 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Structure of the RNA Helicase Mle Reveals the Molecular Mechanisms for Uridine Specificity and RNA-ATP Coupling.
Mol.Cell, 60, 2015
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5ANR
 | | Structure of a human 4E-T - DDX6 - CNOT1 complex | | Descriptor: | CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER, PROBABLE ATP-DEPENDENT RNA HELICASE DDX6 | | Authors: | Basquin, J, Oezguer, S, Conti, E. | | Deposit date: | 2015-09-08 | | Release date: | 2015-10-21 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.102 Å) | | Cite: | Structure of a Human 4E-T/Ddx6/Cnot1 Complex Reveals the Different Interplay of Ddx6-Binding Proteins with the Ccr4-not Complex.
Cell Rep., 13, 2015
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7PW8
 | | Human SMG1-8-9 kinase complex bound to AMPPNP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Langer, L.M, Conti, E. | | Deposit date: | 2021-10-06 | | Release date: | 2021-12-01 | | Method: | ELECTRON MICROSCOPY (2.82 Å) | | Cite: | Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.
Elife, 10, 2021
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7PW4
 | | Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor | | Descriptor: | 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea, ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | Authors: | Langer, L.M, Conti, E. | | Deposit date: | 2021-10-06 | | Release date: | 2021-12-01 | | Method: | ELECTRON MICROSCOPY (3.27 Å) | | Cite: | Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.
Elife, 10, 2021
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7PW9
 | | Human SMG1-9 kinase complex bound to AMPPNP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Langer, L.M, Conti, E. | | Deposit date: | 2021-10-06 | | Release date: | 2021-12-01 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.
Elife, 10, 2021
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7PW5
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7PW7
 | | Human SMG1-9 kinase complex bound to a SMG1 inhibitor | | Descriptor: | 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea, ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | Authors: | Langer, L.M, Conti, E. | | Deposit date: | 2021-10-06 | | Release date: | 2021-12-01 | | Method: | ELECTRON MICROSCOPY (3.59 Å) | | Cite: | Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.
Elife, 10, 2021
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5MZN
 | | Helicase Sen1 | | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Leonaite, B, Basquin, J, Conti, E. | | Deposit date: | 2017-02-01 | | Release date: | 2017-04-19 | | Last modified: | 2017-06-14 | | Method: | X-RAY DIFFRACTION (1.787 Å) | | Cite: | Sen1 has unique structural features grafted on the architecture of the Upf1-like helicase family.
EMBO J., 36, 2017
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1FT8
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