1BCU
| ALPHA-THROMBIN COMPLEXED WITH HIRUGEN AND PROFLAVIN | Descriptor: | ALPHA-THROMBIN, HIRUGEN, PROFLAVIN | Authors: | Conti, E, Rivetti, C, Wonacott, A, Brick, P. | Deposit date: | 1998-05-02 | Release date: | 1998-10-14 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | X-ray and spectrophotometric studies of the binding of proflavin to the S1 specificity pocket of human alpha-thrombin. FEBS Lett., 425, 1998
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2FAL
| X-RAY CRYSTAL STRUCTURE OF FERRIC APLYSIA LIMACINA MYOGLOBIN IN DIFFERENT LIGANDED STATES | Descriptor: | CYANIDE ION, MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Conti, E, Moser, C, Rizzi, M, Mattevi, A, Lionetti, C, Coda, A, Ascenzi, P, Brunori, M, Bolognesi, M. | Deposit date: | 1993-06-14 | Release date: | 1993-10-31 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | X-ray crystal structure of ferric Aplysia limacina myoglobin in different liganded states. J.Mol.Biol., 233, 1993
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2FAM
| X-RAY CRYSTAL STRUCTURE OF FERRIC APLYSIA LIMACINA MYOGLOBIN IN DIFFERENT LIGANDED STATES | Descriptor: | MYOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE, THIOCYANATE ION | Authors: | Conti, E, Moser, C, Rizzi, M, Mattevi, A, Lionetti, C, Coda, A, Ascenzi, P, Brunori, M, Bolognesi, M. | Deposit date: | 1993-07-20 | Release date: | 1993-10-31 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | X-ray crystal structure of ferric Aplysia limacina myoglobin in different liganded states. J.Mol.Biol., 233, 1993
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1BK6
| KARYOPHERIN ALPHA (YEAST) + SV40 T ANTIGEN NLS | Descriptor: | KARYOPHERIN ALPHA, LARGE T ANTIGEN | Authors: | Conti, E, Uy, M, Leighton, L, Blobel, G, Kuriyan, J. | Deposit date: | 1998-07-14 | Release date: | 1999-01-13 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha. Cell(Cambridge,Mass.), 94, 1998
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1BK5
| KARYOPHERIN ALPHA FROM SACCHAROMYCES CEREVISIAE | Descriptor: | COBALT (II) ION, KARYOPHERIN ALPHA | Authors: | Conti, E, Uy, M, Leighton, L, Blobel, G, Kuriyan, J. | Deposit date: | 1998-07-14 | Release date: | 1999-01-06 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha. Cell(Cambridge,Mass.), 94, 1998
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1AMU
| PHENYLALANINE ACTIVATING DOMAIN OF GRAMICIDIN SYNTHETASE 1 IN A COMPLEX WITH AMP AND PHENYLALANINE | Descriptor: | ADENOSINE MONOPHOSPHATE, GRAMICIDIN SYNTHETASE 1, MAGNESIUM ION, ... | Authors: | Conti, E, Stachelhaus, T, Marahiel, M.A, Brick, P. | Deposit date: | 1997-06-18 | Release date: | 1998-07-01 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for the activation of phenylalanine in the non-ribosomal biosynthesis of gramicidin S. EMBO J., 16, 1997
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1LCI
| FIREFLY LUCIFERASE | Descriptor: | LUCIFERASE | Authors: | Conti, E, Franks, N.P, Brick, P. | Deposit date: | 1996-06-01 | Release date: | 1997-03-26 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes. Structure, 4, 1996
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1EE4
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1EE5
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4WFC
| Structure of the Rrp6-Rrp47 interaction | Descriptor: | Exosome complex exonuclease RRP6, Exosome complex protein LRP1, SULFATE ION | Authors: | Schuch, B, Conti, E. | Deposit date: | 2014-09-14 | Release date: | 2014-10-29 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | The exosome-binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase. Embo J., 33, 2014
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8RXB
| Human UPF1 CH domain in complex with SMG6 peptide | Descriptor: | Regulator of nonsense transcripts 1, Telomerase-binding protein EST1A, ZINC ION | Authors: | Langer, L, Basquin, J, Conti, E. | Deposit date: | 2024-02-06 | Release date: | 2024-05-15 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | UPF1 helicase orchestrates mutually exclusive interactions with the SMG6 endonuclease and UPF2. Nucleic Acids Res., 52, 2024
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5LXY
| Structure of the minimal RBM7 - ZCCHC8 Complex | Descriptor: | BROMIDE ION, RNA-binding protein 7, Zinc finger CCHC domain-containing protein 8 | Authors: | Falk, S, Finogenova, K, Benda, C, Conti, E. | Deposit date: | 2016-09-23 | Release date: | 2016-12-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors. Nat Commun, 7, 2016
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5LXR
| Structure of the minimal RBM7 - ZCCHC8 Complex | Descriptor: | BROMIDE ION, CHLORIDE ION, RNA-binding protein 7, ... | Authors: | Falk, S, Finogenova, K, Benda, C, Conti, E. | Deposit date: | 2016-09-22 | Release date: | 2016-12-14 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors. Nat Commun, 7, 2016
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4UM2
| Crystal structure of the TPR domain of SMG6 | Descriptor: | GLYCEROL, TELOMERASE-BINDING PROTEIN EST1A | Authors: | Chakrabarti, S, Bonneau, F, Schuessler, S, Eppinger, E, Conti, E. | Deposit date: | 2014-05-14 | Release date: | 2014-07-23 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Phospho-Dependent and Phospho-Independent Interactions of the Helicase Upf1 with the Nmd Factors Smg5-Smg7 and Smg6. Nucleic Acids Res., 42, 2014
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4W8W
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4WFD
| Structure of the Rrp6-Rrp47-Mtr4 interaction | Descriptor: | ATP-dependent RNA helicase DOB1, Exosome complex exonuclease RRP6, Exosome complex protein LRP1, ... | Authors: | Schuch, B, Conti, E. | Deposit date: | 2014-09-14 | Release date: | 2014-10-29 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The exosome-binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase. Embo J., 33, 2014
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1W3B
| The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha. | Descriptor: | CALCIUM ION, UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 | Authors: | Jinek, M, Rehwinkel, J, Lazarus, B.D, Izaurralde, E, Hanover, J.A, Conti, E. | Deposit date: | 2004-07-14 | Release date: | 2004-09-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | The Superhelical Tpr-Repeat Domain of O-Linked Glcnac Transferase Exhibits Structural Similarities to Importin Alpha Nat.Struct.Mol.Biol., 11, 2004
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2QFA
| Crystal structure of a Survivin-Borealin-INCENP core complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Baculoviral IAP repeat-containing protein 5, Borealin, ... | Authors: | Jeyaprakash, A.A, Klein, U.R, Lindner, D, Ebert, J, Nigg, E.A, Conti, E. | Deposit date: | 2007-06-27 | Release date: | 2007-11-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure of a Survivin-Borealin-INCENP Core Complex Reveals How Chromosomal Passengers Travel Together. Cell(Cambridge,Mass.), 131, 2007
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4W8Z
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6H25
| Human nuclear RNA exosome EXO-10-MPP6 complex | Descriptor: | Exosome complex component CSL4, Exosome complex component MTR3, Exosome complex component RRP4, ... | Authors: | Gerlach, P, Schuller, J.M, Falk, S, Basquin, J, Conti, E. | Deposit date: | 2018-07-13 | Release date: | 2018-08-15 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Distinct and evolutionary conserved structural features of the human nuclear exosome complex. Elife, 7, 2018
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4W8Y
| Structure of full length Cmr2 from Pyrococcus furiosus (Manganese bound form) | Descriptor: | CRISPR system Cmr subunit Cmr2, MANGANESE (II) ION, ZINC ION | Authors: | Benda, C, Ebert, J, Baumgaertner, M, Conti, E. | Deposit date: | 2014-08-26 | Release date: | 2014-10-15 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Model of a CRISPR RNA-Silencing Complex Reveals the RNA-Target Cleavage Activity in Cmr4. Mol.Cell, 56, 2014
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5OOQ
| Structure of the Mtr4 Nop53 Complex | Descriptor: | ATP-dependent RNA helicase DOB1, Ribosome biogenesis protein NOP53, SULFATE ION | Authors: | Falk, S, Basquin, J, Conti, E. | Deposit date: | 2017-08-08 | Release date: | 2017-09-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the preribosomal protein Nop53. RNA, 23, 2017
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5JEA
| Structure of a cytoplasmic 11-subunit RNA exosome complex including Ski7, bound to RNA | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Exosome complex component CSL4, Exosome complex component MTR3, ... | Authors: | Kowalinski, E, Ebert, J, Stegmann, E, Conti, E. | Deposit date: | 2016-04-18 | Release date: | 2016-07-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex. Mol.Cell, 63, 2016
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3ICQ
| Karyopherin nuclear state | Descriptor: | Exportin-T, GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Cook, A.G, Fukuhara, N, Jinek, M, Conti, E. | Deposit date: | 2009-07-18 | Release date: | 2009-08-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structures of the tRNA export factor in the nuclear and cytosolic states Nature, 461, 2009
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7AQO
| yeast THO-Sub2 complex dimer | Descriptor: | BJ4_G0025130.mRNA.1.CDS.1, EM14S01-3B_G0007820.mRNA.1.CDS.1, TEX1 isoform 1, ... | Authors: | Schuller, S.K, Schuller, J.M, Prabu, R.J, Baumgartner, M, Bonneau, F, basquin, J, Conti, E. | Deposit date: | 2020-10-22 | Release date: | 2020-12-02 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structural insights into the nucleic acid remodeling mechanisms of the yeast THO-Sub2 complex. Elife, 9, 2020
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