2R68
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8CPE
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8DIK
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7AWH
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![BU of 7awh by Molmil](/molmil-images/mine/7awh) | Crystal structure of human butyrylcholinesterase in complex with tert-butyl 3-(((2-((1-(benzenesulfonyl)-1H-indol-4-yl)oxy)ethyl)amino)methyl)piperidine-1-carboxylate | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Brazzolotto, X, Wichur, T, Wieckowska, A. | Deposit date: | 2020-11-08 | Release date: | 2021-09-29 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT 6 R antagonists with beta-amyloid anti-aggregation properties. Eur.J.Med.Chem., 225, 2021
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2R60
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5M1U
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5MAA
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![BU of 5maa by Molmil](/molmil-images/mine/5maa) | PCE reductive dehalogenase from S. multivorans in complex with 3-bromophenol | Descriptor: | 3-bromophenol, 5-Methoxybenzimidazolyl-norcobamide, BENZAMIDINE, ... | Authors: | Kunze, C, Bommer, M, Hagen, W.R, Uksa, M, Dobbek, H, Schubert, T, Diekert, G. | Deposit date: | 2016-11-03 | Release date: | 2017-07-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.686 Å) | Cite: | Cobamide-mediated enzymatic reductive dehalogenation via long-range electron transfer. Nat Commun, 8, 2017
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5MA0
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![BU of 5ma0 by Molmil](/molmil-images/mine/5ma0) | PCE reductive dehalogenase from S. multivorans in complex with 2,6-dichlorophenol | Descriptor: | 2,6-dichlorophenol, GLYCEROL, IRON/SULFUR CLUSTER, ... | Authors: | Kunze, C, Bommer, M, Hagen, W.R, Uksa, M, Dobbek, H, Schubert, T, Diekert, G. | Deposit date: | 2016-11-02 | Release date: | 2017-07-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Cobamide-mediated enzymatic reductive dehalogenation via long-range electron transfer. Nat Commun, 8, 2017
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5MA1
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![BU of 5ma1 by Molmil](/molmil-images/mine/5ma1) | PCE reductive dehalogenase from S. multivorans in complex with 2,4,6-trichlorophenol | Descriptor: | 2,4,6-trichlorophenol, GLYCEROL, IRON/SULFUR CLUSTER, ... | Authors: | Kunze, C, Bommer, M, Hagen, W.R, Uksa, M, Dobbek, H, Schubert, T, Diekert, G. | Deposit date: | 2016-11-02 | Release date: | 2017-07-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.498 Å) | Cite: | Cobamide-mediated enzymatic reductive dehalogenation via long-range electron transfer. Nat Commun, 8, 2017
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4B9D
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![BU of 4b9d by Molmil](/molmil-images/mine/4b9d) | Crystal Structure of Human NIMA-related Kinase 1 (NEK1) with inhibitor. | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, SERINE/THREONINE-PROTEIN KINASE NEK1, ... | Authors: | Elkins, J.M, Hanchuk, T.D.M, Lovato, D.V, Basei, F.L, Meirelles, G.V, Kobarg, J, Szklarz, M, Vollmar, M, Mahajan, P, Rellos, P, Zhang, Y, Krojer, T, Pike, A.C.W, Canning, P, von Delft, F, Raynor, J, Bountra, C, Arrowsmith, C, Edwards, A, Knapp, S. | Deposit date: | 2012-09-04 | Release date: | 2012-09-19 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin. Sci Rep, 7, 2017
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1PZ7
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![BU of 1pz7 by Molmil](/molmil-images/mine/1pz7) | Modulation of agrin function by alternative splicing and Ca2+ binding | Descriptor: | Agrin, CALCIUM ION | Authors: | Stetefeld, J, Alexandrescu, A.T, Maciejewski, M.W, Jenny, M, Rathgeb-Szabo, K, Schulthess, T, Landwehr, R, Frank, S, Ruegg, M.A, Kammerer, R.A. | Deposit date: | 2003-07-10 | Release date: | 2004-04-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.421 Å) | Cite: | Modulation of agrin function by alternative splicing and Ca2+ binding. STRUCTURE, 12, 2004
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1Q56
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![BU of 1q56 by Molmil](/molmil-images/mine/1q56) | NMR structure of the B0 isoform of the agrin G3 domain in its Ca2+ bound state | Descriptor: | Agrin | Authors: | Stetefeld, J, Alexandrescu, A.T, Maciejewski, M.W, Jenny, M, Rathgeb-Szabo, K, Schulthess, T, Landwehr, R, Frank, S, Ruegg, M.A, Kammerer, R.A. | Deposit date: | 2003-08-06 | Release date: | 2004-04-13 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Modulation of agrin function by alternative splicing and Ca2+ binding Structure, 12, 2004
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1PZ8
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![BU of 1pz8 by Molmil](/molmil-images/mine/1pz8) | Modulation of agrin function by alternative splicing and Ca2+ binding | Descriptor: | Agrin, CALCIUM ION | Authors: | Stetefeld, J, Alexandrescu, A.T, Maciejewski, M.W, Jenny, M, Rathgeb-Szabo, K, Schulthess, T, Landwehr, R, Frank, S, Ruegg, M.A, Kammerer, R.A. | Deposit date: | 2003-07-10 | Release date: | 2004-04-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Modulation of agrin function by alternative splicing and Ca2+ binding. STRUCTURE, 12, 2004
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6CEQ
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4APC
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![BU of 4apc by Molmil](/molmil-images/mine/4apc) | Crystal Structure of Human NIMA-related Kinase 1 (NEK1) | Descriptor: | CHLORIDE ION, SERINE/THREONINE-PROTEIN KINASE NEK1 | Authors: | Elkins, J.M, Hanchuk, T.D.M, Lovato, D.V, Basei, F.L, Meirelles, G.V, Kobarg, J, Szklarz, M, Vollmar, M, Mahajan, P, Rellos, P, Zhang, Y, Krojer, T, Pike, A.C.W, Bountra, C, Arrowsmith, C, Edwards, A, Knapp, S. | Deposit date: | 2012-04-02 | Release date: | 2012-04-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin. Sci Rep, 7, 2017
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1PZ9
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![BU of 1pz9 by Molmil](/molmil-images/mine/1pz9) | Modulation of agrin function by alternative splicing and Ca2+ binding | Descriptor: | Agrin | Authors: | Stetefeld, J, Alexandrescu, A.T, Maciejewski, M.W, Jenny, M, Rathgeb-Szabo, K, Schulthess, T, Landwehr, R, Frank, S, Ruegg, M.A, Kammerer, R.A. | Deposit date: | 2003-07-10 | Release date: | 2004-04-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Modulation of agrin function by alternative splicing and Ca2+ binding. STRUCTURE, 12, 2004
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7KH8
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![BU of 7kh8 by Molmil](/molmil-images/mine/7kh8) | Human LMPTP in complex with inhibitor | Descriptor: | 3-[(2,6-dichlorophenyl)methyl]-8-(2-methylphenyl)-3H-purin-6-amine, Low molecular weight phosphotyrosine protein phosphatase, NITRATE ION | Authors: | Stanford, S.M, Diaz, M.A, Ardecky, R.J, Zou, J, Roosild, T, Holmes, Z.J, Hedrick, M.P, Rodiles, S, Santelli, E, Chung, T.D.Y, Jackson, M.R, Bottini, N, Pinkerton, A.B. | Deposit date: | 2020-10-20 | Release date: | 2021-05-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase. J.Med.Chem., 64, 2021
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3O4F
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![BU of 3o4f by Molmil](/molmil-images/mine/3o4f) | Crystal Structure of Spermidine Synthase from E. coli | Descriptor: | SULFATE ION, Spermidine synthase | Authors: | Zhou, X, Tkaczuk, K.L, Chruszcz, M, Chua, T.K, Minor, W, Sivaraman, J. | Deposit date: | 2010-07-27 | Release date: | 2010-08-18 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The crystal structure of Escherichia coli spermidine synthase SpeE reveals a unique substrate-binding pocket J.Struct.Biol., 169, 2010
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2AWT
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![BU of 2awt by Molmil](/molmil-images/mine/2awt) | Solution Structure of Human Small Ubiquitin-Like Modifier Protein Isoform 2 (SUMO-2) | Descriptor: | Small ubiquitin-related modifier 2 | Authors: | Chang, C.K, Wang, Y.H, Chung, T.L, Chang, C.F, Li, S.S.L, Huang, T.H. | Deposit date: | 2005-09-02 | Release date: | 2006-10-24 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution Structure of Human Small Ubiquitin-Like Modifier Protein Isoform 2 (SUMO-2) To be Published
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5BQ1
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![BU of 5bq1 by Molmil](/molmil-images/mine/5bq1) | Capturing Carbon Dioxide in beta Carbonic Anhydrase | Descriptor: | CARBON DIOXIDE, Carbonic anhydrase, ZINC ION | Authors: | Aggarwal, M, Chua, T.K, Pinard, M.A, Szebenyi, D.M, McKenna, R. | Deposit date: | 2015-05-28 | Release date: | 2015-10-28 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Carbon Dioxide "Trapped" in a beta-Carbonic Anhydrase. Biochemistry, 54, 2015
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5OBP
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![BU of 5obp by Molmil](/molmil-images/mine/5obp) | PCE reductive dehalogenase from S. multivorans with 6-hydroxybenzimidazolyl norcobamide cofactor | Descriptor: | 6-hydroxybenzimidazolyl-norcobamide, BENZAMIDINE, GLYCEROL, ... | Authors: | Keller, S, Kunze, C, Bommer, M, Paetz, C, Menezes, R.C, Svatos, A, Dobbek, H, Schubert, T. | Deposit date: | 2017-06-28 | Release date: | 2018-02-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.593 Å) | Cite: | Selective Utilization of Benzimidazolyl-Norcobamides as Cofactors by the Tetrachloroethene Reductive Dehalogenase of Sulfurospirillum multivorans. J. Bacteriol., 200, 2018
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5OBI
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![BU of 5obi by Molmil](/molmil-images/mine/5obi) | PCE reductive dehalogenase from S. multivorans with 5-METHOXYBENZIMIDAZOLYL-NORCOBAMIDE cofactor | Descriptor: | 5-Methoxybenzimidazolyl-norcobamide, BENZAMIDINE, GLYCEROL, ... | Authors: | Keller, S, Kunze, C, Bommer, M, Paetz, C, Menezes, R.C, Svatos, A, Dobbek, H, Schubert, T. | Deposit date: | 2017-06-27 | Release date: | 2018-02-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.599 Å) | Cite: | Selective Utilization of Benzimidazolyl-Norcobamides as Cofactors by the Tetrachloroethene Reductive Dehalogenase of Sulfurospirillum multivorans. J. Bacteriol., 200, 2018
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1FBM
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![BU of 1fbm by Molmil](/molmil-images/mine/1fbm) | ASSEMBLY DOMAIN OF CARTILAGE OLIGOMERIC MATRIX PROTEIN IN COMPLEX WITH ALL-TRANS RETINOL | Descriptor: | PROTEIN (CARTILAGE OLIGOMERIC MATRIX PROTEIN), RETINOL | Authors: | Guo, Y, Bozic, D, Malashkevich, V.N, Kammerer, R.A, Schulthess, T. | Deposit date: | 2000-07-16 | Release date: | 2000-08-02 | Last modified: | 2018-02-28 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | All-trans retinol, vitamin D and other hydrophobic compounds bind in the axial pore of the five-stranded coiled-coil domain of cartilage oligomeric matrix protein. EMBO J., 17, 1998
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