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7AWH

Crystal structure of human butyrylcholinesterase in complex with tert-butyl 3-(((2-((1-(benzenesulfonyl)-1H-indol-4-yl)oxy)ethyl)amino)methyl)piperidine-1-carboxylate

Summary for 7AWH
Entry DOI10.2210/pdb7awh/pdb
DescriptorCholinesterase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywordsbutyrylcholinesterase, inhibitor complex, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight63277.98
Authors
Brazzolotto, X.,Wichur, T.,Wieckowska, A. (deposition date: 2020-11-08, release date: 2021-09-29, Last modification date: 2024-01-31)
Primary citationWichur, T.,Godyn, J.,Goral, I.,Latacz, G.,Bucki, A.,Siwek, A.,Gluch-Lutwin, M.,Mordyl, B.,Sniecikowska, J.,Walczak, M.,Knez, D.,Jukic, M.,Salat, K.,Gobec, S.,Kolaczkowski, M.,Malawska, B.,Brazzolotto, X.,Wieckowska, A.
Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT 6 R antagonists with beta-amyloid anti-aggregation properties.
Eur.J.Med.Chem., 225:113792-113792, 2021
Cited by
PubMed: 34530376
DOI: 10.1016/j.ejmech.2021.113792
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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