5TZF
 
 | | Structure of the BldD CTD(D116A)-(c-di-GMP)2 intermediate, form 1 | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DNA-binding protein | | Authors: | Schumacher, M.A. | | Deposit date: | 2016-11-21 | | Release date: | 2017-04-19 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex.
Nucleic Acids Res., 45, 2017
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5WBF
 | | Double CACHE (dCACHE) sensing domain of TlpC chemoreceptor from Helicobacter pylori | | Descriptor: | GLYCEROL, LACTIC ACID, Methyl-accepting chemotaxis transducer (TlpC) | | Authors: | Machuca, M.A, Johnson, K.S, Liu, Y.C, Steer, D.L, Ottemann, K.M, Roujeinikova, A. | | Deposit date: | 2017-06-28 | | Release date: | 2017-11-08 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | Helicobacter pylori chemoreceptor TlpC mediates chemotaxis to lactate.
Sci Rep, 7, 2017
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4YG1
 | | HipB-O1-O2 complex/P21212 crystal form | | Descriptor: | Antitoxin HipB, DNA (48-MER) | | Authors: | Schumacher, M.A. | | Deposit date: | 2015-02-25 | | Release date: | 2015-07-29 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.25 Å) | | Cite: | HipBA-promoter structures reveal the basis of heritable multidrug tolerance.
Nature, 524, 2015
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5U1G
 | | Structure of TP228 ParA-AMPPNP-ParB complex | | Descriptor: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ParA, TP228 ParB fragment | | Authors: | Schumacher, M.A. | | Deposit date: | 2016-11-28 | | Release date: | 2017-04-19 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.64 Å) | | Cite: | Structures of partition protein ParA with nonspecific DNA and ParB effector reveal molecular insights into principles governing Walker-box DNA segregation.
Genes Dev., 31, 2017
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5TZG
 | | Structure of the BldD CTD(D116A)-(c-di-GMP)2, form 2 | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DNA-binding protein, ZINC ION | | Authors: | Schumacher, M.A. | | Deposit date: | 2016-11-21 | | Release date: | 2017-04-19 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex.
Nucleic Acids Res., 45, 2017
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8T5Y
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4YZV
 | | Precleavage 70S structure of the P. vulgaris HigB deltaH92 toxin bound to the ACA codon | | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | Authors: | Schureck, M.A, Dunkle, J.A, Maehigashi, T, Dunham, C.M. | | Deposit date: | 2015-03-25 | | Release date: | 2015-10-21 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Defining the mRNA recognition signature of a bacterial toxin protein.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4ZSN
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1BIW
 | | DESIGN AND SYNTHESIS OF CONFORMATIONALLY-CONSTRAINED MMP INHIBITORS | | Descriptor: | CALCIUM ION, N1-HYDROXY-2-(3-HYDROXY-PROPYL)-3-ISOBUTYL-N4-[1-(2-METHOXY-ETHYL)-2-OXO-AZEPAN-3-YL]-SUCCINAMIDE, PROTEIN (STROMELYSIN-1 COMPLEX), ... | | Authors: | Natchus, M.G, Cheng, M, Wahl, C.T, Pikul, S, Almstead, N.G, Bradley, R.S, Taiwo, Y.O, Mieling, G.E, Dunaway, C.M, Snider, C.E, McIver, J.M, Barnett, B.L, McPhail, S.J, Anastasio, M.B, De, B. | | Deposit date: | 1998-06-19 | | Release date: | 1999-07-16 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Design and synthesis of conformationally-constrained MMP inhibitors.
Bioorg.Med.Chem.Lett., 8, 1998
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4YG4
 | | HipB-O1-O1* complex | | Descriptor: | Antitoxin HipB, DNA (28-MER), DNA (5'-D(*AP*TP*AP*TP*CP*CP*CP*CP*TP*TP*AP*AP*GP*GP*GP*GP*AP*TP*AP*A)-3') | | Authors: | Schumacher, M.A. | | Deposit date: | 2015-02-25 | | Release date: | 2015-07-29 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | HipBA-promoter structures reveal the basis of heritable multidrug tolerance.
Nature, 524, 2015
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4YG7
 | | Structure of FL autorepression promoter complex | | Descriptor: | Antitoxin HipB, DNA (50-MER), Serine/threonine-protein kinase HipA | | Authors: | Schumacher, M.A. | | Deposit date: | 2015-02-25 | | Release date: | 2015-07-29 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.77 Å) | | Cite: | HipBA-promoter structures reveal the basis of heritable multidrug tolerance.
Nature, 524, 2015
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5HTG
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4YPB
 | | Precleavage 70S structure of the P. vulgaris HigB DeltaH92 toxin bound to the AAA codon | | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | Authors: | Schureck, M.A, Dunkle, J.A, Maehigashi, T, Dunham, C.M. | | Deposit date: | 2015-03-12 | | Release date: | 2015-10-21 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Defining the mRNA recognition signature of a bacterial toxin protein.
Proc.Natl.Acad.Sci.USA, 112, 2015
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7OMX
 | | Thermus sp. 2.9 DarT in complex with carba-NAD+ | | Descriptor: | CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, DarT domain-containing protein, THIOCYANATE ION | | Authors: | Schuller, M, Ariza, A. | | Deposit date: | 2021-05-24 | | Release date: | 2021-06-23 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | Molecular basis for DarT ADP-ribosylation of a DNA base.
Nature, 596, 2021
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7OMV
 | | Thermus sp. 2.9 DarT | | Descriptor: | CHLORIDE ION, DarT domain-containing protein, THIOCYANATE ION | | Authors: | Schuller, M, Ariza, A. | | Deposit date: | 2021-05-24 | | Release date: | 2021-06-23 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.29 Å) | | Cite: | Molecular basis for DarT ADP-ribosylation of a DNA base.
Nature, 596, 2021
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7ON0
 | | Thermus sp. 2.9 DarT in complex with ADP-ribosylated ssDNA | | Descriptor: | DNA (5'-D(*AP*TP*GP*TP*C)-3'), DarT domain-containing protein, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | | Authors: | Schuller, M, Ariza, A. | | Deposit date: | 2021-05-24 | | Release date: | 2021-06-23 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.46 Å) | | Cite: | Molecular basis for DarT ADP-ribosylation of a DNA base.
Nature, 596, 2021
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7OMW
 | | Thermus sp. 2.9 DarT in complex with NAD+ | | Descriptor: | DarT domain-containing protein, GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | Authors: | Schuller, M, Ariza, A. | | Deposit date: | 2021-05-24 | | Release date: | 2021-06-23 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Molecular basis for DarT ADP-ribosylation of a DNA base.
Nature, 596, 2021
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7OMY
 | | Thermus sp. 2.9 DarT in complex with carba-NAD+ and ssDNA | | Descriptor: | CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, DNA (5'-D(*AP*TP*GP*TP*C)-3'), DarT domain-containing protein, ... | | Authors: | Schuller, M, Ariza, A. | | Deposit date: | 2021-05-24 | | Release date: | 2021-06-23 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Molecular basis for DarT ADP-ribosylation of a DNA base.
Nature, 596, 2021
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7OMZ
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3MKY
 | | Structure of SopB(155-323)-18mer DNA complex, I23 form | | Descriptor: | DNA (5'-D(*CP*TP*GP*GP*GP*AP*CP*CP*AP*TP*GP*GP*TP*CP*CP*CP*AP*G)-3'), Protein sopB, SULFATE ION | | Authors: | Schumacher, M.A, Piro, K, Xu, W. | | Deposit date: | 2010-04-15 | | Release date: | 2010-05-05 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.86 Å) | | Cite: | Insight into F plasmid DNA segregation revealed by structures of SopB and SopB-DNA complexes.
Nucleic Acids Res., 38, 2010
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5TZD
 | | Structure of the WT S. venezulae BldD-(CTD-c-di-GMP)2 assembly intermediate | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DNA-binding protein | | Authors: | Schumacher, M. | | Deposit date: | 2016-11-21 | | Release date: | 2017-04-19 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.749 Å) | | Cite: | The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex.
Nucleic Acids Res., 45, 2017
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3MKW
 | | Structure of sopB(155-272)-18mer complex, I23 form | | Descriptor: | DNA (5'-D(*CP*TP*GP*GP*GP*AP*CP*CP*AP*TP*GP*GP*TP*CP*CP*CP*AP*G)-3'), Protein sopB, SULFATE ION | | Authors: | Schumacher, M.A, Piro, K, Xu, W. | | Deposit date: | 2010-04-15 | | Release date: | 2010-05-05 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.99 Å) | | Cite: | Insight into F plasmid DNA segregation revealed by structures of SopB and SopB-DNA complexes.
Nucleic Acids Res., 38, 2010
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5I41
 | | Structure of the apo RacA DNA binding domain | | Descriptor: | Chromosome-anchoring protein RacA | | Authors: | schumacher, M.A. | | Deposit date: | 2016-02-11 | | Release date: | 2016-05-04 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Molecular insights into DNA binding and anchoring by the Bacillus subtilis sporulation kinetochore-like RacA protein.
Nucleic Acids Res., 44, 2016
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1HY7
 | | A CARBOXYLIC ACID BASED INHIBITOR IN COMPLEX WITH MMP3 | | Descriptor: | CALCIUM ION, R-2-{[4'-METHOXY-(1,1'-BIPHENYL)-4-YL]-SULFONYL}-AMINO-6-METHOXY-HEX-4-YNOIC ACID, STROMELYSIN-1, ... | | Authors: | Natchus, M.G, Bookland, R.G, Laufersweiler, M.J, Pikul, S, Almstead, N.G, De, B, Janusz, M.J, Hsieh, L.C, Gu, F, Pokross, M.E, Patel, V.S, Garver, S.M, Peng, S.X, Branch, T.M, King, S.L, Baker, T.R, Foltz, D.J, Mieling, G.E. | | Deposit date: | 2001-01-18 | | Release date: | 2002-01-18 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines.
J.Med.Chem., 44, 2001
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4OB4
 | | Structure of the S. venezulae BldD DNA-binding domain | | Descriptor: | Putative DNA-binding protein | | Authors: | schumacher, M.A, Tschowri, N, Buttner, M, Brennan, R. | | Deposit date: | 2014-01-06 | | Release date: | 2014-11-19 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development.
Cell(Cambridge,Mass.), 158, 2014
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