1BIW

DESIGN AND SYNTHESIS OF CONFORMATIONALLY-CONSTRAINED MMP INHIBITORS

Summary for 1BIW

• Entry DOI: 10.2210/pdb1biw/pdb
• Descriptor: PROTEIN (STROMELYSIN-1 COMPLEX), ZINC ION, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: stromelysin, matrix metalloprotease, osteoarthritis, structure-based drug design, protein crystal structure, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Secreted, extracellular space, extracellular matrix (Probable): P08254
• Total number of polymer chains: 2
• Total formula weight: 39750.69

Authors

Natchus, M.G.,Cheng, M.,Wahl, C.T.,Pikul, S.,Almstead, N.G.,Bradley, R.S.,Taiwo, Y.O.,Mieling, G.E.,Dunaway, C.M.,Snider, C.E.,McIver, J.M.,Barnett, B.L.,McPhail, S.J.,Anastasio, M.B.,De, B. (deposition date: 1998-06-19, release date: 1999-07-16, Last modification date: 2023-12-27)

• Primary citation: Natchus, M.G.,Cheng, M.,Wahl, C.T.,Pikul, S.,Almstead, N.G.,Bradley, R.S.,Taiwo, Y.O.,Mieling, G.E.,Dunaway, C.M.,Snider, C.E.,McIver, J.M.,Barnett, B.L.,McPhail, S.J.,Anastasio, M.B.,De, B.; Design and synthesis of conformationally-constrained MMP inhibitors.; Bioorg.Med.Chem.Lett., 8:2077-2080, 1998; PubMed: 9873489; DOI: 10.1016/S0960-894X(98)00370-9

Experimental method

X-RAY DIFFRACTION (2.5 Å)