7VSX
 
 | | Crystal structure of QL-nanoKAZ (Reverse mutant of nanoKAZ with L18Q and V27L) | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, QLnK | | 著者 | Tomabechi, Y, Sekine, S, Shirouzu, M, Takamitsu, H, Satoshi, I. | | 登録日 | 2021-10-27 | | 公開日 | 2022-08-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.698 Å) | | 主引用文献 | Reverse mutants of the catalytic 19 kDa mutant protein (nanoKAZ/nanoLuc) from Oplophorus luciferase with coelenterazine as preferred substrate.
Plos One, 17, 2022
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7YRU
 | | ALK2 antibody complex | | 分子名称: | Activin receptor type-1, antibody heavy chain, antibody light chain | | 著者 | Kawaguchi, Y, Nakamura, K, Suzuki, M, Tsuji, S, Katagiri, T. | | 登録日 | 2022-08-10 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-06-07 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | A blocking monoclonal antibody reveals dimerization of intracellular domains of ALK2 associated with genetic disorders.
Nat Commun, 14, 2023
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7DHL
 | | Crystal structure of FGFR3 in complex with pyrimidine derivative | | 分子名称: | 5-[2-(3,5-dimethoxyphenyl)ethyl]-N-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidin-2-amine, Fibroblast growth factor receptor 3 | | 著者 | Echizen, Y, Tateishi, Y, Amano, Y. | | 登録日 | 2020-11-16 | | 公開日 | 2021-02-03 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency.
Bioorg.Med.Chem., 33, 2021
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2FFN
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2EWK
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8IDQ
 | | Crystal structure of reducing-end xylose-releasing exoxylanase in GH30 from Talaromyces cellulolyticus with xylose | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | 著者 | Nakamichi, Y, Watanabe, M, Fujii, T, Inoue, H, Morita, T. | | 登録日 | 2023-02-14 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structure of reducing-end xylose-releasing exoxylanase in subfamily 7 of glycoside hydrolase family 30.
Proteins, 91, 2023
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8IDP
 | | Crystal structure of reducing-end xylose-releasing exoxylanase in GH30 from Talaromyces cellulolyticus | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Nakamichi, Y, Watanabe, M, Fujii, T, Inoue, H, Morita, T. | | 登録日 | 2023-02-14 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of reducing-end xylose-releasing exoxylanase in subfamily 7 of glycoside hydrolase family 30.
Proteins, 91, 2023
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2ZJW
 | | Crystal structure of human CK2 alpha complexed with Ellagic acid | | 分子名称: | 2,3,7,8-tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione, Casein kinase II subunit alpha | | 著者 | Sekiguchi, Y, Kinoshita, T, Nakaniwa, T, Tada, T. | | 登録日 | 2008-03-11 | | 公開日 | 2009-03-17 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid
Bioorg.Med.Chem.Lett., 19, 2009
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3ANI
 | | Crystal structure of unsaturated glucuronyl hydrolase mutant D175N from Streptcoccus agalactiae | | 分子名称: | Putative uncharacterized protein gbs1889 | | 著者 | Nakamichi, Y, Maruyama, Y, Mikami, B, Hashimoto, W, Murata, K. | | 登録日 | 2010-09-02 | | 公開日 | 2010-10-06 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural determinants in streptococcal unsaturated glucuronyl hydrolase for recognition of glycosaminoglycan sulfate groups
J.Biol.Chem., 286, 2011
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2ZWP
 | | Crystal structure of Ca3 site mutant of Pro-S324A | | 分子名称: | CALCIUM ION, Tk-subtilisin | | 著者 | Takeuchi, Y, Tanaka, S, Matsumura, H, Koga, Y, Takano, K, Kanaya, S. | | 登録日 | 2008-12-17 | | 公開日 | 2009-06-23 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Requirement of a unique Ca(2+)-binding loop for folding of Tk-subtilisin from a hyperthermophilic archaeon.
Biochemistry, 48, 2009
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3ANJ
 | | Crystal structure of unsaturated glucuronyl hydrolase from Streptcoccus agalactiae | | 分子名称: | Putative uncharacterized protein gbs1889 | | 著者 | Nakamichi, Y, Maruyama, Y, Mikami, B, Hashimoto, W, Murata, K. | | 登録日 | 2010-09-02 | | 公開日 | 2010-10-06 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structural determinants in streptococcal unsaturated glucuronyl hydrolase for recognition of glycosaminoglycan sulfate groups
J.Biol.Chem., 286, 2011
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3ANK
 | | Crystal structure of unsaturated glucuronyl hydrolase mutant D175N from Streptcoccus agalactiae complexed with dGlcA-GalNAc6S | | 分子名称: | 1,2-ETHANEDIOL, 4-deoxy-alpha-L-threo-hex-4-enopyranuronic acid-(1-3)-2-acetamido-2-deoxy-6-O-sulfo-beta-D-galactopyranose, Putative uncharacterized protein gbs1889 | | 著者 | Nakamichi, Y, Maruyama, Y, Mikami, B, Hashimoto, W, Murata, K. | | 登録日 | 2010-09-02 | | 公開日 | 2010-10-06 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Structural determinants in streptococcal unsaturated glucuronyl hydrolase for recognition of glycosaminoglycan sulfate groups
J.Biol.Chem., 286, 2011
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5X70
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5X6X
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5X6Z
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5X6Y
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5X71
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6LVM
 | | Crystal structure of FGFR3 in complex with pyrimidine derivative | | 分子名称: | 2-[[5-[2-(3,5-dimethoxyphenyl)ethyl]-2-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]pyrimidin-4-yl]amino]-N-ethyl-benzenesulfonamide, Fibroblast growth factor receptor 3 | | 著者 | Echizen, Y, Tateishi, Y, Amano, Y. | | 登録日 | 2020-02-04 | | 公開日 | 2020-04-08 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | | 主引用文献 | Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2.
Bioorg.Med.Chem., 28, 2020
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6LVL
 | | Crystal structure of FGFR2 in complex with 1,3,5-triazine derivative | | 分子名称: | Fibroblast growth factor receptor 2, N-ethyl-2-[[4-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-1,3,5-triazin-2-yl]amino]benzenesulfonamide, SULFATE ION | | 著者 | Echizen, Y, Tateishi, Y, Amano, Y. | | 登録日 | 2020-02-04 | | 公開日 | 2020-04-08 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2.
Bioorg.Med.Chem., 28, 2020
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6LVK
 | | Crystal structure of FGFR2 in complex with 1,3,5-triazine derivative | | 分子名称: | Fibroblast growth factor receptor 2, N-ethyl-2-[[4-[[4-(4-methylpiperazin-1-yl)-3-(2-morpholin-4-ylethoxy)phenyl]amino]-1,3,5-triazin-2-yl]amino]benzenesulfonamide, SULFATE ION | | 著者 | Echizen, Y, Amano, Y, Tateishi, Y. | | 登録日 | 2020-02-04 | | 公開日 | 2020-04-08 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2.
Bioorg.Med.Chem., 28, 2020
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2CDV
 | | REFINED STRUCTURE OF CYTOCHROME C3 AT 1.8 ANGSTROMS RESOLUTION | | 分子名称: | CYTOCHROME C3, HEME C | | 著者 | Higuchi, Y, Kusunoki, M, Matsuura, Y, Yasuoka, N, Kakudo, M. | | 登録日 | 1983-11-15 | | 公開日 | 1984-02-02 | | 最終更新日 | 2021-03-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Refined structure of cytochrome c3 at 1.8 A resolution
J.Mol.Biol., 172, 1984
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2EWI
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7EG2
 | | Crystal structure of the apoAequorin complex with (S)-daCTZ | | 分子名称: | (2~{S})-2-(hydroxymethyl)-6-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-4-(phenylmethyl)-3~{H}-inden-1-one, Aequorin-2 | | 著者 | Tomabechi, Y, Shirouzu, M. | | 登録日 | 2021-03-24 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | Chiral deaza-coelenterazine analogs for probing a substrate-binding site in the Ca2+-binding photoprotein aequorin.
Plos One, 16, 2021
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7EG3
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2FMY
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