2ZJW

Crystal structure of human CK2 alpha complexed with Ellagic acid

Summary for 2ZJW

Entry DOI	10.2210/pdb2zjw/pdb
Descriptor	Casein kinase II subunit alpha, 2,3,7,8-tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione (3 entities in total)
Functional Keywords	protein-inhibitor complex, atp-binding, kinase, nucleotide-binding, serine/threonine-protein kinase, transferase, wnt signaling pathway
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	40780.38
Authors	Sekiguchi, Y.,Kinoshita, T.,Nakaniwa, T.,Tada, T. (deposition date: 2008-03-11, release date: 2009-03-17, Last modification date: 2023-11-01)
Primary citation	Sekiguchi, Y.,Nakaniwa, T.,Kinoshita, T.,Nakanishi, I.,Kitaura, K.,Hirasawa, A.,Tsujimoto, G.,Tada, T. Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid Bioorg.Med.Chem.Lett., 19:2920-2923, 2009 Cited by PubMed Abstract: We determined the 2.35-A crystal structure of a human CK2 catalytic subunit (referred to as CK2alpha complexed with the ATP-competitive, potent CK2 inhibitor ellagic acid. The inhibitor binds to CK2alpha with a novel binding mode, including water-mediated hydrogen bonds. This structural information may support discovery of potent CK2 inhibitors. PubMed: 19414254 DOI: 10.1016/j.bmcl.2009.04.076 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation