Crystal structure of human CK2 alpha complexed with Ellagic acid

Summary for 2ZJW

DescriptorCasein kinase II subunit alpha, 2,3,7,8-tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione (3 entities in total)
Functional Keywordsprotein-inhibitor complex, atp-binding, kinase, nucleotide-binding, serine/threonine-protein kinase, transferase, wnt signaling pathway
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight40780.38
Sekiguchi, Y.,Kinoshita, T.,Nakaniwa, T.,Tada, T. (deposition date: 2008-03-11, release date: 2009-03-17, Last modification date: 2011-07-13)
Primary citation
Sekiguchi, Y.,Nakaniwa, T.,Kinoshita, T.,Nakanishi, I.,Kitaura, K.,Hirasawa, A.,Tsujimoto, G.,Tada, T.
Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid
Bioorg.Med.Chem.Lett., 19:2920-2923, 2009
PubMed: 19414254 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2009.04.076
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21017 2.7% 7.2% 7.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-21