6LVK
Crystal structure of FGFR2 in complex with 1,3,5-triazine derivative
Summary for 6LVK
Entry DOI | 10.2210/pdb6lvk/pdb |
Descriptor | Fibroblast growth factor receptor 2, N-ethyl-2-[[4-[[4-(4-methylpiperazin-1-yl)-3-(2-morpholin-4-ylethoxy)phenyl]amino]-1,3,5-triazin-2-yl]amino]benzenesulfonamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | protein kinase, signaling protein, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 73352.15 |
Authors | Echizen, Y.,Amano, Y.,Tateishi, Y. (deposition date: 2020-02-04, release date: 2020-04-08, Last modification date: 2023-11-29) |
Primary citation | Kuriwaki, I.,Kameda, M.,Hisamichi, H.,Kikuchi, S.,Iikubo, K.,Kawamoto, Y.,Moritomo, H.,Kondoh, Y.,Amano, Y.,Tateishi, Y.,Echizen, Y.,Iwai, Y.,Noda, A.,Tomiyama, H.,Suzuki, T.,Hirano, M. Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2. Bioorg.Med.Chem., 28:115453-115453, 2020 Cited by PubMed: 32278710DOI: 10.1016/j.bmc.2020.115453 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.29 Å) |
Structure validation
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