6LVK
Crystal structure of FGFR2 in complex with 1,3,5-triazine derivative
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue EVC A 801 |
| Chain | Residue |
| A | LYS485 |
| A | GLY570 |
| A | GLU574 |
| A | ARG630 |
| A | LEU633 |
| A | HOH912 |
| A | HOH915 |
| A | HOH921 |
| A | LEU487 |
| A | VAL495 |
| A | ALA515 |
| A | LYS517 |
| A | GLU565 |
| A | TYR566 |
| A | ALA567 |
| A | SER568 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 802 |
| Chain | Residue |
| A | ARG625 |
| A | ARG649 |
| A | THR660 |
| A | ARG664 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | binding site for residue EVC B 801 |
| Chain | Residue |
| B | LYS485 |
| B | LEU487 |
| B | PHE492 |
| B | ALA515 |
| B | LYS517 |
| B | GLU565 |
| B | TYR566 |
| B | ALA567 |
| B | SER568 |
| B | GLY570 |
| B | GLU574 |
| B | ARG630 |
| B | ASN631 |
| B | LEU633 |
| B | ALA643 |
| B | HOH911 |
| B | HOH912 |
| B | HOH934 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 802 |
| Chain | Residue |
| B | ARG625 |
| B | ARG649 |
| B | ARG664 |
| B | HOH901 |
| B | HOH902 |
| B | HOH903 |
| B | HOH918 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 803 |
| Chain | Residue |
| A | VAL743 |
| A | PRO744 |
| A | SER745 |
| B | ARG737 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 804 |
| Chain | Residue |
| B | THR635 |
| B | GLU636 |
| B | ASN637 |
| B | VAL639 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 31 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGCFGQVVmAeavgidkdkpkeavt...VAVK |
| Chain | Residue | Details |
| A | LEU487-LYS517 |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV |
| Chain | Residue | Details |
| A | CYS622-VAL634 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19060208","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19060208","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"17803937","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19060208","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19410646","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
