6LVK
Crystal structure of FGFR2 in complex with 1,3,5-triazine derivative
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Fibroblast growth factor receptor 2 | polymer | 313 | 35886.2 | 2 | UniProt (P21802) Pfam (PF07714) | Homo sapiens (Human) | FGFR-2,K-sam,KGFR,Keratinocyte growth factor receptor |
| 2 | C, E (A, B) | N-ethyl-2-[[4-[[4-(4-methylpiperazin-1-yl)-3-(2-morpholin-4-ylethoxy)phenyl]amino]-1,3,5-triazin-2-yl]amino]benzenesulfonamide | non-polymer | 597.7 | 2 | Chemie (EVC) | |||
| 3 | D, F, G, H (A, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | I, J (A, B) | water | water | 18.0 | 122 | Chemie (HOH) |
Sequence modifications
A, B: 459 - 768 (UniProt: P21802)
| PDB | External Database | Details |
|---|---|---|
| Gly 456 | - | expression tag |
| Ser 457 | - | expression tag |
| His 458 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71772.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1579.7 | |
| All* | Total formula weight | 73352.1 |
