1F34
 
 | | CRYSTAL STRUCTURE OF ASCARIS PEPSIN INHIBITOR-3 BOUND TO PORCINE PEPSIN | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, MAJOR PEPSIN INHIBITOR PI-3, PEPSIN A | | Authors: | Ng, K.K, Petersen, J.F, Cherney, M.M, Garen, C, James, M.N. | | Deposit date: | 2000-05-31 | | Release date: | 2001-02-01 | | Last modified: | 2018-04-04 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Structural basis for the inhibition of porcine pepsin by Ascaris pepsin inhibitor-3.
Nat.Struct.Biol., 7, 2000
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1F32
 | | CRYSTAL STRUCTURE OF ASCARIS PEPSIN INHIBITOR-3 | | Descriptor: | MAJOR PEPSIN INHIBITOR PI-3 | | Authors: | Ng, K.K, Petersen, J.F, Cherney, M.M, Garen, C, James, M.N. | | Deposit date: | 2000-05-31 | | Release date: | 2001-02-01 | | Last modified: | 2018-04-04 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural basis for the inhibition of porcine pepsin by Ascaris pepsin inhibitor-3.
Nat.Struct.Biol., 7, 2000
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2I3A
 | | Crystal structure of N-Acetyl-gamma-Glutamyl-Phosphate Reductase (Rv1652) from Mycobacterium tuberculosis | | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, N-acetyl-gamma-glutamyl-phosphate reductase | | Authors: | Cherney, L.T, Cherney, M.M, Garen, C.R, Moraidin, F, James, M.N.G, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | | Deposit date: | 2006-08-17 | | Release date: | 2006-08-29 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Crystal Structure of N-acetyl-gamma-glutamyl-phosphate Reductase from Mycobacterium tuberculosis in Complex with NADP(+).
J.Mol.Biol., 367, 2007
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1JK7
 | | CRYSTAL STRUCTURE OF THE TUMOR-PROMOTER OKADAIC ACID BOUND TO PROTEIN PHOSPHATASE-1 | | Descriptor: | BETA-MERCAPTOETHANOL, MANGANESE (II) ION, OKADAIC ACID, ... | | Authors: | Maynes, J.T, Bateman, K.S, Cherney, M.M, Das, A.K, James, M.N. | | Deposit date: | 2001-07-11 | | Release date: | 2001-08-15 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of the tumor-promoter okadaic acid bound to protein phosphatase-1.
J.Biol.Chem., 276, 2001
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2QVB
 | | Crystal Structure of Haloalkane Dehalogenase Rv2579 from Mycobacterium tuberculosis | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Haloalkane dehalogenase 3 | | Authors: | Mazumdar, P.A, Hulecki, J, Cherney, M.M, Garen, C.R, James, M.N.G, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2007-08-08 | | Release date: | 2008-02-12 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.19 Å) | | Cite: | X-ray crystal structure of Mycobacterium tuberculosis haloalkane dehalogenase Rv2579.
Biochim.Biophys.Acta, 1784, 2008
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2Q9J
 | | Crystal structure of the C217S mutant of diaminopimelate epimerase | | Descriptor: | 1,2-ETHANEDIOL, Diaminopimelate epimerase, SULFATE ION | | Authors: | Pillai, B, Cherney, M, Diaper, C.M, Sutherland, A, Blanchard, J.S, Vederas, J.C. | | Deposit date: | 2007-06-12 | | Release date: | 2007-10-23 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase.
Biochem.Biophys.Res.Commun., 363, 2007
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2IFR
 | | Crystal structure of Scytalido-glutamic peptidase with a peptide based transition state analog | | Descriptor: | ACETIC ACID, Octapeptide, Scytalidopepsin B | | Authors: | Pillai, B, Cherney, M.M, Hiraga, K, Takada, K, Oda, K, James, M.N. | | Deposit date: | 2006-09-21 | | Release date: | 2006-10-03 | | Last modified: | 2024-07-10 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal structure of scytalidoglutamic peptidase with its first potent inhibitor provides insights into substrate specificity and catalysis.
J.Mol.Biol., 365, 2007
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2JEK
 | | Crystal structure of the conserved hypothetical protein Rv1873 from Mycobacterium tuberculosis at 1.38 A | | Descriptor: | GLYCEROL, RV1873, SULFATE ION | | Authors: | Garen, C.R, Cherney, M.M, Bergmann, E.M, James, M.N.G, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2007-01-17 | | Release date: | 2007-01-30 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.38 Å) | | Cite: | The Molecular Structure of Rv1873, a Conserved Hypothetical Protein from Mycobacterium Tuberculosis, at 1.38A Resolution
Acta Crystallogr.,Sect.F, 62, 2006
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2O2I
 | | Crystal structure of haloalkane dehalogenase Rv2579 from Mycobacterium tuberculosis complexed with 1,3-propandiol | | Descriptor: | 1,3-PROPANDIOL, BROMIDE ION, Haloalkane dehalogenase 3 | | Authors: | Mazumdar, P.A, Hulecki, J, Cherney, M.M, Garen, C.R, James, M.N.G, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2006-11-29 | | Release date: | 2007-11-13 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal structure of haloalkane dehalogenase Rv2579 from Mycobacterium tuberculosis complexed with 1,3-propandiol
To be Published
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2Q9H
 | | Crystal structure of the C73S mutant of diaminopimelate epimerase | | Descriptor: | ACETIC ACID, Diaminopimelate epimerase, L(+)-TARTARIC ACID | | Authors: | Pillai, B, Cherney, M, Diaper, C.M, Sutherland, A, Blanchard, J.S, Vederas, J.C, James, M.N.G. | | Deposit date: | 2007-06-12 | | Release date: | 2007-10-23 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase.
Biochem.Biophys.Res.Commun., 363, 2007
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2NR9
 | | Crystal structure of GlpG, Rhomboid Peptidase from Haemophilus influenzae | | Descriptor: | (R)-2-(FORMYLOXY)-3-(PHOSPHONOOXY)PROPYL PENTANOATE, 3,6,12,15,18,21,24-HEPTAOXAHEXATRIACONTAN-1-OL, Protein glpG homolog | | Authors: | Lemieux, M.J, Fischer, S.J, Cherney, M.M, Bateman, K.S, James, M.N.G. | | Deposit date: | 2006-11-01 | | Release date: | 2006-11-14 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis.
Proc.Natl.Acad.Sci.USA, 104, 2007
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2O2H
 | | Crystal structure of haloalkane dehalogenase Rv2579 from Mycobacterium tuberculosis complexed with 1,2-dichloroethane | | Descriptor: | 1,2-DICHLOROETHANE, ACETATE ION, CHLORIDE ION, ... | | Authors: | Mazumdar, P.A, Hulecki, J, Cherney, M.M, Garen, C.R, James, M.N.G, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2006-11-29 | | Release date: | 2007-11-13 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structure of haloalkane dehalogenase Rv2579 from Mycobacterium tuberculosis complexed with 1,2-dichloroethane
TO BE PUBLISHED
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3LMY
 | | The Crystal Structure of beta-hexosaminidase B in complex with Pyrimethamine | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Bateman, K.S, Cherney, M.M, Withers, S.G, Mahuran, D.J, Tropak, M, James, M.N.G. | | Deposit date: | 2010-02-01 | | Release date: | 2011-02-16 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The Crystal Structure of beta-hexosaminidase B in complex with Pyrimethamine
To be Published
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2Z20
 | | Crystal structure of LL-Diaminopimelate Aminotransferase from Arabidopsis thaliana | | Descriptor: | GLYCEROL, LL-diaminopimelate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, ... | | Authors: | Watanabe, N, Cherney, M.M, van Belkum, M.J, Marcus, S.L, Flegel, M.D, Clay, M.D, Deyholos, M.K, Vederas, J.C, James, M.N.G. | | Deposit date: | 2007-05-17 | | Release date: | 2007-07-17 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal structure of LL-diaminopimelate aminotransferase from Arabidopsis thaliana: a recently discovered enzyme in the biosynthesis of L-lysine by plants and Chlamydia
J.Mol.Biol., 371, 2007
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2Z1Z
 | | Crystal structure of LL-Diaminopimelate Aminotransferase from Arabidopsis thaliana complexed with L-malate ion | | Descriptor: | D-MALATE, LL-diaminopimelate aminotransferase, PYRIDOXAL-5'-PHOSPHATE | | Authors: | Watanabe, N, Cherney, M.M, van Belkum, M.J, Marcus, S.L, Flegel, M.D, Clay, M.D, Deyholos, M.K, Vederas, J.C, James, M.N.G. | | Deposit date: | 2007-05-16 | | Release date: | 2007-07-17 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of LL-diaminopimelate aminotransferase from Arabidopsis thaliana: a recently discovered enzyme in the biosynthesis of L-lysine by plants and Chlamydia
J.Mol.Biol., 371, 2007
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1NHV
 | | Hepatitis C virus RNA polymerase in complex with non-nucleoside analogue inhibitor | | Descriptor: | (2S)-2-[(5-BENZOFURAN-2-YL-THIOPHEN-2-YLMETHYL)-(2,4-DICHLORO-BENZOYL)-AMINO]-3-PHENYL-PROPIONIC ACID, HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE | | Authors: | Wang, M, Ng, K.K.S, Cherney, M.M, Chan, L, Yannopoulos, C.G, Bedard, J, Morin, N, Nguyen-Ba, N, Alaoui-Ismaili, M.H, Bethell, R.C, James, M.N.G. | | Deposit date: | 2002-12-19 | | Release date: | 2003-03-18 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Non-Nucleoside Analogue Inhibitors Bind to an Allosteric Site on
HCV NS5B Polymerase: Crystal Structures and Mechanism of Inhibition
J.Biol.Chem., 278, 2003
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1NHU
 | | Hepatitis C virus RNA polymerase in complex with non-nucleoside analogue inhibitor | | Descriptor: | (2S)-2-[(2,4-DICHLORO-BENZOYL)-(3-TRIFLUOROMETHYL-BENZYL)-AMINO]-3-PHENYL-PROPIONIC ACID, HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE | | Authors: | Wang, M, Ng, K.K.S, Cherney, M.M, Chan, L, Yannopoulos, C.G, Bedard, J, Morin, N, Nguyen-Ba, N, Alaoui-Ismaili, M.H, Bethell, R.C, James, M.N.G. | | Deposit date: | 2002-12-19 | | Release date: | 2003-03-18 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Non-Nucleoside Analogue Inhibitors Bind to an Allosteric Site on
HCV NS5B Polymerase: Crystal Structures and Mechanism of Inhibition
J.Biol.Chem., 278, 2003
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1KHW
 | | Crystal Structure of Rabbit Hemorrhagic Disease Virus RNA-dependent RNA polymerase complexed with Mn2+ | | Descriptor: | MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE | | Authors: | Ng, K.K, Cherney, M.M, Vazquez, A.L, Machin, A, Alonso, J.M, Parra, F, James, M.N. | | Deposit date: | 2001-12-01 | | Release date: | 2002-01-16 | | Last modified: | 2019-07-24 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase.
J.Biol.Chem., 277, 2002
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1KHV
 | | Crystal Structure of Rabbit Hemorrhagic Disease Virus RNA-dependent RNA polymerase complexed with Lu3+ | | Descriptor: | LUTETIUM (III) ION, RNA-DIRECTED RNA POLYMERASE | | Authors: | Ng, K.K, Cherney, M.M, Vazquez, A.L, Machin, A, Alonso, J.M, Parra, F, James, M.N. | | Deposit date: | 2001-12-01 | | Release date: | 2002-01-16 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase.
J.Biol.Chem., 277, 2002
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3EI9
 | | Crystal structure of K270N variant of LL-diaminopimelate aminotransferase from Arabidopsis thaliana complexed with L-Glu: External aldimine form | | Descriptor: | (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-glutamic acid, GLYCEROL, LL-diaminopimelate aminotransferase, ... | | Authors: | Watanabe, N, Clay, M.D, van Belkum, M.J, Cherney, M.M, Vederas, J.C, James, M.N.G. | | Deposit date: | 2008-09-15 | | Release date: | 2008-10-14 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Mechanism of substrate recognition and PLP-induced conformational changes in LL-diaminopimelate aminotransferase from Arabidopsis thaliana.
J.Mol.Biol., 384, 2008
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3EI8
 | | Crystal structure of K270N variant of LL-diaminopimelate aminotransferase from Arabidopsis thaliana complexed with LL-DAP: External aldimine form | | Descriptor: | (2S,6S)-2-amino-6-{[(1E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}heptanedioic acid, GLYCEROL, LL-diaminopimelate aminotransferase, ... | | Authors: | Watanabe, N, Clay, M.D, van Belkum, M.J, Cherney, M.M, Vederas, J.C, James, M.N.G. | | Deposit date: | 2008-09-15 | | Release date: | 2008-10-14 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Mechanism of substrate recognition and PLP-induced conformational changes in LL-diaminopimelate aminotransferase from Arabidopsis thaliana.
J.Mol.Biol., 384, 2008
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3EI6
 | | Crystal structure of LL-diaminopimelate aminotransferase from Arabidopsis thaliana complexed with PLP-DAP: an external aldimine mimic | | Descriptor: | (2S,6S)-2-amino-6-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]heptanedioic acid, GLYCEROL, LL-diaminopimelate aminotransferase, ... | | Authors: | Watanabe, N, Clay, M.D, van Belkum, M.J, Cherney, M.M, Vederas, J.C, James, M.N.G. | | Deposit date: | 2008-09-15 | | Release date: | 2008-10-14 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Mechanism of substrate recognition and PLP-induced conformational changes in LL-diaminopimelate aminotransferase from Arabidopsis thaliana.
J.Mol.Biol., 384, 2008
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3EIB
 | | Crystal structure of K270N variant of LL-diaminopimelate aminotransferase from Arabidopsis thaliana | | Descriptor: | GLYCEROL, LL-diaminopimelate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, ... | | Authors: | Watanabe, N, Clay, M.D, van Belkum, M.J, Cherney, M.M, Vederas, J.C, James, M.N.G. | | Deposit date: | 2008-09-15 | | Release date: | 2008-10-14 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Mechanism of substrate recognition and PLP-induced conformational changes in LL-diaminopimelate aminotransferase from Arabidopsis thaliana.
J.Mol.Biol., 384, 2008
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3EJX
 | | Crystal structure of diaminopimelate epimerase from Arabidopsis thaliana in complex with LL-AziDAP | | Descriptor: | (2S,6S)-2,6-DIAMINO-2-METHYLHEPTANEDIOIC ACID, Diaminopimelate epimerase, chloroplastic | | Authors: | Pillai, B, Moorthie, V.A, Cherney, M.M, Vederas, J.C, James, M.N.G. | | Deposit date: | 2008-09-18 | | Release date: | 2009-02-17 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal structure of diaminopimelate epimerase from Arabidopsis thaliana, an amino acid racemase critical for L-lysine biosynthesis.
J.Mol.Biol., 385, 2009
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3C9E
 | | Crystal structure of the cathepsin K : chondroitin sulfate complex. | | Descriptor: | 2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid, CALCIUM ION, Cathepsin K, ... | | Authors: | Kienetz, M, Cherney, M.M, James, M.N.G, Bromme, D. | | Deposit date: | 2008-02-15 | | Release date: | 2008-08-26 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The crystal and molecular structures of a cathepsin K:chondroitin sulfate complex.
J.Mol.Biol., 383, 2008
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