8HM1
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8HM2
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8HM4
| Crystal structure of PPIase | 分子名称: | Peptidylprolyl isomerase | 著者 | Xu, J.H, Chen, Z, Gao, X. | 登録日 | 2022-12-02 | 公開日 | 2023-11-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.79 Å) | 主引用文献 | Bacteroides fragilis ubiquitin homologue drives intraspecies bacterial competition in the gut microbiome. Nat Microbiol, 9, 2024
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8HM3
| Complex of PPIase-BfUbb | 分子名称: | GLYCEROL, MAGNESIUM ION, Peptidylprolyl isomerase, ... | 著者 | Xu, J.H, Chen, Z, Gao, X. | 登録日 | 2022-12-02 | 公開日 | 2023-11-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Bacteroides fragilis ubiquitin homologue drives intraspecies bacterial competition in the gut microbiome. Nat Microbiol, 9, 2024
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7VJS
| Human AlkB homolog ALKBH6 in complex with Tris and Ni | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6, NICKEL (II) ION | 著者 | Ma, L, Chen, Z. | 登録日 | 2021-09-28 | 公開日 | 2022-02-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.792 Å) | 主引用文献 | Structural insights into the interactions and epigenetic functions of human nucleic acid repair protein ALKBH6. J.Biol.Chem., 298, 2022
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7VJV
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7EXM
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6GIP
| Crystal structure of the ACVR1 (ALK2) kinase in complex with a Quinazolinone based ALK2 inhibitor with a 2, 5-dimethyl core. | 分子名称: | 1,2-ETHANEDIOL, 2,5-dimethyl-6-quinolin-4-yl-3~{H}-quinazolin-4-one, Activin receptor type-1, ... | 著者 | Williams, E, Hudson, L, Bezerra, G.A, Sorrell, F, Mathea, S, Chen, Z, Mahajan, P, Kupinska, K, Hoelder, S, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N. | 登録日 | 2018-05-14 | 公開日 | 2018-05-23 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Novel Quinazolinone Inhibitors of ALK2 Flip between Alternate Binding Modes: Structure-Activity Relationship, Structural Characterization, Kinase Profiling, and Cellular Proof of Concept. J. Med. Chem., 61, 2018
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4QQN
| Protein arginine methyltransferase 3 in complex with compound MTV044246 | 分子名称: | 1-{2-[1-(aminomethyl)cyclohexyl]ethyl}-3-isoquinolin-6-ylurea, CHLORIDE ION, GLYCEROL, ... | 著者 | Dong, A, Dobrovetsky, E, Tempel, W, He, H, Zhao, K, Smil, D, Landon, M, Luo, X, Chen, Z, Dai, M, Yu, Z, Lin, Y, Zhang, H, Zhao, K, Schapira, M, Brown, P.J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Vedadi, M, Structural Genomics Consortium (SGC) | 登録日 | 2014-06-27 | 公開日 | 2014-09-17 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3). J. Med. Chem., 61, 2018
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7YDT
| Crystal structure of mouse MPND | 分子名称: | MPN domain containing protein | 著者 | Yang, M, Chen, Z. | 登録日 | 2022-07-04 | 公開日 | 2023-02-15 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.055 Å) | 主引用文献 | Structures of MPND Reveal the Molecular Recognition of Nucleosomes. Int J Mol Sci, 24, 2023
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7YDW
| Crystal structure of the MPND-DNA complex | 分子名称: | DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), MPN domain-containing protein | 著者 | Yang, M, Chen, Z. | 登録日 | 2022-07-04 | 公開日 | 2023-02-15 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Structures of MPND Reveal the Molecular Recognition of Nucleosomes. Int J Mol Sci, 24, 2023
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7X3X
| Cryo-EM structure of N1 nucleosome-RA | 分子名称: | DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | 著者 | Lifei, L, Kangjing, C, Chen, Z. | 登録日 | 2022-03-01 | 公開日 | 2023-09-20 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure of the ISW1a complex bound to the dinucleosome. Nat.Struct.Mol.Biol., 31, 2024
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7X3W
| Cryo-EM structure of ISW1-N1 nucleosome | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (146-MER), ... | 著者 | Lifei, L, Kangjing, C, Chen, Z. | 登録日 | 2022-03-01 | 公開日 | 2023-09-20 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of the ISW1a complex bound to the dinucleosome. Nat.Struct.Mol.Biol., 31, 2024
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7X3V
| Cryo-EM structure of IOC3-N2 nucleosome | 分子名称: | DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | 著者 | Lifei, L, Kangjing, C, Chen, Z. | 登録日 | 2022-03-01 | 公開日 | 2023-09-20 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structure of the ISW1a complex bound to the dinucleosome. Nat.Struct.Mol.Biol., 31, 2024
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7X3T
| Cryo-EM structure of ISW1a-dinucleosome | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (343-MER), ... | 著者 | Lifei, L, Kangjing, C, Chen, Z. | 登録日 | 2022-03-01 | 公開日 | 2023-09-20 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (5.4 Å) | 主引用文献 | Structure of the ISW1a complex bound to the dinucleosome. Nat.Struct.Mol.Biol., 31, 2024
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7Y9I
| Complex structure of AtYchF1 with ppGpp | 分子名称: | GUANOSINE-5',3'-TETRAPHOSPHATE, MAGNESIUM ION, Obg-like ATPase 1 | 著者 | Li, X, Chen, Z. | 登録日 | 2022-06-24 | 公開日 | 2023-07-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Co-crystalization reveals the interaction between AtYchF1 and ppGpp. Front Mol Biosci, 9, 2022
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7WC8
| Crystal structure of serotonin 2A receptor in complex with lumateperone | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1-(4-fluorophenyl)-4-[(10~{R},15~{S})-4-methyl-1,4,12-triazatetracyclo[7.6.1.0^{5,16}.0^{10,15}]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one, 5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ... | 著者 | Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S. | 登録日 | 2021-12-18 | 公開日 | 2022-01-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structure-based discovery of nonhallucinogenic psychedelic analogs. Science, 375, 2022
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7WC4
| Crystal structure of serotonin 2A receptor in complex with serotonin | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, CHOLESTEROL, ... | 著者 | Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S. | 登録日 | 2021-12-18 | 公開日 | 2022-01-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structure-based discovery of nonhallucinogenic psychedelic analogs. Science, 375, 2022
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7WC6
| Crystal structure of serotonin 2A receptor in complex with LSD | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ... | 著者 | Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S. | 登録日 | 2021-12-18 | 公開日 | 2022-01-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure-based discovery of nonhallucinogenic psychedelic analogs. Science, 375, 2022
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7WC5
| Crystal structure of serotonin 2A receptor in complex with psilocin | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[2-(dimethylamino)ethyl]-1~{H}-indol-4-ol, 5-hydroxytryptamine receptor 2A, ... | 著者 | Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S. | 登録日 | 2021-12-18 | 公開日 | 2022-01-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structure-based discovery of nonhallucinogenic psychedelic analogs. Science, 375, 2022
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7WC7
| Crystal structure of serotonin 2A receptor in complex with lisuride | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, CHOLESTEROL, ... | 著者 | Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S. | 登録日 | 2021-12-18 | 公開日 | 2022-01-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure-based discovery of nonhallucinogenic psychedelic analogs. Science, 375, 2022
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7WC9
| Crystal structure of serotonin 2A receptor in complex with non-hallucinogenic psychedelic analog | 分子名称: | (10~{R},15~{S})-12-[3-(2-methoxyphenyl)propyl]-4-methyl-1,4,12-triazatetracyclo[7.6.1.0^{5,16}.0^{10,15}]hexadeca-5(16),6,8-triene, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2A,5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ... | 著者 | Cao, D, Yu, J, Wang, H, Luo, Z, Liu, X, He, L, Qi, J, Fan, L, Tang, L, Chen, Z, Li, J, Cheng, J, Wang, S. | 登録日 | 2021-12-18 | 公開日 | 2022-01-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure-based discovery of nonhallucinogenic psychedelic analogs. Science, 375, 2022
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7EV8
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7Y36
| Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, HYDROXIDE ION, ... | 著者 | Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z. | 登録日 | 2022-06-10 | 公開日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex to be published
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7Y35
| Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex | 分子名称: | Abaloparatide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z. | 登録日 | 2022-06-09 | 公開日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex To Be Published
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