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PDB: 731 件
1C6V
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BU of 1c6v by Molmil
SIV INTEGRASE (CATALYTIC DOMAIN + DNA BIDING DOMAIN COMPRISING RESIDUES 50-293) MUTANT WITH PHE 185 REPLACED BY HIS (F185H)
分子名称: PROTEIN (SIU89134), PROTEIN (SIV INTEGRASE)
著者Chen, Z, Yan, Y, Munshi, S, Li, Y, Zruygay-Murphy, J, Xu, B, Witmer, M, Felock, P, Wolfe, A, Sardana, V, Emini, E.A, Hazuda, D, Kuo, L.C.
登録日1999-12-21
公開日2000-12-27
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293)--an initial glance of the viral DNA binding platform.
J.Mol.Biol., 296, 2000
1SHZ
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BU of 1shz by Molmil
Crystal Structure of the p115RhoGEF rgRGS Domain in A Complex with Galpha(13):Galpha(i1) Chimera
分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine Nucleotide-Binding Protein Galpha(13):Galpha(i1) Chimera, MAGNESIUM ION, ...
著者Chen, Z, Singer, W.D, Sternweis, P.C, Sprang, S.R.
登録日2004-02-26
公開日2005-01-18
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Structure of the p115RhoGEF rgRGS domain-Galpha13/i1 chimera complex suggests convergent evolution of a GTPase activator.
Nat.Struct.Mol.Biol., 12, 2005
3CMT
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BU of 3cmt by Molmil
Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures
分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(*DTP*DTP*DTP*DTP*DTP*DCP*DCP*DCP*DAP*DCP*DCP*DTP*DTP*DTP*DT)-3'), DNA (5'-D(P*DGP*DGP*DTP*DGP*DGP*DG)-3'), ...
著者Chen, Z, Yang, H, Pavletich, N.P.
登録日2008-03-24
公開日2008-05-20
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures.
Nature, 453, 2008
7VOE
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BU of 7voe by Molmil
Crystal structure of 5-HT2AR in complex with aripiprazole
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, 7-[4-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one, ...
著者Chen, Z, Fan, L, Wang, H, Yu, J, Lu, D, Qi, J, Nie, F, Luo, Z, Liu, Z, Cheng, J, Wang, S.
登録日2021-10-13
公開日2021-12-22
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties.
Nat.Neurosci., 25, 2022
7VOD
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BU of 7vod by Molmil
Crystal structure of 5-HT2AR in complex with cariprazine
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[4-[2-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethyl-urea, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ...
著者Chen, Z, Fan, L, Wang, H, Yu, J, Lu, D, Qi, J, Nie, F, Luo, Z, Liu, Z, Cheng, J, Wang, S.
登録日2021-10-13
公開日2021-12-22
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties.
Nat.Neurosci., 25, 2022
7VWC
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BU of 7vwc by Molmil
Cryo-EM structure of human very long-chain fatty acid ABC transporter ABCD1
分子名称: Peroxisomal Membrane Protein related,ATP-binding cassette sub-family D member 1, [(2R)-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-oxidanyl-propyl] octadecanoate
著者Chen, Z.P, Xu, D, Wang, L, Mao, Y.X, Yang, L, Cheng, M.T, Hou, W.T, Chen, Y.X, Zhou, C.Z.
登録日2021-11-10
公開日2022-05-18
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.53 Å)
主引用文献Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1.
Nat Commun, 13, 2022
7VX8
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BU of 7vx8 by Molmil
Cryo-EM structure of ATP-bound human very long-chain fatty acid ABC transporter ABCD1
分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Peroxisomal Membrane Protein related,ATP-binding cassette sub-family D member 1
著者Chen, Z.P, Xu, D, Wang, L, Mao, Y.X, Yang, L, Cheng, M.T, Hou, W.T, Chen, Y.X, Zhou, C.Z.
登録日2021-11-12
公開日2022-05-18
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1.
Nat Commun, 13, 2022
7VZB
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BU of 7vzb by Molmil
Cryo-EM structure of C22:0-CoA bound human very long-chain fatty acid ABC transporter ABCD1
分子名称: CHOLESTEROL HEMISUCCINATE, Peroxisomal Membrane Protein related,ATP-binding cassette sub-family D member 1, S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] docosanethioate
著者Chen, Z.P, Xu, D, Wang, L, Mao, Y.X, Yang, L, Cheng, M.T, Hou, W.T, Chen, Y.X, Zhou, C.Z.
登録日2021-11-15
公開日2022-05-18
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.59 Å)
主引用文献Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1.
Nat Commun, 13, 2022
1HSI
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BU of 1hsi by Molmil
CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES
分子名称: HIV-2 PROTEASE
著者Chen, Z.
登録日1995-03-31
公開日1996-04-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases.
J.Biol.Chem., 269, 1994
1HSG
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BU of 1hsg by Molmil
CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES
分子名称: HIV-1 PROTEASE, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE
著者Chen, Z.
登録日1995-03-31
公開日1996-04-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases.
J.Biol.Chem., 269, 1994
1HSH
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BU of 1hsh by Molmil
CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES
分子名称: HIV-II PROTEASE, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE
著者Chen, Z.
登録日1995-03-31
公開日1996-04-03
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases.
J.Biol.Chem., 269, 1994
5ZBN
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BU of 5zbn by Molmil
Structure of glycolate oxidase without FMN from Nicotiana benthamiana
分子名称: Glycolate oxidase, PHOSPHATE ION
著者Chen, Z, Liu, Y.
登録日2018-02-12
公開日2018-12-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Structures of glycolate oxidase from Nicotiana benthamiana reveal a conserved pH sensor affecting the binding of FMN.
Biochem.Biophys.Res.Commun., 503, 2018
4XOH
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BU of 4xoh by Molmil
Mechanistic insights into anchorage of the contractile ring from yeast to humans
分子名称: Division mal foutue 1 protein
著者Chen, Z, Wu, J.-Q, Wang, J, Guan, R, Sun, L, Lee, I.-J, Liu, Y, Chen, M.
登録日2015-01-16
公開日2015-07-15
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.801 Å)
主引用文献Mechanistic insights into the anchorage of the contractile ring by anillin and mid1
Dev.Cell, 33, 2015
1TOM
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BU of 1tom by Molmil
ALPHA-THROMBIN COMPLEXED WITH HIRUGEN
分子名称: ALPHA-THROMBIN, HIRUGEN, METHYL-PHE-PRO-AMINO-CYCLOHEXYLGLYCINE
著者Chen, Z.
登録日1996-12-06
公開日1997-03-12
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Synthesis, evaluation, and crystallographic analysis of L-371,912: A potent and selective active-site thrombin inhibitor.
Bioorg.Med.Chem.Lett., 7, 1997
5KU6
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BU of 5ku6 by Molmil
Crystal structure for the complex of human carbonic anhydrase IV and methazolamide
分子名称: ACETATE ION, Carbonic anhydrase 4, GLYCEROL, ...
著者Chen, Z, Waheed, A, Di Cera, E, Sly, W.S.
登録日2016-07-12
公開日2017-07-26
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV.
Eur. Biophys. J., 47, 2018
8SYN
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BU of 8syn by Molmil
Human VPS35L/VPS29/VPS26C Complex
分子名称: VPS35 endosomal protein-sorting factor-like, Vacuolar protein sorting-associated protein 26C, Vacuolar protein sorting-associated protein 29
著者Chen, Z, Chen, B, Burstein, E, Han, Y.
登録日2023-05-25
公開日2023-11-01
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (2.94 Å)
主引用文献Structural organization of the retriever-CCC endosomal recycling complex.
Nat.Struct.Mol.Biol., 31, 2024
8SYM
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BU of 8sym by Molmil
Human VPS29/VPS35L Complex (Locally refined map)
分子名称: VPS35 endosomal protein-sorting factor-like, Vacuolar protein sorting-associated protein 29
著者Chen, Z, Chen, B, Burstein, E, Han, Y.
登録日2023-05-25
公開日2023-11-01
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural organization of the retriever-CCC endosomal recycling complex.
Nat.Struct.Mol.Biol., 31, 2024
8SYO
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BU of 8syo by Molmil
Human Retriever VPS35L/VPS29/VPS26C Complex (Composite Map)
分子名称: VPS35 endosomal protein-sorting factor-like, Vacuolar protein sorting-associated protein 26C, Vacuolar protein sorting-associated protein 29
著者Chen, Z, Chen, B, Burstein, E, Han, Y.
登録日2023-05-25
公開日2023-11-01
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (2.94 Å)
主引用文献Structural organization of the retriever-CCC endosomal recycling complex.
Nat.Struct.Mol.Biol., 31, 2024
2GC4
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BU of 2gc4 by Molmil
Structural comparison of the oxidized ternary electron transfer complex of methylamine dehydrogenase, amicyanin and cytochrome c551i from Paracoccus denitrificans with the substrate-reduced, copper free complex at 1.9 A resolution.
分子名称: Amicyanin, COPPER (II) ION, Cytochrome c-L, ...
著者Chen, Z, Durley, R, Davidson, V.L, Mathews, F.S.
登録日2006-03-13
公開日2006-11-28
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural comparison of the oxidized ternary electron transfer complex of methylamine dehydrogenase, amicyanin and cytochrome c551i from Paracoccus denitrificans with the substrate-reduced, copper free complex at 1.9 A resolution.
To be Published
2GC7
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BU of 2gc7 by Molmil
Substrate reduced, copper free complex of methylamine dehydrogenase, amicyanin and cytochrome c551i from Paracoccus denitrificans.
分子名称: Amicyanin, Cytochrome c-L, HEME C, ...
著者Chen, Z, Durley, R, Davidson, V.L, Mathews, F.S.
登録日2006-03-13
公開日2007-02-06
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structral comparison of the oxidized ternary electron transfer complex of methylamine dehydrogenase, amicyanin and cytochrome c551i from Paracoccus denitrificans with the substrate-reduced, copper free complex at 1.9 A resolution.
To be Published
1KV9
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BU of 1kv9 by Molmil
Structure at 1.9 A Resolution of a Quinohemoprotein Alcohol Dehydrogenase from Pseudomonas putida HK5
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETONE, CALCIUM ION, ...
著者Chen, Z.-W, Matsushita, K, Yamashita, T, Fujii, T, Toyama, H, Adachi, O, Bellamy, H.D, Mathews, F.S.
登録日2002-01-25
公開日2002-07-10
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure at 1.9 A resolution of a quinohemoprotein alcohol dehydrogenase from Pseudomonas putida HK5.
Structure, 10, 2002
5NKP
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BU of 5nkp by Molmil
Crystal structure of the human KLHL3 Kelch domain in complex with a WNK3 peptide
分子名称: CHLORIDE ION, CITRIC ACID, Kelch-like protein 3, ...
著者Chen, Z, Sorrell, F.J, Pinkas, D.M, Williams, E, Mathea, S, Goubin, S, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Burgess-Brown, N, Bountra, C, Bullock, A.
登録日2017-03-31
公開日2017-05-03
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of the human KLHL3 Kelch domain in complex with a WNK3 peptide
To Be Published
4N78
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BU of 4n78 by Molmil
The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton
分子名称: Abl interactor 2, CHLORIDE ION, Cytoplasmic FMR1-interacting protein 1, ...
著者Chen, Z.C.
登録日2013-10-15
公開日2014-02-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton.
Cell(Cambridge,Mass.), 156, 2014
6TTK
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BU of 6ttk by Molmil
Crystal structure of the kelch domain of human KLHL12 in complex with DVL1 peptide
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DVL1, ...
著者Chen, Z, Williams, E, Pike, A.C.W, Strain-Damerell, C, Wang, D, Chalk, R, Burgess-Brown, N, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N.
登録日2019-12-27
公開日2020-02-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.383 Å)
主引用文献Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12.
Open Biology, 10, 2020
5J9U
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BU of 5j9u by Molmil
Crystal structure of the NuA4 core complex
分子名称: Chromatin modification-related protein EAF6, Chromatin modification-related protein YNG2, Enhancer of polycomb-like protein 1, ...
著者Chen, Z.C, Xu, P.
登録日2016-04-11
公開日2016-10-26
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism
Mol.Cell, 63, 2016

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