1TOM

ALPHA-THROMBIN COMPLEXED WITH HIRUGEN

Summary for 1TOM

• Entry DOI: 10.2210/pdb1tom/pdb
• Descriptor: ALPHA-THROMBIN, HIRUGEN, METHYL-PHE-PRO-AMINO-CYCLOHEXYLGLYCINE, ... (5 entities in total)
• Functional Keywords: hydrolase, serine protease, kringle, disease mutation, complex (hydrolase-inhibitor), hydrolase-hydrolase inhibitor complex, blood coagulation-hydrolase inhibitor complex, blood coagulation/hydrolase inhibitor
• Biological source: Hirudo medicinalis (medicinal leech); More
• Cellular location: Secreted, extracellular space: P00734 P00734; Secreted: P28507
• Total number of polymer chains: 3
• Total formula weight: 35869.90

Authors

Chen, Z. (deposition date: 1996-12-06, release date: 1997-03-12, Last modification date: 2013-03-13)

• Primary citation: Lyle, T.A.,Chen, Z.G.,Appleby, S.D.,Freidinger, R.M.,Gardell, S.J.,Lewis, S.D.,Li, Y.,Lyle, E.A.,Lynch, J.J.,Mulichak, A.M.,Ng, A.S.,NaylorOlsen, A.M.,Sanders, W.M.; Synthesis, evaluation, and crystallographic analysis of L-371,912: A potent and selective active-site thrombin inhibitor.; Bioorg.Med.Chem.Lett., 7:67-72, 1997

Experimental method

X-RAY DIFFRACTION (1.8 Å)