1TOM

ALPHA-THROMBIN COMPLEXED WITH HIRUGEN

Summary for 1TOM
DescriptorALPHA-THROMBIN, HIRUGEN, METHYL-PHE-PRO-AMINO-CYCLOHEXYLGLYCINE, ... (5 entities in total)
Functional Keywordshydrolase, serine protease, kringle, disease mutation, complex (hydrolase-inhibitor), hydrolase-hydrolase inhibitor complex, blood coagulation-hydrolase inhibitor complex, blood coagulation/hydrolase inhibitor
Biological sourceHirudo medicinalis (medicinal leech)
More
Cellular locationSecreted, extracellular space: P00734 P00734
Secreted: P28507
Total number of polymer chains3
Total formula weight35869.90
Authors
Chen, Z. (deposition date: 1996-12-06, release date: 1997-03-12, Last modification date: 2013-03-13)
Primary citationAppleby, S.D.,Chen, Z.G.,Freidinger, R.M.,Gardell, S.J.,Lewis, S.D.,Li, Y.,Lyle, E.A.,Lyle, T.A.,Lynch, J.J.,Mulichak, A.M.,NaylorOlsen, A.M.,Ng, A.S.,Sanders, W.M.
Synthesis, evaluation, and crystallographic analysis of L-371,912: A potent and selective active-site thrombin inhibitor.
Bioorg.Med.Chem.Lett., 7:67-72, 1997
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation
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PDB entries from 2021-06-23