2ASQ
| Solution Structure of SUMO-1 in Complex with a SUMO-binding Motif (SBM) | Descriptor: | Protein inhibitor of activated STAT2, Small ubiquitin-related modifier 1 | Authors: | Song, J, Zhang, Z, Hu, W, Chen, Y. | Deposit date: | 2005-08-23 | Release date: | 2005-10-11 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Small Ubiquitin-like Modifier (SUMO) Recognition of a SUMO Binding Motif: A reversal of the bound orientation J.Biol.Chem., 280, 2005
|
|
6JPJ
| Crystal structure of FGF401 in complex of FGFR4 | Descriptor: | Fibroblast growth factor receptor 4, N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide, SULFATE ION | Authors: | Zhou, Z, Chen, X, Chen, Y. | Deposit date: | 2019-03-27 | Release date: | 2019-05-15 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.638 Å) | Cite: | Characterization of FGF401 as a reversible covalent inhibitor of fibroblast growth factor receptor 4. Chem.Commun.(Camb.), 55, 2019
|
|
2B6E
| X-Ray Crystal Structure of Protein HI1161 from Haemophilus influenzae. Northeast Structural Genomics Consortium Target IR63. | Descriptor: | ACETIC ACID, Hypothetical UPF0152 protein HI1161 | Authors: | Kuzin, A.P, Benach, J, Chen, Y, Acton, T, Xiao, R, Conover, K, Ma, L.-C, Kellie, R, Cunningham, K.E, Montelione, G, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2005-10-01 | Release date: | 2005-10-11 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | X-Ray structure of the different crystal form of the hypothetical UPF0152 protein HI1161: NESG target IR63 TO BE PUBLISHED
|
|
2AJA
| X-Ray structure of an ankyrin repeat family protein Q5ZSV0 from Legionella pneumophila. Northeast Structural Genomics Consortium target LgR21. | Descriptor: | ankyrin repeat family protein | Authors: | Kuzin, A.P, Chen, Y, Acton, T, Xiao, R, Conover, K, Ma, C, Kellie, R, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2005-08-01 | Release date: | 2005-08-16 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | X-Ray structure of an ankyrin repeat family protein Q5ZSV0 from Legionella pneumophila. To be Published
|
|
1YUD
| X-ray Crystal Structure of Protein SO0799 from Shewanella oneidensis. Northeast Structural Genomics Consortium Target SoR12. | Descriptor: | hypothetical protein SO0799 | Authors: | Kuzin, A.P, Vorobiev, S, Chen, Y, Forouhar, F, Acton, T, Ma, L.-C, Xiao, R, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2005-02-14 | Release date: | 2005-03-08 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of hypothetical protein SO0799 from Shewanella oneidensis To be Published
|
|
2JWS
| Solution NMR structures of two designed proteins with 88% sequence identity but different fold and function | Descriptor: | Ga88 | Authors: | He, Y, Chen, Y, Alexander, P, Bryan, P, Orban, J. | Deposit date: | 2007-10-24 | Release date: | 2008-09-09 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | NMR structures of two designed proteins with high sequence identity but different fold and function Proc.Natl.Acad.Sci.Usa, 105, 2008
|
|
1ZNP
| X-Ray Crystal Structure of Protein Q8U9W0 from Agrobacterium tumefaciens. Northeast Structural Genomics Consortium Target AtR55. | Descriptor: | hypothetical protein Atu3615 | Authors: | Kuzin, A.P, Chen, Y, Forouhar, F, Vorobiev, S.M, Xiao, R, Ma, L.-C, Acton, T, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2005-05-11 | Release date: | 2005-05-24 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | X-Ray structure of the hypothetical protein Q8U9W0 from Agrobacterium tumefaciens. Northeast Structural Genomics Consortium target AtR55. To be Published
|
|
2LHE
| Gb98-T25I,L20A | Descriptor: | Gb98 | Authors: | He, Y, Chen, Y, Alexander, P, Bryan, P, Orban, J. | Deposit date: | 2011-08-08 | Release date: | 2012-02-29 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Mutational tipping points for switching protein folds and functions. Structure, 20, 2012
|
|
2LHG
| GB98-T25I solution structure | Descriptor: | GB98 | Authors: | He, Y, Chen, Y, Alexander, P, Bryan, P, Orban, J. | Deposit date: | 2011-08-08 | Release date: | 2012-02-29 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Mutational tipping points for switching protein folds and functions. Structure, 20, 2012
|
|
2LHD
| GB98 solution structure | Descriptor: | GB98 | Authors: | He, Y, Chen, Y, Alexander, P, Bryan, P, Orban, J. | Deposit date: | 2011-08-08 | Release date: | 2012-02-29 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Mutational tipping points for switching protein folds and functions. Structure, 20, 2012
|
|
2LU1
| pfsub2 solution NMR structure | Descriptor: | Subtilase | Authors: | He, Y, Chen, Y, Ruan, B, O'Brochta, D, Bryan, P, Orban, J. | Deposit date: | 2012-06-06 | Release date: | 2012-10-03 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of a sheddase inhibitor prodomain from the malarial parasite Plasmodium falciparum. Proteins, 80, 2012
|
|
2KDL
| NMR structures of GA95 and GB95, two designed proteins with 95% sequence identity but different folds and functions | Descriptor: | designed protein | Authors: | He, Y, Alexander, P, Chen, Y, Bryan, P, Orban, J. | Deposit date: | 2009-01-12 | Release date: | 2009-12-29 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | A minimal sequence code for switching protein structure and function. Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
2BX9
| Crystal structure of B.subtilis Anti-TRAP protein, an antagonist of TRAP-RNA interactions | Descriptor: | TRYPTOPHAN RNA-BINDING ATTENUATOR PROTEIN-INHIBITORY PROTEIN, ZINC ION | Authors: | Shevtsov, M.B, Chen, Y, Gollnick, P, Antson, A.A. | Deposit date: | 2005-07-26 | Release date: | 2005-11-30 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of Bacillus Subtilis Anti-Trap Protein, an Antagonist of Trap/RNA Interaction. Proc.Natl.Acad.Sci.USA, 102, 2005
|
|
2JWU
| Solution NMR structures of two designed proteins with 88% sequence identity but different fold and function | Descriptor: | Gb88 | Authors: | He, Y, Chen, Y, Alexander, P, Bryan, P, Orban, J. | Deposit date: | 2007-10-25 | Release date: | 2008-09-09 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | NMR structures of two designed proteins with high sequence identity but different fold and function Proc.Natl.Acad.Sci.Usa, 105, 2008
|
|
2MH8
| GA-79-MBP cs-rosetta structures | Descriptor: | GA-79-MBP, maltose binding protein | Authors: | He, Y, Chen, Y, Porter, L, Bryan, P, Orban, J. | Deposit date: | 2013-11-19 | Release date: | 2015-04-08 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Subdomain interactions foster the design of two protein pairs with 80% sequence identity but different folds. Biophys.J., 108, 2015
|
|
2KDM
| NMR structures of GA95 and GB95, two designed proteins with 95% sequence identity but different folds and functions | Descriptor: | DESIGNED PROTEIN | Authors: | He, Y, Alexander, P, Chen, Y, Bryan, P, Orban, J. | Deposit date: | 2009-01-12 | Release date: | 2009-12-29 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | From the Cover: A minimal sequence code for switching protein structure and function. Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
4CXY
| Crystal structure of human FTO in complex with acylhydrazine inhibitor 21 | Descriptor: | (E)-4-(2-Nicotinoylhydrazinyl)-4-oxobut-2-enoic acid, ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO, NICKEL (II) ION | Authors: | Toh, D.W, Sun, L, Tan, J, Chen, Y, Lau, L.Z.M, Hong, W, Woon, E.C.Y, Gao, Y.G. | Deposit date: | 2014-04-09 | Release date: | 2014-10-01 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor ofN6-methyladenosine demethylase FTO. Chem Sci, 6, 2015
|
|
4CXX
| Crystal structure of human FTO in complex with acylhydrazine inhibitor 16 | Descriptor: | (2E)-4-{N'-[4-(4-tert-Butyl-benzyl)-pyridine-3-carbonyl]-hydrazino}-4-oxo-but-2-enoic acid, ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO, NICKEL (II) ION | Authors: | Toh, D.W, Sun, L, Tan, J, Chen, Y, Lau, L.Z.M, Hong, W, Woon, E.C.Y, Gao, Y.G. | Deposit date: | 2014-04-09 | Release date: | 2014-10-01 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor ofN6-methyladenosine demethylase FTO. Chem Sci, 6, 2015
|
|
4M7C
| Crystal structure of the TRF2-binding motif of SLX4 in complex with the TRFH domain of TRF2 | Descriptor: | Peptide from Structure-specific endonuclease subunit SLX4, Telomeric repeat-binding factor 2 | Authors: | Wan, B, Chen, Y, Wu, J, Liu, Y, Lei, M. | Deposit date: | 2013-08-12 | Release date: | 2013-09-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres Cell Rep, 4, 2013
|
|
4XXR
| Atomic Resolution X-Ray Crystal Structure of a Ruthenocene Conjugated Beta-Lactam Antibiotic in Complex with CTX-M-14 E166A Beta-Lactamase | Descriptor: | CTX-M-14 Class A Beta-Lactamase, POTASSIUM ION, [(1,2,3,4,5-eta)-1-(4-{[(4-carboxy-5,5-dimethyl-1,3-thiazolidin-2-yl)methyl]amino}-4-oxobutanoyl)cyclopentadienyl][(1,2,3,4,5-eta)-cyclopentadienyl]ruthenium, ... | Authors: | Lewandowski, E.M, Chen, Y. | Deposit date: | 2015-01-30 | Release date: | 2015-03-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.18 Å) | Cite: | Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated beta-lactam antibiotic. Chem.Commun.(Camb.), 51, 2015
|
|
4CXW
| Crystal structure of human FTO in complex with subfamily-selective inhibitor 12 | Descriptor: | (2E)-4-[N'-(4-benzyl-pyridine-3-carbonyl)-hydrazino]-4-oxo-but-2-enoic acid, ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO, NICKEL (II) ION | Authors: | Toh, D.W, Sun, L, Tan, J, Chen, Y, Lau, L.Z.M, Hong, W, Woon, E.C.Y, Gao, Y.G. | Deposit date: | 2014-04-09 | Release date: | 2014-10-01 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor ofN6-methyladenosine demethylase FTO. Chem Sci, 6, 2015
|
|
4D6V
| Crystal structure of signal transducing protein | Descriptor: | G PROTEIN BETA SUBUNIT GIB2 | Authors: | Ero, R, Dimitrova, V.T, Chen, Y, Bu, W, Feng, S, Liu, T, Wang, P, Xue, C, Tan, S.M, Gao, Y.G. | Deposit date: | 2014-11-17 | Release date: | 2015-03-18 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure of Gib2, a Signal-Transducing Protein Scaffold Associated with Ribosomes in Cryptococcus Neoformans. Sci.Rep., 5, 2015
|
|
2DLB
| X-ray Crystal Structure of Protein yopT from Bacillus subtilis. Northeast Structural Genomics Consortium Target SR412 | Descriptor: | yopT | Authors: | Kuzin, A.P, Chen, Y, Seetharaman, J, Ho, C.-K, Cunningham, K, Janjua, H, Conover, K, Ma, L.-C, Xiao, R, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2006-04-18 | Release date: | 2006-04-25 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | X-ray structure of hypothetical protein from Bacillus subtilis O34498 at the resolution of 1.2A. NESG target SR412 To be published
|
|
4BV7
| Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV. | Descriptor: | 3-(4-piperidyl)propanoic acid, ACETATE ION, APOLIPOPROTEIN(A) | Authors: | Sandmark, J, Althage, M, Andersson, G.M.K, Antonsson, T, Blaho, S, Bodin, C, Bostrom, J, Chen, Y, Dahlen, A, Eriksson, P.O, Evertsson, E, Fex, T, Fjellstrom, O, Gustafsson, D, Hallberg, C, Hicks, R, Jarkvist, E, Johansson, C, Kalies, I, Kang, D, Svalstedt Karlsson, B, Kartberg, F, Legnehed, A, Lindqvist, A.M, Martinsson, S.A, Moberg, A, Petersson, A.U, Ridderstrom, M, Thelin, A, Tigerstrom, A, Vinblad, J, Xu, B, Knecht, W. | Deposit date: | 2013-06-25 | Release date: | 2014-07-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A) To be Published
|
|
4BVD
| Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV. | Descriptor: | 5-chloro-2-fluoro-N-[1-(4-piperidyl)pyrazol-4-yl]benzenesulfonamide, APOLIPOPROTEIN(A), CHLORIDE ION | Authors: | Sandmark, J, Althage, M, Andersson, G.M.K, Antonsson, T, Blaho, S, Bodin, C, Bostrom, J, Chen, Y, Dahlen, A, Eriksson, P.O, Evertsson, E, Fex, T, Fjellstrom, O, Gustafsson, D, Hallberg, C, Hicks, R, Jarkvist, E, Johansson, C, Kalies, I, Kang, D, Svalstedt Karlsson, B, Kartberg, F, Legnehed, A, Lindqvist, A.M, Martinsson, S.A, Moberg, A, Petersson, A.U, Ridderstrom, M, Thelin, A, Tigerstrom, A, Vinblad, J, Xu, B, Knecht, W. | Deposit date: | 2013-06-25 | Release date: | 2014-07-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A) To be Published
|
|