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PDB: 710 件
7CLD
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BU of 7cld by Molmil
Crystal structure of T2R-TTL-Cevipabulin complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-[2,6-bis(fluoranyl)-4-[3-(methylamino)propoxy]phenyl]-5-chloranyl-N-[(2S)-1,1,1-tris(fluoranyl)propan-2-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, CALCIUM ION, ...
著者Chen, L.J, Chen, Q, Yu, Y, Yang, J.H.
登録日2020-07-20
公開日2021-07-07
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.611 Å)
主引用文献Cevipabulin-tubulin complex reveals a novel agent binding site on alpha-tubulin with tubulin degradation effect.
Sci Adv, 7, 2021
7DP8
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Crystal structure of T2R-TTL-Cevipabulin-eribulin complex
分子名称: (1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33R,35R,36S)-20-[(2S)-3-amino-2-hydroxypropyl]-21-methoxy-14-methyl-8,15-dimethylidene-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9.2.1~3,32~.1~3,33~.1~6,9~.1~12,16~.0~18,22~.0~29,36~.0~31,35~]hentetracontan-24-one (non-preferred name), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-[2,6-bis(fluoranyl)-4-[3-(methylamino)propoxy]phenyl]-5-chloranyl-N-[(2S)-1,1,1-tris(fluoranyl)propan-2-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, ...
著者Chen, L.J, Chen, Q, Yu, Y, Yang, J.H.
登録日2020-12-18
公開日2021-07-07
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.446 Å)
主引用文献Cevipabulin-tubulin complex reveals a novel agent binding site on alpha-tubulin with tubulin degradation effect.
Sci Adv, 7, 2021
6BV3
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Crystal structure of porcine aminopeptidase-N with Leucine
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Chen, L, Lin, Y.-L, Li, F.
登録日2017-12-12
公開日2018-01-17
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach.
Sci Rep, 7, 2017
6BV0
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Crystal structure of porcine aminopeptidase-N with Arginine
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Chen, L, Lin, Y.-L, Li, F.
登録日2017-12-12
公開日2018-01-17
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach.
Sci Rep, 7, 2017
6BV1
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Crystal structure of porcine aminopeptidase-N with Aspartic acid
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Chen, L, Lin, Y.-L, Li, F.
登録日2017-12-12
公開日2018-01-17
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach.
Sci Rep, 7, 2017
6BV4
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Crystal structure of porcine aminopeptidase-N with Methionine
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Chen, L, Lin, Y.-L, Li, F.
登録日2017-12-12
公開日2018-01-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach.
Sci Rep, 7, 2017
6BUY
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BU of 6buy by Molmil
Crystal structure of porcine aminopeptidase-N with Glycine
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Chen, L, Lin, Y.-L, Li, F.
登録日2017-12-11
公開日2018-01-10
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach.
Sci Rep, 7, 2017
6BV2
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Crystal structure of porcine aminopeptidase-N with Isoleucine
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Chen, L, Lin, Y.-L, Li, F.
登録日2017-12-12
公開日2018-01-17
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach.
Sci Rep, 7, 2017
3MQ0
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BU of 3mq0 by Molmil
Crystal Structure of Agobacterium tumefaciens repressor BlcR
分子名称: Transcriptional repressor of the blcABC operon
著者Chen, L.
登録日2010-04-27
公開日2011-03-30
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.793 Å)
主引用文献The Agrobacterium tumefaciens Transcription Factor BlcR Is Regulated via Oligomerization.
J.Biol.Chem., 286, 2011
3RJ2
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BU of 3rj2 by Molmil
Structural and functional characterization of a novel histone H3 binding protein ORF158L from the Singapore grouper iridovirus (SGIV)
分子名称: Putative uncharacterized protein
著者Chen, L, Liu, Y, Sivaraman, J, Hew, C.L.
登録日2011-04-15
公開日2012-02-29
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Novel histone H3 binding protein ORF158L from the Singapore grouper iridovirus
J.Virol., 85, 2011
3LLP
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BU of 3llp by Molmil
1.8 Angstrom human fascin 1 crystal structure
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BROMIDE ION, Fascin, ...
著者Chen, L, Yang, S, Jakoncic, J, Zhang, J.J, Huang, X.-Y.
登録日2010-01-29
公開日2010-04-07
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Migrastatin analogues target fascin to block tumour metastasis.
Nature, 464, 2010
7CDA
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BU of 7cda by Molmil
Crystal structure of T2R-TTL-PAC complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ...
著者Chen, L.J, Chen, Q, Yu, Y, Yang, J.H.
登録日2020-06-19
公開日2021-06-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.659 Å)
主引用文献Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond.
J.Med.Chem., 65, 2022
7CEK
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BU of 7cek by Molmil
Crystal structure of T2R-TTL-BML-284 complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ...
著者Chen, L.J, Chen, Q, Yu, Y, Yang, J.H.
登録日2020-06-23
公開日2021-06-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.696 Å)
主引用文献Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond.
J.Med.Chem., 65, 2022
3RPT
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BU of 3rpt by Molmil
Crystal structure of the anti-HIV b12 scaffold protein
分子名称: Endoglucanase E-2, SULFATE ION
著者Chen, L, Kwong, P.D.
登録日2011-04-27
公開日2011-12-21
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (1.303 Å)
主引用文献Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold.
Science, 334, 2011
7CE6
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BU of 7ce6 by Molmil
Crystal structure of T2R-TTL-Compound9 complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ...
著者Chen, L.J, Chen, Q, Yu, Y, Yang, J.H.
登録日2020-06-22
公開日2021-06-30
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.695 Å)
主引用文献Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond.
J.Med.Chem., 65, 2022
7C34
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BU of 7c34 by Molmil
Crystal structure of Serratia marcescens Chitinase B complexed with Berberine
分子名称: BERBERINE, Chitinase
著者Chen, L, Chen, J, Yang, Q.
登録日2020-05-11
公開日2020-05-27
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.938 Å)
主引用文献Crystal structure-guided design of berberine-based novel chitinase inhibitors.
J Enzyme Inhib Med Chem, 35, 2020
2M1N
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BU of 2m1n by Molmil
Solution structure of a chaperone in type III secretion system
分子名称: Type III secretion system filament chaperone CesA
著者Chen, L, Economou, A, Kalodimos, C.
登録日2012-12-03
公開日2013-04-10
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Substrate-Activated Conformational Switch on Chaperones Encodes a Targeting Signal in Type III Secretion.
Cell Rep, 3, 2013
6JB1
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BU of 6jb1 by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with repaglinide and ATPgammaS at 3.3A resolution
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
著者Chen, L, Ding, D, Wang, M, Wu, J.-X, Kang, Y.
登録日2019-01-25
公開日2019-05-22
最終更新日2021-09-29
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献The Structural Basis for the Binding of Repaglinide to the Pancreatic KATPChannel.
Cell Rep, 27, 2019
2P8T
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BU of 2p8t by Molmil
Hypothetical protein PH0730 from Pyrococcus horikoshii OT3
分子名称: Hypothetical protein PH0730
著者Chen, L, Zhao, M, Ebihara, A, Shinkai, A, Kuramitsu, S, Yokoyama, S, Zhu, J, Swindell, J.T, Fu, Z.-Q, Chrzas, J, Rose, J.P, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG), RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-23
公開日2007-04-24
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Hypothetical protein PH0730 from Pyrococcus horikoshii OT3
To be Published
2P91
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BU of 2p91 by Molmil
Crystal structure of Enoyl-[acyl-carrier-protein] reductase (NADH) from Aquifex aeolicus VF5
分子名称: Enoyl-[acyl-carrier-protein] reductase [NADH]
著者Chen, L, Li, Y, Ebihara, A, Shinkai, A, Kuramitsu, S, Yokoyama, S, Zhao, M, Rose, J.P, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG), RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-03-23
公開日2007-04-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of Enoyl-[acyl-carrier-protein] reductase (NADH) from Aquifex aeolicus VF5
To be Published
5XSK
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BU of 5xsk by Molmil
Crystal structure of PWWP-DNA complex for human hepatoma-derived growth factor
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(P*TP*GP*GP*TP*CP*TP*TP*GP*AP*A)-3'), DNA (5'-D(P*TP*TP*CP*AP*AP*GP*AP*CP*CP*A)-3'), ...
著者Chen, L.Y, Huang, Y.C, Hsieh, Y.C, Lin, P.J, Chen, C.J.
登録日2017-06-14
公開日2018-06-20
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.84 Å)
主引用文献Structure of PWWP-DNA complex at 2.84 Angstroms resolution
To Be Published
5XSL
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BU of 5xsl by Molmil
Crystal structure of the PWWP domain of human hepatoma-derived growth factor
分子名称: Hepatoma-derived growth factor
著者Chen, L.Y, Huang, Y.C, Hsieh, Y.C, Lin, P.J, Chen, C.J.
登録日2017-06-14
公開日2018-06-20
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structure of the PWWP domain at 3.3 Angstroms resolution
To Be Published
3RJQ
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BU of 3rjq by Molmil
Crystal structure of anti-HIV llama VHH antibody A12 in complex with C186 gp120
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, C186 gp120, Llama VHH A12
著者Chen, L, McLellan, J.S, Kwon, Y.D, Schmidt, S, Wu, X, Zhou, T, Yang, Y, Zhang, B, Forsman, A, Weiss, R.A, Verrips, T, Mascola, J, Kwong, P.D.
登録日2011-04-15
公開日2012-05-02
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.601 Å)
主引用文献Crystal structure of anti-HIV A12 VHH of llama antibody in complex with C1086 gp120
To be Published
3R0M
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BU of 3r0m by Molmil
Crystal structure of anti-HIV llama VHH antibody A12
分子名称: Llama VHH A12, SULFATE ION
著者Chen, L, McLellan, J.S, Kwon, Y.D, Schmidt, S, Wu, X, Zhou, T, Yang, Y, Zhang, B, Forsman, A, Weiss, R.A, Verrips, T, Mascola, J, Kwong, P.D.
登録日2011-03-08
公開日2012-03-14
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Single-Headed Immunoglobulins Efficiently Penetrate CD4-Binding Site and Effectively Neutralize HIV-1
To be Published
3MCA
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BU of 3mca by Molmil
Structure of the Dom34-Hbs1 Complex and implications for its role in No-Go decay
分子名称: Elongation factor 1 alpha-like protein, Protein dom34
著者Chen, L, Song, H.
登録日2010-03-28
公開日2010-10-06
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Structure of the Dom34-Hbs1 complex and implications for no-go decay
Nat.Struct.Mol.Biol., 17, 2010

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