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PDB: 621 件
4EAK
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Co-crystal structure of an AMPK core with ATP
分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
著者Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W.
登録日2012-03-22
公開日2012-06-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
Nat.Struct.Mol.Biol., 19, 2012
4EAJ
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BU of 4eaj by Molmil
Co-crystal of AMPK core with AMP soaked with ATP
分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
著者Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W.
登録日2012-03-22
公開日2012-06-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.609 Å)
主引用文献AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
Nat.Struct.Mol.Biol., 19, 2012
4EP4
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Thermus thermophilus RuvC structure
分子名称: Crossover junction endodeoxyribonuclease RuvC, GLYCEROL, MAGNESIUM ION
著者Chen, L, Shi, K, Yin, Z.Q, Aihara, H.
登録日2012-04-17
公開日2012-11-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献Structural asymmetry in the Thermus thermophilus RuvC dimer suggests a basis for sequential strand cleavages during Holliday junction resolution.
Nucleic Acids Res., 41, 2013
4EAG
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BU of 4eag by Molmil
Co-crystal structure of an chimeric AMPK core with ATP
分子名称: 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W.
登録日2012-03-22
公開日2012-06-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.701 Å)
主引用文献AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
Nat.Struct.Mol.Biol., 19, 2012
4EAL
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BU of 4eal by Molmil
Co-crystal of AMPK core with ATP soaked with AMP
分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
著者Chen, L, Wang, J, Zhang, Y.-Y, Yan, S.F, Neumann, D, Schlattner, U, Wang, Z.-X, Wu, J.-W.
登録日2012-03-22
公開日2012-06-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.506 Å)
主引用文献AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
Nat.Struct.Mol.Biol., 19, 2012
4EP5
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BU of 4ep5 by Molmil
Thermus thermophilus RuvC structure
分子名称: Crossover junction endodeoxyribonuclease RuvC, GLYCEROL, SULFATE ION
著者Chen, L, Shi, K, Yin, Z.Q, Aihara, H.
登録日2012-04-17
公開日2012-11-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Structural asymmetry in the Thermus thermophilus RuvC dimer suggests a basis for sequential strand cleavages during Holliday junction resolution.
Nucleic Acids Res., 41, 2013
2JTK
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BU of 2jtk by Molmil
A functional domain of a Wnt signal protein
分子名称: Dickkopf-related protein 2
著者Chen, L, Shao, Y, Huang, J, Zheng, J.
登録日2007-08-02
公開日2008-07-08
最終更新日2022-03-16
実験手法SOLUTION NMR
主引用文献Structural insight into the mechanisms of wnt signaling antagonism by dkk
J.Biol.Chem., 283, 2008
5YKF
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Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (3D class1 at 4.33A)
分子名称: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
著者Chen, L, Wu, J.X.
登録日2017-10-14
公開日2018-04-18
最終更新日2019-11-06
実験手法ELECTRON MICROSCOPY (4.33 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YKG
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Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (Class2 at 4.57A)
分子名称: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
著者Chen, L, Wu, J.X.
登録日2017-10-14
公開日2018-04-18
最終更新日2018-06-13
実験手法ELECTRON MICROSCOPY (4.57 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YKE
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Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (focused refinement on TM at 4.11A)
分子名称: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11
著者Chen, L, Wu, J.X.
登録日2017-10-14
公開日2018-04-18
最終更新日2018-06-13
実験手法ELECTRON MICROSCOPY (4.11 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YWC
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BU of 5ywc by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (CTD class1 at 4.3A)
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-02
最終更新日2018-06-13
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YW9
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BU of 5yw9 by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (class1 5.0A)
分子名称: ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-02
最終更新日2018-06-13
実験手法ELECTRON MICROSCOPY (5 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YWB
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BU of 5ywb by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (CTD class2 at 5.2A)
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-30
最終更新日2019-11-06
実験手法ELECTRON MICROSCOPY (5.2 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
2ICU
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BU of 2icu by Molmil
Crystal Structure of Hypothetical Protein YedK From Escherichia coli
分子名称: Hypothetical protein yedK
著者Chen, L, Liu, Z.J, Li, Y, Zhao, M, Rose, J, Ebihara, A, Yokoyama, S, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG), RIKEN Structural Genomics/Proteomics Initiative, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2006-09-13
公開日2006-11-07
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structure of Hypothetical Protein YedK From Escherichia coli
To be Published
5YW8
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BU of 5yw8 by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (all particles at 4.4A)
分子名称: ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-02
最終更新日2018-06-13
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
4NZ8
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BU of 4nz8 by Molmil
Crystal structure of porcine aminopeptidase-N complexed with cleaved poly-alanine
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ...
著者Chen, L, Lin, Y.L, Peng, G, Li, F.
登録日2013-12-11
公開日2013-12-25
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for multifunctional roles of mammalian aminopeptidase N.
Proc.Natl.Acad.Sci.USA, 109, 2012
5YWA
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BU of 5ywa by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (CTD class 2 at 6.1A)
分子名称: ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-02
最終更新日2018-06-13
実験手法ELECTRON MICROSCOPY (6.1 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
1A02
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BU of 1a02 by Molmil
STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA
分子名称: AP-1 FRAGMENT FOS, AP-1 FRAGMENT JUN, DNA (5'-D(*DAP*DAP*DCP*DTP*DAP*DTP*DGP*DAP*DAP*DAP*DCP*DAP*DAP*DAP*DTP*DTP*DTP*DTP*DCP*DC)-3'), ...
著者Chen, L, Glover, J.N.M, Hogan, P.G, Rao, A, Harrison, S.C.
登録日1997-12-08
公開日1998-05-27
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA.
Nature, 392, 1998
2KNO
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BU of 2kno by Molmil
NMR Solution Structure of SH2 Domain of the Human Tensin Like C1 Domain Containing Phosphatase (TENC1)
分子名称: Tensin-like C1 domain-containing phosphatase
著者Chen, L, Feng, R, Liu, C, Zhu, G.
登録日2009-08-27
公開日2010-09-01
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献NMR Solution Structure of SH2 Domain of the Human Tensin Like C1 Domain Containing Phosphatase (TENC1)
To be Published
1DK7
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BU of 1dk7 by Molmil
CRYSTAL STRUCTURE OF AN ISOLATED APICAL DOMAIN OF GROEL
分子名称: GROEL
著者Chen, L, Sigler, P.B.
登録日1999-12-06
公開日2000-01-05
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献The crystal structure of a GroEL/peptide complex: plasticity as a basis for substrate diversity.
Cell(Cambridge,Mass.), 99, 1999
2LHK
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BU of 2lhk by Molmil
Structural analysis of a chaperone in type III secretion system
分子名称: L0052
著者Chen, L, Economou, A, Kalodimos, C.G.
登録日2011-08-11
公開日2011-12-28
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural instability tuning as a regulatory mechanism in protein-protein interactions.
Mol.Cell, 44, 2011
3WQV
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BU of 3wqv by Molmil
Crystal structure of Ostrinia furnacalis Group I chitinase catalytic domain in complex with a(GlcN)5
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Chen, L, Zhou, Y, Yang, Q.
登録日2014-02-03
公開日2014-05-28
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.043 Å)
主引用文献Fully deacetylated chitooligosaccharides act as efficient glycoside hydrolase family 18 chitinase inhibitors.
J.Biol.Chem., 289, 2014
3WQW
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BU of 3wqw by Molmil
Crystal structure of Ostrinia furnacalis Group I chitinase catalytic domain in complex with a(GlcN)6
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Chen, L, Zhou, Y, Yang, Q.
登録日2014-02-03
公開日2014-05-28
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Fully deacetylated chitooligosaccharides act as efficient glycoside hydrolase family 18 chitinase inhibitors.
J.Biol.Chem., 289, 2014
5CH9
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Gkap mutant B12
分子名称: COBALT (II) ION, Phosphotriesterase
著者Chen, L.-Q.
登録日2015-07-10
公開日2015-09-09
最終更新日2019-11-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Active site loop architecture enhance the promiscuous PTE activity in lactonase from Geobacillus kaustophilus HTA426
To Be Published
8K5H
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Structure of the SARS-CoV-2 BA.1 spike with UT28-RD
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者Chen, L, Kita, S, Anraku, Y, Maenaka, K.
登録日2023-07-21
公開日2023-12-27
実験手法ELECTRON MICROSCOPY (3.22 Å)
主引用文献In silico-designed UT28K with two amino acid substitutions is capable of neutralization of resistant SARS-CoV2 Omicrons BA.1 valiant.
To Be Published

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件を2024-06-12に公開中

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