7LL8
 
 | | D-Protein RFX-V1 Bound to the VEGFR1 Domain 2 Site on VEGF-A | | Descriptor: | Isoform L-VEGF189 of Vascular endothelial growth factor A, RFX-V1 | | Authors: | Marinec, P.S, Landgraf, K.E, Uppalapati, M, Chen, G, Xie, D, Jiang, Q, Zhao, Y, Petriello, A, Deshayes, K, Kent, S.B.H, Ault-Riche, D, Sidhu, S.S. | | Deposit date: | 2021-02-03 | | Release date: | 2021-02-17 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth.
Acs Chem.Biol., 16, 2021
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7LL9
 | | D-Protein RFX-V2 Bound to the VEGFR1 Domain 3 Site on VEGF-A | | Descriptor: | Isoform L-VEGF189 of Vascular endothelial growth factor A, RFX-V2 | | Authors: | Marinec, P.S, Landgraf, K.E, Uppalapati, M, Chen, G, Xie, D, Jiang, Q, Zhao, Y, Petriello, A, Deshayes, K, Kent, S.B.H, Ault-Riche, D, Sidhu, S.S. | | Deposit date: | 2021-02-03 | | Release date: | 2021-03-03 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth.
Acs Chem.Biol., 16, 2021
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8WMK
 | | Structure of ConA/Man2 | | Descriptor: | 4-[3-(4-carboxyphenyl)phenyl]benzoic acid, CALCIUM ION, Concanavalin-A, ... | | Authors: | Li, L, Chen, G. | | Deposit date: | 2023-10-03 | | Release date: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.17 Å) | | Cite: | Rational design of inducing ligands with three-dimensional supramolecular interactions to build protein crystalline frameworks.
To Be Published
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8WMG
 | | Structure of ConA/Man3 | | Descriptor: | 4-[3,5-bis(4-carboxyphenyl)phenyl]benzoic acid, CALCIUM ION, Concanavalin-A, ... | | Authors: | Li, L, Chen, G. | | Deposit date: | 2023-10-03 | | Release date: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | Rational design of inducing ligands with three-dimensional supramolecular interactions to build protein crystalline frameworks.
To Be Published
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5BOD
 | | Crystal structure of Streptococcus pneumonia ParE inhibitor | | Descriptor: | (2R)-N-[3-(3,5-dimethylphenyl)-1H-pyrazol-5-yl]-1,4-dioxane-2-carboxamide, DNA topoisomerase 4 subunit B | | Authors: | Tan, Y.W, Chen, G, Hung, A.W, Hill, J. | | Deposit date: | 2015-05-27 | | Release date: | 2015-06-17 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Application of Fragment-based Drug Discovery against DNA GyraseB
to be published
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1RH1
 | | crystal structure of the cytotoxic bacterial protein colicin B at 2.5 A resolution | | Descriptor: | Colicin B | | Authors: | Hilsenbeck, J.L, Park, H, Chen, G, Youn, B, Postle, K, Kang, C. | | Deposit date: | 2003-11-13 | | Release date: | 2004-03-09 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of the cytotoxic bacterial protein colicin B at 2.5 A resolution
Mol.Microbiol., 51, 2004
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7CUK
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3V93
 | | unliganded structure of TcrPDEC1 catalytic domain | | Descriptor: | Cyclic nucleotide specific phosphodiesterase, MAGNESIUM ION, ZINC ION | | Authors: | Wang, H, Kunz, S, Chen, G, Seebeck, T, Wan, Y, Robinson, H, Martinelli, S, Ke, H. | | Deposit date: | 2011-12-23 | | Release date: | 2012-02-22 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors.
J.Biol.Chem., 287, 2012
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3V94
 | | TcrPDEC1 catalytic domain in complex with inhibitor wyq16 | | Descriptor: | Cyclic nucleotide specific phosphodiesterase, MAGNESIUM ION, ZINC ION, ... | | Authors: | Wang, H, Kunz, S, Chen, G, Seebeck, T, Wan, Y, Robinson, H, Martinelli, S, Ke, H. | | Deposit date: | 2011-12-23 | | Release date: | 2012-02-22 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | TcrPDEC1 catalytic domain in complex with inhibitor wyq16
To be Published
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6LK0
 | | Crystal structure of human wild type TRIP13 | | Descriptor: | Pachytene checkpoint protein 2 homolog | | Authors: | Wang, Y, Huang, J, Li, B, Xue, H, Tricot, G, Hu, L, Xu, Z, Sun, X, Chang, S, Gao, L, Tao, Y, Xu, H, Xie, Y, Xiao, W, Yu, D, Kong, Y, Chen, G, Sun, X, Lian, F, Zhang, N, Wu, X, Mao, Z, Zhan, F, Zhu, W, Shi, J. | | Deposit date: | 2019-12-17 | | Release date: | 2020-01-22 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | A Small-Molecule Inhibitor Targeting TRIP13 Suppresses Multiple Myeloma Progression.
Cancer Res., 80, 2020
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6LQZ
 | | Solution structure of Taf14ET-Sth1EBMC | | Descriptor: | Nuclear protein STH1/NPS1, Transcription initiation factor TFIID subunit 14 | | Authors: | Wu, B, Chen, G, Chen, Y. | | Deposit date: | 2020-01-15 | | Release date: | 2020-08-05 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation.
Nat Commun, 11, 2020
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6L5Z
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7VFX
 | | The structure of Formyl Peptide Receptor 1 in complex with Gi and peptide agonist fMIFL | | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Wang, X.K, Chen, G, Liao, Q.W, Du, Y, Hu, H.L, Ye, D.Q. | | Deposit date: | 2021-09-14 | | Release date: | 2022-09-21 | | Last modified: | 2022-12-07 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns.
Nat Commun, 13, 2022
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7EUO
 | | The structure of formyl peptide receptor 1 in complex with Gi and peptide agonist fMLF | | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Wang, X.K, Chen, G, Liao, Q.W, Du, Y, Hu, H.L, Ye, D.Q. | | Deposit date: | 2021-05-18 | | Release date: | 2022-05-25 | | Last modified: | 2022-12-07 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns.
Nat Commun, 13, 2022
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2MFZ
 | | NMR structure of C-terminal domain from A. ventricosus minor ampullate spidroin (MiSp) | | Descriptor: | Minor ampullate spidroin | | Authors: | Otikovs, M, Jaudzems, K, Andersson, M, Chen, G, Landreh, M, Nordling, K, Kronqvist, N, Westermark, P, Jornvall, H, Knight, S, Ridderstrale, Y, Holm, L, Meng, Q, Chesler, M, Johansson, J, Rising, A. | | Deposit date: | 2013-10-24 | | Release date: | 2014-08-20 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Carbonic Anhydrase Generates CO2 and H+ That Drive Spider Silk Formation Via Opposite Effects on the Terminal Domains
Plos Biol., 12, 2014
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2MX9
 | | NMR structure of N-terminal domain from A. ventricosus minor ampullate spidroin (MiSp) at pH 5.5 | | Descriptor: | Minor ampullate spidroin | | Authors: | Otikovs, M, Jaudzems, K, Chen, G, Nordling, K, Rising, A, Johansson, J. | | Deposit date: | 2014-12-17 | | Release date: | 2015-08-19 | | Method: | SOLUTION NMR | | Cite: | Diversified Structural Basis of a Conserved Molecular Mechanism for pH-Dependent Dimerization in Spider Silk N-Terminal Domains.
Chembiochem, 16, 2015
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2MX8
 | | NMR structure of N-terminal domain from A. ventricosus minor ampullate spidroin (MiSp) at pH 7.2 | | Descriptor: | Minor ampullate spidroin | | Authors: | Otikovs, M, Jaudzems, K, Chen, G, Nordling, K, Rising, A, Johansson, J. | | Deposit date: | 2014-12-17 | | Release date: | 2015-08-19 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Diversified Structural Basis of a Conserved Molecular Mechanism for pH-Dependent Dimerization in Spider Silk N-Terminal Domains.
Chembiochem, 16, 2015
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8IA8
 | | Cryo-EM structure of C3aR-Gi-scFv16 bound with E7 peptide | | Descriptor: | ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG, C3a anaphylatoxin chemotactic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Liao, Q, Chen, G, Du, Y, Ye, R.D. | | Deposit date: | 2023-02-08 | | Release date: | 2023-05-24 | | Method: | ELECTRON MICROSCOPY (2.86 Å) | | Cite: | Cryo-EM structure of C3aR-Gi-scFv16 bound with E7 peptide
To Be Published
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4P9Y
 | | Structure of ConA/Rh4man | | Descriptor: | 2-{2-[2-(2-{4-[(alpha-D-mannopyranosyloxy)methyl]-1H-1,2,3-triazol-1-yl}ethoxy)ethoxy]ethoxy}ethyl 2-[3,6-bis(diethylamino)-9H-xanthen-9-yl]benzoate, CALCIUM ION, Concanavalin-A, ... | | Authors: | Sakai, F, Weiss, M.S, Chen, G. | | Deposit date: | 2014-04-06 | | Release date: | 2014-08-27 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Structure of ConA/Rh4Man
To Be Published
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4P9X
 | | Structure of ConA/Rh3Glu complex | | Descriptor: | 2-[2-(2-{4-[(alpha-D-glucopyranosyloxy)methyl]-1H-1,2,3-triazol-1-yl}ethoxy)ethoxy]ethyl 2-[3,6-bis(diethylamino)-9H-xanthen-9-yl]benzoate, CALCIUM ION, Concanavalin-A, ... | | Authors: | Sakai, F, Weiss, M.S, Chen, G. | | Deposit date: | 2014-04-06 | | Release date: | 2014-08-27 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Structure of ConA/Rh3Glu complex
To Be Published
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6KVB
 | | Structure of an intra-locked G-quadruplex | | Descriptor: | DNA (28-mer) | | Authors: | Maity, A, Winnerdy, F.R, Chang, W.D, Chen, G, Phan, A.T. | | Deposit date: | 2019-09-03 | | Release date: | 2020-03-04 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Intra-locked G-quadruplex structures formed by irregular DNA G-rich motifs.
Nucleic Acids Res., 48, 2020
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6OTC
 | | Synthetic Fab bound to Marburg virus VP35 interferon inhibitory domain | | Descriptor: | CHLORIDE ION, GLYCEROL, Polymerase cofactor VP35, ... | | Authors: | Amatya, P, Chen, G, Borek, D, Sidhu, S.S, Leung, D.W. | | Deposit date: | 2019-05-02 | | Release date: | 2019-06-05 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Inhibition of Marburg Virus RNA Synthesis by a Synthetic Anti-VP35 Antibody.
Acs Infect Dis., 5, 2019
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7VF1
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7WZ4
 | | Structure of an orphan GPCR-G protein signaling complex | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Xu, J, Chen, G, Liu, Z, Du, Y. | | Deposit date: | 2022-02-17 | | Release date: | 2022-10-26 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex.
Nat Commun, 13, 2022
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7X2E
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