5K7X
 
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3R3G
 | | Structure of human thrombin with residues 145-150 of murine thrombin. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, Thrombin Heavy Chain, ... | | Authors: | Pozzi, N, Chen, R, Chen, Z, Bah, A, Di Cera, E. | | Deposit date: | 2011-03-15 | | Release date: | 2011-05-11 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Rigidification of the autolysis loop enhances Na(+) binding to thrombin.
Biophys.Chem., 159, 2011
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4TQ9
 | | Crystal Structure of a GDP-bound G12V Oncogenic Mutant of Human GTPase KRas | | Descriptor: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Hunter, J.C, Manandhar, A, Gurbani, D, Chen, Z, Westover, K.D. | | Deposit date: | 2014-06-10 | | Release date: | 2015-06-10 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.491 Å) | | Cite: | Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.
Mol Cancer Res., 13, 2015
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4JDA
 | | Complex structure of abscisic acid receptor PYL3 with (-)-ABA | | Descriptor: | (2Z,4E)-5-[(1R)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, Abscisic acid receptor PYL3 | | Authors: | Zhang, X, Wang, G, Chen, Z. | | Deposit date: | 2013-02-24 | | Release date: | 2013-07-24 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structural Insights into the Abscisic Acid Stereospecificity by the ABA Receptors PYR/PYL/RCAR
Plos One, 8, 2013
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6AOI
 | | Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-phenylpiperazin-1-yl)-6-propylpyrimidine-2,4-diamine (TRC-2528) | | Descriptor: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-(4-phenylpiperazin-1-yl)-6-propylpyrimidine-2,4-diamine, ... | | Authors: | Thomas, S.B, Li, Y, Chen, Z, Lu, H. | | Deposit date: | 2017-08-16 | | Release date: | 2018-08-22 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.97 Å) | | Cite: | Identification of selective, brain penetrant Toxoplasma gondii dihydrofolate reductase inhibitors for the treatment of toxoplasmosis
To Be Published
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4TQA
 | | Crystal Structure of a GDP-bound G13D Oncogenic Mutant of Human GTPase KRas | | Descriptor: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Hunter, J.C, Manandhar, A, Gurbani, D, Chen, Z, Westover, K.D. | | Deposit date: | 2014-06-10 | | Release date: | 2015-06-10 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.13 Å) | | Cite: | Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.
Mol Cancer Res., 13, 2015
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5Z3V
 | | Structure of Snf2-nucleosome complex at shl-2 in ADP BeFx state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (167-MER), ... | | Authors: | Li, M, Xia, X, Liu, X, Li, X, Chen, Z. | | Deposit date: | 2018-01-08 | | Release date: | 2019-05-22 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.22 Å) | | Cite: | Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
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5Z3O
 | | Structure of Snf2-nucleosome complex in ADP state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (167-MER), Histone H2A, ... | | Authors: | Li, M, Xia, X, Liu, X, Li, X, Chen, Z. | | Deposit date: | 2018-01-08 | | Release date: | 2019-04-03 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.62 Å) | | Cite: | Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
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1KBI
 | | Crystallographic Study of the Recombinant Flavin-binding Domain of Baker's Yeast Flavocytochrome b2: Comparison with the Intact Wild-type Enzyme | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CYTOCHROME B2, FLAVIN MONONUCLEOTIDE, ... | | Authors: | Cunane, L.M, Barton, J.D, Chen, Z.-W, Welsh, F.E, Chapman, S.K, Reid, G.A, Mathews, F.S. | | Deposit date: | 2001-11-06 | | Release date: | 2002-04-03 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystallographic study of the recombinant flavin-binding domain of Baker's yeast flavocytochrome b(2): comparison with the intact wild-type enzyme.
Biochemistry, 41, 2002
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5Z3L
 | | Structure of Snf2-nucleosome complex in apo state | | Descriptor: | DNA (167-MER), Histone H2A, Histone H2B 1.1, ... | | Authors: | Li, M, Xia, X, Liu, X, Li, X, Chen, Z. | | Deposit date: | 2018-01-08 | | Release date: | 2019-04-03 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.31 Å) | | Cite: | Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
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4HZH
 | | Structure of recombinant Gla-domainless prothrombin mutant S525A | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Prothrombin | | Authors: | Pozzi, N, Niu, W, Gohara, D.W, Chen, Z, Di Cera, E. | | Deposit date: | 2012-11-15 | | Release date: | 2013-06-26 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Crystal structure of prothrombin reveals conformational flexibility and mechanism of activation.
J.Biol.Chem., 288, 2013
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5Z3U
 | | Structure of Snf2-nucleosome complex at shl2 in ADP BeFx state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (167-MER), ... | | Authors: | Li, M, Xia, X, Liu, X, Li, X, Chen, Z. | | Deposit date: | 2018-01-08 | | Release date: | 2019-05-22 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.31 Å) | | Cite: | Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
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3BEI
 | | Crystal structure of the slow form of thrombin in a self_inhibited conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Prothrombin | | Authors: | Gandhi, P.S, Chen, Z, Mathews, F.S, Di Cera, E. | | Deposit date: | 2007-11-19 | | Release date: | 2007-12-25 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structural identification of the pathway of long-range communication in an allosteric enzyme.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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3BHF
 | | Crystal structure of R49K mutant of Monomeric Sarcosine Oxidase crystallized in PEG as precipitant | | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Monomeric sarcosine oxidase | | Authors: | Hassan-Abdallah, A, Zhao, G, Chen, Z, Mathews, F.S, Jorns, M.S. | | Deposit date: | 2007-11-28 | | Release date: | 2008-02-26 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Arginine 49 is a bifunctional residue important in catalysis and biosynthesis of monomeric sarcosine oxidase: a context-sensitive model for the electrostatic impact of arginine to lysine mutations.
Biochemistry, 47, 2008
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1QCW
 | | Flavocytochrome B2, ARG289LYS mutant | | Descriptor: | FLAVOCYTOCHROME B2, N-SULFO-FLAVIN MONONUCLEOTIDE | | Authors: | Mowat, C.G, Durley, R.C.E, Pike, A.D, Barton, J.D, Chen, Z.-W, Mathews, F.S, Lederer, F, Reid, G.A, Chapman, S.K. | | Deposit date: | 1999-05-07 | | Release date: | 1999-05-24 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Kinetic and crystallographic studies on the active site Arg289Lys mutant of flavocytochrome b2 (yeast L-lactate dehydrogenase)
Biochemistry, 39, 2000
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1G72
 | | CATALYTIC MECHANISM OF QUINOPROTEIN METHANOL DEHYDROGENASE: A THEORETICAL AND X-RAY CRYSTALLOGRAPHIC INVESTIGATION | | Descriptor: | CALCIUM ION, METHANOL DEHYDROGENASE HEAVY SUBUNIT, METHANOL DEHYDROGENASE LIGHT SUBUNIT, ... | | Authors: | Zheng, Y, Xia, Z, Chen, Z, Bruice, T.C, Mathews, F.S. | | Deposit date: | 2000-11-08 | | Release date: | 2001-01-24 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Catalytic mechanism of quinoprotein methanol dehydrogenase: A theoretical and x-ray crystallographic investigation.
Proc.Natl.Acad.Sci.USA, 98, 2001
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3BHK
 | | Crystal structure of R49K mutant of monomeric sarcosine oxidase crystallized in phosphate as precipitant | | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | | Authors: | Hassan-Abdallah, A, Zhao, G, Chen, Z, Mathews, F.S, Jorns, M.S. | | Deposit date: | 2007-11-28 | | Release date: | 2008-02-26 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | Arginine 49 is a bifunctional residue important in catalysis and biosynthesis of monomeric sarcosine oxidase: a context-sensitive model for the electrostatic impact of arginine to lysine mutations.
Biochemistry, 47, 2008
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3B5H
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3BEF
 | | Crystal structure of thrombin bound to the extracellular fragment of PAR1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Proteinase-activated receptor 1, Prothrombin | | Authors: | Gandhi, P.S, Bah, A, Chen, Z, Mathews, F.S, Di Cera, E. | | Deposit date: | 2007-11-17 | | Release date: | 2008-01-01 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural identification of the pathway of long-range communication in an allosteric enzyme.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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1INP
 | | CRYSTAL STRUCTURE OF INOSITOL POLYPHOSPHATE 1-PHOSPHATASE AT 2.3 ANGSTROMS RESOLUTION | | Descriptor: | INOSITOL POLYPHOSPHATE 1-PHOSPHATASE, MAGNESIUM ION | | Authors: | York, J.D, Ponder, J.W, Chen, Z, Mathews, F.S, Majerus, P.W. | | Deposit date: | 1994-10-04 | | Release date: | 1995-01-26 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of inositol polyphosphate 1-phosphatase at 2.3-A resolution.
Biochemistry, 33, 1994
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3OJI
 | | X-ray crystal structure of the Py13 -pyrabactin complex | | Descriptor: | 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide, Abscisic acid receptor PYL3, SULFATE ION | | Authors: | Zhang, X, Zhang, Q, Wang, G, Chen, Z. | | Deposit date: | 2010-08-23 | | Release date: | 2011-08-10 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Complex Structures of the Abscisic Acid Receptor PYL3/RCAR13 Reveal a Unique Regulatory Mechanism
Structure, 20, 2012
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2PKA
 | | REFINED 2 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF PORCINE PANCREATIC KALLIKREIN A, A SPECIFIC TRYPSIN-LIKE SERINE PROTEINASE. CRYSTALLIZATION, STRUCTURE DETERMINATION, CRYSTALLOGRAPHIC REFINEMENT, STRUCTURE AND ITS COMPARISON WITH BOVINE TRYPSIN | | Descriptor: | BENZAMIDINE, KALLIKREIN A | | Authors: | Bode, W, Chen, Z. | | Deposit date: | 1984-05-21 | | Release date: | 1984-07-19 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Refined 2 A X-ray crystal structure of porcine pancreatic kallikrein A, a specific trypsin-like serine proteinase. Crystallization, structure determination, crystallographic refinement, structure and its comparison with bovine trypsin.
J.Mol.Biol., 164, 1983
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2L67
 | | Solution Structure of Human Apo L-FABP | | Descriptor: | Fatty acid-binding protein, liver | | Authors: | Cai, J, Luecke, C, Chen, Z, Qiao, Y, Klimtchuk, E.S, Hamilton, J.A. | | Deposit date: | 2010-11-17 | | Release date: | 2011-11-23 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Solution structure and backbone dynamics of human liver fatty acid binding protein: fatty acid binding revisited.
Biophys.J., 102, 2012
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1MUE
 | | Thrombin-Hirugen-L405,426 | | Descriptor: | 2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDO-2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUOROPHENYL)METHYL]ACETAMIDE, HIRUDIN IIB, THROMBIN | | Authors: | Burgey, C.S, Robinson, K.A, Lyle, T.A, Nantermet, P.G, Selnick, H.G, Isaacs, R.C, Lewis, S.D, Lucas, B.J, Krueger, J.A, Singh, R, Miller-Stein, C, White, R.B, Wong, B, Lyle, E.A, Stranieri, M.T, Cook, J.J, McMasters, D.R, Pellicore, J.M, Pal, S, Wallace, A.A, Clayton, F.C, Bohn, D, Welsh, D.C, Lynch, J.J, Yan, Y, Chen, Z, Kuo, L, Gardell, S.J, Shafer, J.A, Vacca, J.P. | | Deposit date: | 2002-09-23 | | Release date: | 2004-04-06 | | Last modified: | 2013-03-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. Implementation of P3 pyridine N-oxides to deliver an orally bioavailable series containing P1 N-benzylamides.
Bioorg.Med.Chem.Lett., 13, 2003
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2LKK
 | | Human L-FABP in complex with oleate | | Descriptor: | Fatty acid-binding protein, liver, OLEIC ACID | | Authors: | Cai, J, Luecke, C, Chen, Z, Qiao, Y, Klimtchuk, E.S, Hamilton, J.A. | | Deposit date: | 2011-10-13 | | Release date: | 2012-06-20 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Solution structure and backbone dynamics of human liver fatty acid binding protein: fatty acid binding revisited.
Biophys.J., 102, 2012
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