4MTG
 
 | | Structural Basis for Ca2+ Selectivity of a Voltage-gated Calcium Channel | | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, Ion transport protein | | Authors: | Tang, L, Gamal El-Din, T.M, Payandeh, J, Martinez, G.Q, Heard, T.M, Scheuer, T, Zheng, N, Catterall, W.A. | | Deposit date: | 2013-09-19 | | Release date: | 2013-11-27 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.296 Å) | | Cite: | Structural basis for Ca2+ selectivity of a voltage-gated calcium channel.
Nature, 505, 2014
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2JDG
 | | Affilin based on HUMAN GAMMA-B CRYSTALLIN | | Descriptor: | GAMMA CRYSTALLIN B | | Authors: | Ebersbach, H, Fiedler, E, Scheuermann, T, Fiedler, M, Stubbs, M.T, Reimann, C, Proetzel, G, Rudolph, R, Fiedler, U. | | Deposit date: | 2007-01-08 | | Release date: | 2007-07-24 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Affilin-Novel Binding Molecules Based on Human Gamma-B-Crystallin, an All Beta-Sheet Protein.
J.Mol.Biol., 372, 2007
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4MVO
 | | Structural Basis for Ca2+ Selectivity of a Voltage-gated Calcium Channel | | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, Ion transport protein | | Authors: | Tang, L, Gamal El-Din, T.M, Payandeh, J, Martinez, G.Q, Heard, T.M, Scheuer, T, Zheng, N, Catterall, W.A. | | Deposit date: | 2013-09-24 | | Release date: | 2013-11-27 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.296 Å) | | Cite: | Structural basis for Ca2+ selectivity of a voltage-gated calcium channel.
Nature, 505, 2014
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2LAG
 | | Structure of the 44 kDa complex of interferon-alpha2 with the extracellular part of IFNAR2 obtained by 2D-double difference NOESY | | Descriptor: | Interferon alpha-2, Interferon alpha/beta receptor 2 | | Authors: | Nudelman, I, Akabayov, S.R, Scherf, T, Anglister, J. | | Deposit date: | 2011-03-13 | | Release date: | 2011-08-17 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | Observation of Intermolecular Interactions in Large Protein Complexes by 2D-Double Difference Nuclear Overhauser Enhancement Spectroscopy: Application to the 44 kDa Interferon-Receptor Complex.
J.Am.Chem.Soc., 133, 2011
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3CF5
 | | Thiopeptide antibiotic Thiostrepton bound to the large ribosomal subunit of Deinococcus radiodurans | | Descriptor: | 50S RIBOSOMAL PROTEIN L11, 50S RIBOSOMAL PROTEIN L13, 50S RIBOSOMAL PROTEIN L14, ... | | Authors: | Harms, J.M, Wilson, D.N, Schluenzen, F, Connell, S.R, Stachelhaus, T, Zaborowska, Z, Spahn, C.M.T, Fucini, P. | | Deposit date: | 2008-03-02 | | Release date: | 2008-06-17 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Translational Regulation Via L11: Molecular Switches on the Ribosome Turned on and Off by Thiostrepton and Micrococcin.
Mol.Cell, 30, 2008
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2BYC
 | | BlrB - a BLUF protein, dark state structure | | Descriptor: | BLUE-LIGHT RECEPTOR OF THE BLUF-FAMILY, FLAVIN MONONUCLEOTIDE | | Authors: | Jung, A, Domratcheva, T, Tarutina, M, Wu, Q, Ko, W.H, Shoeman, R.L, Gomelsky, M, Gardner, K.H, Schlichting, I. | | Deposit date: | 2005-07-29 | | Release date: | 2005-08-24 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of a Bacterial Bluf Photoreceptor: Insights Into Blue Light-Mediated Signal Transduction.
Proc.Natl.Acad.Sci.USA, 102, 2005
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2C3Z
 | | Crystal structure of a truncated variant of indole-3-glycerol phosphate synthase from Sulfolobus solfataricus | | Descriptor: | INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE, SULFATE ION | | Authors: | Schneider, A, Knoechel, T, Darimont, B, Hennig, M, Dietrich, S, Kirschner, K, Sterner, R. | | Deposit date: | 2005-10-13 | | Release date: | 2005-10-13 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Role of the N-Terminal Extension of the (Betaalpha)(8)-Barrel Enzyme Indole-3-Glycerol Phosphate Synthase for its Fold, Stability, and Catalytic Activity.
Biochemistry, 44, 2005
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2L87
 | | The 27-residue N-terminus CCR5-peptide in a ternary complex with HIV-1 gp120 and a CD4-mimic peptide | | Descriptor: | C-C chemokine receptor type 5 | | Authors: | Schnur, E, Noah, E, Ayzenshtat, I, Sargsyan, H, Inui, T, Ding, F.X, Arshava, B, Sagi, Y, Kessler, N, Levy, R, Scherf, T, Naider, F, Anglister, J. | | Deposit date: | 2011-01-06 | | Release date: | 2011-07-27 | | Last modified: | 2024-11-06 | | Method: | SOLUTION NMR | | Cite: | The Conformation and Orientation of a 27-Residue CCR5 Peptide in a Ternary Complex with HIV-1 gp120 and a CD4-Mimic Peptide.
J.Mol.Biol., 410, 2011
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1KA4
 | | Structure of Pyrococcus furiosus carboxypeptidase Nat-Pb | | Descriptor: | LEAD (II) ION, M32 carboxypeptidase | | Authors: | Arndt, J.W, Hao, B, Ramakrishnan, V, Cheng, T, Chan, S.I, Chan, M.K. | | Deposit date: | 2001-10-31 | | Release date: | 2002-11-06 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal Structure of a Novel Carboxypeptidase from the Hyperthermophilic Archaeon Pyrococcus furiosus
Structure, 10, 2002
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1K9X
 | | Structure of Pyrococcus furiosus carboxypeptidase Apo-Yb | | Descriptor: | M32 carboxypeptidase | | Authors: | Arndt, J.W, Hao, B, Ramakrishnan, V, Cheng, T, Chan, S.I, Chan, M.K. | | Deposit date: | 2001-10-31 | | Release date: | 2002-11-06 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structure of a Novel Carboxypeptidase from the Hyperthermophilic Archaeon Pyrococcus furiosus
Structure, 10, 2002
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1KA2
 | | Structure of Pyrococcus furiosus Carboxypeptidase Apo-Mg | | Descriptor: | M32 carboxypeptidase, MAGNESIUM ION | | Authors: | Arndt, J.W, Hao, B, Ramakrishnan, V, Cheng, T, Chan, S.I, Chan, M.K. | | Deposit date: | 2001-10-31 | | Release date: | 2002-11-06 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal Structure of a Novel Carboxypeptidase from the Hyperthermophilic Archaeon Pyrococcus furiosus
Structure, 10, 2002
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5A5Z
 | | Approved Drugs Containing Thiols as Inhibitors of Metallo-beta- lactamases: Strategy To Combat Multidrug-Resistant Bacteria | | Descriptor: | BETA-LACTAMASE NDM-1, TIOPRONIN, ZINC ION | | Authors: | Klingler, F.M, Wichelhaus, T.A, Frank, D, Cuesta-Bernal, J, El-Delik, J, Mueller, H.F, Sjuts, H, Goettig, S, Koenigs, A, Pogoryelov, D, Proschak, E. | | Deposit date: | 2015-06-23 | | Release date: | 2015-07-08 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Approved Drugs Containing Thiols as Inhibitors of Metallo-beta-lactamases: Strategy To Combat Multidrug-Resistant Bacteria.
J. Med. Chem., 58, 2015
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2WHJ
 | | Understanding how diverse mannanases recognise heterogeneous substrates | | Descriptor: | ACETATE ION, BETA-MANNANASE, GLYCEROL, ... | | Authors: | Tailford, L.E, Ducros, V.M.A, Flint, J.E, Roberts, S.M, Morland, C, Zechel, D.L, Smith, N, Bjornvad, M.E, Borchert, T.V, Wilson, K.S, Davies, G.J, Gilbert, H.J. | | Deposit date: | 2009-05-05 | | Release date: | 2009-05-26 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Understanding How Diverse -Mannanases Recognise Heterogeneous Substrates.
Biochemistry, 48, 2009
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3QWD
 | | Crystal structure of ClpP from Staphylococcus aureus | | Descriptor: | ATP-dependent Clp protease proteolytic subunit, CHLORIDE ION | | Authors: | Geiger, S.R, Boettcher, T, Sieber, S.A, Cramer, P. | | Deposit date: | 2011-02-28 | | Release date: | 2011-05-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | A Conformational Switch Underlies ClpP Protease Function.
Angew.Chem.Int.Ed.Engl., 50, 2011
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2IYG
 | | Dark state structure of the BLUF domain of the rhodobacterial protein AppA | | Descriptor: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, APPA, ... | | Authors: | Jung, A, Reinstein, J, Domratcheva, T, Shoeman, R.-L, Schlichting, I. | | Deposit date: | 2006-07-17 | | Release date: | 2006-09-06 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structures of the Appa Bluf Domain Photoreceptor Provide Insights Into Blue Light- Mediated Signal Transduction.
J.Mol.Biol., 362, 2006
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2IYI
 | | structure of a light-induced intermediate of the BLUF domain of the rhodobacterial protein AppA | | Descriptor: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, APPA, ... | | Authors: | Jung, A, Reinstein, J, Domratcheva, T, Shoeman, R.-L, Schlichting, I. | | Deposit date: | 2006-07-17 | | Release date: | 2006-09-06 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Crystal structures of the AppA BLUF domain photoreceptor provide insights into blue light-mediated signal transduction.
J. Mol. Biol., 362, 2006
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1LJZ
 | | NMR structure of an AChR-peptide (Torpedo Californica, alpha-subunit residues 182-202) in complex with alpha-Bungarotoxin | | Descriptor: | Acetylcholine receptor protein, alpha-Bungarotoxin | | Authors: | Samson, A.O, Scherf, T, Eisenstein, M, Chill, J.H, Anglister, J. | | Deposit date: | 2002-04-23 | | Release date: | 2002-07-17 | | Last modified: | 2024-11-20 | | Method: | SOLUTION NMR | | Cite: | The mechanism for acetylcholine receptor inhibition by alpha-neurotoxins and species-specific resistance to alpha-bungarotoxin revealed by NMR.
Neuron, 35, 2002
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2I58
 | | Crystal Structure of RafE from Streptococcus pneumoniae complexed with raffinose | | Descriptor: | CHLORIDE ION, Sugar ABC transporter, sugar-binding protein, ... | | Authors: | Paterson, N.G, Riboldi-Tunnicliffe, A, Mitchell, T.J, Isaacs, N.W. | | Deposit date: | 2006-08-24 | | Release date: | 2007-08-07 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of apo and bound forms of RafE from Streptococcus pneumoniae
To be Published
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1L4W
 | | NMR structure of an AChR-peptide (Torpedo Californica, alpha-subunit residues 182-202) in complex with alpha-Bungarotoxin | | Descriptor: | Acetylcholine receptor protein, alpha-Bungarotoxin | | Authors: | Samson, A.O, Scherf, T, Rodriguez, E, Eisenstein, M, Anglister, J. | | Deposit date: | 2002-03-06 | | Release date: | 2002-07-17 | | Last modified: | 2024-11-20 | | Method: | SOLUTION NMR | | Cite: | The mechanism for acetylcholine receptor inhibition by alpha-neurotoxins and species-specific resistance to alpha-bungarotoxin revealed by NMR.
Neuron, 35, 2002
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5N2L
 | | Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogue | | Descriptor: | 1,2-ETHANEDIOL, Bromodomain-containing protein 2, SULFATE ION, ... | | Authors: | Tallant, C, Slavish, P.J, Siejka, P, Bharatham, N, Shadrick, W.R, Chai, S, Young, B.M, Boyd, V.A, Heroven, C, Wiggers, H.J, Picaud, S, Fedorov, O, Krojer, T, Chen, T, Lee, R.E, Guy, R.K, Shelat, A.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2017-02-07 | | Release date: | 2018-02-28 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogue
To Be Published
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5NWL
 | | Crystal structure of a human RAD51-ATP filament. | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA repair protein RAD51 homolog 1, MAGNESIUM ION | | Authors: | Pellegrini, L, Moschetti, T. | | Deposit date: | 2017-05-06 | | Release date: | 2018-03-07 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.93 Å) | | Cite: | Two distinct conformational states define the interaction of human RAD51-ATP with single-stranded DNA.
EMBO J., 37, 2018
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3B8K
 | | Structure of the Truncated Human Dihydrolipoyl Acetyltransferase (E2) | | Descriptor: | Dihydrolipoyllysine-residue acetyltransferase | | Authors: | Yu, X, Hiromasa, Y, Tsen, H, Stoops, J.K, Roche, T.E, Zhou, Z.H. | | Deposit date: | 2007-11-01 | | Release date: | 2008-01-22 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (8.8 Å) | | Cite: | Structures of the human pyruvate dehydrogenase complex cores: a highly conserved catalytic center with flexible N-terminal domains
Structure, 16, 2008
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2J9Y
 | | Tryptophan Synthase Q114N mutant in complex with Compound II | | Descriptor: | (3E)-4-{3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}-2-IMINOBUT-3-ENOIC ACID, SODIUM ION, TRYPTOPHAN SYNTHASE ALPHA CHAIN, ... | | Authors: | Blumenstein, L, Domratcheva, T, Niks, D, Ngo, H, Seidel, R, Dunn, M.F, Schlichting, I. | | Deposit date: | 2006-11-16 | | Release date: | 2007-12-04 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Betaq114N and Betat110V Mutations Reveal a Critically Important Role of the Substrate Alpha-Carboxylate Site in the Reaction Specificity of Tryptophan Synthase.
Biochemistry, 46, 2007
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2J9Z
 | | Tryptophan Synthase T110 mutant complex | | Descriptor: | PYRIDOXAL-5'-PHOSPHATE, SODIUM ION, TRYPTOPHAN SYNTHASE ALPHA CHAIN, ... | | Authors: | Blumenstein, L, Domratcheva, T, Niks, D, Ngo, H, Seidel, R, Dunn, M.F, Schlichting, I. | | Deposit date: | 2006-11-16 | | Release date: | 2007-12-04 | | Last modified: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Betaq114N and Betat110V Mutations Reveal a Critically Important Role of the Substrate Alpha-Carboxylate Site in the Reaction Specificity of Tryptophan Synthase.
Biochemistry, 46, 2007
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3C09
 | | Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, Matuzumab Fab Heavy chain, ... | | Authors: | Ferguson, K.M, Schmiedel, J, Knoechel, T. | | Deposit date: | 2008-01-18 | | Release date: | 2008-04-15 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Matuzumab binding to EGFR prevents the conformational rearrangement required for dimerization.
Cancer Cell, 13, 2008
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