3C09

Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR

Summary for 3C09

• Entry DOI: 10.2210/pdb3c09/pdb
• Related: 3C08
• Descriptor: Matuzumab Fab Light chain, Matuzumab Fab Heavy chain, Epidermal growth factor receptor, ... (6 entities in total)
• Functional Keywords: cell surface receptor, glycoprotein, antigen, antibody complex, fab fragment, antitumor, drug immune system-transferase complex, immune system-transferase complex, immune system/transferase
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 6
• Total formula weight: 144883.62

Authors

Ferguson, K.M.,Schmiedel, J.,Knoechel, T. (deposition date: 2008-01-18, release date: 2008-04-15, Last modification date: 2023-11-01)

• Primary citation: Schmiedel, J.,Blaukat, A.,Li, S.,Knochel, T.,Ferguson, K.M.; Matuzumab binding to EGFR prevents the conformational rearrangement required for dimerization.; Cancer Cell, 13:365-373, 2008; PubMed: 18394559; DOI: 10.1016/j.ccr.2008.02.019

Experimental method

X-RAY DIFFRACTION (3.2 Å)