3C09

Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	L, B	Matuzumab Fab Light chain	polymer	212	23235.7	2		Mus musculus (house mouse)
2	H, C	Matuzumab Fab Heavy chain	polymer	223	24043.8	2		Mus musculus (house mouse)
3	A, D	Epidermal growth factor receptor	polymer	214	23786.1	2	UniProt (P00533) Pfam (PF01030) In PDB	Homo sapiens (human)	Receptor tyrosine-protein kinase ErbB-1
4	A, D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	10	Chemie (NAG)
5	A, D	beta-D-mannopyranose	non-polymer		180.2	2	Chemie (BMA)
6	A	alpha-D-mannopyranose	non-polymer		180.2	1	Chemie (MAN)

Sequence modifications

A, D: 312 - 514 (UniProt: P00533)

PDB	External Database	Details
Leu 307	-	expression tag
Glu 308	-	expression tag
Glu 309	-	expression tag
Lys 310	-	expression tag
Lys 311	-	expression tag
His 515	-	expression tag
His 516	-	expression tag
His 517	-	expression tag
His 518	-	expression tag
His 519	-	expression tag
His 520	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	142131.1
Non-Polymers*	Number of molecules	13
	Total formula weight	2752.5
All*	Total formula weight	144883.6

*Water molecules are not included.