7N09
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4GGP
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6NIE
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![BU of 6nie by Molmil](/molmil-images/mine/6nie) | BesD with Fe(II), chloride, and alpha-ketoglutarate | Descriptor: | 2-OXOGLUTARIC ACID, BesD, lysine halogenase, ... | Authors: | Neugebauer, M.E, Chang, M.C.Y. | Deposit date: | 2018-12-27 | Release date: | 2019-10-02 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | A family of radical halogenases for the engineering of amino-acid-based products. Nat.Chem.Biol., 15, 2019
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7TWA
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![BU of 7twa by Molmil](/molmil-images/mine/7twa) | Crystal structure of apo BesC from Streptomyces cattleya | Descriptor: | 1,3-BUTANEDIOL, 4-chloro-allylglycine synthase, ACETATE ION, ... | Authors: | Neugebauer, M.E, McBride, M.J, Boal, A.K, Chang, M.C.Y. | Deposit date: | 2022-02-07 | Release date: | 2022-04-13 | Last modified: | 2022-04-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Substrate-Triggered mu-Peroxodiiron(III) Intermediate in the 4-Chloro-l-Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, the Intermediate. Biochemistry, 61, 2022
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7U6J
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![BU of 7u6j by Molmil](/molmil-images/mine/7u6j) | HalB with lysine and succinate | Descriptor: | Halogenase B, LYSINE, SUCCINIC ACID | Authors: | Sumida, K.H, Neugebauer, M.E, Kissman, E.N, Chang, M.C.Y. | Deposit date: | 2022-03-04 | Release date: | 2023-03-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Biocatalytic control of site-selectivity and chain length-selectivity in radical amino acid halogenases. Proc.Natl.Acad.Sci.USA, 120, 2023
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7U6H
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![BU of 7u6h by Molmil](/molmil-images/mine/7u6h) | HalD with ornithine and alpha-ketoglutarate | Descriptor: | 2-OXOGLUTARIC ACID, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Swenson, C.V, Neugebauer, M.E, Kissman, E.N, Chang, M.C.Y. | Deposit date: | 2022-03-04 | Release date: | 2023-03-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Biocatalytic control of site-selectivity and chain length-selectivity in radical amino acid halogenases. Proc.Natl.Acad.Sci.USA, 120, 2023
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7U6I
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![BU of 7u6i by Molmil](/molmil-images/mine/7u6i) | HalB with glycine and succinate | Descriptor: | GLYCEROL, GLYCINE, Halogenase B, ... | Authors: | Neugebauer, M.E, Kissman, E.N, Chang, M.C.Y. | Deposit date: | 2022-03-04 | Release date: | 2023-03-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Biocatalytic control of site-selectivity and chain length-selectivity in radical amino acid halogenases. Proc.Natl.Acad.Sci.USA, 120, 2023
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4G2C
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![BU of 4g2c by Molmil](/molmil-images/mine/4g2c) | DyP2 from Amycolatopsis sp. ATCC 39116 | Descriptor: | ACETATE ION, DyP2, MANGANESE (II) ION, ... | Authors: | Brown, M.E, Barros, T, Chang, M.C.Y. | Deposit date: | 2012-07-11 | Release date: | 2012-10-24 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Identification and characterization of a multifunctional dye peroxidase from a lignin-reactive bacterium. Acs Chem.Biol., 7, 2012
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4GGO
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7JSD
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![BU of 7jsd by Molmil](/molmil-images/mine/7jsd) | Hydroxylase homolog of BesD with Fe(II), alpha-ketoglutarate, and lysine | Descriptor: | 2-OXOGLUTARIC ACID, FE (II) ION, LYSINE, ... | Authors: | Kissman, E.N, Neugebauer, M.E, Chang, M.C.Y. | Deposit date: | 2020-08-14 | Release date: | 2021-08-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Reaction pathway engineering converts a radical hydroxylase into a halogenase. Nat.Chem.Biol., 18, 2022
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6BJ9
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6BJA
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6BJB
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3P3I
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![BU of 3p3i by Molmil](/molmil-images/mine/3p3i) | Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate and CoA | Descriptor: | COENZYME A, Fluoroacetyl coenzyme A thioesterase, fluoroacetic acid | Authors: | Weeks, A.M, Coyle, S.M, Jinek, M, Doudna, J.A, Chang, M.C.Y. | Deposit date: | 2010-10-04 | Release date: | 2010-10-20 | Last modified: | 2011-11-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity. Biochemistry, 49, 2010
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3P2S
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![BU of 3p2s by Molmil](/molmil-images/mine/3p2s) | Crystal structure of the fluoroacetyl-CoA-specific thioesterase FlK in an open conformation | Descriptor: | Fluoroacetyl coenzyme A thioesterase | Authors: | Weeks, A.M, Coyle, S.M, Jinek, M, Doudna, J.A, Chang, M.C.Y. | Deposit date: | 2010-10-04 | Release date: | 2010-10-20 | Last modified: | 2011-11-16 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity. Biochemistry, 49, 2010
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3P2R
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![BU of 3p2r by Molmil](/molmil-images/mine/3p2r) | Crystal structure of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate | Descriptor: | Fluoroacetyl coenzyme A thioesterase, fluoroacetic acid | Authors: | Weeks, A.M, Coyle, S.M, Jinek, M, Doudna, J.A, Chang, M.C.Y. | Deposit date: | 2010-10-03 | Release date: | 2010-10-20 | Last modified: | 2011-11-16 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity. Biochemistry, 49, 2010
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3P3F
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![BU of 3p3f by Molmil](/molmil-images/mine/3p3f) | Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK | Descriptor: | Fluoroacetyl coenzyme A thioesterase | Authors: | Weeks, A.M, Coyle, S.M, Jinek, M, Doudna, J.A, Chang, M.C.Y. | Deposit date: | 2010-10-04 | Release date: | 2010-10-20 | Last modified: | 2011-11-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity. Biochemistry, 49, 2010
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3P2Q
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![BU of 3p2q by Molmil](/molmil-images/mine/3p2q) | Crystal structure of the fluoroacetyl-CoA-specific thioesterase, FlK | Descriptor: | Fluoroacetyl coenzyme A thioesterase | Authors: | Weeks, A.M, Coyle, S.M, Jinek, M, Doudna, J.A, Chang, M.C.Y. | Deposit date: | 2010-10-03 | Release date: | 2010-10-20 | Last modified: | 2011-11-16 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity. Biochemistry, 49, 2010
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7WQY
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1V1Q
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![BU of 1v1q by Molmil](/molmil-images/mine/1v1q) | Crystal structure of PriB- a primosomal DNA replication protein of Escherichia coli | Descriptor: | CYSTEINE, PRIMOSOMAL REPLICATION PROTEIN N | Authors: | Liu, J.-H, Chang, T.-W, Huang, C.-Y, Chang, M.-C, Chen, S.-U, Wu, H.-N, Hsiao, C.-D. | Deposit date: | 2004-04-22 | Release date: | 2004-10-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure of Prib- a Primosomal DNA Replication Protein of Escherichia Coli J.Biol.Chem., 279, 2004
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6INW
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![BU of 6inw by Molmil](/molmil-images/mine/6inw) | A Pericyclic Reaction enzyme | Descriptor: | O-methyltransferase lepI, S-ADENOSYLMETHIONINE | Authors: | Feng, Y, Chang, M, Wang, H, Liu, Z, Zhou, Y. | Deposit date: | 2018-10-28 | Release date: | 2019-07-03 | Method: | X-RAY DIFFRACTION (1.798 Å) | Cite: | Crystal structure of the multifunctional SAM-dependent enzyme LepI provides insights into its catalytic mechanism. Biochem.Biophys.Res.Commun., 515, 2019
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6KG6
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![BU of 6kg6 by Molmil](/molmil-images/mine/6kg6) | Crystal structure of MavC/UBE2N-Ub complex | Descriptor: | MavC, Ubiquitin-40S ribosomal protein S27a, Ubiquitin-conjugating enzyme E2 N | Authors: | Wang, Y, Huang, Y, Chang, M, Feng, Y. | Deposit date: | 2019-07-10 | Release date: | 2020-04-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC. Nat Commun, 11, 2020
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7T3F
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![BU of 7t3f by Molmil](/molmil-images/mine/7t3f) | Development of BRD4 inhibitors as arsenicals antidotes | Descriptor: | 4-fluoro-3-methyl-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzene-1-sulfonamide, Bromodomain-containing protein 4, GLYCEROL | Authors: | Wu, M, Yatchang, M, Mathew, B, Zhai, L, Ruiz, P, Bostwick, R, Augelli-Szafran, C.E, Suto, M.J. | Deposit date: | 2021-12-07 | Release date: | 2022-08-31 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.28 Å) | Cite: | Development of BRD4 inhibitors as anti-inflammatory agents and antidotes for arsenicals. Bioorg.Med.Chem.Lett., 64, 2022
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