Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 16 件
5FJH
DownloadVisualize
BU of 5fjh by Molmil
Crystal structure of human JMJD2C catalytic domain in complex with epitherapuetic compound 2-(((2-((2-(dimethylamino)ethyl) (ethyl)amino) -2-oxoethyl)amino)methyl)isonicotinic acid
分子名称: 1,2-ETHANEDIOL, 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, CHLORIDE ION, ...
著者Cecatiello, V, Pasqualato, S.
登録日2015-10-09
公開日2015-10-21
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structures of Human Jmjd2C Catalytic Domain Bound to Inhibitors
To be Published
5FJK
DownloadVisualize
BU of 5fjk by Molmil
Crystal structure of human JMJD2C catalytic domain in complex 6-ethyl- 5-methyl-7-oxo-4,7-dihydropyrazolo(1,5-a)pyrimidine-3-carbonitrile
分子名称: 1,2-ETHANEDIOL, 6-ethyl-5-methyl-7-oxidanylidene-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile, CHLORIDE ION, ...
著者Cecatiello, V, Pasqualato, S.
登録日2015-10-09
公開日2015-10-21
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Crystal Structures of Human Jmjd2C Catalytic Domain Bound to Inhibitors
To be Published
5LHG
DownloadVisualize
BU of 5lhg by Molmil
Structure of the KDM1A/CoREST complex with the inhibitor 4-methyl-N-[4-[[4-(1-methylpiperidin-4-yl)oxyphenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide
分子名称: 4-methyl-N-[4-[[4-[(1-methyl-4-piperidyl)oxy]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ...
著者Cecatiello, V, Pasqualato, S.
登録日2016-07-11
公開日2017-02-22
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.34 Å)
主引用文献Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.
J. Med. Chem., 60, 2017
5LHI
DownloadVisualize
BU of 5lhi by Molmil
Structure of the KDM1A/CoREST complex with the inhibitor N-[3-(ethoxymethyl)-2-[[4-[[(3R)-pyrrolidin-3-yl]methoxy]phenoxy]methyl]phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamide
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ...
著者Cecatiello, V, Pasqualato, S.
登録日2016-07-12
公開日2017-02-22
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.
J. Med. Chem., 60, 2017
5LHH
DownloadVisualize
BU of 5lhh by Molmil
Structure of the KDM1A/CoREST complex with the inhibitor 4-ethyl-N-[3-(methoxymethyl)-2-[[4-[[(3R)-pyrrolidin-3-yl]methoxy]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide
分子名称: 4-ethyl-~{N}-[3-(methoxymethyl)-2-[[4-[[(3~{R})-pyrrolidin-3-yl]methoxy]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ...
著者Cecatiello, V, Pasqualato, S.
登録日2016-07-11
公開日2017-02-22
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.
J. Med. Chem., 60, 2017
4WAU
DownloadVisualize
BU of 4wau by Molmil
Crystal structure of CENP-M solved by native-SAD phasing
分子名称: Centromere protein M
著者Weinert, T, Basilico, F, Cecatiello, V, Pasqualato, S, Wang, M.
登録日2014-09-01
公開日2014-12-10
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Fast native-SAD phasing for routine macromolecular structure determination.
Nat.Methods, 12, 2015
6QJA
DownloadVisualize
BU of 6qja by Molmil
Organizational principles of the NuMA-Dynein interaction interface and implications for mitotic spindle functions
分子名称: CHLORIDE ION, MAGNESIUM ION, Nuclear mitotic apparatus protein 1
著者Renna, C, Rizzelli, F, Carminati, M, Gaddoni, C, Pirovano, L, Cecatiello, V, Pasqualato, S, Mapelli, M.
登録日2019-01-23
公開日2020-02-05
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Organizational Principles of the NuMA-Dynein Interaction Interface and Implications for Mitotic Spindle Functions.
Structure, 28, 2020
6TE1
DownloadVisualize
BU of 6te1 by Molmil
Structure of the KDM1A/CoREST complex with the inhibitor 2-[3-{4-chloro-3-[(4-chlorophenyl)ethynyl]phenyl}-1-(3-morpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoethanol
分子名称: 5-[4-cyclobutyl-1-[2-(4-piperidin-4-yloxyphenoxy)ethyl]imidazol-2-yl]-4-methyl-thieno[3,2-b]pyrrole, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ...
著者Pasqualato, S, Cecatiello, V.
登録日2019-11-11
公開日2020-06-03
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.11 Å)
主引用文献Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models.
Acs Med.Chem.Lett., 11, 2020
6ZT0
DownloadVisualize
BU of 6zt0 by Molmil
Crystal structure of the Eiger TNF domain/Grindelwald extracellular domain complex
分子名称: 1,2-ETHANEDIOL, Protein eiger, Protein grindelwald
著者Palmerini, V, Cecatiello, V, Pasqualato, S, Mapelli, M.
登録日2020-07-17
公開日2021-03-03
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions.
Nat Commun, 12, 2021
6ZSZ
DownloadVisualize
BU of 6zsz by Molmil
Crystal structure of the Grindelwald extracellular domain complex
分子名称: Protein grindelwald
著者Palmerini, V, Cecatiello, V, Pasqualato, S, Mapelli, M.
登録日2020-07-17
公開日2021-03-31
最終更新日2021-10-13
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions.
Nat Commun, 12, 2021
6ZSY
DownloadVisualize
BU of 6zsy by Molmil
Crystal structure of the Grindelwald extracellular domain complex
分子名称: Protein grindelwald
著者Palmerini, V, Cecatiello, V, Pasqualato, S, Mapelli, M.
登録日2020-07-17
公開日2021-03-31
最終更新日2021-10-13
実験手法X-RAY DIFFRACTION (0.926 Å)
主引用文献Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions.
Nat Commun, 12, 2021
4A7J
DownloadVisualize
BU of 4a7j by Molmil
Symmetric Dimethylation of H3 Arginine 2 is a Novel Histone Mark that Supports Euchromatin Maintenance
分子名称: HISTONE H3.1T, WD REPEAT-CONTAINING PROTEIN 5
著者Migliori, V, Muller, J, Phalke, S, Low, D, Bezzi, M, ChuenMok, W, Gunaratne, J, Capasso, P, Bassi, C, Cecatiello, V, DeMarco, A, Blackstock, W, Kuznetsov, V, Amati, B, Mapelli, M, Guccione, E.
登録日2011-11-14
公開日2012-01-11
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Symmetric Dimethylation of H3R2 is a Newly Identified Histone Mark that Supports Euchromatin Maintenance
Nat.Struct.Mol.Biol., 19, 2012
4BE8
DownloadVisualize
BU of 4be8 by Molmil
NEDD4 HECT A889F structure
分子名称: E3 UBIQUITIN-PROTEIN LIGASE NEDD4
著者Maspero, E, Valentini, E, Mari, S, Cecatiello, V, Polo, S, Pasqualato, S.
登録日2013-03-06
公開日2013-05-01
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.996 Å)
主引用文献Structure of a Ubiquitin-Loaded Hect Ligase Reveals the Molecular Basis for Catalytic Priming
Nat.Struct.Mol.Biol., 20, 2013
4BBN
DownloadVisualize
BU of 4bbn by Molmil
NEDD4 HECT-Ub:Ub complex
分子名称: E3 UBIQUITIN-PROTEIN LIGASE NEDD4, POLYUBIQUITIN-B
著者Maspero, E, Valentini, E, Mari, S, Cecatiello, V, Polo, S, Pasqualato, S.
登録日2012-09-27
公開日2013-05-01
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Structure of a Ubiquitin-Loaded Hect Ligase Reveals the Molecular Basis for Catalytic Priming
Nat.Struct.Mol.Biol., 20, 2013
2XBF
DownloadVisualize
BU of 2xbf by Molmil
Nedd4 HECT structure
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE NEDD4
著者Maspero, E, Cecatiello, V, Musacchio, A, Polo, S, Pasqualato, S.
登録日2010-04-09
公開日2011-03-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.503 Å)
主引用文献Structure of the Hect:Ubiquitin Complex and its Role in Ubiquitin Chain Elongation
Embo Rep., 12, 2011
2XBB
DownloadVisualize
BU of 2xbb by Molmil
Nedd4 HECT:Ub complex
分子名称: E3 UBIQUITIN-PROTEIN LIGASE NEDD4, GLYCEROL, UBIQUITIN
著者Maspero, E, Cecatiello, V, Musacchio, A, Polo, S, Pasqualato, S.
登録日2010-04-08
公開日2011-03-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Structure of the Hect:Ubiquitin Complex and its Role in Ubiquitin Chain Elongation
Embo Rep., 12, 2011

226707

件を2024-10-30に公開中

PDB statisticsPDBj update infoContact PDBjnumon