1ANT
 
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2RIV
 | | Crystal structure of the reactive loop cleaved human Thyroxine Binding Globulin | | 分子名称: | GLYCEROL, SULFATE ION, Thyroxine-binding globulin | | 著者 | Zhou, A, Wei, Z, Stanley, P.L.D, Read, R.J, Stein, P.E, Carrell, R.W. | | 登録日 | 2007-10-12 | | 公開日 | 2008-10-14 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins
J.Biol.Chem., 286, 2011
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2RIW
 | | The Reactive loop cleaved human Thyroxine Binding Globulin complexed with thyroxine | | 分子名称: | 3,5,3',5'-TETRAIODO-L-THYRONINE, Thyroxine-binding globulin | | 著者 | Zhou, A, Wei, Z, Stanley, P.L.D, Read, R.J, Stein, P.E, Carrell, R.W. | | 登録日 | 2007-10-12 | | 公開日 | 2008-10-14 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins
J.Biol.Chem., 286, 2011
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1EZX
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2CEO
 | | thyroxine-binding globulin complex with thyroxine | | 分子名称: | 3,5,3',5'-TETRAIODO-L-THYRONINE, GLYCEROL, THYROXINE-BINDING GLOBULIN | | 著者 | Zhou, A, Wei, Z, Read, R.J, Carrell, R.W. | | 登録日 | 2006-02-08 | | 公開日 | 2006-08-14 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural Mechanism for the Carriage and Release of Thyroxine in the Blood.
Proc.Natl.Acad.Sci.USA, 103, 2006
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2ANT
 | | THE 2.6 A STRUCTURE OF ANTITHROMBIN INDICATES A CONFORMATIONAL CHANGE AT THE HEPARIN BINDING SITE | | 分子名称: | 2-acetamido-2-deoxy-beta-D-allopyranose, ANTITHROMBIN | | 著者 | Skinner, R, Abrahams, J.-P, Whisstock, J.C, Lesk, A.M, Carrell, R.W, Wardell, M.R. | | 登録日 | 1997-01-28 | | 公開日 | 1997-06-16 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site.
J.Mol.Biol., 266, 1997
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1JVQ
 | | Crystal structure at 2.6A of the ternary complex between antithrombin, a P14-P8 reactive loop peptide, and an exogenous tetrapeptide | | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, ... | | 著者 | Zhou, A, Huntington, J.A, Lomas, D.A, Carrell, R.W, Stein, P.E. | | 登録日 | 2001-08-31 | | 公開日 | 2003-06-03 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | How small peptides block and reverse serpin polymerisation
J.Mol.Biol., 342, 2004
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1JMO
 | | Crystal Structure of the Heparin Cofactor II-S195A Thrombin Complex | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Baglin, T.P, Carrell, R.W, Esmon, C.T, Huntington, J.A. | | 登録日 | 2001-07-19 | | 公開日 | 2002-08-30 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.
Proc.Natl.Acad.Sci.USA, 99, 2002
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1LK6
 | | Structure of dimeric antithrombin complexed with a P14-P9 reactive loop peptide and an exogenous tripeptide | | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | | 著者 | Zhou, A, Huntington, J.A, Lomas, D.A, Carrell, R.W, Stein, P.E. | | 登録日 | 2002-04-24 | | 公開日 | 2003-06-03 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Serpin Polymerization Is Prevented by a Hydrogen Bond Network That Is Centered on His-334 and Stabilized by Glycerol
J.Biol.Chem., 278, 2003
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1JMJ
 | | Crystal Structure of Native Heparin Cofactor II | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, HEPARIN COFACTOR II, ... | | 著者 | Baglin, T.P, Carrell, R.W, Church, F.C, Huntington, J.A. | | 登録日 | 2001-07-18 | | 公開日 | 2002-08-30 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.
Proc.Natl.Acad.Sci.USA, 99, 2002
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1OC0
 | | plasminogen activator inhibitor-1 complex with somatomedin B domain of vitronectin | | 分子名称: | PLASMINOGEN ACTIVATOR INHIBITOR-1, VITRONECTIN | | 著者 | Read, R.J, Zhou, A, Huntington, J.A, Pannu, N.S, Carrell, R.W. | | 登録日 | 2003-02-03 | | 公開日 | 2003-06-19 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | How Vitronectin Binds Pai-1 to Modulate Fibrinolysis and Cell Migration
Nat.Struct.Biol., 10, 2003
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1PSI
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1QMB
 | | Cleaved alpha-1-antitrypsin polymer | | 分子名称: | ALPHA-1-ANTITRYPSIN | | 著者 | Huntington, J.A, Pannu, N.S, Hazes, B, Read, R.J, Lomas, D.A, Carrell, R.W. | | 登録日 | 1999-09-24 | | 公開日 | 2000-02-06 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | A 2.6A Structure of a Serpin Polymer and Implications for Conformational Disease
J.Mol.Biol., 293, 1999
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1R1L
 | | Structure of dimeric antithrombin complexed with a P14-P9 reactive loop peptide and an exogenous tripeptide (formyl-norleucine-LF) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin P14-P9 peptide, Antithrombin-III, ... | | 著者 | Zhou, A, Huntington, J.A, Lomas, D.A, Stein, P.E, Carrell, R.W. | | 登録日 | 2003-09-24 | | 公開日 | 2004-10-05 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Serpins and the design of peptides to block intermolecular beta-linkages
To be Published
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2WY1
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2WXW
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2WXZ
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2WXX
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2WY0
 | | Crystal structure of mouse angiotensinogen in the oxidised form with space group P6122 | | 分子名称: | 1,2-ETHANEDIOL, ANGIOTENSINOGEN, SODIUM ION | | 著者 | Zhou, A, Wei, Z, Carrell, R.W, Read, R.J. | | 登録日 | 2009-11-11 | | 公開日 | 2010-10-20 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | | 主引用文献 | A Redox Switch in Angiotensinogen Modulates Angiotensin Release.
Nature, 468, 2010
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2WXY
 | | Crystal structure of mouse angiotensinogen in the reduced form | | 分子名称: | 1,2-ETHANEDIOL, ANGIOTENSINOGEN, SODIUM ION | | 著者 | Zhou, A, Wei, Z, Carrell, R.W, Read, R.J. | | 登録日 | 2009-11-11 | | 公開日 | 2010-10-20 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | A Redox Switch in Angiotensinogen Modulates Angiotensin Release.
Nature, 468, 2010
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2X0B
 | | Crystal structure of human angiotensinogen complexed with renin | | 分子名称: | ANGIOTENSINOGEN, RENIN | | 著者 | Zhou, A, Wei, Z, Yan, Y, Carrell, R.W, Read, R.J. | | 登録日 | 2009-12-08 | | 公開日 | 2010-10-20 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (4.33 Å) | | 主引用文献 | A Redox Switch in Angiotensinogen Modulates Angiotensin Release.
Nature, 468, 2010
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2B5T
 | | 2.1 Angstrom structure of a nonproductive complex between antithrombin, synthetic heparin mimetic SR123781 and two S195A thrombin molecules | | 分子名称: | 2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-sulfonato-beta-D-glucopyranose-(1-4)-2,3-di-O-methyl-6-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3-di-O-methyl-6-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-alpha-L-idopyranuronic acid-(1-4)-methyl 3-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Johnson, D.J, Li, W, Luis, S.A, Carrell, R.W, Huntington, J.A. | | 登録日 | 2005-09-29 | | 公開日 | 2006-09-19 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation.
J.Biol.Chem., 281, 2006
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1QLP
 | | 2.0 ANGSTROM STRUCTURE OF INTACT ALPHA-1-ANTITRYPSIN: A CANONICAL TEMPLATE FOR ACTIVE SERPINS | | 分子名称: | ALPHA-1-ANTITRYPSIN | | 著者 | Elliott, P.R, Pei, X.Y, Dafforn, T, Read, R.J, Carrell, R.W, Lomas, D.A. | | 登録日 | 1999-09-10 | | 公開日 | 1999-09-27 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Topography of a 2.0 A structure of alpha1-antitrypsin reveals targets for rational drug design to prevent conformational disease.
Protein Sci., 9, 2000
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1BR8
 | | IMPLICATIONS FOR FUNCTION AND THERAPY OF A 2.9A STRUCTURE OF BINARY-COMPLEXED ANTITHROMBIN | | 分子名称: | PROTEIN (ANTITHROMBIN-III), PROTEIN (PEPTIDE) | | 著者 | Skinner, R, Chang, W.S.W, Jin, L, Pei, X.Y, Huntington, J.A, Abrahams, J.P, Carrell, R.W, Lomas, D.A. | | 登録日 | 1998-08-26 | | 公開日 | 1998-09-02 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin.
J.Mol.Biol., 283, 1998
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1AZX
 | | ANTITHROMBIN/PENTASACCHARIDE COMPLEX | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, ANTITHROMBIN | | 著者 | Jin, L, Abrahams, J.P, Skinner, R, Petitou, M, Pike, R.N, Carrell, R.W. | | 登録日 | 1997-11-23 | | 公開日 | 1999-01-13 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | The anticoagulant activation of antithrombin by heparin.
Proc.Natl.Acad.Sci.USA, 94, 1997
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