9BWT
| human sodium chloride cotransporter NCC S344E in the phosphorylation state and in complex with hydrochlorothiazide | 分子名称: | 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, ADENOSINE-5'-TRIPHOSPHATE, Solute carrier family 12 member 3 | 著者 | Cao, E.H, Zhao, Y.X. | 登録日 | 2024-05-21 | 公開日 | 2024-09-04 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Structural bases for Na + -Cl - cotransporter inhibition by thiazide diuretic drugs and activation by kinases. Nat Commun, 15, 2024
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7S1X
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7S1Z
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7S1Y
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8VPN
| Phosphorylated human NCC in complex with indapamide | 分子名称: | 4-chloro-N-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfamoylbenzamide, ADENOSINE-5'-TRIPHOSPHATE, Solute carrier family 12 member 3 | 著者 | Zhao, Y.X, Cao, E.H. | 登録日 | 2024-01-16 | 公開日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural bases for Na + -Cl - cotransporter inhibition by thiazide diuretic drugs and activation by kinases. Nat Commun, 15, 2024
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8VPP
| Phosphorylated human NCC in complex with chlorthalidone | 分子名称: | 2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide, Solute carrier family 12 member 3 | 著者 | Zhao, Y.X, Cao, E.H. | 登録日 | 2024-01-16 | 公開日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural bases for Na + -Cl - cotransporter inhibition by thiazide diuretic drugs and activation by kinases. Nat Commun, 15, 2024
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7TTI
| Human KCC1 bound with VU0463271 In an outward-open state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-cyclopropyl-N-(4-methyl-1,3-thiazol-2-yl)-2-[(6-phenylpyridazin-3-yl)sulfanyl]acetamide, Solute carrier family 12 member 4 | 著者 | Zhao, Y.X, Cao, E.H. | 登録日 | 2022-02-01 | 公開日 | 2022-06-29 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of the human cation-chloride cotransport KCC1 in an outward-open state. Proc.Natl.Acad.Sci.USA, 119, 2022
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7TTH
| Human potassium-chloride cotransporter 1 in inward-open state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, POTASSIUM ION, Solute carrier family 12 member 4 | 著者 | Zhao, Y.X, Cao, E.H. | 登録日 | 2022-02-01 | 公開日 | 2022-06-29 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Structure of the human cation-chloride cotransport KCC1 in an outward-open state. Proc.Natl.Acad.Sci.USA, 119, 2022
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