6HLQ
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![BU of 6hlq by Molmil](/molmil-images/mine/6hlq) | Yeast RNA polymerase I* elongation complex bound to nucleotide analog GMPCPP | Descriptor: | DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... | Authors: | Tafur, L, Sadian, Y, Weis, F, Muller, C.W. | Deposit date: | 2018-09-11 | Release date: | 2019-04-03 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2. Elife, 8, 2019
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6HQN
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![BU of 6hqn by Molmil](/molmil-images/mine/6hqn) | Crystal structure of GcoA F169L bound to guaiacol | Descriptor: | Cytochrome P450, Guaiacol, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Mallinson, S.J.B, Hinchen, D.J, Allen, M.D, Johnson, C.W, Beckham, G.T, McGeehan, J.E. | Deposit date: | 2018-09-25 | Release date: | 2019-07-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Enabling microbial syringol conversion through structure-guided protein engineering. Proc.Natl.Acad.Sci.USA, 116, 2019
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6HQO
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![BU of 6hqo by Molmil](/molmil-images/mine/6hqo) | Crystal structure of GcoA F169S bound to guaiacol | Descriptor: | Cytochrome P450, Guaiacol, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Mallinson, S.J.B, Hinchen, D.J, Allen, M.D, Johnson, C.W, Beckham, G.T, McGeehan, J.E. | Deposit date: | 2018-09-25 | Release date: | 2019-07-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Enabling microbial syringol conversion through structure-guided protein engineering. Proc.Natl.Acad.Sci.USA, 116, 2019
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4OG8
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![BU of 4og8 by Molmil](/molmil-images/mine/4og8) | Human menin with bound inhibitor MIV-6R | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, 4-(3-{4-[(R)-amino(cyclopentyl)phenylmethyl]piperidin-1-yl}propoxy)benzonitrile, DIMETHYL SULFOXIDE, ... | Authors: | He, S, Senter, T.J, Pollock, J.W, Han, C, Upadhyay, S.K, Purohit, T, Gogliotti, R.D, Lindsley, C.W, Cierpicki, T, Stauffer, S.R, Grembecka, J. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction. J.Med.Chem., 57, 2014
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6QZ1
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![BU of 6qz1 by Molmil](/molmil-images/mine/6qz1) | Structure of MHETase from Ideonella sakaiensis | Descriptor: | BENZOIC ACID, CALCIUM ION, Mono(2-hydroxyethyl) terephthalate hydrolase | Authors: | Allen, M.D, Johnson, C.W, Knott, B.C, Beckham, G.T, McGeehan, J.E. | Deposit date: | 2019-03-10 | Release date: | 2020-09-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Characterization and engineering of a two-enzyme system for plastics depolymerization. Proc.Natl.Acad.Sci.USA, 117, 2020
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6KE9
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![BU of 6ke9 by Molmil](/molmil-images/mine/6ke9) | The Human Telomeric Nucleosome Displays Distinct Structural and Dynamic Properties | Descriptor: | Histone H2A type 1-B/E, Histone H2B type 1-K, Histone H3.1, ... | Authors: | Soman, A, Liew, C.W, Teo, H.L, Berezhnoy, N, Korolev, N, Rhodes, D, Nordenskiold, L. | Deposit date: | 2019-07-04 | Release date: | 2020-04-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | The human telomeric nucleosome displays distinct structural and dynamic properties. Nucleic Acids Res., 48, 2020
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6JQS
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![BU of 6jqs by Molmil](/molmil-images/mine/6jqs) | Structure of Transcription factor, GerE | Descriptor: | DNA-binding response regulator | Authors: | Lee, J.H, Lee, C.W. | Deposit date: | 2019-04-01 | Release date: | 2019-04-24 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Crystal structure of a transcription factor, GerE (PaGerE), from spore-forming bacterium Paenisporosarcina sp. TG-14. Biochem.Biophys.Res.Commun., 513, 2019
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4N8I
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![BU of 4n8i by Molmil](/molmil-images/mine/4n8i) | M31G mutant, RipA structure | Descriptor: | 4-hydroxybutyrate coenzyme A transferase, ACETATE ION, COENZYME A | Authors: | Torres, R, Goulding, C.W. | Deposit date: | 2013-10-17 | Release date: | 2014-04-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.011 Å) | Cite: | Structural snapshots along the reaction pathway of Yersinia pestis RipA, a putative butyryl-CoA transferase. Acta Crystallogr.,Sect.D, 70, 2014
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4OG6
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![BU of 4og6 by Molmil](/molmil-images/mine/4og6) | Human menin with bound inhibitor MIV-4 | Descriptor: | 4-(3-{4-[(R)-cyclopentyl(3-fluorophenyl)hydroxymethyl]piperidin-1-yl}propoxy)benzonitrile, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | Authors: | He, S, Senter, T.J, Pollock, J.W, Han, C, Upadhyay, S.K, Purohit, T, Gogliotti, R.D, Lindsley, C.W, Cierpicki, T, Stauffer, S.R, Grembecka, J. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction. J.Med.Chem., 57, 2014
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4OG5
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![BU of 4og5 by Molmil](/molmil-images/mine/4og5) | Human menin with bound inhibitor MIV-5 | Descriptor: | 4-(3-{4-[(S)-cyclopentyl(hydroxy)pyridin-2-ylmethyl]piperidin-1-yl}propoxy)benzonitrile, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | Authors: | He, S, Senter, T.J, Pollock, J.W, Han, C, Upadhyay, S.K, Purohit, T, Gogliotti, R.D, Lindsley, C.W, Cierpicki, T, Stauffer, S.R, Grembecka, J. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction. J.Med.Chem., 57, 2014
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4N8L
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![BU of 4n8l by Molmil](/molmil-images/mine/4n8l) | E249D mutant, RipA structure | Descriptor: | Putative 4-hydroxybutyrate coenzyme A transferase | Authors: | Torres, R, Goulding, C.W. | Deposit date: | 2013-10-17 | Release date: | 2014-04-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.817 Å) | Cite: | Structural snapshots along the reaction pathway of Yersinia pestis RipA, a putative butyryl-CoA transferase. Acta Crystallogr.,Sect.D, 70, 2014
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4N8H
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![BU of 4n8h by Molmil](/molmil-images/mine/4n8h) | E61V mutant, RipA structure | Descriptor: | 4-hydroxybutyrate coenzyme A transferase | Authors: | Torres, R, Goulding, C.W. | Deposit date: | 2013-10-17 | Release date: | 2014-04-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural snapshots along the reaction pathway of Yersinia pestis RipA, a putative butyryl-CoA transferase. Acta Crystallogr.,Sect.D, 70, 2014
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4N8J
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![BU of 4n8j by Molmil](/molmil-images/mine/4n8j) | F60M mutant, RipA structure | Descriptor: | ACETATE ION, COENZYME A, PHOSPHATE ION, ... | Authors: | Torres, R, Goulding, C.W. | Deposit date: | 2013-10-17 | Release date: | 2014-04-09 | Last modified: | 2014-04-16 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structural snapshots along the reaction pathway of Yersinia pestis RipA, a putative butyryl-CoA transferase. Acta Crystallogr.,Sect.D, 70, 2014
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4OG7
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![BU of 4og7 by Molmil](/molmil-images/mine/4og7) | Human menin with bound inhibitor MIV-7 | Descriptor: | 4-(3-{4-[(S)-cyclopentyl(hydroxy)pyridin-2-ylmethyl]piperidin-1-yl}propoxy)benzenesulfonamide, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | Authors: | He, S, Senter, T.J, Pollock, J.W, Han, C, Upadhyay, S.K, Purohit, T, Gogliotti, R.D, Lindsley, C.W, Cierpicki, T, Stauffer, S.R, Grembecka, J. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction. J.Med.Chem., 57, 2014
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6L8P
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![BU of 6l8p by Molmil](/molmil-images/mine/6l8p) | Crystal structure of RidA from Antarctic bacterium Psychrobacter sp. PAMC 21119 | Descriptor: | MALONATE ION, RidA family protein | Authors: | Kwon, S, Lee, C.W, Koh, H.Y, Lee, J.H, Park, H.H. | Deposit date: | 2019-11-06 | Release date: | 2019-12-18 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.601 Å) | Cite: | Crystal structure of the reactive intermediate/imine deaminase A homolog from the Antarctic bacterium Psychrobacter sp. PAMC 21119. Biochem.Biophys.Res.Commun., 522, 2020
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4NTQ
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![BU of 4ntq by Molmil](/molmil-images/mine/4ntq) | |
4LPM
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![BU of 4lpm by Molmil](/molmil-images/mine/4lpm) | Frog M-ferritin with magnesium, D127E mutant | Descriptor: | CHLORIDE ION, Ferritin, middle subunit, ... | Authors: | Torres, R, Behera, R, Goulding, C.W, Theil, E.C. | Deposit date: | 2013-07-16 | Release date: | 2014-07-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | D127E ion channel exit modification in ferritin nanocages entraps Fe(II) and impairs its distribution to diiron catalytic centers To be Published
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4PN8
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![BU of 4pn8 by Molmil](/molmil-images/mine/4pn8) | A de novo designed pentameric coiled coil CC-Pent. | Descriptor: | CC-Pent | Authors: | Wood, C.W, Burton, A.J, Thomson, A.R, Brady, R.L, Woolfson, D.N. | Deposit date: | 2014-05-23 | Release date: | 2014-10-22 | Last modified: | 2017-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Computational design of water-soluble alpha-helical barrels. Science, 346, 2014
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2TDD
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![BU of 2tdd by Molmil](/molmil-images/mine/2tdd) | STRUCTURES OF THYMIDYLATE SYNTHASE WITH A C-TERMINAL DELETION: ROLE OF THE C-TERMINUS IN ALIGNMENT OF D/UMP AND CH2H4FOLATE | Descriptor: | 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5-HYDROXYMETHYLENE-6-HYDROFOLIC ACID, THYMIDYLATE SYNTHASE | Authors: | Perry, K.M, Carreras, C.W, Chang, L.C, Santi, D.V, Stroud, R.M. | Deposit date: | 1993-04-05 | Release date: | 1993-07-15 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate. Biochemistry, 32, 1993
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2WP2
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![BU of 2wp2 by Molmil](/molmil-images/mine/2wp2) | Structure of Brdt bromodomain BD1 bound to a diacetylated histone H4 peptide. | Descriptor: | BROMODOMAIN TESTIS-SPECIFIC PROTEIN, HISTONE H4 | Authors: | Moriniere, J, Rousseaux, S, Steuerwald, U, Soler-Lopez, M, Curtet, S, Vitte, A.-L, Govin, J, Gaucher, J, Sadoul, K, Hart, D.J, Krijgsveld, J, Khochbin, S, Mueller, C.W, Petosa, C. | Deposit date: | 2009-08-02 | Release date: | 2009-09-22 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Cooperative Binding of Two Acetylation Marks on a Histone Tail by a Single Bromodomain. Nature, 461, 2009
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2X23
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![BU of 2x23 by Molmil](/molmil-images/mine/2x23) | crystal structure of M. tuberculosis InhA inhibited by PT70 | Descriptor: | 5-HEXYL-2-(2-METHYLPHENOXY)PHENOL, DIMETHYL SULFOXIDE, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], ... | Authors: | Luckner, S.R, Liu, N, am Ende, C.W, Tonge, P.J, Kisker, C. | Deposit date: | 2010-01-10 | Release date: | 2010-03-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.807 Å) | Cite: | A Slow, Tight Binding Inhibitor of Inha, the Enoyl-Acyl Carrier Protein Reductase from Mycobacterium Tuberculosis. J.Biol.Chem., 285, 2010
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2WH9
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![BU of 2wh9 by Molmil](/molmil-images/mine/2wh9) | Solution structure of GxTX-1E | Descriptor: | GUANGXITOXIN-1EGXTX-1E | Authors: | Lee, S.K, Jung, H.H, Lee, J.Y, Lee, C.W, Kim, J.I. | Deposit date: | 2009-05-02 | Release date: | 2010-05-26 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Solution Structure of Gxtx-1E, a High Affinity Tarantula Toxin Interacting with Voltage Sensors in Kv2.1 Potassium Channels. Biochemistry, 49, 2010
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2W3X
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![BU of 2w3x by Molmil](/molmil-images/mine/2w3x) | Crystal structure of a bifunctional hotdog fold thioesterase in enediyne biosynthesis, CalE7 | Descriptor: | CALE7, GLYCEROL, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500), ... | Authors: | Kotaka, M, Kong, R, Qureshi, I, Ho, Q.S, Sun, H, Liew, C.W, Goh, L.P, Cheung, P, Mu, Y, Lescar, J, Liang, Z.X. | Deposit date: | 2008-11-17 | Release date: | 2009-04-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure and Catalytic Mechanism of the Thioesterase Cale7 in Enediyne Biosynthesis. J.Biol.Chem., 284, 2009
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2VA7
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![BU of 2va7 by Molmil](/molmil-images/mine/2va7) | X-ray crystal structure of beta secretase complexed with compound 27 | Descriptor: | (6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one, BETA-SECRETASE 1 ., IODIDE ION | Authors: | Edwards, P.D, Albert, J.S, Sylvester, M, Aharony, D, Andisik, D, Callaghan, O, Campbell, J.B, Carr, R.A, Chessari, G, Congreve, M, Frederickson, M, Folmer, R.H.A, Geschwindner, S, Koether, G, Kolmodin, K, Krumrine, J, Mauger, R.C, Murray, C.W, Olsson, L.L, Patel, S, Spear, N, Tian, G. | Deposit date: | 2007-08-30 | Release date: | 2007-11-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine Beta-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency. J.Med.Chem., 50, 2007
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2VPV
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![BU of 2vpv by Molmil](/molmil-images/mine/2vpv) | Dimerization Domain of Mif2p | Descriptor: | PROTEIN MIF2, SULFATE ION | Authors: | Cohen, R.L, Espelin, C.W, Sorger, P.K, Harrison, S.C, Simons, K.T. | Deposit date: | 2008-03-05 | Release date: | 2008-08-26 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural and Functional Dissection of Mif2P, a Conserved DNA-Binding Kinetochore Protein. Mol.Biol.Cell, 19, 2008
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