8C49
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![BU of 8c49 by Molmil](/molmil-images/mine/8c49) | Crystal structure of pyrrolysyl-tRNA synthetase from Methanomethylophilus alvus engineered for 3-Methyl-L-histidine, bound to AMPPNP | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... | Authors: | Hardy, F.J, Levy, C.W. | Deposit date: | 2023-01-03 | Release date: | 2023-07-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Engineering mutually orthogonal PylRS/tRNA pairs for dual encoding of functional histidine analogues. Protein Sci., 32, 2023
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4H1S
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![BU of 4h1s by Molmil](/molmil-images/mine/4h1s) | Crystal Structure of a Truncated Soluble form of Human CD73 with Ecto-5'-Nucleotidase activity | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5'-nucleotidase, PHOSPHATE ION, ... | Authors: | Heuts, D.P, Weissenborn, M.J, Olkhov, R.V, Shaw, A.M, Levy, C.W, Scrutton, N.S. | Deposit date: | 2012-09-11 | Release date: | 2012-10-03 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of a soluble form of human CD73 with ecto-5'-nucleotidase activity. Chembiochem, 13, 2012
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6KZ6
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![BU of 6kz6 by Molmil](/molmil-images/mine/6kz6) | Crystal structure of ASFV dUTPase | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, E165R, MAGNESIUM ION | Authors: | Guo, Y, Chen, C, Li, G.B, Cao, L, Wang, C.W. | Deposit date: | 2019-09-23 | Release date: | 2019-11-13 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.187 Å) | Cite: | Structural Insight into African Swine Fever Virus dUTPase Reveals a Novel Folding Pattern in the dUTPase Family. J.Virol., 94, 2020
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8W77
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![BU of 8w77 by Molmil](/molmil-images/mine/8w77) | Human Consensus Olfactory Receptor OR52c in apo state, OR52c only | Descriptor: | Human Consensus Olfactory Receptor OR52c in apo state, receptor only,Soluble cytochrome b562 | Authors: | Choi, C.W, Bae, J, Choi, H.-J, Kim, J. | Deposit date: | 2023-08-30 | Release date: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.61 Å) | Cite: | Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family. Nat Commun, 14, 2023
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1EJZ
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![BU of 1ejz by Molmil](/molmil-images/mine/1ejz) | SOLUTION STRUCTURE OF A HNA-RNA HYBRID | Descriptor: | DNA (5'-H(*(6HG)P*(6HC)P*(6HG)P*(6HT)P*(6HA)P*(6HG)P*(6HC)P*(6HG))-3'), PHOSPHORIC ACID MONO-(3-HYDROXY-PROPYL) ESTER, RNA (5'-R(*CP*GP*CP*UP*AP*CP*GP*C)-3') | Authors: | Lescrnier, E, Esnouf, R, Heus, H.A, Hilbers, C.W, Herdewijn, P. | Deposit date: | 2000-03-06 | Release date: | 2000-10-23 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of a HNA-RNA hybrid. Chem.Biol., 7, 2000
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6Z1K
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![BU of 6z1k by Molmil](/molmil-images/mine/6z1k) | |
6Z1L
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![BU of 6z1l by Molmil](/molmil-images/mine/6z1l) | |
5GPG
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![BU of 5gpg by Molmil](/molmil-images/mine/5gpg) | Co-crystal structure of the FK506 binding domain of human FKBP25, Rapamycin and the FRB domain of human mTOR | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP3, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, Serine/threonine-protein kinase mTOR | Authors: | Lee, H.B, Lee, S.Y, Rhee, H.W, Lee, C.W. | Deposit date: | 2016-08-02 | Release date: | 2016-10-12 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Proximity-Directed Labeling Reveals a New Rapamycin-Induced Heterodimer of FKBP25 and FRB in Live Cells Acs Cent.Sci., 2, 2016
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3K8E
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![BU of 3k8e by Molmil](/molmil-images/mine/3k8e) | Crystal structure of E. coli lipopolysaccharide specific CMP-KDO synthetase | Descriptor: | 3-deoxy-manno-octulosonate cytidylyltransferase | Authors: | Heyes, D.J, Levy, C.W, Lafite, P, Scrutton, N.S, Leys, D. | Deposit date: | 2009-10-14 | Release date: | 2009-11-10 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Structure-based mechanism of CMP-2-keto-3-deoxymanno-octulonic acid synthetase: convergent evolution of a sugar-activating enzyme with DNA/RNA polymerases J.Biol.Chem., 284, 2009
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3K8D
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![BU of 3k8d by Molmil](/molmil-images/mine/3k8d) | Crystal structure of E. coli lipopolysaccharide specific CMP-KDO synthetase in complex with CTP and 2-deoxy-Kdo | Descriptor: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, 3-deoxy-manno-octulosonate cytidylyltransferase, CYTIDINE-5'-TRIPHOSPHATE, ... | Authors: | Heyes, D.J, Levy, C.W, Lafite, P, Scrutton, N.S, Leys, D. | Deposit date: | 2009-10-14 | Release date: | 2009-11-10 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure-based mechanism of CMP-2-keto-3-deoxymanno-octulonic acid synthetase: convergent evolution of a sugar-activating enzyme with DNA/RNA polymerases J.Biol.Chem., 284, 2009
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3HR5
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3KP0
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![BU of 3kp0 by Molmil](/molmil-images/mine/3kp0) | Crystal Structure of ORNITHINE 4,5 AMINOMUTASE in complex with 2,4-diaminobutyrate (DAB) (Aerobic) | Descriptor: | (2S)-2-amino-4-{[(1Z)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}butanoic acid, 5'-DEOXYADENOSINE, COBALAMIN, ... | Authors: | Wolthers, K.R, Levy, C.W, Scrutton, N.S, Leys, D. | Deposit date: | 2009-11-14 | Release date: | 2010-01-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Large-scale domain dynamics and adenosylcobalamin reorientation orchestrate radical catalysis in ornithine 4,5-aminomutase. J.Biol.Chem., 285, 2010
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3KFT
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![BU of 3kft by Molmil](/molmil-images/mine/3kft) | Crystal structure of Pentaerythritol Tetranitrate Reductase complex with 1,4,5,6-tetrahydro NADH | Descriptor: | FLAVIN MONONUCLEOTIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Pentaerythritol tetranitrate reductase | Authors: | Pudney, C.R, Levy, C.W, Leys, D, Scrutton, N.S. | Deposit date: | 2009-10-28 | Release date: | 2010-02-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction. J.Am.Chem.Soc., 131, 2009
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3KOY
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![BU of 3koy by Molmil](/molmil-images/mine/3koy) | Crystal Structure of ornithine 4,5 aminomutase in complex with ornithine (Aerobic) | Descriptor: | (E)-N~5~-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-ornithine, 5'-DEOXYADENOSINE, COBALAMIN, ... | Authors: | Wolthers, K.R, Levy, C.W, Scrutton, N.S, Leys, D. | Deposit date: | 2009-11-14 | Release date: | 2010-01-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Large-scale domain dynamics and adenosylcobalamin reorientation orchestrate radical catalysis in ornithine 4,5-aminomutase. J.Biol.Chem., 285, 2010
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3KP1
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![BU of 3kp1 by Molmil](/molmil-images/mine/3kp1) | Crystal structure of ornithine 4,5 aminomutase (Resting State) | Descriptor: | 5'-DEOXYADENOSINE, COBALAMIN, D-ornithine aminomutase E component, ... | Authors: | Wolthers, K.R, Levy, C.W, Scrutton, N.S, Leys, D. | Deposit date: | 2009-11-14 | Release date: | 2010-01-26 | Last modified: | 2019-10-30 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Large-scale domain dynamics and adenosylcobalamin reorientation orchestrate radical catalysis in ornithine 4,5-aminomutase. J.Biol.Chem., 285, 2010
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3KOW
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![BU of 3kow by Molmil](/molmil-images/mine/3kow) | Crystal Structure of ornithine 4,5 aminomutase backsoaked complex | Descriptor: | 5'-DEOXYADENOSINE, COBALAMIN, D-ornithine aminomutase E component, ... | Authors: | Wolthers, K.R, Levy, C.W, Scrutton, N.S, Leys, D. | Deposit date: | 2009-11-14 | Release date: | 2010-01-26 | Last modified: | 2012-10-24 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Large-scale domain dynamics and adenosylcobalamin reorientation orchestrate radical catalysis in ornithine 4,5-aminomutase. J.Biol.Chem., 285, 2010
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2AAD
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![BU of 2aad by Molmil](/molmil-images/mine/2aad) | THE ROLE OF HISTIDINE-40 IN RIBONUCLEASE T1 CATALYSIS: THREE-DIMENSIONAL STRUCTURES OF THE PARTIALLY ACTIVE HIS40LYS MUTANT | Descriptor: | CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, RIBONUCLEASE T1 ISOZYME | Authors: | Zegers, I, Verhelst, P, Choe, C.W, Steyaert, J, Heinemann, U, Wyns, L, Saenger, W. | Deposit date: | 1992-09-15 | Release date: | 1994-01-31 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Role of histidine-40 in ribonuclease T1 catalysis: three-dimensionalstructures of the partially active His40Lys mutant. Biochemistry, 31, 1992
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2AAE
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![BU of 2aae by Molmil](/molmil-images/mine/2aae) | THE ROLE OF HISTIDINE-40 IN RIBONUCLEASE T1 CATALYSIS: THREE-DIMENSIONAL STRUCTURES OF THE PARTIALLY ACTIVE HIS40LYS MUTANT | Descriptor: | CALCIUM ION, PHOSPHATE ION, RIBONUCLEASE T1 | Authors: | Zegers, I, Verhelst, P, Choe, C.W, Steyaert, J, Heinemann, U, Wyns, L, Saenger, W. | Deposit date: | 1992-09-15 | Release date: | 1994-01-31 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Role of histidine-40 in ribonuclease T1 catalysis: three-dimensionalstructures of the partially active His40Lys mutant. Biochemistry, 31, 1992
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6S7E
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![BU of 6s7e by Molmil](/molmil-images/mine/6s7e) | Plant Cysteine Oxidase PCO4 from Arabidopsis thaliana (using PEG 3350 and NaF as precipitants) | Descriptor: | FE (III) ION, Plant cysteine oxidase 4 | Authors: | White, M.D, Levy, C.W, Flashman, E, McDonough, M.A. | Deposit date: | 2019-07-04 | Release date: | 2020-07-22 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Structures of Arabidopsis thaliana oxygen-sensing plant cysteine oxidases 4 and 5 enable targeted manipulation of their activity. Proc.Natl.Acad.Sci.USA, 117, 2020
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4KVS
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![BU of 4kvs by Molmil](/molmil-images/mine/4kvs) | Crystal Structure of Prochlorococcus marinus aldehyde-deformylating oxygenase (mutant A134F) | Descriptor: | Aldehyde decarbonylase, FE (III) ION, HEXANOIC ACID | Authors: | Levy, C.W, Khara, B, Menon, N, Mansell, D, Das, D, Marsh, E.N.G, Leys, D, Scrutton, N.S. | Deposit date: | 2013-05-23 | Release date: | 2013-06-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Production of propane and other short-chain alkanes by structure-based engineering of ligand specificity in aldehyde-deformylating oxygenase. Chembiochem, 14, 2013
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4KVQ
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![BU of 4kvq by Molmil](/molmil-images/mine/4kvq) | Crystal Structure of Prochlorococcus marinus aldehyde-deformylating oxygenase wild type with palmitic acid bound | Descriptor: | Aldehyde decarbonylase, FE (III) ION, PALMITIC ACID | Authors: | Levy, C.W, Khara, B, Menon, N, Mansell, D, Das, D, Marsh, E.N.G, Leys, D, Scrutton, N.S. | Deposit date: | 2013-05-23 | Release date: | 2013-06-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.842 Å) | Cite: | Production of propane and other short-chain alkanes by structure-based engineering of ligand specificity in aldehyde-deformylating oxygenase. Chembiochem, 14, 2013
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4KVR
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![BU of 4kvr by Molmil](/molmil-images/mine/4kvr) | Crystal Structure of Prochlorococcus marinus aldehyde-deformylating oxygenase (mutant V41Y) | Descriptor: | Aldehyde decarbonylase, FE (III) ION, HEXANOIC ACID | Authors: | Levy, C.W, Khara, B, Menon, N, Mansell, D, Das, D, Marsh, E.N.G, Leys, D, Scrutton, N.S. | Deposit date: | 2013-05-23 | Release date: | 2013-06-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Production of propane and other short-chain alkanes by structure-based engineering of ligand specificity in aldehyde-deformylating oxygenase. Chembiochem, 14, 2013
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4O1Q
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![BU of 4o1q by Molmil](/molmil-images/mine/4o1q) | |
2OTO
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![BU of 2oto by Molmil](/molmil-images/mine/2oto) | |
5J48
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![BU of 5j48 by Molmil](/molmil-images/mine/5j48) | PKG I's Carboyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-pCPT-cGMP | Descriptor: | 1,2-ETHANEDIOL, 2-amino-8-[(4-chlorophenyl)sulfanyl]-9-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-3,9-dihydro-6H-purin-6-one, CALCIUM ION, ... | Authors: | Campbell, J.C, Sankaran, B, Kim, C.W. | Deposit date: | 2016-03-31 | Release date: | 2017-04-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Structural Basis of Analog Specificity in PKG I and II. ACS Chem. Biol., 12, 2017
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