3K8E

Crystal structure of E. coli lipopolysaccharide specific CMP-KDO synthetase

Summary for 3K8E

• Entry DOI: 10.2210/pdb3k8e/pdb
• Related: 3K8D
• Descriptor: 3-deoxy-manno-octulosonate cytidylyltransferase (2 entities in total)
• Functional Keywords: kdsb synthetase deoxy kdo complex, lipopolysaccharide biosynthesis, magnesium, nucleotidyltransferase, transferase
• Biological source: Escherichia coli
• Cellular location: Cytoplasm (Potential): P04951
• Total number of polymer chains: 4
• Total formula weight: 117825.51

Authors

Heyes, D.J.,Levy, C.W.,Lafite, P.,Scrutton, N.S.,Leys, D. (deposition date: 2009-10-14, release date: 2009-11-10, Last modification date: 2023-11-01)

• Primary citation: Heyes, D.J.,Levy, C.,Lafite, P.,Roberts, I.S.,Goldrick, M.,Stachulski, A.V.,Rossington, S.B.,Stanford, D.,Rigby, S.E.J.,Scrutton, N.S.,Leys, D.; Structure-based mechanism of CMP-2-keto-3-deoxymanno-octulonic acid synthetase: convergent evolution of a sugar-activating enzyme with DNA/RNA polymerases; J.Biol.Chem., 284:35514-35523, 2009; PubMed: 19815542; DOI: 10.1074/jbc.M109.056630

Experimental method

X-RAY DIFFRACTION (2.51 Å)