3CO0
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3CNQ
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3BGO
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7MP7
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![BU of 7mp7 by Molmil](/molmil-images/mine/7mp7) | Rules for designing protein fold switches and their implications for the folding code | Descriptor: | Sb3 | Authors: | He, Y, Chen, Y, Ruan, B, Choi, J, Chen, Y, Motabar, D, Solomon, T, Simmerman, R, Kauffman, T, Gallagher, T, Bryan, P, Orban, J. | Deposit date: | 2021-05-04 | Release date: | 2022-05-18 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Design and characterization of a protein fold switching network. Nat Commun, 14, 2023
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7MN1
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![BU of 7mn1 by Molmil](/molmil-images/mine/7mn1) | Rules for designing protein fold switches and their implications for the folding code | Descriptor: | Sa1 | Authors: | He, Y, Chen, Y, Ruan, B, Choi, J, Chen, Y, Motabar, D, Solomon, T, Simmerman, R, Kauffman, T, Gallagher, T, Bryan, P, Orban, J. | Deposit date: | 2021-04-30 | Release date: | 2022-05-18 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Design and characterization of a protein fold switching network. Nat Commun, 14, 2023
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7MQ4
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![BU of 7mq4 by Molmil](/molmil-images/mine/7mq4) | Rules for designing protein fold switches and their implications for the folding code | Descriptor: | Sb1 | Authors: | He, Y, Chen, Y, Ruan, B, Choi, J, Chen, Y, Motabar, D, Solomon, T, Simmerman, R, Kauffman, T, Gallagher, T, Bryan, P, Orban, J. | Deposit date: | 2021-05-05 | Release date: | 2022-05-18 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Design and characterization of a protein fold switching network. Nat Commun, 14, 2023
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2MH8
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![BU of 2mh8 by Molmil](/molmil-images/mine/2mh8) | GA-79-MBP cs-rosetta structures | Descriptor: | GA-79-MBP, maltose binding protein | Authors: | He, Y, Chen, Y, Porter, L, Bryan, P, Orban, J. | Deposit date: | 2013-11-19 | Release date: | 2015-04-08 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Subdomain interactions foster the design of two protein pairs with 80% sequence identity but different folds. Biophys.J., 108, 2015
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1PGA
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![BU of 1pga by Molmil](/molmil-images/mine/1pga) | |
1PGB
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3F49
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1ZXH
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![BU of 1zxh by Molmil](/molmil-images/mine/1zxh) | G311 mutant protein | Descriptor: | Immunoglobulin G binding protein G | Authors: | He, Y, Yeh, D.C, Alexander, P, Bryan, P.N, Orban, J. | Deposit date: | 2005-06-08 | Release date: | 2005-11-08 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution NMR structures of IgG binding domains with artificially evolved high levels of sequence identity but different folds. Biochemistry, 44, 2005
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1ZXG
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![BU of 1zxg by Molmil](/molmil-images/mine/1zxg) | Solution structure of A219 | Descriptor: | Immunoglobulin G binding protein A | Authors: | He, Y, Yeh, D.C, Alexander, P, Bryan, P.N, Orban, J. | Deposit date: | 2005-06-08 | Release date: | 2005-11-08 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution NMR structures of IgG binding domains with artificially evolved high levels of sequence identity but different folds. Biochemistry, 44, 2005
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2FS1
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![BU of 2fs1 by Molmil](/molmil-images/mine/2fs1) | solution structure of PSD-1 | Descriptor: | PSD-1 | Authors: | He, Y, Rozak, D.A, Sari, N, Chen, Y, Bryan, P, Orban, J. | Deposit date: | 2006-01-20 | Release date: | 2006-12-05 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure, dynamics, and stability variation in bacterial albumin binding modules: implications for species specificity. Biochemistry, 45, 2006
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6UAI
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![BU of 6uai by Molmil](/molmil-images/mine/6uai) | Imidazole-triggered RAS-specific subtilisin SUBT_BACAM complexed with YSAM peptide | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Toth, E.A, Bryan, P.N, Orban, J. | Deposit date: | 2019-09-10 | Release date: | 2020-09-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Engineering subtilisin proteases that specifically degrade active RAS. Commun Biol, 4, 2021
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6UAO
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![BU of 6uao by Molmil](/molmil-images/mine/6uao) | Imidazole-triggered RAS-specific subtilisin SUBT_BACAM complexed with the peptide EEYSAM | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Peptide EEYSAM, ... | Authors: | Toth, E.A, Bryan, P.N, Orban, J. | Deposit date: | 2019-09-11 | Release date: | 2020-09-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Engineering subtilisin proteases that specifically degrade active RAS. Commun Biol, 4, 2021
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6UBE
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![BU of 6ube by Molmil](/molmil-images/mine/6ube) | Azide-triggered subtilisin SUBT_BACAM complexed with the peptide LFRAL | Descriptor: | AZIDE ION, GLYCEROL, Peptide LFRAL, ... | Authors: | Toth, E.A, Bryan, P.N, Orban, J, Gallagher, D.T, Custer, G. | Deposit date: | 2019-09-11 | Release date: | 2020-09-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Engineering subtilisin proteases that specifically degrade active RAS. Commun Biol, 4, 2021
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6U9L
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![BU of 6u9l by Molmil](/molmil-images/mine/6u9l) | Imidazole-triggered RAS-specific subtilisin SUBT_BACAM | Descriptor: | GLYCEROL, POTASSIUM ION, SUBTILISIN BPN', ... | Authors: | Toth, E.A, Bryan, P.N, Orban, J. | Deposit date: | 2019-09-09 | Release date: | 2020-09-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Engineering subtilisin proteases that specifically degrade active RAS. Commun Biol, 4, 2021
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7MN2
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![BU of 7mn2 by Molmil](/molmil-images/mine/7mn2) | Rules for designing protein fold switches and their implications for the folding code | Descriptor: | Sb2 | Authors: | He, Y, Chen, Y, Ruan, B, Choi, J, Chen, Y, Motabar, D, Solomon, T, Simmerman, R, Kauffman, T, Gallagher, T, Bryan, P, Orban, J. | Deposit date: | 2021-04-30 | Release date: | 2022-05-18 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Design and characterization of a protein fold switching network. Nat Commun, 14, 2023
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1SUC
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1SUD
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![BU of 1sud by Molmil](/molmil-images/mine/1sud) | CALCIUM-INDEPENDENT SUBTILISIN BY DESIGN | Descriptor: | ACETONE, CALCIUM ION, POTASSIUM ION, ... | Authors: | Gallagher, T, Bryan, P, Gilliland, G.L. | Deposit date: | 1992-06-10 | Release date: | 1994-01-31 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Calcium-independent subtilisin by design. Proteins, 16, 1993
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1SPB
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![BU of 1spb by Molmil](/molmil-images/mine/1spb) | SUBTILISIN BPN' PROSEGMENT (77 RESIDUES) COMPLEXED WITH A MUTANT SUBTILISIN BPN' (266 RESIDUES). CRYSTAL PH 4.6. CRYSTALLIZATION TEMPERATURE 20 C DIFFRACTION TEMPERATURE-160 C | Descriptor: | SODIUM ION, SUBTILISIN BPN', SUBTILISIN BPN' PROSEGMENT | Authors: | Gallagher, D.T, Gilliland, G.L, Wang, L, Bryan, P.N. | Deposit date: | 1995-06-21 | Release date: | 1995-10-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The prosegment-subtilisin BPN' complex: crystal structure of a specific 'foldase'. Structure, 3, 1995
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1SUB
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![BU of 1sub by Molmil](/molmil-images/mine/1sub) | CALCIUM-INDEPENDENT SUBTILISIN BY DESIGN | Descriptor: | ACETONE, CALCIUM ION, POTASSIUM ION, ... | Authors: | Gallagher, T, Bryan, P, Gilliland, G.L. | Deposit date: | 1992-06-10 | Release date: | 1994-01-31 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Calcium-independent subtilisin by design. Proteins, 16, 1993
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2KDM
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![BU of 2kdm by Molmil](/molmil-images/mine/2kdm) | NMR structures of GA95 and GB95, two designed proteins with 95% sequence identity but different folds and functions | Descriptor: | DESIGNED PROTEIN | Authors: | He, Y, Alexander, P, Chen, Y, Bryan, P, Orban, J. | Deposit date: | 2009-01-12 | Release date: | 2009-12-29 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | From the Cover: A minimal sequence code for switching protein structure and function. Proc.Natl.Acad.Sci.USA, 106, 2009
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2KDL
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![BU of 2kdl by Molmil](/molmil-images/mine/2kdl) | NMR structures of GA95 and GB95, two designed proteins with 95% sequence identity but different folds and functions | Descriptor: | designed protein | Authors: | He, Y, Alexander, P, Chen, Y, Bryan, P, Orban, J. | Deposit date: | 2009-01-12 | Release date: | 2009-12-29 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | A minimal sequence code for switching protein structure and function. Proc.Natl.Acad.Sci.USA, 106, 2009
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2LHE
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![BU of 2lhe by Molmil](/molmil-images/mine/2lhe) | Gb98-T25I,L20A | Descriptor: | Gb98 | Authors: | He, Y, Chen, Y, Alexander, P, Bryan, P, Orban, J. | Deposit date: | 2011-08-08 | Release date: | 2012-02-29 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Mutational tipping points for switching protein folds and functions. Structure, 20, 2012
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