5C6Q
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![BU of 5c6q by Molmil](/molmil-images/mine/5c6q) | Crystal structure of the apo TOPLESS related protein 2 (TPR2) N-terminal domain (1-209) from rice | Descriptor: | ASPR2 protein, ZINC ION | Authors: | Ke, J, Ma, H, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | Deposit date: | 2015-06-23 | Release date: | 2015-08-05 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.251 Å) | Cite: | Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors. Sci Adv, 1, 2015
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5T9D
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![BU of 5t9d by Molmil](/molmil-images/mine/5t9d) | |
4PXQ
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![BU of 4pxq by Molmil](/molmil-images/mine/4pxq) | Crystal structure of D-glucuronyl C5-epimerase in complex with heparin hexasaccharide | Descriptor: | 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, D-glucuronyl C5 epimerase B | Authors: | Ke, J, Qin, Y, Gu, X, Tan, J, Brunzelle, J.S, Xu, H.E, Ding, K. | Deposit date: | 2014-03-24 | Release date: | 2015-01-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural and Functional Study of d-Glucuronyl C5-epimerase. J.Biol.Chem., 290, 2015
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4OC9
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![BU of 4oc9 by Molmil](/molmil-images/mine/4oc9) | 2.35 Angstrom resolution crystal structure of putative O-acetylhomoserine (thiol)-lyase (metY) from Campylobacter jejuni subsp. jejuni NCTC 11168 with N'-Pyridoxyl-Lysine-5'-Monophosphate at position 205 | Descriptor: | GLYCEROL, IMIDAZOLE, PHOSPHATE ION, ... | Authors: | Halavaty, A.S, Brunzelle, J.S, Wawrzak, Z, Onopriyenko, O, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2014-01-08 | Release date: | 2014-03-12 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | 2.35 Angstrom resolution crystal structure of putative O-acetylhomoserine (thiol)-lyase (metY) from Campylobacter jejuni subsp. jejuni NCTC 11168 with N'-Pyridoxyl-Lysine-5'-Monophosphate at position 205 To be Published
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5IZQ
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![BU of 5izq by Molmil](/molmil-images/mine/5izq) | Crystal structure of human folate receptor alpha in complex with novel antifolate AGF183 | Descriptor: | Folate receptor alpha, N-(4-{[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzene-1-carbonyl)-L-glutamic acid | Authors: | Ke, J, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | Deposit date: | 2016-03-25 | Release date: | 2016-08-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor alpha and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. J.Med.Chem., 59, 2016
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4PW2
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![BU of 4pw2 by Molmil](/molmil-images/mine/4pw2) | Crystal structure of D-glucuronyl C5 epimerase | Descriptor: | CITRIC ACID, D-glucuronyl C5 epimerase B | Authors: | Ke, J, Qin, Y, Gu, X, Brunzelle, J.S, Xu, H.E, Ding, K. | Deposit date: | 2014-03-18 | Release date: | 2015-01-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural and Functional Study of d-Glucuronyl C5-epimerase. J.Biol.Chem., 290, 2015
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3PRP
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![BU of 3prp by Molmil](/molmil-images/mine/3prp) | Structural analysis of a viral OTU domain protease from the Crimean-Congo Hemorrhagic Fever virus in complex with human ubiquitin | Descriptor: | Polyubiquitin-B (Fragment), RNA-directed RNA polymerase L | Authors: | Capodagli, G.C, McKercher, M.A, Baker, E.A, Masters, E.M, Brunzelle, J.S, Pegan, S.D. | Deposit date: | 2010-11-30 | Release date: | 2011-01-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.699 Å) | Cite: | Structural analysis of a viral ovarian tumor domain protease from the crimean-congo hemorrhagic Fever virus in complex with covalently bonded ubiquitin. J.Virol., 85, 2011
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3PRM
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![BU of 3prm by Molmil](/molmil-images/mine/3prm) | Structural analysis of a viral OTU domain protease from the Crimean-Congo Hemorrhagic Fever virus in complex with human ubiquitin | Descriptor: | Polyubiquitin-B (Fragment), RNA-directed RNA polymerase L | Authors: | Capodagli, G.C, McKercher, M.A, Baker, E.A, Masters, E.M, Brunzelle, J.S, Pegan, S.D. | Deposit date: | 2010-11-30 | Release date: | 2011-01-26 | Last modified: | 2023-02-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural analysis of a viral ovarian tumor domain protease from the crimean-congo hemorrhagic Fever virus in complex with covalently bonded ubiquitin. J.Virol., 85, 2011
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3RUY
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![BU of 3ruy by Molmil](/molmil-images/mine/3ruy) | Crystal Structure of the Ornithine-oxo acid transaminase RocD from Bacillus anthracis | Descriptor: | Ornithine aminotransferase | Authors: | Anderson, S.M, Wawrzak, Z, Brunzelle, J.S, Onopriyenko, O, Peterson, S.N, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2011-05-05 | Release date: | 2011-05-18 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Crystal Structure of the Ornithine-oxo acid transaminase RocD from Bacillus anthracis To be Published
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3S32
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![BU of 3s32 by Molmil](/molmil-images/mine/3s32) | Crystal structure of Ash2L N-terminal domain | Descriptor: | Set1/Ash2 histone methyltransferase complex subunit ASH2, ZINC ION | Authors: | Sarvan, S, Avdic, V, Tremblay, V, Chaturvedi, C.-P, Zhang, P, Lanouette, S, Blais, A, Brunzelle, J.S, Brand, M, Couture, J.-F. | Deposit date: | 2011-05-17 | Release date: | 2011-06-08 | Last modified: | 2012-01-11 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Crystal structure of the trithorax group protein ASH2L reveals a forkhead-like DNA binding domain. Nat.Struct.Mol.Biol., 18, 2011
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3SPK
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![BU of 3spk by Molmil](/molmil-images/mine/3spk) | Tipranavir in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant | Descriptor: | HIV-1 protease, N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE | Authors: | Wang, Y, Liu, Z, Brunzelle, J.S, Kovari, I.A, Kovari, L.C. | Deposit date: | 2011-07-01 | Release date: | 2011-10-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.24 Å) | Cite: | The higher barrier of darunavir and tipranavir resistance for HIV-1 protease. Biochem.Biophys.Res.Commun., 412, 2011
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6B6I
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![BU of 6b6i by Molmil](/molmil-images/mine/6b6i) | 2.4A resolution structure of human Norovirus GII.4 protease | Descriptor: | 3C-like protease | Authors: | Muzzarelli, K.M, Kuiper, B.D, Spellmon, N.S, Hackett, J, Brunzelle, J.S, Kovari, I.A, Amblard, F, Yang, Z, Schinazi, R.F, Kovari, L.C. | Deposit date: | 2017-10-02 | Release date: | 2018-10-03 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Structural and Antiviral Studies of the Human Norovirus GII.4 Protease. Biochemistry, 58, 2019
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3IRH
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![BU of 3irh by Molmil](/molmil-images/mine/3irh) | Structure of an Enterococcus Faecalis HD-domain protein complexed with dGTP and dATP | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... | Authors: | Vorontsov, I.I, Minasov, G, Shuvalova, L, Brunzelle, J.S, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2009-08-24 | Release date: | 2009-09-22 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Characterization of the deoxynucleotide triphosphate triphosphohydrolase (dNTPase) activity of the EF1143 protein from Enterococcus faecalis and crystal structure of the activator-substrate complex. J.Biol.Chem., 286, 2011
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3JWI
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![BU of 3jwi by Molmil](/molmil-images/mine/3jwi) | |
3JWJ
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![BU of 3jwj by Molmil](/molmil-images/mine/3jwj) | |
3K28
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![BU of 3k28 by Molmil](/molmil-images/mine/3k28) | Crystal Structure of a glutamate-1-semialdehyde aminotransferase from Bacillus anthracis with bound Pyridoxal 5'Phosphate | Descriptor: | CALCIUM ION, CHLORIDE ION, Glutamate-1-semialdehyde 2,1-aminomutase 2, ... | Authors: | Sharma, S.S, Brunzelle, J.S, Wawrzak, Z, Skarina, T, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2009-09-29 | Release date: | 2010-01-19 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal Structure of a glutamate-1-semialdehyde aminotransferase from Bacillus anthracis with bound Pyridoxal 5'Phosphate To be Published
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3JWH
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![BU of 3jwh by Molmil](/molmil-images/mine/3jwh) | Crystal structure analysis of the methyltransferase domain of bacterial-AvHen1-C | Descriptor: | Hen1, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Huang, R.H, Chan, C.M, Zhou, C, Brunzelle, J.S. | Deposit date: | 2009-09-18 | Release date: | 2009-10-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural and biochemical insights into 2'-O-methylation at the 3'-terminal nucleotide of RNA by Hen1. Proc.Natl.Acad.Sci.USA, 106, 2009
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3JWG
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![BU of 3jwg by Molmil](/molmil-images/mine/3jwg) | Crystal structure analysis of the methyltransferase domain of bacterial-CtHen1-C | Descriptor: | MAGNESIUM ION, Methyltransferase type 12 | Authors: | Huang, R.H, Chan, C.M, Zhou, C, Brunzelle, J.S. | Deposit date: | 2009-09-18 | Release date: | 2009-10-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural and biochemical insights into 2'-O-methylation at the 3'-terminal nucleotide of RNA by Hen1. Proc.Natl.Acad.Sci.USA, 106, 2009
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3LG3
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![BU of 3lg3 by Molmil](/molmil-images/mine/3lg3) | 1.4A Crystal Structure of Isocitrate Lyase from Yersinia pestis CO92 | Descriptor: | Isocitrate lyase | Authors: | Sharma, S.S, Brunzelle, J.S, Skarina, T, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2010-01-19 | Release date: | 2010-04-14 | Last modified: | 2011-12-14 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | 1.4A Crystal Structure of Isocitrate Lyase from Yersinia pestis CO92 To be Published
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3M57
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![BU of 3m57 by Molmil](/molmil-images/mine/3m57) | SET7/9 Y245A in complex with TAF10 peptide and AdoHcy | Descriptor: | GLYCEROL, Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. | Deposit date: | 2010-03-12 | Release date: | 2010-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
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3M54
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![BU of 3m54 by Molmil](/molmil-images/mine/3m54) | SET7/9 Y305F in complex with TAF10 peptide and AdoHcy | Descriptor: | Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, TAF10 peptide | Authors: | Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. | Deposit date: | 2010-03-12 | Release date: | 2010-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
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2O9B
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![BU of 2o9b by Molmil](/molmil-images/mine/2o9b) | Crystal Structure of Bacteriophytochrome chromophore binding domain | Descriptor: | 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, Bacteriophytochrome | Authors: | Wagner, J.R, Brunzelle, J.S, Vierstra, R.D, Forest, K.T. | Deposit date: | 2006-12-13 | Release date: | 2007-03-06 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | High resolution structure of deinococcus bacteriophytochrome yields new insights into phytochrome architecture and evolution. J.Biol.Chem., 282, 2007
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3M56
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![BU of 3m56 by Molmil](/molmil-images/mine/3m56) | SET7/9 Y305F in complex with TAF10-K189me2 peptide and AdoHcy | Descriptor: | Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, TAF10-K189me2 PEPTIDE | Authors: | Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. | Deposit date: | 2010-03-12 | Release date: | 2010-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
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2NWF
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![BU of 2nwf by Molmil](/molmil-images/mine/2nwf) | Soluble domain of Rieske Iron Sulfur Protein | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, GLYCEROL, Ubiquinol-cytochrome c reductase iron-sulfur subunit | Authors: | Kolling, D, Brunzelle, J.S, Lhee, S, Crofts, A.R, Nair, S.K. | Deposit date: | 2006-11-14 | Release date: | 2007-04-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Atomic resolution structures of rieske iron-sulfur protein: role of hydrogen bonds in tuning the redox potential of iron-sulfur clusters. Structure, 15, 2007
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3M5A
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![BU of 3m5a by Molmil](/molmil-images/mine/3m5a) | SET7/9 Y245A in complex with TAF10-K189me3 peptide and AdoHcy | Descriptor: | COBALT (II) ION, GLYCEROL, Histone-lysine N-methyltransferase SETD7, ... | Authors: | Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. | Deposit date: | 2010-03-12 | Release date: | 2010-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
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