2ISH
 
 | | Botulinum Neurotoxin A Light Chain WT Crystal Form C | | Descriptor: | Neurotoxin BoNT/A, ZINC ION | | Authors: | Brunger, A.T, Stegmann, C.M. | | Deposit date: | 2006-10-17 | | Release date: | 2006-11-07 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons.
J.Biol.Chem., 282, 2007
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2ISE
 | | Botulinum Neurotoxin A Light Chain WT Crystal Form A | | Descriptor: | Neurotoxin BoNT/A, ZINC ION | | Authors: | Brunger, A.T, Stegmann, C.M. | | Deposit date: | 2006-10-17 | | Release date: | 2006-11-07 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons.
J.Biol.Chem., 282, 2007
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2ISG
 | | Botulinum Neurotoxin A Light Chain WT Crystal Form B | | Descriptor: | NICKEL (II) ION, Neurotoxin BoNT/A, ZINC ION | | Authors: | Brunger, A.T, Stegmann, C.M. | | Deposit date: | 2006-10-17 | | Release date: | 2006-11-07 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons.
J.Biol.Chem., 282, 2007
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3J97
 | | Structure of 20S supercomplex determined by single particle cryoelectron microscopy (State II) | | Descriptor: | Alpha-soluble NSF attachment protein, Synaptosomal-associated protein 25, Syntaxin-1A, ... | | Authors: | Zhao, M, Wu, S, Cheng, Y, Brunger, A.T. | | Deposit date: | 2014-12-05 | | Release date: | 2015-01-28 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (7.8 Å) | | Cite: | Mechanistic insights into the recycling machine of the SNARE complex.
Nature, 518, 2015
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6MDO
 | | The D1 and D2 domain rings of NSF engaging the SNAP-25 N-terminus within the 20S supercomplex (focused refinement on D1/D2 rings, class 1) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Synaptosomal-associated protein 25, ... | | Authors: | White, K.I, Zhao, M, Brunger, A.T. | | Deposit date: | 2018-09-04 | | Release date: | 2018-09-19 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural principles of SNARE complex recognition by the AAA+ protein NSF.
Elife, 7, 2018
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6MDP
 | | The D1 and D2 domain rings of NSF engaging the SNAP-25 N-terminus within the 20S supercomplex (focused refinement on D1/D2 rings, class 2) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Synaptosomal-associated protein 25, ... | | Authors: | White, K.I, Zhao, M, Brunger, A.T. | | Deposit date: | 2018-09-04 | | Release date: | 2018-09-19 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural principles of SNARE complex recognition by the AAA+ protein NSF.
Elife, 7, 2018
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8CZI
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8FA1
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8FA2
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3BIX
 | | Crystal structure of the extracellular esterase domain of Neuroligin-1 | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, NICKEL (II) ION, ... | | Authors: | Arac, D, Boucard, A.A, Ozkan, E, Strop, P, Newell, E, Sudhof, T.C, Brunger, A.T. | | Deposit date: | 2007-12-01 | | Release date: | 2007-12-18 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structures of Neuroligin-1 and the Neuroligin-1/Neurexin-1beta Complex Reveal Specific Protein-Protein and Protein-Ca(2+) Interactions.
Neuron, 56, 2007
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3BBG
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1QQE
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4WMG
 | | Structure of hen egg-white lysozyme from a microfludic harvesting device using synchrotron radiation (2.5A) | | Descriptor: | Lysozyme C | | Authors: | Lyubimov, A.Y, Murray, T.D, Koehl, A, Uervirojnangkoorn, M, Zeldin, O.B, Cohen, A.E, Soltis, S.M, Baxter, E.M, Brewster, A.S, Sauter, N.K, Brunger, A.T, Berger, J.M. | | Deposit date: | 2014-10-08 | | Release date: | 2015-04-22 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Capture and X-ray diffraction studies of protein microcrystals in a microfluidic trap array.
Acta Crystallogr.,Sect.D, 71, 2015
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4WY4
 | | Crystal structure of autophagic SNARE complex | | Descriptor: | Synaptosomal-associated protein 29, Syntaxin-17, Vesicle-associated membrane protein 8 | | Authors: | Zhao, M, Brunger, A.T. | | Deposit date: | 2014-11-15 | | Release date: | 2015-02-11 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes.
Nature, 520, 2015
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3BBP
 | | Rab6-GTP:GCC185 Rab binding domain complex | | Descriptor: | GRIP and coiled-coil domain-containing protein 2, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Schweizer Burguete, A, Fenn, T.D, Brunger, A.T, Pfeffer, S.R. | | Deposit date: | 2007-11-09 | | Release date: | 2008-02-05 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185.
Cell(Cambridge,Mass.), 132, 2008
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4FE1
 | | Improving the Accuracy of Macromolecular Structure Refinement at 7 A Resolution | | Descriptor: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, BETA-CAROTENE, ... | | Authors: | Fromme, R, Adams, P.D, Fromme, P, Levitt, M, Schroeder, G.F, Brunger, A.T. | | Deposit date: | 2012-05-29 | | Release date: | 2012-08-15 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (4.9228 Å) | | Cite: | Improving the accuracy of macromolecular structure refinement at 7 A resolution.
Structure, 20, 2012
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6MDN
 | | The 20S supercomplex engaging the SNAP-25 N-terminus (class 2) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Alpha-soluble NSF attachment protein, ... | | Authors: | White, K.I, Zhao, M, Brunger, A.T. | | Deposit date: | 2018-09-04 | | Release date: | 2018-09-19 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structural principles of SNARE complex recognition by the AAA+ protein NSF.
Elife, 7, 2018
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6MDM
 | | The 20S supercomplex engaging the SNAP-25 N-terminus (class 1) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Alpha-soluble NSF attachment protein, ... | | Authors: | White, K.I, Zhao, M, Brunger, A.T. | | Deposit date: | 2018-09-04 | | Release date: | 2018-09-19 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structural principles of SNARE complex recognition by the AAA+ protein NSF.
Elife, 7, 2018
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6WVW
 | | Crystal structure of the R59P-SNAP25 containing SNARE complex | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, Synaptosomal-associated protein 25, ... | | Authors: | Zhou, Q, White, K.I, Brunger, A.T. | | Deposit date: | 2020-05-07 | | Release date: | 2021-03-17 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.11 Å) | | Cite: | Role of Aberrant Spontaneous Neurotransmission in SNAP25-Associated Encephalopathies.
Neuron, 109, 2021
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3BIW
 | | Crystal structure of the Neuroligin-1/Neurexin-1beta synaptic adhesion complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Arac, D, Boucard, A.A, Ozkan, E, Strop, P, Newell, E, Sudhof, T.C, Brunger, A.T. | | Deposit date: | 2007-12-01 | | Release date: | 2007-12-18 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structures of Neuroligin-1 and the Neuroligin-1/Neurexin-1beta Complex Reveal Specific Protein-Protein and Protein-Ca(2+) Interactions.
Neuron, 56, 2007
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9BRU
 | | Intact V-ATPase State 1 in synaptophysin knock-out isolated synaptic vesicles | | Descriptor: | Renin receptor cytoplasmic fragment, Ribonuclease kappa, V-type proton ATPase 116 kDa subunit a 1, ... | | Authors: | Wang, C, Jiang, W, Yang, K, Wang, X, Guo, Q, Brunger, A.T. | | Deposit date: | 2024-05-11 | | Release date: | 2024-06-19 | | Last modified: | 2024-08-07 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structure and topography of the synaptic V-ATPase-synaptophysin complex.
Nature, 631, 2024
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9BRT
 | | Intact V-ATPase State 1 and synaptophysin complex in mouse brain isolated synaptic vesicles | | Descriptor: | Renin receptor cytoplasmic fragment, Ribonuclease kappa, Synaptophysin, ... | | Authors: | Wang, C, Jiang, W, Yang, K, Wang, X, Guo, Q, Brunger, A.T. | | Deposit date: | 2024-05-11 | | Release date: | 2024-06-19 | | Last modified: | 2024-08-07 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Structure and topography of the synaptic V-ATPase-synaptophysin complex.
Nature, 631, 2024
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9BRA
 | | Intact V-ATPase State 2 and synaptophysin complex in mouse brain isolated synaptic vesicles | | Descriptor: | Renin receptor cytoplasmic fragment, Ribonuclease kappa, Synaptophysin, ... | | Authors: | Wang, C, Jiang, W, Yang, K, Wang, X, Guo, Q, Brunger, A.T. | | Deposit date: | 2024-05-11 | | Release date: | 2024-06-19 | | Last modified: | 2024-08-07 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Structure and topography of the synaptic V-ATPase-synaptophysin complex.
Nature, 631, 2024
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9BRR
 | | Intact V-ATPase State 3 in synaptophysin knock-out isolated synaptic vesicles | | Descriptor: | Renin receptor cytoplasmic fragment, Ribonuclease kappa, V-type proton ATPase 116 kDa subunit a 1, ... | | Authors: | Wang, C, Jiang, W, Yang, K, Wang, X, Guo, Q, Brunger, A.T. | | Deposit date: | 2024-05-11 | | Release date: | 2024-06-19 | | Last modified: | 2024-08-07 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Structure and topography of the synaptic V-ATPase-synaptophysin complex.
Nature, 631, 2024
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9BRS
 | | Intact V-ATPase State 2 in synaptophysin knock-out isolated synaptic vesicles | | Descriptor: | Renin receptor cytoplasmic fragment, Ribonuclease kappa, V-type proton ATPase 116 kDa subunit a 1, ... | | Authors: | Wang, C, Jiang, W, Yang, K, Wang, X, Guo, Q, Brunger, A.T. | | Deposit date: | 2024-05-11 | | Release date: | 2024-06-19 | | Last modified: | 2024-08-07 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structure and topography of the synaptic V-ATPase-synaptophysin complex.
Nature, 631, 2024
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