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PDB: 32 件

1QMZ
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PHOSPHORYLATED CDK2-CYCLYIN A-SUBSTRATE PEPTIDE COMPLEX
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION PROTEIN KINASE 2, G2/MITOTIC-SPECIFIC CYCLIN A, ...
著者Brown, N.R, Noble, M.E.M, Endicott, J.A, Johnson, L.N.
登録日1999-10-11
公開日1999-12-14
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The Structural Basis for Specificity of Substrate and Recruitment Peptides for Cyclin-Dependent Kinases
Nat.Cell Biol., 1, 1999
4Y72
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Human CDK1/CyclinB1/CKS2 With Inhibitor
分子名称: Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, G2/mitotic-specific cyclin-B1, ...
著者Brown, N.R, Korolchuk, S, Martin, M.P, Stanley, W, Moukhametzianov, R, Noble, M.E.M, Endicott, J.A.
登録日2015-02-13
公開日2015-08-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
4YC3
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CDK1/CyclinB1/CKS2 Apo
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, ...
著者Brown, N.R, Korolchuk, S, Martin, M.P, Stanley, W, Moukhametzianov, R, Noble, M.E.M, Endicott, J.A.
登録日2015-02-19
公開日2016-04-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
4YC6
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CDK1/CKS1
分子名称: Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 1
著者Brown, N.R, Korolchuk, S, Martin, M.P, Stanley, W, Moukhametzianov, R, Noble, M.E.M, Endicott, J.A.
登録日2015-02-19
公開日2015-05-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
2JGZ
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Crystal structure of phospho-CDK2 in complex with Cyclin B
分子名称: CELL DIVISION PROTEIN KINASE 2, G2/MITOTIC-SPECIFIC CYCLIN-B1
著者Brown, N.R, Petri, E, Lowe, E.D, Skamnaki, V, Johnson, L.N.
登録日2007-02-17
公開日2007-05-22
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Cyclin B and cyclin A confer different substrate recognition properties on CDK2.
Cell Cycle, 6, 2007
1B39
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HUMAN CYCLIN-DEPENDENT KINASE 2 PHOSPHORYLATED ON THR 160
分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PROTEIN (CELL DIVISION PROTEIN KINASE 2)
著者Brown, N.R, Noble, M.E.M, Lawrie, A.M, Morris, M.C, Tunnah, P, Divita, G, Johnson, L.N, Endicott, J.A.
登録日1998-12-17
公開日1998-12-23
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity.
J.Biol.Chem., 274, 1999
1B38
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HUMAN CYCLIN-DEPENDENT KINASE 2
分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PROTEIN (CELL DIVISION PROTEIN KINASE 2)
著者Brown, N.R, Noble, M.E.M, Lawrie, A.M, Morris, M.C, Tunnah, P, Divita, G, Johnson, L.N, Endicott, J.A.
登録日1998-12-17
公開日1998-12-23
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity.
J.Biol.Chem., 274, 1999
1H25
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CDK2/Cyclin A in complex with an 11-residue recruitment peptide from retinoblastoma-associated protein
分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, RETINOBLASTOMA-ASSOCIATED PROTEIN
著者Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N.
登録日2002-07-31
公開日2003-02-01
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H24
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CDK2/CyclinA in complex with a 9 residue recruitment peptide from E2F
分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, TRANSCRIPTION FACTOR E2F1
著者Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N.
登録日2002-07-31
公開日2003-02-01
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H28
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CDK2/CyclinA in complex with an 11-residue recruitment peptide from p107
分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, RETINOBLASTOMA-LIKE PROTEIN 1
著者Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N.
登録日2002-07-31
公開日2003-02-01
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
3M3J
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A new crystal form of Lys48-linked diubiquitin
分子名称: 1,2-ETHANEDIOL, SULFATE ION, Ubiquitin
著者Trempe, J.F, Brown, N.R, Noble, M.E.M, Endicott, J.A.
登録日2010-03-09
公開日2010-03-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献A new crystal form of Lys48-linked diubiquitin.
Acta Crystallogr.,Sect.F, 66, 2010
1VIN
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BOVINE CYCLIN A3
分子名称: CYCLIN A
著者Noble, M.E.M, Endicott, J.A.E, Brown, N.R.
登録日1996-03-15
公開日1996-08-17
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of cyclin A.
Structure, 3, 1995
1PKD
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THE CRYSTAL STRUCTURE OF UCN-01 IN COMPLEX WITH PHOSPHO-CDK2/CYCLIN A
分子名称: 7-HYDROXYSTAUROSPORINE, Cell division protein kinase 2, Cyclin A2
著者Johnson, L.N, De Moliner, E, Brown, N.R, Song, H.
登録日2003-06-05
公開日2003-06-24
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The Crystal Structure of UCN-01 in Complex with Phospho-CDK2/Cyclin A
To be Published
1Z96
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Crystal structure of the Mud1 UBA domain
分子名称: UBA-domain protein mud1
著者Trempe, J.-F, Brown, N.R, Lowe, E.D, Noble, M.E.M, Gordon, C, Campbell, I.D, Johnson, L.N, Endicott, J.A.
登録日2005-03-31
公開日2005-10-04
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain
Embo J., 24, 2005
2X5N
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Crystal Structure of the SpRpn10 VWA domain
分子名称: 26S PROTEASOME REGULATORY SUBUNIT RPN10, SULFATE ION
著者Riedinger, C, Boehringer, J, Trempe, J.-F, Lowe, E.D, Brown, N.R, Gehring, K, Noble, M.E.M, Gordon, C, Endicott, J.A.
登録日2010-02-10
公開日2010-08-25
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献The Structure of Rpn10 and its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12.
J.Biol.Chem., 285, 2010
1P5E
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The structure of phospho-CDK2/cyclin A in complex with the inhibitor 4,5,6,7-tetrabromobenzotriazole (TBS)
分子名称: 4,5,6,7-TETRABROMOBENZOTRIAZOLE, Cell division protein kinase 2, Cyclin A2
著者De Moliner, E, Brown, N.R, Johnson, L.N.
登録日2003-04-26
公開日2003-07-01
最終更新日2016-12-21
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Alternative binding modes of an inhibitor to two different kinases
Eur.J.Biochem., 270, 2003
1UA2
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Crystal Structure of Human CDK7
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cell division protein kinase 7
著者Lolli, G, Lowe, E.D, Brown, N.R, Johnson, L.N.
登録日2004-08-11
公開日2004-12-07
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.02 Å)
主引用文献The Crystal Structure of Human CDK7 and Its Protein Recognition Properties
Structure, 12, 2004
1H26
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CDK2/CyclinA in complex with an 11-residue recruitment peptide from p53
分子名称: CELL DIVISION PROTEIN KINASE 2, CELLULAR TUMOR ANTIGEN P53, CYCLIN A2
著者Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N.
登録日2002-07-31
公開日2003-02-01
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H27
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CDK2/CyclinA in complex with an 11-residue recruitment peptide from p27
分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, CYCLIN-DEPENDENT KINASE INHIBITOR 1B
著者Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N.
登録日2002-07-31
公開日2003-02-01
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
2BWB
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Crystal structure of the UBA domain of Dsk2 from S. cerevisiae
分子名称: UBIQUITIN-LIKE PROTEIN DSK2
著者Lowe, E.D, Hasan, N, Trempe, J.-F, Fonso, L, Noble, M.E.M, Endicott, J.A, Johnson, L.N, Brown, N.R.
登録日2005-07-13
公開日2006-01-25
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structures of the Dsk2 Ubl and Uba Domains and Their Complex.
Acta Crystallogr.,Sect.D, 62, 2006
2BWF
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Crystal structure of the UBL domain of Dsk2 from S. cerevisiae
分子名称: FORMIC ACID, UBIQUITIN-LIKE PROTEIN DSK2
著者Lowe, E.D, Hasan, N, Trempe, J.-F, Fonso, L, Noble, M.E.M, Endicott, J.A, Johnson, L.N, Brown, N.R.
登録日2005-07-13
公開日2006-01-25
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Structures of the Dsk2 Ubl and Uba Domains and Their Complex.
Acta Crystallogr.,Sect.D, 62, 2006
2BWE
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The crystal structure of the complex between the UBA and UBL domains of Dsk2
分子名称: DSK2
著者Lowe, E.D, Hasan, N, Trempe, J.-F, Fonso, L, Noble, M.E.M, Endicott, J.A, Johnson, L.N, Brown, N.R.
登録日2005-07-13
公開日2006-01-25
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structures of the Dsk2 Ubl and Uba Domains and Their Complex.
Acta Crystallogr.,Sect.D, 62, 2006
5HQ0
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Ternary complex of human proteins CDK1, Cyclin B and CKS2, bound to an inhibitor
分子名称: Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, G2/mitotic-specific cyclin-B1, ...
著者Noble, M.E, Martin, M.P, Korolchuk, S, Brown, N.R, Moukhametzianov, R, Stanley, W.A.
登録日2016-01-21
公開日2016-03-02
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
2CCI
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Crystal structure of phospho-CDK2 Cyclin A in complex with a peptide containing both the substrate and recruitment sites of CDC6
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6 homolog, Cyclin-A2, ...
著者Cheng, K.Y, Noble, M.E.M, Skamnaki, V, Brown, N.R, Lowe, E.D, Kontogiannis, L, Shen, K, Cole, P.A, Siligardi, G, Johnson, L.N.
登録日2006-01-16
公開日2006-05-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition.
J. Biol. Chem., 281, 2006
2CCH
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The crystal structure of CDK2 cyclin A in complex with a substrate peptide derived from CDC modified with a gamma-linked ATP analogue
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION CONTROL PROTEIN 6 HOMOLOG, CELL DIVISION PROTEIN KINASE 2, ...
著者Cheng, K.Y, Noble, M.E.M, Skamnaki, V, Brown, N.R, Lowe, E.D, Kontogiannis, L, Shen, K, Cole, P.A, Siligardi, G, Johnson, L.N.
登録日2006-01-16
公開日2006-05-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The Role of the Phospho-Cdk2/Cyclin a Recruitment Site in Substrate Recognition
J.Biol.Chem., 281, 2006

 

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