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PDB: 13 件
6PXF
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BU of 6pxf by Molmil
Structure of human Cathepsin K with an ectosteric inhibitor at 1.85 Angstrom resolution
分子名称: 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-2-sulfonic acid, Cathepsin K
著者Law, S, Aguda, A.H, Nguyen, N.T, Brayer, G.D, Bromme, D.
登録日2019-07-25
公開日2020-07-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure of human Cathepsin K with an ectosteric inhibitor at 1.85 Angstrom resolution
To Be Published
3H7D
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BU of 3h7d by Molmil
The crystal structure of the cathepsin K Variant M5 in complex with chondroitin-4-sulfate
分子名称: 2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid, CALCIUM ION, Cathepsin K, ...
著者Cherney, M.M, Kienetz, M, Bromme, D, James, M.N.G.
登録日2009-04-24
公開日2010-04-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.242 Å)
主引用文献Structure-activity analysis of cathepsin K/chondroitin 4-sulfate interactions.
J.Biol.Chem., 286, 2011
3C9E
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BU of 3c9e by Molmil
Crystal structure of the cathepsin K : chondroitin sulfate complex.
分子名称: 2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid, CALCIUM ION, Cathepsin K, ...
著者Kienetz, M, Cherney, M.M, James, M.N.G, Bromme, D.
登録日2008-02-15
公開日2008-08-26
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The crystal and molecular structures of a cathepsin K:chondroitin sulfate complex.
J.Mol.Biol., 383, 2008
4YV8
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BU of 4yv8 by Molmil
Crystal structure of cathepsin K bound to the covalent inhibitor lichostatinal
分子名称: Cathepsin K, Lichostatinal, SULFATE ION
著者Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D.
登録日2015-03-19
公開日2016-05-04
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts.
J.Nat.Prod., 79, 2016
4YVA
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BU of 4yva by Molmil
Cathepsin K co-crystallized with actinomycetes extract
分子名称: Cathepsin K, SULFATE ION
著者Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D.
登録日2015-03-19
公開日2016-05-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts.
J.Nat.Prod., 79, 2016
2ATO
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BU of 2ato by Molmil
Crystal structure of Human Cathepsin K in complex with myocrisin
分子名称: (S)-(1,2-DICARBOXYETHYLTHIO)GOLD, Cathepsin K, SULFATE ION
著者Weidauer, E, Yasuda, Y, Biswal, B.K, Kerr, L.D, Cherney, M.M, Gordon, R.E, James, M.N.G, Bromme, D.
登録日2005-08-25
公開日2006-08-29
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Effects of disease-modifying anti-rheumatic drugs (DMARDs) on the activities of rheumatoid arthritis-associated cathepsins K and S.
Biol.Chem., 388, 2007
4N8W
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BU of 4n8w by Molmil
cathepsin K - chondroitin sulfate complex
分子名称: 2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid, Cathepsin K
著者Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D.
登録日2013-10-18
公開日2014-11-26
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Structural basis of collagen fiber degradation by cathepsin K.
Proc.Natl.Acad.Sci.USA, 111, 2014
6ASH
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BU of 6ash by Molmil
Crystal structure of human Cathepsin K with a non-active site inhibitor at 1.42 Angstrom resolution
分子名称: 2-{[(carbamoylsulfanyl)acetyl]amino}benzoic acid, Cathepsin K
著者Law, S, Aguda, A, Nguyen, N, Brayer, G, Bromme, D.
登録日2017-08-24
公開日2018-08-29
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.423 Å)
主引用文献Crystal structure of human Cathepsin K with a non-active site inhibitor at 1.42 Angstrom resolution.
To Be Published
6BKI
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Crystal structure of T101A variant mouse cathepsin K at 2.94 Angstrom resolution.
分子名称: Cathepsin K, SULFATE ION
著者Law, S, Aguda, A, Brayer, G, Bromme, D.
登録日2017-11-08
公開日2018-11-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.94 Å)
主引用文献Crystal structure of T101A variant mouse cathepsin K at 2.94 Angstrom resolution.
To Be Published
4N79
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BU of 4n79 by Molmil
Structure of Cathepsin K-dermatan sulfate complex
分子名称: Cathepsin K, alpha-L-idopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-alpha-L-idopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-alpha-L-idopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose
著者Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D.
登録日2013-10-15
公開日2014-11-26
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献Structural basis of collagen fiber degradation by cathepsin K.
Proc.Natl.Acad.Sci.USA, 111, 2014
5T6U
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BU of 5t6u by Molmil
Crystal structure of mouse cathepsin K at 2.9 Angstroms resolution.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cathepsin K, SULFATE ION
著者Law, S, Aguda, A, Nguyen, N, Brayer, G, Bromme, D.
登録日2016-09-01
公開日2017-01-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Identification of mouse cathepsin K structural elements that regulate the potency of odanacatib.
Biochem. J., 474, 2017
5TDI
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BU of 5tdi by Molmil
Crystal structure of Cathepsin K with a covalently-linked inhibitor at 1.4 Angstrom resolution.
分子名称: 4-fluoro-N-{1-[(Z)-iminomethyl]cyclopropyl}-N~2~-{(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl }-L-leucinamide, Cathepsin K
著者Law, S, Aguda, A, Nguyen, N, Brayer, G, Bromme, D.
登録日2016-09-19
公開日2017-01-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Identification of mouse cathepsin K structural elements that regulate the potency of odanacatib.
Biochem. J., 474, 2017
5TUN
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BU of 5tun by Molmil
Crystal structure of uninhibited human Cathepsin K at 1.62 Angstrom resolution
分子名称: Cathepsin K
著者Aguda, A.H, Kruglyak, N, Nguyen, N.T, Law, S, Bromme, D, Brayer, G.D.
登録日2016-11-06
公開日2017-01-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Identification of mouse cathepsin K structural elements that regulate the potency of odanacatib.
Biochem. J., 474, 2017

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