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PDB: 53 件
6PIS
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Mouse two pore domain K+ channel TRAAK (K2P4.1) - Fab complex structure
分子名称: ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, POTASSIUM ION, ...
著者Brohawn, S.G.
登録日2019-06-27
公開日2019-12-25
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.77 Å)
主引用文献The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier.
Elife, 8, 2019
4I9W
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Human two pore domain K+ channel TRAAK (K2P4.1) - Fab complex structure
分子名称: ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
著者Brohawn, S.G, Mackinnon, R.
登録日2012-12-05
公開日2013-01-23
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel.
Proc.Natl.Acad.Sci.USA, 110, 2013
3UM7
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Crystal structure of the human two pore domain K+ ion channel TRAAK (K2P4.1)
分子名称: POTASSIUM ION, Potassium channel subfamily K member 4
著者Brohawn, S.G, MacKinnon, R.
登録日2011-11-12
公開日2012-02-08
実験手法X-RAY DIFFRACTION (3.31 Å)
主引用文献Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel.
Science, 335, 2012
3JRP
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SEC13 with NUP145C (AA109-179) insertion blade
分子名称: FUSION PROTEIN OF PROTEIN TRANSPORT PROTEIN SEC13 AND NUCLEOPORIN NUP145
著者Brohawn, S.G, Gogola, M, Schwartz, T.U.
登録日2009-09-08
公開日2009-10-27
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Molecular architecture of the Nup84-Nup145C-Sec13 edge element in the nuclear pore complex lattice.
Nat.Struct.Mol.Biol., 16, 2009
3JRO
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BU of 3jro by Molmil
NUP84-NUP145C-SEC13 edge element of the NPC lattice
分子名称: Fusion Protein of Protein Transport Protein SEC13 and Nucleoporin NUP145, Nucleoporin NUP84
著者Brohawn, S.G, Schwartz, T.U.
登録日2009-09-08
公開日2009-10-27
最終更新日2017-08-02
実験手法X-RAY DIFFRACTION (4.004 Å)
主引用文献Molecular architecture of the Nup84-Nup145C-Sec13 edge element in the nuclear pore complex lattice.
Nat.Struct.Mol.Biol., 16, 2009
4WFG
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BU of 4wfg by Molmil
Human TRAAK K+ channel in a Tl+ bound conductive conformation
分子名称: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
著者Brohawn, S.G, MacKinnon, R.
登録日2014-09-15
公開日2014-12-03
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
4WFH
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Human TRAAK K+ channel in a Tl+ bound nonconductive conformation
分子名称: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
著者Brohawn, S.G, MacKinnon, R.
登録日2014-09-15
公開日2014-12-03
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
4WFE
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Human TRAAK K+ channel in a K+ bound conductive conformation
分子名称: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
著者Brohawn, S.G, MacKinnon, R.
登録日2014-09-15
公開日2014-12-03
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
4WFF
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Human TRAAK K+ channel in a K+ bound nonconductive conformation
分子名称: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
著者Brohawn, S.G, MacKinnon, R.
登録日2014-09-15
公開日2014-12-03
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
3EWE
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BU of 3ewe by Molmil
Crystal Structure of the Nup85/Seh1 Complex
分子名称: Nucleoporin NUP85, Nucleoporin SEH1
著者Brohawn, S.G, Leksa, N.C, Rajashankar, K.R, Schwartz, T.U.
登録日2008-10-14
公開日2008-11-11
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structural evidence for common ancestry of the nuclear pore complex and vesicle coats.
Science, 322, 2008
8CTJ
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BU of 8ctj by Molmil
Cryo-EM structure of TMEM87A
分子名称: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Transmembrane protein 87A
著者Hoel, C.M, Zhang, L, Brohawn, S.G.
登録日2022-05-15
公開日2022-07-20
最終更新日2022-11-30
実験手法ELECTRON MICROSCOPY (4.74 Å)
主引用文献Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A.
Elife, 11, 2022
8CTK
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Cryo-EM structure of SARS-CoV-2 M protein in a lipid nanodisc
分子名称: Membrane protein
著者Dolan, K.A, Brohawn, S.G.
登録日2022-05-15
公開日2022-06-22
最終更新日2022-11-02
実験手法ELECTRON MICROSCOPY (3.52 Å)
主引用文献Structure of SARS-CoV-2 M protein in lipid nanodiscs.
Elife, 11, 2022
6XDC
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BU of 6xdc by Molmil
Cryo-EM structure of SARS-CoV-2 ORF3a
分子名称: ORF3a protein
著者Kern, D.M, Hoel, C.M, Brohawn, S.G.
登録日2020-06-10
公開日2020-06-17
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs.
Nat.Struct.Mol.Biol., 28, 2021
7KJR
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BU of 7kjr by Molmil
Cryo-EM structure of SARS-CoV-2 ORF3a
分子名称: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Apolipoprotein A-I, ORF3a protein
著者Kern, D.M, Hoel, C.M, Kotecha, A, Brohawn, S.G.
登録日2020-10-26
公開日2020-11-18
最終更新日2022-08-31
実験手法ELECTRON MICROSCOPY (2.08 Å)
主引用文献Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs.
Nat.Struct.Mol.Biol., 28, 2021
6WLV
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BU of 6wlv by Molmil
TASK2 in MSP1D1 lipid nanodisc at pH 6.5
分子名称: POTASSIUM ION, Potassium channel TASK2
著者Li, B, Brohawn, S.G.
登録日2020-04-20
公開日2020-07-15
最終更新日2020-10-28
実験手法ELECTRON MICROSCOPY (3.45 Å)
主引用文献Structural basis for pH gating of the two-pore domain K + channel TASK2.
Nature, 586, 2020
6WM0
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TASK2 in MSP1D1 lipid nanodisc at pH 8.5
分子名称: POTASSIUM ION, Potassium channel TASK2
著者Li, B, Brohawn, S.G.
登録日2020-04-20
公開日2020-07-15
最終更新日2020-10-28
実験手法ELECTRON MICROSCOPY (3.52 Å)
主引用文献Structural basis for pH gating of the two-pore domain K + channel TASK2.
Nature, 586, 2020
6UKN
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BU of 6ukn by Molmil
Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs
分子名称: CHLORIDE ION, POTASSIUM ION, Solute carrier family 12 member 7, ...
著者Reid, M.S, Kern, D.M, Brohawn, S.G.
登録日2019-10-05
公開日2020-06-10
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.65 Å)
主引用文献Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs.
Elife, 9, 2020
7KFU
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BU of 7kfu by Molmil
Cas6-RT-Cas1--Cas2 complex
分子名称: Cas2, Cas6-RT-Cas1
著者Hoel, C.M, Wang, J.Y, Doudna, J.A, Brohawn, S.G.
登録日2020-10-14
公開日2021-03-31
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural coordination between active sites of a CRISPR reverse transcriptase-integrase complex.
Nat Commun, 12, 2021
7KFT
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BU of 7kft by Molmil
Partial Cas6-RT-Cas1--Cas2 complex
分子名称: Cas2, Cas6-RT-Cas1
著者Hoel, C.M, Wang, J.Y, Doudna, J.A, Brohawn, S.G.
登録日2020-10-14
公開日2021-03-31
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural coordination between active sites of a CRISPR reverse transcriptase-integrase complex.
Nat Commun, 12, 2021
7SK1
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BU of 7sk1 by Molmil
TWIK1 in MSP1E3D1 Lipid Nanodisc at pH 5.5
分子名称: N-OCTANE, POTASSIUM ION, Potassium channel subfamily K member 1, ...
著者Turney, T.S, Brohawn, S.G.
登録日2021-10-19
公開日2021-11-24
最終更新日2022-06-22
実験手法ELECTRON MICROSCOPY (3.43 Å)
主引用文献Structural Basis for pH-gating of the K + channel TWIK1 at the selectivity filter.
Nat Commun, 13, 2022
7SK0
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TWIK1 in MSP1D1 lipid nanodisc at pH 7.4
分子名称: N-OCTANE, POTASSIUM ION, Potassium channel subfamily K member 1
著者Turney, T.S, Brohawn, S.G.
登録日2021-10-19
公開日2021-11-24
最終更新日2022-06-22
実験手法ELECTRON MICROSCOPY (3.33 Å)
主引用文献Structural Basis for pH-gating of the K + channel TWIK1 at the selectivity filter.
Nat Commun, 13, 2022
3HXR
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BU of 3hxr by Molmil
Nucleoporin Nup120 from S.cerevisiae (aa 1-757)
分子名称: Nucleoporin NUP120
著者Leksa, N.C, Brohawn, S.G, Schwartz, T.U.
登録日2009-06-21
公開日2009-07-28
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The structure of the scaffold nucleoporin Nup120 reveals a new and unexpected domain architecture.
Structure, 17, 2009
7M17
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SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-1)
分子名称: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 7-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}heptanoic acid, Volume-regulated anion channel subunit LRRC8A
著者Kern, D.M, Gerber, E.E, Brohawn, S.G.
登録日2021-03-12
公開日2021-03-24
最終更新日2022-02-23
実験手法ELECTRON MICROSCOPY (3.65 Å)
主引用文献Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes.
Nat Commun, 13, 2022
7M19
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SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-2)
分子名称: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 7-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}heptanoic acid, Volume-regulated anion channel subunit LRRC8A
著者Kern, D.M, Gerber, E.E, Brohawn, S.G.
登録日2021-03-12
公開日2021-03-24
最終更新日2022-02-23
実験手法ELECTRON MICROSCOPY (3.69 Å)
主引用文献Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes.
Nat Commun, 13, 2022
7LJB
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Human TRAAK K+ channel mutant G158D in a K+ bound conductive conformation
分子名称: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
著者Rietmeijer, R.A, Brohawn, S.G.
登録日2021-01-28
公開日2021-06-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.97 Å)
主引用文献Physical basis for distinct basal and mechanically gated activity of the human K + channel TRAAK.
Neuron, 109, 2021

 

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