4Z5C
 
 | | HipB-O3 21mer complex | | 分子名称: | Antitoxin HipB, DNA (5'-D(*TP*TP*TP*AP*TP*CP*CP*CP*GP*TP*AP*GP*AP*GP*CP*GP*GP*AP*TP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*AP*TP*CP*CP*GP*CP*TP*CP*TP*AP*CP*GP*GP*GP*AP*TP*A)-3') | | 著者 | Min, J, Brennan, R.G, Schumacher, M.A. | | 登録日 | 2015-04-02 | | 公開日 | 2016-07-06 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Molecular mechanism on hipBA gene regulation.
To be published
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2PUG
 | | CRYSTAL STRUCTURE OF THE LACI FAMILY MEMBER, PURR, BOUND TO DNA: MINOR GROOVE BINDING BY ALPHA HELICES | | 分子名称: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), HYPOXANTHINE, PROTEIN (PURINE REPRESSOR) | | 著者 | Lu, F, Schumacher, M.A, Arvidson, D.N, Haldimann, A, Wanner, B.L, Zalkin, H, Brennan, R.G. | | 登録日 | 1997-10-04 | | 公開日 | 1998-05-06 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structure-based redesign of corepressor specificity of the Escherichia coli purine repressor by substitution of residue 190.
Biochemistry, 37, 1998
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4Z59
 | | HipB-O4 20mer complex | | 分子名称: | Antitoxin HipB, DNA (5'-D(*TP*TP*AP*TP*CP*CP*GP*CP*GP*AP*TP*CP*GP*CP*GP*GP*AP*TP*AP*A)-3') | | 著者 | Min, J, Brennan, R.G, Schumacher, M.A. | | 登録日 | 2015-04-02 | | 公開日 | 2016-07-06 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Molecular mechanism on hipBA gene regulation.
To be published
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4Z5D
 | | HipB-O4 21mer complex | | 分子名称: | Antitoxin HipB, DNA (5'-D(*TP*TP*TP*AP*TP*CP*CP*GP*CP*GP*AP*TP*CP*GP*CP*GP*GP*AP*TP*A)-3'), DNA (5'-D(*TP*TP*TP*AP*TP*CP*CP*GP*CP*GP*AP*TP*CP*GP*CP*GP*GP*AP*TP*AP*A)-3') | | 著者 | Min, J, Brennan, R.G, Schumacher, M.A. | | 登録日 | 2015-04-02 | | 公開日 | 2016-07-06 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Molecular mechanism on hipBA gene regulation.
To be published
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4Z58
 | | HipB-O3 20mer complex | | 分子名称: | Antitoxin HipB, DNA (5'-D(*TP*TP*AP*TP*CP*CP*GP*CP*TP*CP*TP*AP*CP*GP*GP*GP*AP*TP*AP*A)-3') | | 著者 | Min, J, Brennan, R.G, Schumacher, M.A. | | 登録日 | 2015-04-02 | | 公開日 | 2016-07-06 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Molecular mechanism on hipBA gene regulation.
To be published
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2PUD
 | | CRYSTAL STRUCTURE OF THE LACI FAMILY MEMBER, PURR, BOUND TO DNA: MINOR GROOVE BINDING BY ALPHA HELICES | | 分子名称: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), HYPOXANTHINE, PROTEIN (PURINE REPRESSOR) | | 著者 | Schumacher, M.A, Choi, K.Y, Zalkin, H, Brennan, R.G. | | 登録日 | 1997-10-04 | | 公開日 | 1998-05-06 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices.
Science, 266, 1994
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2PUC
 | | CRYSTAL STRUCTURE OF THE LACI FAMILY MEMBER, PURR, BOUND TO DNA: MINOR GROOVE BINDING BY ALPHA HELICES | | 分子名称: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), GUANINE, PROTEIN (PURINE REPRESSOR) | | 著者 | Schumacher, M.A, Choi, K.Y, Zalkin, H, Brennan, R.G. | | 登録日 | 1997-10-04 | | 公開日 | 1998-05-06 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices.
Science, 266, 1994
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5HK0
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5HUU
 | | Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP and glucose-6-phosphate | | 分子名称: | 6-O-phosphono-alpha-D-glucopyranose, Alpha,alpha-trehalose-phosphate synthase [UDP-forming], URIDINE-5'-DIPHOSPHATE | | 著者 | Miao, Y, Brennan, R.G. | | 登録日 | 2016-01-27 | | 公開日 | 2017-05-03 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | | 主引用文献 | Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.
MBio, 8, 2017
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5HUS
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5HVM
 | | Structure of Aspergillus fumigatus trehalose-6-phosphate synthase A in complex with UDP and validoxylamine A | | 分子名称: | (1S,2S,3R,6S)-4-(HYDROXYMETHYL)-6-{[(1S,2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL]AMINO}CYCLOHEX-4-ENE-1,2,3-TRIOL, Alpha,alpha-trehalose-phosphate synthase (UDP-forming), URIDINE-5'-DIPHOSPHATE | | 著者 | Miao, Y, Brennan, R.G. | | 登録日 | 2016-01-28 | | 公開日 | 2017-05-03 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.815 Å) | | 主引用文献 | Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.
MBio, 8, 2017
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5HUT
 | | Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP-glucose | | 分子名称: | Alpha,alpha-trehalose-phosphate synthase [UDP-forming], PENTAETHYLENE GLYCOL, SODIUM ION, ... | | 著者 | Miao, Y, Brennan, R.G. | | 登録日 | 2016-01-27 | | 公開日 | 2017-05-03 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.
MBio, 8, 2017
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3D70
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3GIB
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1Z9C
 | | Crystal structure of OhrR bound to the ohrA promoter: Structure of MarR family protein with operator DNA | | 分子名称: | DNA (29-MER), Organic hydroperoxide resistance transcriptional regulator | | 著者 | Hong, M, Fuangthong, M, Helmann, J.D, Brennan, R.G. | | 登録日 | 2005-04-01 | | 公開日 | 2005-10-25 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | | 主引用文献 | Structure of an OhrR-ohrA Operator Complex Reveals the DNA Binding Mechanism of the MarR Family.
Mol.Cell, 20, 2005
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1Z91
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1ZVV
 | | Crystal structure of a ccpa-crh-dna complex | | 分子名称: | DNA recognition strand CRE, Glucose-resistance amylase regulator, HPr-like protein crh, ... | | 著者 | Schumacher, M.A, Brennan, R.G, Hillen, W, Seidel, G. | | 登録日 | 2005-06-02 | | 公開日 | 2006-02-07 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation.
J.Biol.Chem., 281, 2006
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1Z3E
 | | Crystal Structure of Spx in Complex with the C-terminal Domain of the RNA Polymerase Alpha Subunit | | 分子名称: | DNA-directed RNA polymerase alpha chain, Regulatory protein spx, SULFATE ION | | 著者 | Newberry, K.J, Nakano, S, Zuber, P, Brennan, R.G. | | 登録日 | 2005-03-11 | | 公開日 | 2005-10-11 | | 最終更新日 | 2017-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystal structure of the Bacillus subtilis anti-alpha, global transcriptional regulator, Spx, in complex with the {alpha} C-terminal domain of RNA polymerase
Proc.Natl.Acad.Sci.Usa, 102, 2005
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1ZAY
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2H1C
 | | Crystal Structure of FitAcB from Neisseria gonorrhoeae | | 分子名称: | ACETATE ION, MAGNESIUM ION, SULFATE ION, ... | | 著者 | Mattison, K, Wilbur, J.S, So, M, Brennan, R.G. | | 登録日 | 2006-05-16 | | 公開日 | 2006-09-26 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs.
J.Biol.Chem., 281, 2006
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2H1O
 | | Structure of FitAB bound to IR36 DNA fragment | | 分子名称: | IR36-strand 1, IR36-strand 2, Trafficking protein A, ... | | 著者 | Mattison, K, Wilbur, J.S, So, M, Brennan, R.G. | | 登録日 | 2006-05-16 | | 公開日 | 2006-09-26 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs.
J.Biol.Chem., 281, 2006
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3TPE
 | | The phipa p3121 structure | | 分子名称: | Serine/threonine-protein kinase HipA | | 著者 | Schumacher, M.A, Link, T, Brennan, R.G. | | 登録日 | 2011-09-07 | | 公開日 | 2012-10-03 | | 最終更新日 | 2018-03-07 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Role of Unusual P Loop Ejection and Autophosphorylation in HipA-Mediated Persistence and Multidrug Tolerance.
Cell Rep, 2, 2012
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2HQ5
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3TPD
 | | Structure of pHipA, monoclinic form | | 分子名称: | CHLORIDE ION, PHOSPHATE ION, Serine/threonine-protein kinase HipA | | 著者 | schumacher, M.A, link, T, Brennan, R.G. | | 登録日 | 2011-09-07 | | 公開日 | 2012-10-03 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Role of Unusual P Loop Ejection and Autophosphorylation in HipA-Mediated Persistence and Multidrug Tolerance.
Cell Rep, 2, 2012
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3T03
 | | Crystal structure of PPAR gamma ligand binding domain in complex with a novel partial agonist GQ-16 | | 分子名称: | (5Z)-5-(5-bromo-2-methoxybenzylidene)-3-(4-methylbenzyl)-1,3-thiazolidine-2,4-dione, Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor gamma | | 著者 | Rajagopalan, S, Webb, P, Baxter, J.D, Brennan, R.G, Phillips, K.J. | | 登録日 | 2011-07-19 | | 公開日 | 2012-05-23 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | GQ-16, a novel peroxisome proliferator-activated receptor (PPAR gamma) ligand, promotes insulin sensitization without weight gain.
J.Biol.Chem., 287, 2012
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